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Items: 1 to 50 of 136

1.

Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow.

Brunk E, Chang RL, Xia J, Hefzi H, Yurkovich JT, Kim D, Buckmiller E, Wang HH, Cho BK, Yang C, Palsson BO, Church GM, Lewis NE.

Proc Natl Acad Sci U S A. 2018 Oct 9. pii: 201811971. doi: 10.1073/pnas.1811971115. [Epub ahead of print]

PMID:
30301795
2.

ERβ targets ZAK and attenuates cellular hypertrophy via SUMO-1 modification in H9c2 cells.

Pai P, Shibu MA, Chang RL, Yang JJ, Su CC, Lai CH, Liao HE, Viswanadha VP, Kuo WW, Huang CY.

J Cell Biochem. 2018 Sep;119(9):7855-7864. doi: 10.1002/jcb.27199. Epub 2018 Jun 22.

PMID:
29932238
3.

A minireview of E4BP4/NFIL3 in heart failure.

Velmurugan BK, Chang RL, Marthandam Asokan S, Chang CF, Day CH, Lin YM, Lin YC, Kuo WW, Huang CY.

J Cell Physiol. 2018 Nov;233(11):8458-8466. doi: 10.1002/jcp.26790. Epub 2018 Jun 1. Review.

PMID:
29856483
4.

GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway.

Chen BC, Hung MY, Wang HF, Yeh LJ, Pandey S, Chen RJ, Chang RL, Viswanadha VP, Lin KH, Huang CY.

Environ Toxicol. 2018 Jul;33(7):789-797. doi: 10.1002/tox.22565. Epub 2018 Apr 30.

PMID:
29708300
5.

Platycodin D Reverses Pathological Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats.

Lin YC, Lin YC, Kuo WW, Shen CY, Cheng YC, Lin YM, Chang RL, Padma VV, Huang CY, Huang CY.

Am J Chin Med. 2018;46(3):537-549. doi: 10.1142/S0192415X18500271. Epub 2018 Mar 29.

PMID:
29595072
6.

Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts.

Feng CC, Pandey S, Lin CY, Shen CY, Chang RL, Chang TT, Chen RJ, Viswanadha VP, Lin YM, Huang CY.

Biomed Pharmacother. 2018 Jan;97:880-885. doi: 10.1016/j.biopha.2017.11.020. Epub 2017 Nov 7.

PMID:
29136764
7.

Short-term hypoxia upregulated Mas receptor expression to repress the AT1 R signaling pathway and attenuate Ang II-induced cardiomyocyte apoptosis.

Chang RL, Chang CF, Ju DT, Ho TJ, Chang TT, Lin JW, Li JC, Cheng SM, Day CH, Viswanadha VP, Huang CY.

J Cell Biochem. 2018 Mar;119(3):2742-2749. doi: 10.1002/jcb.26440. Epub 2017 Nov 24.

PMID:
29052864
8.

β-Catenin overexpression causes an increase in inflammatory cytokines and NF-κB activation in cardiomyocytes.

Lin JC, Chang RL, Chen YF, Yang JJ, Baskaran R, Chung LC, Chen RJ, Day CH, Vijaya Padma V, Huang CY.

Cell Mol Biol (Noisy-le-grand). 2016 Jan 30;63(1):17-22. doi: 10.14715/cmb/2017.63.1.4.

PMID:
28234620
9.

Systems level analysis of the Chlamydomonas reinhardtii metabolic network reveals variability in evolutionary co-conservation.

Chaiboonchoe A, Ghamsari L, Dohai B, Ng P, Khraiwesh B, Jaiswal A, Jijakli K, Koussa J, Nelson DR, Cai H, Yang X, Chang RL, Papin J, Yu H, Balaji S, Salehi-Ashtiani K.

Mol Biosyst. 2016 Jul 19;12(8):2394-407. doi: 10.1039/c6mb00237d.

PMID:
27357594
10.

Angiotensin-(1-7) attenuated long-term hypoxia-stimulated cardiomyocyte apoptosis by inhibiting HIF-1α nuclear translocation via Mas receptor regulation.

Chang RL, Lin JW, Kuo WW, Hsieh DJ, Yeh YL, Shen CY, Day CH, Ho TJ, Viswanadha VP, Huang CY.

Growth Factors. 2016 Feb;34(1-2):11-8. doi: 10.3109/08977194.2016.1155150. Epub 2016 Apr 8.

PMID:
27055565
11.

Systems biology of the structural proteome.

Brunk E, Mih N, Monk J, Zhang Z, O'Brien EJ, Bliven SE, Chen K, Chang RL, Bourne PE, Palsson BO.

BMC Syst Biol. 2016 Mar 11;10:26. doi: 10.1186/s12918-016-0271-6.

12.

Streptomyces thermoautotrophicus does not fix nitrogen.

MacKellar D, Lieber L, Norman JS, Bolger A, Tobin C, Murray JW, Oksaksin M, Chang RL, Ford TJ, Nguyen PQ, Woodward J, Permingeat HR, Joshi NS, Silver PA, Usadel B, Rutherford AW, Friesen ML, Prell J.

Sci Rep. 2016 Feb 1;6:20086. doi: 10.1038/srep20086.

13.

Orbital Infection With Intracranial Involvement.

Steele WJ 3rd, Chang RL, Lam S.

Pediatr Neurol. 2016 Jan;54:93-4. doi: 10.1016/j.pediatrneurol.2015.09.001. Epub 2015 Sep 11. No abstract available.

PMID:
26545858
14.

Do genome-scale models need exact solvers or clearer standards?

Ebrahim A, Almaas E, Bauer E, Bordbar A, Burgard AP, Chang RL, Dräger A, Famili I, Feist AM, Fleming RM, Fong SS, Hatzimanikatis V, Herrgård MJ, Holder A, Hucka M, Hyduke D, Jamshidi N, Lee SY, Le Novère N, Lerman JA, Lewis NE, Ma D, Mahadevan R, Maranas C, Nagarajan H, Navid A, Nielsen J, Nielsen LK, Nogales J, Noronha A, Pal C, Palsson BO, Papin JA, Patil KR, Price ND, Reed JL, Saunders M, Senger RS, Sonnenschein N, Sun Y, Thiele I.

Mol Syst Biol. 2015 Oct 14;11(10):831. doi: 10.15252/msb.20156157. No abstract available.

15.

Long-term hypoxia exposure enhanced IGFBP-3 protein synthesis and secretion resulting in cell apoptosis in H9c2 myocardial cells.

Chang RL, Lin JW, Hsieh DJ, Yeh YL, Shen CY, Day CH, Ho TJ, Viswanadha VP, Kuo WW, Huang CY.

Growth Factors. 2015;33(4):275-81. doi: 10.3109/08977194.2015.1077824. Epub 2015 Sep 4.

PMID:
26340107
16.

Transplantability of a circadian clock to a noncircadian organism.

Chen AH, Lubkowicz D, Yeong V, Chang RL, Silver PA.

Sci Adv. 2015;1(5). pii: e1500358.

17.

Antibacterial mechanisms identified through structural systems pharmacology.

Chang RL, Xie L, Bourne PE, Palsson BO.

BMC Syst Biol. 2013 Oct 10;7:102. doi: 10.1186/1752-0509-7-102.

18.

Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction.

O'Brien EJ, Lerman JA, Chang RL, Hyduke DR, Palsson BØ.

Mol Syst Biol. 2013 Oct 1;9:693. doi: 10.1038/msb.2013.52.

19.

Structural systems biology evaluation of metabolic thermotolerance in Escherichia coli.

Chang RL, Andrews K, Kim D, Li Z, Godzik A, Palsson BO.

Science. 2013 Jun 7;340(6137):1220-3. doi: 10.1126/science.1234012.

20.

Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene.

Chang RL, Wood AW, Huang MT, Xie JG, Cui XX, Reuhl KR, Boyd DR, Lin Y, Shih WJ, Balani SK, Yagi H, Jerina DM, Conney AH.

Carcinogenesis. 2013 Sep;34(9):2184-91. doi: 10.1093/carcin/bgt164. Epub 2013 May 13.

21.

Network context and selection in the evolution to enzyme specificity.

Nam H, Lewis NE, Lerman JA, Lee DH, Chang RL, Kim D, Palsson BO.

Science. 2012 Aug 31;337(6098):1101-4. doi: 10.1126/science.1216861.

22.

Electrical stimulation improves peripheral nerve regeneration in streptozotocin-induced diabetic rats.

Yao CH, Chang RL, Chang SL, Tsai CC, Tsai FJ, Chen YS.

J Trauma Acute Care Surg. 2012 Jan;72(1):199-205. doi: 10.1097/TA.0b013e31822d233c.

PMID:
22310128
23.

[Study on the chemical constituents of aerial part of Ligusticum jeholense].

Sun JM, Zhang B, Chang RL, Ye DD, Zhang H.

Zhong Yao Cai. 2011 Jul;34(7):1057-9. Chinese.

PMID:
22066398
24.

Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism.

Chang RL, Ghamsari L, Manichaikul A, Hom EF, Balaji S, Fu W, Shen Y, Hao T, Palsson BØ, Salehi-Ashtiani K, Papin JA.

Mol Syst Biol. 2011 Aug 2;7:518. doi: 10.1038/msb.2011.52.

25.
26.

Drug off-target effects predicted using structural analysis in the context of a metabolic network model.

Chang RL, Xie L, Xie L, Bourne PE, Palsson BØ.

PLoS Comput Biol. 2010 Sep 23;6(9):e1000938. doi: 10.1371/journal.pcbi.1000938.

27.

Quantification of intracellular proteins and monitoring therapy using flow cytometry.

Chang RL, Yeh CH, Albitar M.

Curr Drug Targets. 2010 Aug;11(8):994-9. Review.

PMID:
20426764
28.

Deterministic graph-theoretic algorithm for detecting modules in biological interaction networks.

Chang RL, Luo F, Johnson S, Scheuermann RH.

Int J Bioinform Res Appl. 2010;6(2):101-19.

PMID:
20223734
30.
31.

[Studies on the chemical constituents of the root and rhizoma of Ligusticum jeholense].

Zhang B, Sun JM, Chang RL, Zhang H.

Zhong Yao Cai. 2009 May;32(5):710-2. Chinese.

PMID:
19771843
32.

Metabolic network analysis integrated with transcript verification for sequenced genomes.

Manichaikul A, Ghamsari L, Hom EF, Lin C, Murray RR, Chang RL, Balaji S, Hao T, Shen Y, Chavali AK, Thiele I, Yang X, Fan C, Mello E, Hill DE, Vidal M, Salehi-Ashtiani K, Papin JA.

Nat Methods. 2009 Aug;6(8):589-92. doi: 10.1038/nmeth.1348. Epub 2009 Jul 13.

34.

Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice.

Zheng X, Chang RL, Cui XX, Avila GE, Hebbar V, Garzotto M, Shih WJ, Lin Y, Lu SE, Rabson AB, Kong AN, Conney AH.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3444-51.

35.

Enhancement of TPA-induced growth inhibition and apoptosis in myeloid leukemia cells by BAY 11-7082, an NF-kappaB inhibitor.

Hansson A, Marín YE, Suh J, Rabson AB, Chen S, Huberman E, Chang RL, Conney AH, Zheng X.

Int J Oncol. 2005 Oct;27(4):941-8.

PMID:
16142309
36.

Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice.

Avila GE, Zheng X, Cui XX, Ryan AD, Hansson A, Suh J, Rabson AB, Chang RL, Shih WJ, Lin Y, Crowell P, Lu YP, Lou YR, Conney AH.

J Pharmacol Exp Ther. 2005 Oct;315(1):170-87. Epub 2005 Jun 23.

37.

Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells.

Zheng X, Ryan A, Patel N, Klemons S, Hansson A, Shih WJ, Lin Y, Huberman E, Chang RL, Conney AH.

Int J Oncol. 2005 Feb;26(2):441-8.

PMID:
15645129
38.

Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans-retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice.

Zheng X, Chang RL, Cui XX, Avila GE, Lee S, Lu YP, Lou YR, Shih WJ, Lin Y, Reuhl K, Newmark H, Rabson A, Conney AH.

Cancer Res. 2004 Mar 1;64(5):1811-20.

39.
40.

Dose-dependent differences in the profile of mutations induced by carcinogenic (R,S,S,R) bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons.

Conney AH, Chang RL, Cui XX, Schiltz M, Yagi H, Jerina DM, Wei SJ.

Adv Exp Med Biol. 2001;500:697-707. Review.

PMID:
11765016
41.

Tumor necrosis factor alpha -238 and -308 polymorphisms do not associate with insulin resistance in hypertensive subjects.

Sheu WH, Lee WJ, Lin LY, Chang RL, Chen YT.

Metabolism. 2001 Dec;50(12):1447-51.

PMID:
11735091
42.
43.

Tumorigenicity of racemic and optically pure bay region diol epoxides and other derivatives of the nitrogen heterocycle dibenz[a,h]acridine on mouse skin.

Kumar S, Chang RL, Wood AW, Xie JG, Huang MT, Cui XX, Kole PL, Sikka HC, Balani SK, Conney AH, Jerina DM.

Carcinogenesis. 2001 Jun;22(6):951-5.

PMID:
11375904
44.
45.

Plasma tumor necrosis factor alpha levels and insulin sensitivity in hypertensive subjects.

Sheu WHH, Lee WJ, Chang RL, Chen YT.

Clin Exp Hypertens. 2000 Aug;22(6):595-606.

PMID:
10972164
46.
47.

Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene.

Wei SJ, Chang RL, Merkler KA, Gwynne M, Cui XX, Murthy B, Huang MT, Xie JG, Lu YP, Lou YR, Jerina DM, Conney AH.

Carcinogenesis. 1999 Sep;20(9):1689-96.

PMID:
10469612
48.
49.

12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs.

Han ZT, Tong YK, He LM, Zhang Y, Sun JZ, Wang TY, Zhang H, Cui YL, Newmark HL, Conney AH, Chang RL.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5362-5.

50.

Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity.

Han ZT, Zhu XX, Yang RY, Sun JZ, Tian GF, Liu XJ, Cao GS, Newmark HL, Conney AH, Chang RL.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5357-61.

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