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Sarcopenia Results in Poor Survival Rates in Oral Cavity Cancer Patients.

Lin SC, Lin YS, Kang BH, Yin CH, Chang KP, Chi CC, Lin MY, Su HH, Chang TS, She YY, Liu YH, Lee CC.

Clin Otolaryngol. 2019 Nov 26. doi: 10.1111/coa.13481. [Epub ahead of print]


Assessment of candidate biomarkers in paired saliva and plasma samples from oral cancer patients by targeted mass spectrometry.

Chi LM, Hsiao YC, Chien KY, Chen SF, Chuang YN, Lin SY, Wang WS, Chang IY, Yang C, Chu LJ, Chiang WF, Chien CY, Chang YS, Chang KP, Yu JS.

J Proteomics. 2020 Jan 16;211:103571. doi: 10.1016/j.jprot.2019.103571. Epub 2019 Nov 2.


Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy.

Hsieh JC, Wang HM, Wu MH, Chang KP, Chang PH, Liao CT, Liau CT.

Head Neck. 2019 Oct;41 Suppl 1:19-45. doi: 10.1002/hed.25932.


Precision Adjuvant Therapy Based on Detailed Pathological Risk Factors for Resected Oral Cavity Squamous Cell Carcinoma: Long Term Outcome Comparison of CGMH and NCCN Guidelines.

Lin CY, Fan KH, Lee LY, Hsueh C, Yang LY, Ng SH, Wang HM, Hsieh CH, Lin CH, Tsao CK, Kang CJ, Fang TJ, Lee LA, Huang SF, Chang KP, Yen TC, Tay ZY, Wen YW, Lee SR, Liao CT.

Int J Radiat Oncol Biol Phys. 2019 Sep 6. pii: S0360-3016(19)33747-2. doi: 10.1016/j.ijrobp.2019.08.058. [Epub ahead of print]


A combined analysis of maximum standardized uptake value on FDG-PET, genetic markers, and clinicopathological risk factors in the prognostic stratification of patients with resected oral cavity squamous cell carcinoma.

Liao CT, Hsieh CH, Fan WL, Ng SH, Cheng NM, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, Lin CH, Tsao CK, Kang CJ, Fang TJ, Huang SF, Chang KP, Lee LA, Fang KH, Wang YC, Yang LY, Yen TC.

Eur J Nucl Med Mol Imaging. 2020 Jan;47(1):84-93. doi: 10.1007/s00259-019-04453-x. Epub 2019 Aug 6.


Targeted sequencing of cancer-related genes in nasopharyngeal carcinoma identifies mutations in the TGF-β pathway.

Chung AK, OuYang CN, Liu H, Chao M, Luo JD, Lee CY, Lu YJ, Chung IC, Chen LC, Wu SM, Tsang NM, Chang KP, Hsu CL, Li HP, Chang YS.

Cancer Med. 2019 Sep;8(11):5116-5127. doi: 10.1002/cam4.2429. Epub 2019 Jul 22.


Proteomic Profiling of Paired Interstitial Fluids Reveals Dysregulated Pathways and Salivary NID1 as a Biomarker of Oral Cavity Squamous Cell Carcinoma.

Hsu CW, Chang KP, Huang Y, Liu HP, Hsueh PC, Gu PW, Yen WC, Wu CC.

Mol Cell Proteomics. 2019 Oct;18(10):1939-1949. doi: 10.1074/mcp.RA119.001654. Epub 2019 Jul 17.


Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness.

Wang CI, Kao HK, Chen TW, Huang Y, Cheng HW, Yi JS, Hung SY, Wu CS, Lee YS, Chang KP.

Oncologist. 2019 Dec;24(12):e1388-e1400. doi: 10.1634/theoncologist.2019-0063. Epub 2019 Jul 4.


Tumor Depth of Invasion (Tumor > 4 cm/Depth > 10 mm and Depth > 20 mm) and Through Cortex/Skin Invasion are Both Valid Criteria for Classifying Tumors as pT4a in AJCC 2018 Oral Cavity Cancer Staging System.

Liao CT, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, Hsieh CH, Ng SH, Lin CH, Tsao CK, Kang CJ, Fang TJ, Huang SF, Chang KP, Lee LA, Fang KH, Wang YC, Lin WN, Hsin LJ, Yang LY, Yen TC.

Ann Surg Oncol. 2019 Oct;26(11):3663-3672. doi: 10.1245/s10434-019-07576-5. Epub 2019 Jul 1.


Identification of Salivary Biomarkers for Oral Cancer Detection with Untargeted and Targeted Quantitative Proteomics Approaches.

Chu HW, Chang KP, Hsu CW, Chang IY, Liu HP, Chen YT, Wu CC.

Mol Cell Proteomics. 2019 Sep;18(9):1796-1806. doi: 10.1074/mcp.RA119.001530. Epub 2019 Jun 28.


In Response to A Nomogram to Predict Osteoradionecrosis in Oral Cancer After Marginal Mandibulectomy and Radiotherapy.

Tsai TY, Tay ZY, Chang KP, Huang YT.

Laryngoscope. 2019 Oct;129(10):E344. doi: 10.1002/lary.28092. Epub 2019 May 31. No abstract available.


Novel phthalocyanines activated by dim light for mosquito larva- and cell-inactivation with inference for their potential as broad-spectrum photodynamic insecticides.

Shiao SH, Weng SC, Luan L, Vicente MDGH, Jiang XJ, Ng DKP, Kolli BK, Chang KP.

PLoS One. 2019 May 29;14(5):e0217355. doi: 10.1371/journal.pone.0217355. eCollection 2019.


Free Flap Outcomes of Microvascular Reconstruction after Repeated Segmental Mandibulectomy in Head and Neck Cancer Patients.

Lin JA, Loh CYY, Tsai CH, Chang KP, Wu JC, Kao HK.

Sci Rep. 2019 May 28;9(1):7951. doi: 10.1038/s41598-019-44467-x.


[Transfection of Leishmania tropica with green fluorescent protein (gfp) gene and investigation of the in vitro drug effect].

Ertabaklar H, Çalışkan SÖ, Kolli B, Ertuğ S, Özbilgin A, Malatyalı E, Chang KP.

Mikrobiyol Bul. 2019 Apr;53(2):213-223. doi: 10.5578/mb.67473. Turkish.


Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in older patients with metastatic cancer.

Chen KH, Tsang NM, Chou WC, Tai SF, Liu SC, Lei KF, Chang KP, Chuang WC, Pai PC.

J Geriatr Oncol. 2019 Sep;10(5):757-762. doi: 10.1016/j.jgo.2019.04.015. Epub 2019 May 10.


Aesthetic single-stage vermilion reconstruction using facial artery musculomucosal flap and radial forearm free flap following cancer resection: A case report.

Hsieh WC, Tee R, Chang KP, Huang JJ.

Microsurgery. 2019 Apr 8. doi: 10.1002/micr.30456. [Epub ahead of print]


Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells.

Tsai CN, Tsai CL, Yi JS, Kao HK, Huang Y, Wang CI, Lee YS, Chang KP.

Sci Rep. 2019 Mar 26;9(1):5197. doi: 10.1038/s41598-019-41396-7.


Analysis of Hormone Receptor Status in Primary and Recurrent Breast Cancer Via Data Mining Pathology Reports.

Chang KP, Chu YW, Wang J.

Open Med (Wars). 2019 Feb 20;14:91-98. doi: 10.1515/med-2019-0013. eCollection 2019.


A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy.

Renda L, Tsai TY, Huang JJ, Ito R, Hsieh WC, Kao HK, Hung SY, Huang Y, Huang YC, Chang YL, Cheng MH, Chang KP.

Laryngoscope. 2020 Jan;130(1):101-107. doi: 10.1002/lary.27870. Epub 2019 Feb 20.


Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma.

Hsu CW, Chen YT, Hsieh YJ, Chang KP, Hsueh PC, Chen TW, Yu JS, Chang YS, Li L, Wu CC.

Anal Chim Acta. 2019 Mar 7;1050:113-122. doi: 10.1016/j.aca.2018.10.070. Epub 2018 Nov 2.


High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma.

Hsieh CE, Hung CY, Lin CY, Chen JS, Chang KP, Aithala SP, Lee LY, Tsang NM, Lu CH, Chen MF, Cheng YF, Yeh KY, Wang CH, Chou WC.

Head Neck. 2019 Jun;41(6):1572-1582. doi: 10.1002/hed.25603. Epub 2019 Jan 16.


Development and Validation of a Nomogram for Assessing Survival in Patients With Metastatic Lung Cancer Referred for Radiotherapy for Bone Metastases.

Yap WK, Shih MC, Kuo C, Pai PC, Chou WC, Chang KP, Tsai MH, Tsang NM.

JAMA Netw Open. 2018 Oct 5;1(6):e183242. doi: 10.1001/jamanetworkopen.2018.3242.


BRAF protein immunoprecipitation, elution, and digestion from cell extract using a microfluidic mixer for mutant BRAF protein quantification by mass spectrometry.

Lin YH, Chang HY, Wu CC, Wu CW, Chang KP, Yu JS.

Anal Bioanal Chem. 2019 Feb;411(5):1085-1094. doi: 10.1007/s00216-018-1536-2. Epub 2019 Jan 2.


Pathological risk factors stratification in pN3b oral cavity squamous cell carcinoma: Focus on the number of positive nodes and extranodal extension.

Liao CT, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, Hsieh CH, Ng SH, Lin CH, Tsao CK, Kang CJ, Fang TJ, Huang SF, Chang KP, Yang LY, Yen TC.

Oral Oncol. 2018 Nov;86:188-194. doi: 10.1016/j.oraloncology.2018.09.021. Epub 2018 Sep 28.


Low expression of pRB predicts disease relapse in early glottic cancer treated with transoral laser microsurgery.

Lee LA, Fang TJ, Li HY, Huang CG, Chen TC, Liao CT, Kang CJ, Chang KP, Yen TC.

Laryngoscope. 2019 Jun;129(6):E220-E226. doi: 10.1002/lary.27612. Epub 2018 Nov 1.


Log margin-to-thickness ratio improves disease-specific survival prediction in oral cancer: A single cancer centre database.

Huang CY, Lin YS, Kang BH, Chang KP, Chi CC, Lin MY, Su HH, Chang TS, Lee HP, Lee CC.

Clin Otolaryngol. 2019 Jan;44(1):63-69. doi: 10.1111/coa.13237. Epub 2018 Oct 25.


Value of early evaluation of treatment response using 18F-FDG PET/CT parameters and the Epstein-Barr virus DNA load for prediction of outcome in patients with primary nasopharyngeal carcinoma.

Chen YH, Chang KP, Chu SC, Yen TC, Wang LY, Chang JT, Hsu CL, Ng SH, Liu SH, Chan SC.

Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):650-660. doi: 10.1007/s00259-018-4172-3. Epub 2018 Sep 27.


Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma.

Hsu CL, Lui KW, Chi LM, Kuo YC, Chao YK, Yeh CN, Lee LY, Huang Y, Lin TL, Huang MY, Lai YR, Yeh YM, Fan HC, Lin AC, Lu YJ, Hsieh CH, Chang KP, Tsang NM, Wang HM, Chang AY, Chang YS, Li HP.

J Exp Clin Cancer Res. 2018 Sep 20;37(1):233. doi: 10.1186/s13046-018-0873-5.


Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma.

Kao HK, Löfstrand J, Loh CY, Lao WW, Yi JS, Chang YL, Chang KP.

Sci Rep. 2018 Aug 30;8(1):13081. doi: 10.1038/s41598-018-31498-z.


Clinical Implications of Tumor-Associated Tissue Eosinophilia in Tongue Squamous Cell Carcinoma.

De Paz D, Chang KP, Kao HK, Lao WW, Huang YC, Chang YL, Huang Y.

Laryngoscope. 2019 May;129(5):1123-1129. doi: 10.1002/lary.27413. Epub 2018 Aug 10.


Prevalence and demographic characteristics of comorbid epilepsy in children and adolescents with cerebral palsy: a nationwide population-based study.

Chiang KL, Kuo FC, Cheng CY, Chang KP.

Childs Nerv Syst. 2019 Jan;35(1):149-156. doi: 10.1007/s00381-018-3920-9. Epub 2018 Aug 3.


Perirenal soft tissue infiltration from immunoglobulin G4-related disease.

Chen PT, Chang KP, Liu KL.

CMAJ. 2018 Jul 3;190(26):E801. doi: 10.1503/cmaj.180264. No abstract available.


Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Lu IL, Chen C, Tung CY, Chen HH, Pan JP, Chang CH, Cheng JS, Chen YA, Wang CH, Huang CW, Kang YN, Chang HY, Li LL, Chang KP, Shih YH, Lin CH, Kwan SY, Tsai JW.

Nat Commun. 2018 Jun 27;9(1):2498. doi: 10.1038/s41467-018-04880-8.


Tobacco-Smoking, Alcohol-Drinking, and Betel-Quid-Chewing Behaviors: Development and Use of a Web-Based Survey System.

Hsu KY, Tsai YF, Huang CC, Yeh WL, Chang KP, Lin CC, Chen CY, Lee HL.

JMIR Mhealth Uhealth. 2018 Jun 11;6(6):e142. doi: 10.2196/mhealth.9783.


Prognostic significance of combined pretreatment lymphocyte counts and body mass index in patients with head and neck cancer treated with radiation therapy.

Wu YY, Chang KP, Lin CY, Pai PC, Wang HM, Hsu CL, Liao CT, Yen TC, Fang TJ, Huang SF, Kang CJ, Fang KH, Lin WN, Wang YC, Hsin LJ, Tsang NM.

Cancer Med. 2018 May 23. doi: 10.1002/cam4.1489. [Epub ahead of print]


Oral Microbiota Community Dynamics Associated With Oral Squamous Cell Carcinoma Staging.

Yang CY, Yeh YM, Yu HY, Chin CY, Hsu CW, Liu H, Huang PJ, Hu SN, Liao CT, Chang KP, Chang YL.

Front Microbiol. 2018 May 3;9:862. doi: 10.3389/fmicb.2018.00862. eCollection 2018.


Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma.

Li HP, Peng CC, Wu CC, Chen CH, Shih MJ, Huang MY, Lai YR, Chen YL, Chen TW, Tang P, Chang YS, Chang KP, Hsu CL.

J Exp Clin Cancer Res. 2018 May 10;37(1):102. doi: 10.1186/s13046-018-0754-y.


Caffeic Acid Phenethyl Ester Induces N-myc Downstream Regulated Gene 1 to Inhibit Cell Proliferation and Invasion of Human Nasopharyngeal Cancer Cells.

Chiang KC, Yang SW, Chang KP, Feng TH, Chang KS, Tsui KH, Shin YS, Chen CC, Chao M, Juang HH.

Int J Mol Sci. 2018 May 8;19(5). pii: E1397. doi: 10.3390/ijms19051397.


Vagus nerve stimulation for 6- to 12-year-old children with refractory epilepsy: Impact on seizure frequency and parenting stress index.

Fan HC, Hsu TR, Chang KP, Chen SJ, Tsai JD; VNS TCNS.

Epilepsy Behav. 2018 Jun;83:119-123. doi: 10.1016/j.yebeh.2017.12.009. Epub 2018 Apr 24.


Pretreatment subcutaneous adipose tissue predicts the outcomes of patients with head and neck cancer receiving definitive radiation and chemoradiation in Taiwan.

Pai PC, Chuang CC, Chuang WC, Tsang NM, Tseng CK, Chen KH, Yen TC, Lin CY, Chang KP, Lei KF.

Cancer Med. 2018 May;7(5):1630-1641. doi: 10.1002/cam4.1365. Epub 2018 Apr 2.


Hyperglycemia and risk of adverse outcomes following microvascular reconstruction of oncologic head and neck defects.

Offodile AC 2nd, Chou HY, Lin JA, Loh CYY, Chang KP, Aycart MA, Kao HK.

Oral Oncol. 2018 Apr;79:15-19. doi: 10.1016/j.oraloncology.2018.02.009. Epub 2018 Feb 14.


Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer.

Wang CI, Yu CJ, Huang Y, Yi JS, Cheng HW, Kao HK, Lao WW, Chang KP.

Head Neck. 2018 Aug;40(8):1719-1733. doi: 10.1002/hed.25145. Epub 2018 Mar 15.


Correction: Multiparametric imaging using 18F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy.

Chan SC, Cheng NM, Hsieh CH, Ng SH, Lin CY, Yen TC, Hsu CL, Wan HM, Liao CT, Chang KP, Wang JJ.

Oncotarget. 2018 Feb 9;9(11):10184. doi: 10.18632/oncotarget.24463. eCollection 2018 Feb 9.


Clinical utility of simultaneous whole-body 18F-FDG PET/MRI as a single-step imaging modality in the staging of primary nasopharyngeal carcinoma.

Chan SC, Yeh CH, Yen TC, Ng SH, Chang JT, Lin CY, Yen-Ming T, Fan KH, Huang BS, Hsu CL, Chang KP, Wang HM, Liao CT.

Eur J Nucl Med Mol Imaging. 2018 Jul;45(8):1297-1308. doi: 10.1007/s00259-018-3986-3. Epub 2018 Mar 3.


Photodynamic Vaccination of BALB/c Mice for Prophylaxis of Cutaneous Leishmaniasis Caused by Leishmania amazonensis.

Viana SM, Celes FS, Ramirez L, Kolli B, Ng DKP, Chang KP, de Oliveira CI.

Front Microbiol. 2018 Feb 6;9:165. doi: 10.3389/fmicb.2018.00165. eCollection 2018.


Cavernous sinus involvement is not a risk factor for the primary tumor site treatment outcome of Sinonasal adenoid cystic carcinoma.

Lee YC, Lee TJ, Tsang NM, Huang Y, Hsu CL, Hsin LJ, Lee YH, Chang KP.

J Otolaryngol Head Neck Surg. 2018 Feb 5;47(1):12. doi: 10.1186/s40463-018-0257-z.


Variability Assessment of 90 Salivary Proteins in Intraday and Interday Samples from Healthy Donors by Multiple Reaction Monitoring-Mass Spectrometry.

Hsiao YC, Chu LJ, Chen YT, Chi LM, Chien KY, Chiang WF, Chang YT, Chen SF, Wang WS, Chuang YN, Lin SY, Chien CY, Chang KP, Chang YS, Yu JS.

Proteomics Clin Appl. 2018 Mar;12(2). doi: 10.1002/prca.201700039. Epub 2018 Feb 7.


The Prediction Value of the Systemic Inflammation Score for Oral Cavity Squamous Cell Carcinoma.

Eltohami YI, Kao HK, Lao WW, Huang Y, Abdelrahman M, Liao CT, Yen TC, Chang KP.

Otolaryngol Head Neck Surg. 2018 Jun;158(6):1042-1050. doi: 10.1177/0194599817751678. Epub 2018 Jan 16.


Anterolateral Thigh Flap Combined with Reconstruction Plate Versus Double Free Flaps for Composite Mandibular Reconstruction: A Propensity Score-Matched Study.

Offodile AC 2nd, Lin JA, Chang KP, Abdelrahman M, Kou HW, Loh CYY, Aycart MA, Kao HK.

Ann Surg Oncol. 2018 Mar;25(3):829-836. doi: 10.1245/s10434-017-6309-1. Epub 2017 Dec 30.


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