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The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease.

Harris KG, Chang EB.

Clin Sci (Lond). 2018 Sep 18;132(18):2013-2028. doi: 10.1042/CS20171110. Print 2018 Sep 28. Review.


Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts.

Pierre JF, Hinterleitner R, Bouziat R, Hubert N, Leone V, Miyoshi J, Jabri B, Chang EB.

Data Brief. 2018 Aug 15;20:387-393. doi: 10.1016/j.dib.2018.08.026. eCollection 2018 Oct.


Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption.

Chang EB, Martinez-Guryn K.

Gut Microbes. 2018 Aug 23:1-6. doi: 10.1080/19490976.2018.1502539. [Epub ahead of print]


Considerations for Best Practices in Studies of Fiber or Other Dietary Components and the Intestinal Microbiome.

Klurfeld DM, Davis CD, Karp RW, Allen-Vercoe E, Chang EB, Chassaing B, Fahey GC, Hamaker BR, Holscher HD, Lampe JW, Marette A, Martens E, O'Keefe SJ, Rose DJ, Saarela M, Schneeman BO, Slavin JL, Sonnenburg JL, Swanson KS, Wu GD, Lynch CJ.

Am J Physiol Endocrinol Metab. 2018 Aug 21. doi: 10.1152/ajpendo.00058.2018. [Epub ahead of print]


Correction: Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues.

Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC.

Chem Sci. 2017 Nov 1;8(11):7879. doi: 10.1039/c7sc90066j. Epub 2017 Oct 12.


Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome.

Miyoshi J, Leone V, Nobutani K, Musch MW, Martinez-Guryn K, Wang Y, Miyoshi S, Bobe AM, Eren AM, Chang EB.

PeerJ. 2018 Jul 12;6:e5166. doi: 10.7717/peerj.5166. eCollection 2018.


Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.

Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri B.

Nature. 2018 May;557(7706):580-584. doi: 10.1038/s41586-018-0125-z. Epub 2018 May 16.


Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100).

Miyoshi J, Nobutani K, Musch MW, Ringus DL, Hubert NA, Yamamoto M, Kase Y, Nishiyama M, Chang EB.

Evid Based Complement Alternat Med. 2018 Feb 22;2018:7415975. doi: 10.1155/2018/7415975. eCollection 2018.


Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.

Martinez-Guryn K, Hubert N, Frazier K, Urlass S, Musch MW, Ojeda P, Pierre JF, Miyoshi J, Sontag TJ, Cham CM, Reardon CA, Leone V, Chang EB.

Cell Host Microbe. 2018 Apr 11;23(4):458-469.e5. doi: 10.1016/j.chom.2018.03.011.


Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues.

Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC.

Chem Sci. 2017 Nov 1;8(11):7588-7592. doi: 10.1039/c7sc02805a. Epub 2017 Sep 11. Erratum in: Chem Sci. 2017 Nov 1;8(11):7879.


Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.

Pierre JF, Hinterleitner R, Bouziat R, Hubert NA, Leone V, Miyoshi J, Jabri B, Chang EB.

J Nutr Biochem. 2018 Apr;54:95-104. doi: 10.1016/j.jnutbio.2017.12.002. Epub 2017 Dec 10.


Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes.

Cason CA, Dolan KT, Sharma G, Tao M, Kulkarni R, Helenowski IB, Doane BM, Avram MJ, McDermott MM, Chang EB, Ozaki CK, Ho KJ.

J Vasc Surg. 2017 Dec 13. pii: S0741-5214(17)32378-9. doi: 10.1016/j.jvs.2017.09.029. [Epub ahead of print]


Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2.

Rentea RM, Guo Y, Zhu X, Musch MW, Chang EB, Gourlay DM, Liedel JL.

Pediatr Surg Int. 2018 Mar;34(3):323-330. doi: 10.1007/s00383-017-4211-3. Epub 2017 Dec 1.


The Human Microbiome and Obesity: Moving beyond Associations.

Maruvada P, Leone V, Kaplan LM, Chang EB.

Cell Host Microbe. 2017 Nov 8;22(5):589-599. doi: 10.1016/j.chom.2017.10.005. Review.


Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.

Wang Y, Lin F, Zhu X, Leone VA, Dalal S, Tao Y, Messer JS, Chang EB.

Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G164-G178. doi: 10.1152/ajpgi.00208.2017. Epub 2017 Oct 19.


Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice.

Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS.

Clin Transl Oncol. 2018 Mar;20(3):425. doi: 10.1007/s12094-017-1766-3.


Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal.

Nobutani K, Miyoshi J, Musch MW, Nishiyama M, Watanabe J, Kaneko A, Yamamoto M, Yoshida M, Kono T, Jeong H, Chang EB.

Pharmacol Res Perspect. 2017 Oct;5(5). doi: 10.1002/prp2.361.


Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.

Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS.

Sci Rep. 2017 Sep 5;7(1):10411. doi: 10.1038/s41598-017-11047-w.


Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice.

Cho S, Tripathi A, Chlipala G, Green S, Lee H, Chang EB, Jeong H.

PLoS One. 2017 Aug 23;12(8):e0182977. doi: 10.1371/journal.pone.0182977. eCollection 2017.


Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected].

Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS.

Clin Transl Oncol. 2018 Mar;20(3):302-312. doi: 10.1007/s12094-017-1717-z. Epub 2017 Aug 14. Erratum in: Clin Transl Oncol. 2018 Mar;20(3):425.


Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions.

Raizada MK, Joe B, Bryan NS, Chang EB, Dewhirst FE, Borisy GG, Galis ZS, Henderson W, Jose PA, Ketchum CJ, Lampe JW, Pepine CJ, Pluznick JL, Raj D, Seals DR, Gioscia-Ryan RA, Tang WHW, Oh YS.

Hypertension. 2017 Jul 31. pii: HYPERTENSIONAHA.117.09699. doi: 10.1161/HYPERTENSIONAHA.117.09699. [Epub ahead of print] Review. No abstract available.


Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring.

Miyoshi J, Bobe AM, Miyoshi S, Huang Y, Hubert N, Delmont TO, Eren AM, Leone V, Chang EB.

Cell Rep. 2017 Jul 11;20(2):491-504. doi: 10.1016/j.celrep.2017.06.060.


A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade.

Chang EB, Rao MC.

Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G14-G15. doi: 10.1152/ajpgi.00166.2017. Epub 2017 May 25. No abstract available.


Microbial metabolites in health and disease: Navigating the unknown in search of function.

Martinez KB, Leone V, Chang EB.

J Biol Chem. 2017 May 26;292(21):8553-8559. doi: 10.1074/jbc.R116.752899. Epub 2017 Apr 7. Review.


Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.

Touw K, Ringus DL, Hubert N, Wang Y, Leone VA, Nadimpalli A, Theriault BR, Huang YE, Tune JD, Herring PB, Farrugia G, Kashyap PC, Antonopoulos DA, Chang EB.

Physiol Rep. 2017 Mar;5(6). pii: e13182. doi: 10.14814/phy2.13182.


Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis.

Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EB.

Inflamm Bowel Dis. 2017 Mar;23(3):366-378. doi: 10.1097/MIB.0000000000001027.


Evolutionary and ecological forces that shape the bacterial communities of the human gut.

Messer JS, Liechty ER, Vogel OA, Chang EB.

Mucosal Immunol. 2017 May;10(3):567-579. doi: 10.1038/mi.2016.138. Epub 2017 Feb 1. Review.


Western diets, gut dysbiosis, and metabolic diseases: Are they linked?

Martinez KB, Leone V, Chang EB.

Gut Microbes. 2017 Mar 4;8(2):130-142. doi: 10.1080/19490976.2016.1270811. Epub 2017 Jan 6. Review.


Patient-Specific Bacteroides Genome Variants in Pouchitis.

Vineis JH, Ringus DL, Morrison HG, Delmont TO, Dalal S, Raffals LH, Antonopoulos DA, Rubin DT, Eren AM, Chang EB, Sogin ML.

MBio. 2016 Nov 15;7(6). pii: e01713-16. doi: 10.1128/mBio.01713-16.


Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.

Corridoni D, Rodriguez-Palacios A, Di Stefano G, Di Martino L, Antonopoulos DA, Chang EB, Arseneau KO, Pizarro TT, Cominelli F.

Mucosal Immunol. 2017 Jul;10(4):971-982. doi: 10.1038/mi.2016.98. Epub 2016 Nov 16.


The Gut Microbiota: The Gateway to Improved Metabolism.

Martinez KB, Pierre JF, Chang EB.

Gastroenterol Clin North Am. 2016 Dec;45(4):601-614. doi: 10.1016/j.gtc.2016.07.001. Review.


Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.

Poroyko VA, Carreras A, Khalyfa A, Khalyfa AA, Leone V, Peris E, Almendros I, Gileles-Hillel A, Qiao Z, Hubert N, Farré R, Chang EB, Gozal D.

Sci Rep. 2016 Oct 14;6:35405. doi: 10.1038/srep35405.


Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer.

Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, Wang CZ, Yuan CS, Bissonnette M, Musch MW, Chang EB.

Phytother Res. 2017 Jan;31(1):90-99. doi: 10.1002/ptr.5735. Epub 2016 Oct 12.


Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota.

Wan JY, Wang CZ, Zhang QH, Liu Z, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS.

Biomed Chromatogr. 2017 Apr;31(4). doi: 10.1002/bmc.3851. Epub 2016 Oct 13.


Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.

Uchiyama K, Sakiyama T, Hasebe T, Musch MW, Miyoshi H, Nakagawa Y, He TC, Lichtenstein L, Naito Y, Itoh Y, Yoshikawa T, Jabri B, Stappenbeck T, Chang EB.

Sci Rep. 2016 Aug 26;6:32094. doi: 10.1038/srep32094.


Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.

Inaba Y, Ueno N, Numata M, Zhu X, Messer JS, Boone DL, Fujiya M, Kohgo Y, Musch MW, Chang EB.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G634-G647. doi: 10.1152/ajpgi.00092.2016. Epub 2016 Aug 11.


Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.

Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS.

Sci Rep. 2016 Jul 21;6:30028. doi: 10.1038/srep30028.


Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats.

Sato H, Zhang LS, Martinez K, Chang EB, Yang Q, Wang F, Howles PN, Hokari R, Miura S, Tso P.

Gastroenterology. 2016 Nov;151(5):923-932. doi: 10.1053/j.gastro.2016.07.009. Epub 2016 Jul 18.


Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.

Raffals LE, Chang EB.

Gut Liver. 2016 Jul 15;10(4):502-8. doi: 10.5009/gnl15491. Review.


The gut microbiota and inflammatory bowel diseases.

Miyoshi J, Chang EB.

Transl Res. 2017 Jan;179:38-48. doi: 10.1016/j.trsl.2016.06.002. Epub 2016 Jun 14. Review.


Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases.

Dolan KT, Chang EB.

Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201600129. Epub 2016 Aug 15. Review.


Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.

Pierre JF, Martinez KB, Ye H, Nadimpalli A, Morton TC, Yang J, Wang Q, Patno N, Chang EB, Yin DP.

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G286-304. doi: 10.1152/ajpgi.00202.2016. Epub 2016 Jun 23.


Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.

Tao Y, Messer JS, Goss KH, Hart J, Bissonnette M, Chang EB.

Carcinogenesis. 2016 Jul;37(7):731-739. doi: 10.1093/carcin/bgw056. Epub 2016 May 4.


Transplanting a Microbial Organ: the Good, the Bad, and the Unknown.

Antonopoulos DA, Chang EB.

MBio. 2016 May 3;7(3). pii: e00572-16. doi: 10.1128/mBio.00572-16.


Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.

Ward MA, Pierre JF, Leal RF, Huang Y, Shogan B, Dalal SR, Weber CR, Leone VA, Musch MW, An GC, Rao MC, Rubin DT, Raffals LE, Antonopoulos DA, Sogin ML, Hyman NH, Alverdy JC, Chang EB.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G973-88. doi: 10.1152/ajpgi.00017.2016. Epub 2016 Apr 14.


Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K.

Hasebe T, Ueno N, Musch MW, Nadimpalli A, Kaneko A, Kaifuchi N, Watanabe J, Yamamoto M, Kono T, Inaba Y, Fujiya M, Kohgo Y, Chang EB.

Pharmacol Res Perspect. 2016 Feb 10;4(1):e00215. doi: 10.1002/prp2.215. eCollection 2016 Feb.


Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

Wan JY, Wang CZ, Liu Z, Zhang QH, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:62-73. doi: 10.1016/j.jchromb.2016.02.008. Epub 2016 Feb 6.


Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.

Kamdar K, Khakpour S, Chen J, Leone V, Brulc J, Mangatu T, Antonopoulos DA, Chang EB, Kahn SA, Kirschner BS, Young G, DePaolo RW.

Cell Host Microbe. 2016 Jan 13;19(1):21-31. doi: 10.1016/j.chom.2015.12.006.


Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury.

Ho KJ, Xiong L, Hubert NA, Nadimpalli A, Wun K, Chang EB, Kibbe MR.

Physiol Rep. 2015 Dec;3(12). pii: e12627. doi: 10.14814/phy2.12627. Erratum in: Physiol Rep. 2016 Nov;4(21):.


Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.

Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, Chang EB, Gajewski TF.

Science. 2015 Nov 27;350(6264):1084-9. doi: 10.1126/science.aac4255. Epub 2015 Nov 5.

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