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Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial.

Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D.

Lancet Oncol. 2020 Feb;21(2):294-305. doi: 10.1016/S1470-2045(19)30728-4. Epub 2020 Jan 14.


Examining the validity of a predictive model for vaginal birth after cesarean.

Wong JWH, Yoshino KDN, Ahn HJ, Choi SY, Chang AL.

J Perinat Med. 2019 Dec 18;48(1):11-15. doi: 10.1515/jpm-2019-0345.


Alterations of Immune and Keratinization Gene Expression in Papulopustular Rosacea by Whole Transcriptome Analysis.

Shih YH, Xu J, Kumar A, Li R, Chang ALS.

J Invest Dermatol. 2019 Nov 6. pii: S0022-202X(19)33380-9. doi: 10.1016/j.jid.2019.09.021. [Epub ahead of print] No abstract available.


Syndesmotic Ligaments of the Ankle: Anatomy, Multimodality Imaging, and Patterns of Injury.

Chang AL, Mandell JC.

Curr Probl Diagn Radiol. 2019 Sep 13. pii: S0363-0188(19)30208-7. doi: 10.1067/j.cpradiol.2019.09.006. [Epub ahead of print] Review.


Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.

Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prélot L, Ang CE, Shibuya Y, Benayoun BA, Chang ALS, Wernig M, Wysocka J, Longaker MT, Snyder MP, Brunet A.

Nature. 2019 Oct;574(7779):553-558. doi: 10.1038/s41586-019-1658-5. Epub 2019 Oct 23.


An open invitation to join the Pediatric Proton/Photon Consortium Registry to standardize data collection in pediatric radiation oncology.

Lawell MP, Indelicato DJ, Paulino AC, Hartsell W, Laack NN, Ermoian RP, Perentesis JP, Vatner R, Perkins S, Mangona VS, Hill-Kayser CE, Wolden SL, Kwok Y, Chang JH, Wilkinson JB, MacEwan I, Chang AL, Eaton BR, Ladra MM, Gallotto SL, Weyman EA, Bajaj BVM, Baliga S, Yeap BY, Berrington de Gonzalez A, Yock TI.

Br J Radiol. 2019 Nov 1:20190673. doi: 10.1259/bjr.20190673. [Epub ahead of print]


Integrated genomic profiling expands clinical options for patients with cancer.

Beaubier N, Bontrager M, Huether R, Igartua C, Lau D, Tell R, Bobe AM, Bush S, Chang AL, Hoskinson DC, Khan AA, Kudalkar E, Leibowitz BD, Lozachmeur A, Michuda J, Parsons J, Perera JF, Salahudeen A, Shah KP, Taxter T, Zhu W, White KP.

Nat Biotechnol. 2019 Nov;37(11):1351-1360. doi: 10.1038/s41587-019-0259-z. Epub 2019 Sep 30.


Long-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase II randomized, double-blind BOLT study.

Dummer R, Guminksi A, Gutzmer R, Lear JT, Lewis KD, Chang ALS, Combemale P, Dirix L, Kaatz M, Kudchadkar R, Loquai C, Plummer R, Schulze HJ, Stratigos AJ, Trefzer U, Squittieri N, Migden MR.

Br J Dermatol. 2019 Sep 23. doi: 10.1111/bjd.18552. [Epub ahead of print]


MiR-99a suppresses cell migration and invasion by regulating IGF1R in gastric cancer.

Xu XL, Guo AX, Pan QY, Chang AL, Zhao CR.

Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7375-7382. doi: 10.26355/eurrev_201909_18845.


Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion.

Satpathy AT, Granja JM, Yost KE, Qi Y, Meschi F, McDermott GP, Olsen BN, Mumbach MR, Pierce SE, Corces MR, Shah P, Bell JC, Jhutty D, Nemec CM, Wang J, Wang L, Yin Y, Giresi PG, Chang ALS, Zheng GXY, Greenleaf WJ, Chang HY.

Nat Biotechnol. 2019 Aug;37(8):925-936. doi: 10.1038/s41587-019-0206-z. Epub 2019 Aug 2.


Clonal replacement of tumor-specific T cells following PD-1 blockade.

Yost KE, Satpathy AT, Wells DK, Qi Y, Wang C, Kageyama R, McNamara KL, Granja JM, Sarin KY, Brown RA, Gupta RK, Curtis C, Bucktrout SL, Davis MM, Chang ALS, Chang HY.

Nat Med. 2019 Aug;25(8):1251-1259. doi: 10.1038/s41591-019-0522-3. Epub 2019 Jul 29.


trans-Trismethoxy resveratrol decreased fat accumulation dependent on fat-6 and fat-7 in Caenorhabditis elegans.

Yue Y, Shen P, Chang AL, Qi W, Kim KH, Kim D, Park Y.

Food Funct. 2019 Aug 1;10(8):4966-4974. doi: 10.1039/c9fo00778d. Epub 2019 Jul 25.


Amine functionalized ZIF-8 as a visible-light-driven photocatalyst for Cr(VI) reduction.

Hu C, Huang YC, Chang AL, Nomura M.

J Colloid Interface Sci. 2019 Oct 1;553:372-381. doi: 10.1016/j.jcis.2019.06.040. Epub 2019 Jun 13.


Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma.

Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang JY, Chang ALS, Rieger KE, Oro AE, Sarin KY.

J Invest Dermatol. 2019 Nov;139(11):2263-2271.e5. doi: 10.1016/j.jid.2019.03.1163. Epub 2019 Jun 15.


HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma.

Miska J, Lee-Chang C, Rashidi A, Muroski ME, Chang AL, Lopez-Rosas A, Zhang P, Panek WK, Cordero A, Han Y, Ahmed AU, Chandel NS, Lesniak MS.

Cell Rep. 2019 Apr 2;27(1):226-237.e4. doi: 10.1016/j.celrep.2019.03.029.


An Automated Assay to Measure Phagocytosis of Cryptococcus neoformans.

Chang AL, Hole CR, Doering TL.

Curr Protoc Microbiol. 2019 Jun;53(1):e79. doi: 10.1002/cpmc.79. Epub 2019 Feb 25.


Cdk8 and Ssn801 Regulate Oxidative Stress Resistance and Virulence in Cryptococcus neoformans.

Chang AL, Kang Y, Doering TL.

mBio. 2019 Feb 12;10(1). pii: e02818-18. doi: 10.1128/mBio.02818-18.


Immune Checkpoint Inhibitors for Treating Advanced Cutaneous Squamous Cell Carcinoma.

Patel R, Chang ALS.

Am J Clin Dermatol. 2019 Aug;20(4):477-482. doi: 10.1007/s40257-019-00426-w.


Anomalous Courses of the Palmar Cutaneous Branch of the Median Nerve in Relation to the Flexor Carpi Radialis Tendon for ORIF of Distal Radius Fractures.

Glickel SZ, Glynn SM, Chang AL, Janowski JW, Barron OA, Catalano LW 3rd.

Hand (N Y). 2019 Jan 31:1558944718825137. doi: 10.1177/1558944718825137. [Epub ahead of print]


Maintenance of Mitochondrial Morphology in Cryptococcus neoformans Is Critical for Stress Resistance and Virulence.

Chang AL, Doering TL.

mBio. 2018 Nov 6;9(6). pii: e01375-18. doi: 10.1128/mBio.01375-18.


Enhancer Connectome Nominates Target Genes of Inherited Risk Variants from Inflammatory Skin Disorders.

Jeng MY, Mumbach MR, Granja JM, Satpathy AT, Chang HY, Chang ALS.

J Invest Dermatol. 2019 Mar;139(3):605-614. doi: 10.1016/j.jid.2018.09.011. Epub 2018 Oct 10.


Reply to: "Use of immortal time within survival analysis".

Min Lee CK, Li S, Tran DC, Zhu GA, Kim J, Kwong BY, Chang ALS.

J Am Acad Dermatol. 2019 Jan;80(1):e19-e20. doi: 10.1016/j.jaad.2018.08.042. Epub 2018 Sep 8. No abstract available.


Pembrolizumab for advanced basal cell carcinoma: An investigator-initiated, proof-of-concept study.

Chang ALS, Tran DC, Cannon JGD, Li S, Jeng M, Patel R, Van der Bokke L, Pague A, Brotherton R, Rieger KE, Satpathy AT, Yost KE, Reddy S, Sarin K, Colevas AD.

J Am Acad Dermatol. 2019 Feb;80(2):564-566. doi: 10.1016/j.jaad.2018.08.017. Epub 2018 Aug 24. No abstract available.


Genome-Wide Quantification of the Effect of Gene Overexpression on Escherichia coli Growth.

Chen H, Venkat S, Wilson J, McGuire P, Chang AL, Gan Q, Fan C.

Genes (Basel). 2018 Aug 16;9(8). pii: E414. doi: 10.3390/genes9080414.


Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility.

Cho HG, Kuo KY, Li S, Bailey I, Aasi S, Chang ALS, Oro AE, Tang JY, Sarin KY.

JCI Insight. 2018 Aug 9;3(15). pii: 122744. doi: 10.1172/jci.insight.122744. eCollection 2018 Aug 9.


Unique Tumor Heterogeneity Within a Single Locally Advanced Basal Cell Carcinoma Resulting in a Partial Response Despite Continuous Vismodegib Treatment.

Nayyar PM, Chang ALS, Sarin K, Ratner D.

Dermatol Surg. 2019 Apr;45(4):608-610. doi: 10.1097/DSS.0000000000001607. No abstract available.


Gene Therapy and Virotherapy of Gliomas.

Kim JW, Chang AL, Kane JR, Young JS, Qiao J, Lesniak MS.

Prog Neurol Surg. 2018;32:112-123. doi: 10.1159/000469685. Epub 2018 Jul 10. Review.


Genetic fine-mapping of the Iowan SNCA gene triplication in a patient with Parkinson's disease.

Zafar F, Valappil RA, Kim S, Johansen KK, Chang ALS, Tetrud JW, Eis PS, Hatchwell E, Langston JW, Dickson DW, Schüle B.

NPJ Parkinsons Dis. 2018 Jun 15;4:18. doi: 10.1038/s41531-018-0054-4. eCollection 2018.


Unintended widespread facial autoinoculation of varicella by home microneedling roller device.

Leatham H, Guan L, Chang ALS.

JAAD Case Rep. 2018 Jun 6;4(6):546-547. doi: 10.1016/j.jdcr.2018.02.004. eCollection 2018 Jul. No abstract available.


An Update From the Pediatric Proton Consortium Registry.

Hess CB, Indelicato DJ, Paulino AC, Hartsell WF, Hill-Kayser CE, Perkins SM, Mahajan A, Laack NN, Ermoian RP, Chang AL, Wolden SL, Mangona VS, Kwok Y, Breneman JC, Perentesis JP, Gallotto SL, Weyman EA, Bajaj BVM, Lawell MP, Yeap BY, Yock TI.

Front Oncol. 2018 May 24;8:165. doi: 10.3389/fonc.2018.00165. eCollection 2018.


PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma.

Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG.

N Engl J Med. 2018 Jul 26;379(4):341-351. doi: 10.1056/NEJMoa1805131. Epub 2018 Jun 4.


Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: A retrospective case-control study.

Min Lee CK, Li S, Tran DC, Zhu GA, Kim J, Kwong BY, Chang ALS.

J Am Acad Dermatol. 2018 Dec;79(6):1047-1052. doi: 10.1016/j.jaad.2018.05.035. Epub 2018 May 29.


A case of metastatic basal cell carcinoma treated with continuous PD-1 inhibitor exposure even after subsequent initiation of radiotherapy and surgery.

Cannon JGD, Russell JS, Kim J, Chang ALS.

JAAD Case Rep. 2018 Mar 2;4(3):248-250. doi: 10.1016/j.jdcr.2018.01.015. eCollection 2018 Apr. No abstract available.


Three-in-one protocol reduces mortality of patients with haemodynamically unstable pelvic fractures-a five year multi-centred review in Hong Kong.

Cheng M, Lee KY, Chang AL, Ho HF, Chan LS, Lee KB, Kwok PH, Lee AW, Wong KK, Kam CW, Leung GK, Wong JS, Cheung NK, Yeung JH, Tang N, Choi SH, Lau TW, Wong HT, Leung M.

Int Orthop. 2018 Oct;42(10):2459-2466. doi: 10.1007/s00264-018-3842-x. Epub 2018 Feb 27.


Emerging trends in the treatment of advanced basal cell carcinoma.

Migden MR, Chang ALS, Dirix L, Stratigos AJ, Lear JT.

Cancer Treat Rev. 2018 Mar;64:1-10. doi: 10.1016/j.ctrv.2017.12.009. Epub 2017 Dec 14. Review.


Dry and wet periods drive rapid shifts in community assembly in an estuarine ecosystem.

Chang AL, Brown CW, Crooks JA, Ruiz GM.

Glob Chang Biol. 2018 Feb;24(2):e627-e642. doi: 10.1111/gcb.13972. Epub 2017 Dec 7.


Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion.

Kim Y, Xia BT, Jung AD, Chang AL, Abplanalp WA, Caldwell CC, Goodman MD, Pritts TA.

Surgery. 2018 Feb;163(2):423-429. doi: 10.1016/j.surg.2017.09.028. Epub 2017 Nov 29.


An exploratory open-label, investigator-initiated study to evaluate the efficacy and safety of combination sonidegib and buparlisib for advanced basal cell carcinomas.

Tran DC, Moffat A, Brotherton R, Pague A, Zhu GA, Chang ALS.

J Am Acad Dermatol. 2018 May;78(5):1011-1013.e3. doi: 10.1016/j.jaad.2017.11.031. Epub 2017 Nov 23. No abstract available.


Evidence-based update on rosacea comorbidities and their common physiologic pathways.

Holmes AD, Spoendlin J, Chien AL, Baldwin H, Chang ALS.

J Am Acad Dermatol. 2018 Jan;78(1):156-166. doi: 10.1016/j.jaad.2017.07.055. Epub 2017 Oct 28. Review.


Long-Term Follow-up of Capsular Interposition Arthroplasty for Hallux Rigidus.

Vulcano E, Chang AL, Solomon D, Myerson M.

Foot Ankle Int. 2018 Jan;39(1):1-5. doi: 10.1177/1071100717732124. Epub 2017 Oct 4.


A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome.

Upadhya R, Lam WC, Maybruck BT, Donlin MJ, Chang AL, Kayode S, Ormerod KL, Fraser JA, Doering TL, Lodge JK.

Fungal Genet Biol. 2017 Nov;108:13-25. doi: 10.1016/j.fgb.2017.08.008. Epub 2017 Sep 12.


Critical Thinking Disposition of Nurse Practitioners in Taiwan.

Hsu HY, Chang SC, Chang AL, Chen SL.

J Contin Educ Nurs. 2017 Sep 1;48(9):425-430. doi: 10.3928/00220124-20170816-09.


Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study.

Lear JT, Migden MR, Lewis KD, Chang ALS, Guminski A, Gutzmer R, Dirix L, Combemale P, Stratigos A, Plummer R, Castro H, Yi T, Mone M, Zhou J, Trefzer U, Kaatz M, Loquai C, Kudchadkar R, Sellami D, Dummer R.

J Eur Acad Dermatol Venereol. 2018 Mar;32(3):372-381. doi: 10.1111/jdv.14542. Epub 2017 Nov 6.


Advanced Imaging Techniques of the Wrist.

Chang AL, Yu HJ, von Borstel D, Nozaki T, Horiuchi S, Terada Y, Yoshioka H.

AJR Am J Roentgenol. 2017 Sep;209(3):497-510. doi: 10.2214/AJR.17.18012. Review.


Fatty Acid Uptake in T Cell Subsets Using a Quantum Dot Fatty Acid Conjugate.

Muroski ME, Miska J, Chang AL, Zhang P, Rashidi A, Moore H, Lopez-Rosas A, Han Y, Lesniak MS.

Sci Rep. 2017 Jul 19;7(1):5790. doi: 10.1038/s41598-017-05556-x.


Timing of stressors alters interactive effects on a coastal foundation species.

Bible JM, Cheng BS, Chang AL, Ferner MC, Wasson K, Zabin CJ, Latta M, Sanford E, Deck A, Grosholz ED.

Ecology. 2017 Sep;98(9):2468-2478. doi: 10.1002/ecy.1943. Epub 2017 Aug 22.


Commentary on Development of Basal Cell Carcinoma With Squamous Differentiation During Vismodegib Treatment.

Chang ALS.

Dermatol Surg. 2017 Jul;43(7):991-992. doi: 10.1097/DSS.0000000000001059. No abstract available.


A daily skincare regimen with a unique ceramide and filaggrin formulation rapidly improves chronic xerosis, pruritus, and quality of life in older adults.

Chang ALS, Chen SC, Osterberg L, Brandt S, von Grote EC, Meckfessel MH.

Geriatr Nurs. 2018 Jan - Feb;39(1):24-28. doi: 10.1016/j.gerinurse.2017.05.002. Epub 2017 Jun 7.


pH modulation ameliorates the red blood cell storage lesion in a murine model of transfusion.

Chang AL, Kim Y, Seitz AP, Schuster RM, Pritts TA.

J Surg Res. 2017 May 15;212:54-59. doi: 10.1016/j.jss.2016.12.025. Epub 2016 Dec 28.


Role of Leukoreduction of Packed Red Blood Cell Units in Trauma Patients: A Review.

Kim Y, Xia BT, Chang AL, Pritts TA.

Int J Hematol Res. 2016 Jun;2(2):124-129. doi: 10.17554/j.issn.2409-3548.2016.02.31. Epub 2016 Jun 27.

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