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Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M; U-BIOPRED Study Group.

PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018.


Dupilumab improves symptoms, quality of life, and productivity in uncontrolled persistent asthma.

Corren J, Castro M, Chanez P, Fabbri L, Joish VN, Amin N, Graham NMH, Mastey V, Abbé A, Taniou C, Mahajan P, Teper A, Pirozzi G, Eckert L.

Ann Allergy Asthma Immunol. 2018 Aug 21. pii: S1081-1206(18)30665-3. doi: 10.1016/j.anai.2018.08.005. [Epub ahead of print]


Reply to Upham: The Bronchial Epithelial Secretory IgA System in Asthma.

Ladjemi MZ, Gras D, Gohy S, Chanez P, Pilette C.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1236-1238. doi: 10.1164/rccm.201806-1128LE. No abstract available.


Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.

Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau LCK, Wilson SJ, Ward JA, Chauhan A, Sousa AR, De Meulder B, Loza MJ, Baribaud F, Sterk PJ, Chung KF, Sun K, Guo Y, Adcock IM, Payne D, Dahlen B, Chanez P, Shaw DE, Krug N, Hohlfeld JM, Sandström T, Djukanovic R, James A, Hinks TSC, Howarth PH, Vaarala O, van Geest M, Olsson H; Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group.

J Allergy Clin Immunol. 2018 Jun 11. pii: S0091-6749(18)30847-9. doi: 10.1016/j.jaci.2018.05.026. [Epub ahead of print]


[The obstructive sleep apnoea syndrome is not only bad for the heart!]

Rajaoarifetra J, Palot A, Tissier Ducamp D, Tummino C, Gouitaa M, Chanez P.

Rev Mal Respir. 2018 May;35(5):562-566. doi: 10.1016/j.rmr.2017.10.666. French.


Bronchial Thermoplasty in Severe Asthma: Best Practice Recommendations from an Expert Panel.

Bonta PI, Chanez P, Annema JT, Shah PL, Niven R.

Respiration. 2018;95(5):289-300. doi: 10.1159/000488291. Epub 2018 Apr 17. Review.


Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4/IL-13.

Ladjemi MZ, Gras D, Dupasquier S, Detry B, Lecocq M, Garulli C, Fregimilicka C, Bouzin C, Gohy S, Chanez P, Pilette C.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1396-1409. doi: 10.1164/rccm.201703-0561OC.


Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Dahlen SE, Krug N, Sandstrom T, Shaw DE, Lutter R, Bakke P, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; , on behalf of the U-BIOPRED study group.

Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017. Print 2018 May.


[Neurofibromatosis as a cause of breathlessness].

Palot A, Ferrandez C, Alagha K, Ilstad-Minnihan A, Tummino C, Gouitaa M, Charpin D, Chanez P.

Rev Mal Respir. 2018 Mar;35(3):338-341. doi: 10.1016/j.rmr.2017.10.662. Epub 2018 Mar 27. French.


HLA-G Haplotypes Are Differentially Associated with Asthmatic Features.

Ribeyre C, Carlini F, René C, Jordier F, Picard C, Chiaroni J, Abi-Rached L, Gouret P, Marin G, Molinari N, Chanez P, Paganini J, Gras D, Di Cristofaro J.

Front Immunol. 2018 Feb 23;9:278. doi: 10.3389/fimmu.2018.00278. eCollection 2018.


Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium.

Khelloufi MK, Loiseau E, Jaeger M, Molinari N, Chanez P, Gras D, Viallat A.

Sci Rep. 2018 Feb 5;8(1):2447. doi: 10.1038/s41598-018-20882-4.


Asthma, COPD, and overlap in a national cohort: ACO on a gradient.

Bourdin A, Suehs CM, Marin G, Vachier I, Matzner-Lober E, Chanez P, Molinari N; COBRA Consortium.

J Allergy Clin Immunol. 2018 Apr;141(4):1516-1518. doi: 10.1016/j.jaci.2017.11.049. Epub 2018 Jan 31. No abstract available.


Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis.

Pahus L, Gouitaa M, Sofalvi T, Alagha K, Gras D, Chanez P, Charpin D.

Eur Ann Allergy Clin Immunol. 2018 Jan;50(1):28-35. doi: 10.23822/EurAnnACI.1764-1489.34.


Circulating tumour cells as a potential screening tool for lung cancer (the AIR study): protocol of a prospective multicentre cohort study in France.

Leroy S, Benzaquen J, Mazzetta A, Marchand-Adam S, Padovani B, Israel-Biet D, Pison C, Chanez P, Cadranel J, Mazières J, Jounieaux V, Cohen C, Hofman V, Ilie M, Hofman P, Marquette CH; AIR Project Study Group.

BMJ Open. 2017 Dec 26;7(12):e018884. doi: 10.1136/bmjopen-2017-018884.


Radiological abnormalities following bronchial thermoplasty: is the pathophysiology understood?

Debray MP, Dombret MC, Pretolani M, Thabut G, Alavoine L, Brillet PY, Taillé C, Khalil A, Chanez P, Aubier M.

Eur Respir J. 2017 Dec 7;50(6). pii: 1702067. doi: 10.1183/13993003.02067-2017. Print 2017 Dec. No abstract available.


Mortality: a neglected outcome in OCS-treated severe asthma.

Bourdin A, Molinari N, Vachier I, Pahus L, Suehs C, Chanez P.

Eur Respir J. 2017 Nov 30;50(5). pii: 1701486. doi: 10.1183/13993003.01486-2017. Print 2017 Nov. No abstract available.


Lung development, regeneration and plasticity: From disease physiopathology to drug design using induced pluripotent stem cells.

Ahmed E, Sansac C, Assou S, Gras D, Petit A, Vachier I, Chanez P, De Vos J, Bourdin A.

Pharmacol Ther. 2018 Mar;183:58-77. doi: 10.1016/j.pharmthera.2017.10.002. Epub 2017 Oct 4. Review.


Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease.

Pavord ID, Chanez P, Criner GJ, Kerstjens HAM, Korn S, Lugogo N, Martinot JB, Sagara H, Albers FC, Bradford ES, Harris SS, Mayer B, Rubin DB, Yancey SW, Sciurba FC.

N Engl J Med. 2017 Oct 26;377(17):1613-1629. doi: 10.1056/NEJMoa1708208. Epub 2017 Sep 11.


How effective is bronchial thermoplasty for severe asthma in clinical practice?

Thomson NC, Chanez P.

Eur Respir J. 2017 Aug 31;50(2). pii: 1701140. doi: 10.1183/13993003.01140-2017. Print 2017 Aug. No abstract available.


Novel Treatments for Airway Disease.

Martinez-Anton A, Humbert M, Chanez P.

N Engl J Med. 2017 Aug 10;377(6):595-6. doi: 10.1056/NEJMc1708004. No abstract available.


Novel Treatments for Airway Disease

Martinez-Anton A, Humbert M, Chanez P.

N Engl J Med. 2017 Aug 10;377(6):595-6. doi: 10.1056/NEJMc1708004. No abstract available.


Relationship between blood eosinophils, clinical characteristics, and mortality in patients with COPD.

Zysman M, Deslee G, Caillaud D, Chanez P, Escamilla R, Court-Fortune I, Nesme-Meyer P, Perez T, Paillasseur JL, Pinet C, Jebrak G, Roche N, Burgel PR.

Int J Chron Obstruct Pulmon Dis. 2017 Jun 20;12:1819-1824. doi: 10.2147/COPD.S129787. eCollection 2017.


[Changing patterns of medication prescription for COPD patients in France. Impact of long-acting muscarinic antagonists' availability].

Jébrak G, Burgel PR, Caillaud D, Deslée G, Brinchault G, Chanez P, Court-Fortune I, Escamilla R, Nesme-Meyer P, Pinet C, Perez T, Paillasseur JL, Roche N; pour le groupe Initiatives BPCO.

Rev Mal Respir. 2017 May;34(5):535-543. doi: 10.1016/j.rmr.2017.02.006. Epub 2017 May 31. French.


Epithelial ciliated beating cells essential for ex vivo ALI culture growth.

Gras D, Petit A, Charriot J, Knabe L, Alagha K, Gamez AS, Garulli C, Bourdin A, Chanez P, Molinari N, Vachier I.

BMC Pulm Med. 2017 May 3;17(1):80. doi: 10.1186/s12890-017-0423-5.


Managing asthma in the era of biological therapies.

Bardin PG, Price D, Chanez P, Humbert M, Bourdin A.

Lancet Respir Med. 2017 May;5(5):376-378. doi: 10.1016/S2213-2600(17)30124-8. Epub 2017 Apr 24. Review. No abstract available.


Severe eosinophilic asthma: a roadmap to consensus.

Buhl R, Humbert M, Bjermer L, Chanez P, Heaney LG, Pavord I, Quirce S, Virchow JC, Holgate S; expert group of the European Consensus Meeting for Severe Eosinophilic Asthma.

Eur Respir J. 2017 May 1;49(5). pii: 1700634. doi: 10.1183/13993003.00634-2017. Print 2017 May. No abstract available.


Cypress Pollinosis: from Tree to Clinic.

Charpin D, Pichot C, Belmonte J, Sutra JP, Zidkova J, Chanez P, Shahali Y, Sénéchal H, Poncet P.

Clin Rev Allergy Immunol. 2017 Apr 11. doi: 10.1007/s12016-017-8602-y. [Epub ahead of print] Review.


Bronchial Epithelial Cells from Asthmatic Patients Display Less Functional HLA-G Isoform Expression.

Carlini F, Picard C, Garulli C, Piquemal D, Roubertoux P, Chiaroni J, Chanez P, Gras D, Di Cristofaro J.

Front Immunol. 2017 Jan 23;8:6. doi: 10.3389/fimmu.2017.00006. eCollection 2017.


Early computed tomography modifications following bronchial thermoplasty in patients with severe asthma.

Debray MP, Dombret MC, Pretolani M, Thabut G, Alavoine L, Brillet PY, Taillé C, Khalil A, Chanez P, Aubier M.

Eur Respir J. 2017 Mar 15;49(3). pii: 1601565. doi: 10.1183/13993003.01565-2016. Print 2017 Mar.


Switch of noninvasive ventilation (NIV) to continuous positive airway pressure (CPAP) in patients with obesity hypoventilation syndrome: a pilot study.

Orfanos S, Jaffuel D, Perrin C, Molinari N, Chanez P, Palot A.

BMC Pulm Med. 2017 Mar 14;17(1):50. doi: 10.1186/s12890-017-0391-9.


Human bronchial epithelium orchestrates dendritic cell activation in severe asthma.

Gras D, Martinez-Anton A, Bourdin A, Garulli C, de Senneville L, Vachier I, Vitte J, Chanez P.

Eur Respir J. 2017 Mar 8;49(3). pii: 1602399. doi: 10.1183/13993003.02399-2016. Print 2017 Mar.


A place for Apnea Hypopnea Index telemonitoring in preventing heart failure exacerbation?

Palot A, Jaffuel D, Gouitaa M, Tummino C, Charpin D, Chanez P.

Sleep Med. 2017 Jan;29:18-19. doi: 10.1016/j.sleep.2016.10.011. Epub 2016 Nov 5. No abstract available.


Club cell secretory protein serum concentration is a surrogate marker of small-airway involvement in asthmatic patients.

Bommart S, Marin G, Molinari N, Knabe L, Petit A, Chanez P, Gamez AS, Devautour C, Vachier I, Bourdin A.

J Allergy Clin Immunol. 2017 Aug;140(2):581-584. doi: 10.1016/j.jaci.2016.09.063. Epub 2017 Jan 17. No abstract available.


Comparison of anti-interleukin-5 therapies in patients with severe asthma: global and indirect meta-analyses of randomized placebo-controlled trials.

Cabon Y, Molinari N, Marin G, Vachier I, Gamez AS, Chanez P, Bourdin A.

Clin Exp Allergy. 2017 Jan;47(1):129-138. doi: 10.1111/cea.12853. Epub 2016 Dec 8. Review.


Rising total costs and mortality rates associated with admissions due to COPD exacerbations.

Molinari N, Chanez P, Roche N, Ahmed E, Vachier I, Bourdin A.

Respir Res. 2016 Nov 14;17(1):149.


Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study.

Wilson SJ, Ward JA, Sousa AR, Corfield J, Bansal AT, De Meulder B, Lefaudeux D, Auffray C, Loza MJ, Baribaud F, Fitch N, Sterk PJ, Chung KF, Gibeon D, Sun K, Guo YK, Adcock I, Djukanovic R, Dahlen B, Chanez P, Shaw D, Krug N, Hohlfeld J, Sandström T, Howarth PH; U-BIOPRED Study Group.

Eur Respir J. 2016 Nov;48(5):1307-1319. doi: 10.1183/13993003.01129-2016. Epub 2016 Oct 6.


Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations.

Pretolani M, Bergqvist A, Thabut G, Dombret MC, Knapp D, Hamidi F, Alavoine L, Taillé C, Chanez P, Erjefält JS, Aubier M.

J Allergy Clin Immunol. 2017 Apr;139(4):1176-1185. doi: 10.1016/j.jaci.2016.08.009. Epub 2016 Sep 5.


U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics.

Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2017 Jun;139(6):1797-1807. doi: 10.1016/j.jaci.2016.08.048. Epub 2016 Oct 20.


Impact of current cough on health-related quality of life in patients with COPD.

Deslee G, Burgel PR, Escamilla R, Chanez P, Court-Fortune I, Nesme-Meyer P, Brinchault-Rabin G, Perez T, Jebrak G, Caillaud D, Paillasseur JL, Roche N.

Int J Chron Obstruct Pulmon Dis. 2016 Sep 13;11:2091-2097. eCollection 2016.


Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial.

Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, Sproule S, Gilmartin G, Aurivillius M, Werkström V, Goldman M; SIROCCO study investigators.

Lancet. 2016 Oct 29;388(10056):2115-2127. doi: 10.1016/S0140-6736(16)31324-1. Epub 2016 Sep 5.


New sociology for better understanding severe eosinophilic asthma: introducing the SOCS family.

Gras D, Chanez P.

Eur Respir J. 2016 Sep;48(3):608-10. doi: 10.1183/13993003.01240-2016. No abstract available.


A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED.

Kuo CS, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, Hoda U, Rossios C, Sousa A, Wilson SJ, Howarth P, Dahlen B, Dahlen SE, Chanez P, Shaw D, Krug N, Sandstrӧm T, De Meulder B, Lefaudeux D, Fowler S, Fleming L, Corfield J, Auffray C, Sterk PJ, Djukanovic R, Guo Y, Adcock IM, Chung KF; U-BIOPRED Project Team ‡ .

Am J Respir Crit Care Med. 2017 Feb 15;195(4):443-455. doi: 10.1164/rccm.201512-2452OC.


Long-term Efficacy and Safety of Mepolizumab in Patients With Severe Eosinophilic Asthma: A Multi-center, Open-label, Phase IIIb Study.

Lugogo N, Domingo C, Chanez P, Leigh R, Gilson MJ, Price RG, Yancey SW, Ortega HG.

Clin Ther. 2016 Sep;38(9):2058-2070.e1. doi: 10.1016/j.clinthera.2016.07.010. Epub 2016 Aug 21.


[How to consider triggers and comorbid conditions in severe asthma in adults].

Barnig C, Veaudor M, Gautier C, Margelidon-Cozzolino V, Pigearias B, Devouassoux G, Raherison C, De Blay F, Chanez P.

Presse Med. 2016 Nov;45(11):1030-1042. doi: 10.1016/j.lpm.2016.07.020. Epub 2016 Aug 18. Review. French.


Asthma-COPD overlap syndrome (ACOS) vs 'pure' COPD: a distinct phenotype?

Caillaud D, Chanez P, Escamilla R, Burgel PR, Court-Fortune I, Nesme-Meyer P, Deslee G, Perez T, Paillasseur JL, Pinet C, Jebrak G, Roche N; Initiatives BPCO scientific committee and investigators.

Allergy. 2017 Jan;72(1):137-145. doi: 10.1111/all.13004. Epub 2016 Sep 27.


Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate.

Marie-Desvergne C, Dubosson M, Touri L, Zimmermann E, Gaude-Môme M, Leclerc L, Durand C, Klerlein M, Molinari N, Vachier I, Chanez P, Mossuz VC.

J Breath Res. 2016 Jul 13;10(3):036006. doi: 10.1088/1752-7155/10/3/036006.


Bronchial epithelium in children: a key player in asthma.

Carsin A, Mazenq J, Ilstad A, Dubus JC, Chanez P, Gras D.

Eur Respir Rev. 2016 Jun;25(140):158-69. doi: 10.1183/16000617.0101-2015. Review.


Updated guidelines (2015) for management and monitoring of adult and adolescent asthmatic patients (from 12 years and older) of the Société de Pneumologie de Langue Française (SPLF) (Full length text).

Raherison C, Bourdin A, Bonniaud P, Deslée G, Garcia G, Leroyer C, Taillé C, De Blic J, Dubus JC, Tillié-Leblond I, Chanez P.

Rev Mal Respir. 2016 Apr;33(4):279-325. doi: 10.1016/j.rmr.2016.03.002. Epub 2016 Apr 14. No abstract available.


Updated guidelines (2015) for management and monitoring of adult and adolescent asthmatic patients (from 12 years and older) of the Société de pneumologie de langue française (SPLF) (summary).

Raherison C, Bourdin A, Bonniaud P, Deslée G, Garcia G, Leroyer C, Taillé C, De Blic J, Dubus JC, Tillié-Leblond I, Chanez P.

Rev Mal Respir. 2016 Apr;33(4):271-8. doi: 10.1016/j.rmr.2016.03.001. Epub 2016 Apr 23. No abstract available.


Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study.

Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg C, Girodet PO, Berger P, Kline JN, Khatri S, Chanez P, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; ADEPT Investigators.

Respir Res. 2016 Apr 23;17:43. doi: 10.1186/s12931-016-0360-5.

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