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Items: 1 to 50 of 416

1.

Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers.

Brandsma J, Goss VM, Yang X, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Sousa AR, Pandis I, Bansal AT, Sterk PJ, Djukanović R, Postle AD; U-BIOPRED Study Group.

Metabolomics. 2018 Sep 17;14(10):123. doi: 10.1007/s11306-018-1412-2.

2.

Randomised controlled trials in severe asthma: selection by phenotype or stereotype.

Pahus L, Jaffuel D, Vachier I, Bourdin A, Suehs CM, Molinari N, Chanez P.

Eur Respir J. 2019 Feb 7;53(2). pii: 1802187. doi: 10.1183/13993003.02187-2018. Print 2019 Feb. No abstract available.

PMID:
30759420
3.

Goblet cell hyperplasia as a feature of neutrophilic asthma.

Alagha K, Bourdin A, Vernisse C, Garulli C, Tummino C, Charriot J, Vachier I, Suehs C, Chanez P, Gras D.

Clin Exp Allergy. 2019 Feb 1. doi: 10.1111/cea.13359. [Epub ahead of print]

PMID:
30710420
4.

Severe asthma treated by bronchial thermoplasty: A success not due to the small airways?

Chanez P, Pahus L, Charriot J, Bourdin A.

Respirology. 2019 Jan 29. doi: 10.1111/resp.13481. [Epub ahead of print] No abstract available.

PMID:
30694006
5.

Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET.

Kuo CS, Pavlidis S, Zhu J, Loza M, Baribaud F, Rowe A, Pandis I, Gibeon D, Hoda U, Sousa A, Wilson SJ, Howarth P, Shaw D, Fowler S, Dahlen B, Chanez P, Krug N, Sandstrom T, Fleming L, Corfield J, Auffray C, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; U-BIOPRED Project Team.

Allergy. 2019 Jan 22. doi: 10.1111/all.13727. [Epub ahead of print]

PMID:
30667542
6.

Early decreases in blood eosinophil levels with reslizumab.

Chanez P, McDonald M, Garin M, Murphy K.

J Allergy Clin Immunol. 2019 Jan 14. pii: S0091-6749(19)30010-7. doi: 10.1016/j.jaci.2018.12.997. [Epub ahead of print] No abstract available.

PMID:
30654046
7.

"T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin.

Pavlidis S, Takahashi K, Ng Kee Kwong F, Xie J, Hoda U, Sun K, Elyasigomari V, Agapow P, Loza M, Baribaud F, Chanez P, Fowler SJ, Shaw DE, Fleming LJ, Howarth PH, Sousa AR, Corfield J, Auffray C, De Meulder B, Knowles R, Sterk PJ, Guo Y, Adcock IM, Djukanovic R, Fan Chung K; on behalf of the U-BIOPRED Study Group.

Eur Respir J. 2019 Jan 3;53(1). pii: 1800938. doi: 10.1183/13993003.00938-2018. Print 2019 Jan.

PMID:
30578390
8.

KIT as a therapeutic target for non-oncological diseases.

Martinez-Anton A, Gras D, Bourdin A, Dubreuil P, Chanez P.

Pharmacol Ther. 2018 Dec 14. pii: S0163-7258(18)30230-4. doi: 10.1016/j.pharmthera.2018.12.008. [Epub ahead of print] Review.

PMID:
30557630
9.

Persistent Reduction of Mucin Production after Bronchial Thermoplasty in Severe Asthma.

Haj Salem I, Gras D, Joubert P, Boulet LP, Lampron N, Martel S, Godbout K, Chanez P, Laviolette M, Chakir J.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):536-538. doi: 10.1164/rccm.201811-2064LE. No abstract available.

PMID:
30540915
10.

Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma.

Brinkman P, Wagener AH, Hekking PP, Bansal AT, Maitland-van der Zee AH, Wang Y, Weda H, Knobel HH, Vink TJ, Rattray NJ, D'Amico A, Pennazza G, Santonico M, Lefaudeux D, De Meulder B, Auffray C, Bakke PS, Caruso M, Chanez P, Chung KF, Corfield J, Dahlén SE, Djukanovic R, Geiser T, Horvath I, Krug N, Musial J, Sun K, Riley JH, Shaw DE, Sandström T, Sousa AR, Montuschi P, Fowler SJ, Sterk PJ; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2018 Dec 6. pii: S0091-6749(18)31722-6. doi: 10.1016/j.jaci.2018.10.058. [Epub ahead of print]

PMID:
30529449
11.

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M; U-BIOPRED Study Group.

PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018.

12.

Dupilumab improves symptoms, quality of life, and productivity in uncontrolled persistent asthma.

Corren J, Castro M, Chanez P, Fabbri L, Joish VN, Amin N, Graham NMH, Mastey V, Abbé A, Taniou C, Mahajan P, Teper A, Pirozzi G, Eckert L.

Ann Allergy Asthma Immunol. 2019 Jan;122(1):41-49.e2. doi: 10.1016/j.anai.2018.08.005. Epub 2018 Aug 21.

13.

Reply to Upham: The Bronchial Epithelial Secretory IgA System in Asthma.

Ladjemi MZ, Gras D, Gohy S, Chanez P, Pilette C.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1236-1238. doi: 10.1164/rccm.201806-1128LE. No abstract available.

PMID:
30059234
14.

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.

Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau LCK, Wilson SJ, Ward JA, Chauhan A, Sousa AR, De Meulder B, Loza MJ, Baribaud F, Sterk PJ, Chung KF, Sun K, Guo Y, Adcock IM, Payne D, Dahlen B, Chanez P, Shaw DE, Krug N, Hohlfeld JM, Sandström T, Djukanovic R, James A, Hinks TSC, Howarth PH, Vaarala O, van Geest M, Olsson H; Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group.

J Allergy Clin Immunol. 2019 Feb;143(2):577-590. doi: 10.1016/j.jaci.2018.05.026. Epub 2018 Jun 11.

15.

[The obstructive sleep apnoea syndrome is not only bad for the heart!]

Rajaoarifetra J, Palot A, Tissier Ducamp D, Tummino C, Gouitaa M, Chanez P.

Rev Mal Respir. 2018 May;35(5):562-566. doi: 10.1016/j.rmr.2017.10.666. French.

PMID:
29773418
16.

Bronchial Thermoplasty in Severe Asthma: Best Practice Recommendations from an Expert Panel.

Bonta PI, Chanez P, Annema JT, Shah PL, Niven R.

Respiration. 2018;95(5):289-300. doi: 10.1159/000488291. Epub 2018 Apr 17. Review.

PMID:
29669351
17.

Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4/IL-13.

Ladjemi MZ, Gras D, Dupasquier S, Detry B, Lecocq M, Garulli C, Fregimilicka C, Bouzin C, Gohy S, Chanez P, Pilette C.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1396-1409. doi: 10.1164/rccm.201703-0561OC.

PMID:
29652177
18.

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Dahlen SE, Krug N, Sandstrom T, Shaw DE, Lutter R, Bakke P, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; , on behalf of the U-BIOPRED study group.

Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017. Print 2018 May.

PMID:
29650557
19.

[Neurofibromatosis as a cause of breathlessness].

Palot A, Ferrandez C, Alagha K, Ilstad-Minnihan A, Tummino C, Gouitaa M, Charpin D, Chanez P.

Rev Mal Respir. 2018 Mar;35(3):338-341. doi: 10.1016/j.rmr.2017.10.662. Epub 2018 Mar 27. French.

PMID:
29602482
20.

HLA-G Haplotypes Are Differentially Associated with Asthmatic Features.

Ribeyre C, Carlini F, René C, Jordier F, Picard C, Chiaroni J, Abi-Rached L, Gouret P, Marin G, Molinari N, Chanez P, Paganini J, Gras D, Di Cristofaro J.

Front Immunol. 2018 Feb 23;9:278. doi: 10.3389/fimmu.2018.00278. eCollection 2018.

21.

Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium.

Khelloufi MK, Loiseau E, Jaeger M, Molinari N, Chanez P, Gras D, Viallat A.

Sci Rep. 2018 Feb 5;8(1):2447. doi: 10.1038/s41598-018-20882-4.

22.

Asthma, COPD, and overlap in a national cohort: ACO on a gradient.

Bourdin A, Suehs CM, Marin G, Vachier I, Matzner-Lober E, Chanez P, Molinari N; COBRA Consortium.

J Allergy Clin Immunol. 2018 Apr;141(4):1516-1518. doi: 10.1016/j.jaci.2017.11.049. Epub 2018 Jan 31. No abstract available.

PMID:
29355677
23.

Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis.

Pahus L, Gouitaa M, Sofalvi T, Alagha K, Gras D, Chanez P, Charpin D.

Eur Ann Allergy Clin Immunol. 2018 Jan;50(1):28-35. doi: 10.23822/EurAnnACI.1764-1489.34.

24.

Circulating tumour cells as a potential screening tool for lung cancer (the AIR study): protocol of a prospective multicentre cohort study in France.

Leroy S, Benzaquen J, Mazzetta A, Marchand-Adam S, Padovani B, Israel-Biet D, Pison C, Chanez P, Cadranel J, Mazières J, Jounieaux V, Cohen C, Hofman V, Ilie M, Hofman P, Marquette CH; AIR Project Study Group.

BMJ Open. 2017 Dec 26;7(12):e018884. doi: 10.1136/bmjopen-2017-018884.

25.

Radiological abnormalities following bronchial thermoplasty: is the pathophysiology understood?

Debray MP, Dombret MC, Pretolani M, Thabut G, Alavoine L, Brillet PY, Taillé C, Khalil A, Chanez P, Aubier M.

Eur Respir J. 2017 Dec 7;50(6). pii: 1702067. doi: 10.1183/13993003.02067-2017. Print 2017 Dec. No abstract available.

PMID:
29217610
26.

Mortality: a neglected outcome in OCS-treated severe asthma.

Bourdin A, Molinari N, Vachier I, Pahus L, Suehs C, Chanez P.

Eur Respir J. 2017 Nov 30;50(5). pii: 1701486. doi: 10.1183/13993003.01486-2017. Print 2017 Nov. No abstract available.

PMID:
29191955
27.

Lung development, regeneration and plasticity: From disease physiopathology to drug design using induced pluripotent stem cells.

Ahmed E, Sansac C, Assou S, Gras D, Petit A, Vachier I, Chanez P, De Vos J, Bourdin A.

Pharmacol Ther. 2018 Mar;183:58-77. doi: 10.1016/j.pharmthera.2017.10.002. Epub 2017 Oct 4. Review.

PMID:
28987320
28.

Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease.

Pavord ID, Chanez P, Criner GJ, Kerstjens HAM, Korn S, Lugogo N, Martinot JB, Sagara H, Albers FC, Bradford ES, Harris SS, Mayer B, Rubin DB, Yancey SW, Sciurba FC.

N Engl J Med. 2017 Oct 26;377(17):1613-1629. doi: 10.1056/NEJMoa1708208. Epub 2017 Sep 11.

29.

How effective is bronchial thermoplasty for severe asthma in clinical practice?

Thomson NC, Chanez P.

Eur Respir J. 2017 Aug 31;50(2). pii: 1701140. doi: 10.1183/13993003.01140-2017. Print 2017 Aug. No abstract available.

30.

Novel Treatments for Airway Disease.

Martinez-Anton A, Humbert M, Chanez P.

N Engl J Med. 2017 Aug 10;377(6):595-6. doi: 10.1056/NEJMc1708004. No abstract available.

PMID:
28813132
31.

Novel Treatments for Airway Disease

Martinez-Anton A, Humbert M, Chanez P.

N Engl J Med. 2017 Aug 10;377(6):595-6. doi: 10.1056/NEJMc1708004. No abstract available.

PMID:
28812851
32.

Relationship between blood eosinophils, clinical characteristics, and mortality in patients with COPD.

Zysman M, Deslee G, Caillaud D, Chanez P, Escamilla R, Court-Fortune I, Nesme-Meyer P, Perez T, Paillasseur JL, Pinet C, Jebrak G, Roche N, Burgel PR.

Int J Chron Obstruct Pulmon Dis. 2017 Jun 20;12:1819-1824. doi: 10.2147/COPD.S129787. eCollection 2017.

33.

[Changing patterns of medication prescription for COPD patients in France. Impact of long-acting muscarinic antagonists' availability].

Jébrak G, Burgel PR, Caillaud D, Deslée G, Brinchault G, Chanez P, Court-Fortune I, Escamilla R, Nesme-Meyer P, Pinet C, Perez T, Paillasseur JL, Roche N; pour le groupe Initiatives BPCO.

Rev Mal Respir. 2017 May;34(5):535-543. doi: 10.1016/j.rmr.2017.02.006. Epub 2017 May 31. French.

PMID:
28578989
34.

Epithelial ciliated beating cells essential for ex vivo ALI culture growth.

Gras D, Petit A, Charriot J, Knabe L, Alagha K, Gamez AS, Garulli C, Bourdin A, Chanez P, Molinari N, Vachier I.

BMC Pulm Med. 2017 May 3;17(1):80. doi: 10.1186/s12890-017-0423-5.

35.

Managing asthma in the era of biological therapies.

Bardin PG, Price D, Chanez P, Humbert M, Bourdin A.

Lancet Respir Med. 2017 May;5(5):376-378. doi: 10.1016/S2213-2600(17)30124-8. Epub 2017 Apr 24. Review. No abstract available.

PMID:
28463176
36.

Severe eosinophilic asthma: a roadmap to consensus.

Buhl R, Humbert M, Bjermer L, Chanez P, Heaney LG, Pavord I, Quirce S, Virchow JC, Holgate S; expert group of the European Consensus Meeting for Severe Eosinophilic Asthma.

Eur Respir J. 2017 May 1;49(5). pii: 1700634. doi: 10.1183/13993003.00634-2017. Print 2017 May. No abstract available.

37.

Cypress Pollinosis: from Tree to Clinic.

Charpin D, Pichot C, Belmonte J, Sutra JP, Zidkova J, Chanez P, Shahali Y, Sénéchal H, Poncet P.

Clin Rev Allergy Immunol. 2017 Apr 11. doi: 10.1007/s12016-017-8602-y. [Epub ahead of print] Review.

PMID:
28401436
38.

Bronchial Epithelial Cells from Asthmatic Patients Display Less Functional HLA-G Isoform Expression.

Carlini F, Picard C, Garulli C, Piquemal D, Roubertoux P, Chiaroni J, Chanez P, Gras D, Di Cristofaro J.

Front Immunol. 2017 Jan 23;8:6. doi: 10.3389/fimmu.2017.00006. eCollection 2017.

39.

Early computed tomography modifications following bronchial thermoplasty in patients with severe asthma.

Debray MP, Dombret MC, Pretolani M, Thabut G, Alavoine L, Brillet PY, Taillé C, Khalil A, Chanez P, Aubier M.

Eur Respir J. 2017 Mar 15;49(3). pii: 1601565. doi: 10.1183/13993003.01565-2016. Print 2017 Mar.

40.

Switch of noninvasive ventilation (NIV) to continuous positive airway pressure (CPAP) in patients with obesity hypoventilation syndrome: a pilot study.

Orfanos S, Jaffuel D, Perrin C, Molinari N, Chanez P, Palot A.

BMC Pulm Med. 2017 Mar 14;17(1):50. doi: 10.1186/s12890-017-0391-9.

41.

Human bronchial epithelium orchestrates dendritic cell activation in severe asthma.

Gras D, Martinez-Anton A, Bourdin A, Garulli C, de Senneville L, Vachier I, Vitte J, Chanez P.

Eur Respir J. 2017 Mar 8;49(3). pii: 1602399. doi: 10.1183/13993003.02399-2016. Print 2017 Mar.

42.

A place for Apnea Hypopnea Index telemonitoring in preventing heart failure exacerbation?

Palot A, Jaffuel D, Gouitaa M, Tummino C, Charpin D, Chanez P.

Sleep Med. 2017 Jan;29:18-19. doi: 10.1016/j.sleep.2016.10.011. Epub 2016 Nov 5. No abstract available.

PMID:
28153209
43.

Club cell secretory protein serum concentration is a surrogate marker of small-airway involvement in asthmatic patients.

Bommart S, Marin G, Molinari N, Knabe L, Petit A, Chanez P, Gamez AS, Devautour C, Vachier I, Bourdin A.

J Allergy Clin Immunol. 2017 Aug;140(2):581-584. doi: 10.1016/j.jaci.2016.09.063. Epub 2017 Jan 17. No abstract available.

PMID:
28108336
44.

Comparison of anti-interleukin-5 therapies in patients with severe asthma: global and indirect meta-analyses of randomized placebo-controlled trials.

Cabon Y, Molinari N, Marin G, Vachier I, Gamez AS, Chanez P, Bourdin A.

Clin Exp Allergy. 2017 Jan;47(1):129-138. doi: 10.1111/cea.12853. Epub 2016 Dec 8. Review.

PMID:
27859832
45.

Rising total costs and mortality rates associated with admissions due to COPD exacerbations.

Molinari N, Chanez P, Roche N, Ahmed E, Vachier I, Bourdin A.

Respir Res. 2016 Nov 14;17(1):149.

46.

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study.

Wilson SJ, Ward JA, Sousa AR, Corfield J, Bansal AT, De Meulder B, Lefaudeux D, Auffray C, Loza MJ, Baribaud F, Fitch N, Sterk PJ, Chung KF, Gibeon D, Sun K, Guo YK, Adcock I, Djukanovic R, Dahlen B, Chanez P, Shaw D, Krug N, Hohlfeld J, Sandström T, Howarth PH; U-BIOPRED Study Group.

Eur Respir J. 2016 Nov;48(5):1307-1319. doi: 10.1183/13993003.01129-2016. Epub 2016 Oct 6.

47.

Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations.

Pretolani M, Bergqvist A, Thabut G, Dombret MC, Knapp D, Hamidi F, Alavoine L, Taillé C, Chanez P, Erjefält JS, Aubier M.

J Allergy Clin Immunol. 2017 Apr;139(4):1176-1185. doi: 10.1016/j.jaci.2016.08.009. Epub 2016 Sep 5.

PMID:
27609656
48.

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics.

Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2017 Jun;139(6):1797-1807. doi: 10.1016/j.jaci.2016.08.048. Epub 2016 Oct 20.

49.

Impact of current cough on health-related quality of life in patients with COPD.

Deslee G, Burgel PR, Escamilla R, Chanez P, Court-Fortune I, Nesme-Meyer P, Brinchault-Rabin G, Perez T, Jebrak G, Caillaud D, Paillasseur JL, Roche N.

Int J Chron Obstruct Pulmon Dis. 2016 Sep 13;11:2091-2097. eCollection 2016.

50.

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial.

Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, Sproule S, Gilmartin G, Aurivillius M, Werkström V, Goldman M; SIROCCO study investigators.

Lancet. 2016 Oct 29;388(10056):2115-2127. doi: 10.1016/S0140-6736(16)31324-1. Epub 2016 Sep 5.

PMID:
27609408

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