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Items: 18


SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites.

Hemachandra LP, Patel H, Chandrasena RE, Choi J, Piyankarage SC, Wang S, Wang Y, Thayer EN, Scism RA, Michalsen BT, Xiong R, Siklos MI, Bolton JL, Thatcher GR.

Cancer Prev Res (Phila). 2014 May;7(5):505-15. doi: 10.1158/1940-6207.CAPR-13-0296. Epub 2014 Mar 5.


Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol.

Michalsen BT, Gherezghiher TB, Choi J, Chandrasena RE, Qin Z, Thatcher GR, Bolton JL.

Chem Res Toxicol. 2012 Jul 16;25(7):1472-83. doi: 10.1021/tx300142h. Epub 2012 Jun 14.


The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.

Gherezghiher TB, Michalsen B, Chandrasena RE, Qin Z, Sohn J, Thatcher GR, Bolton JL.

Chem Biol Interact. 2012 Mar 5;196(1-2):1-10. doi: 10.1016/j.cbi.2012.01.004. Epub 2012 Jan 28.


NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor.

Abdul-Hay S, Schiefer IT, Chandrasena RE, Li M, Abdelhamid R, Wang YT, Tavassoli E, Michalsen B, Asghodom RT, Luo J, Thatcher GR.

ACS Med Chem Lett. 2011 Sep 8;2(9):656-661.


Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors.

Sinha V, Wijewickrama GT, Chandrasena RE, Xu H, Edirisinghe PD, Schiefer IT, Thatcher GR.

ACS Chem Biol. 2010 Jul 16;5(7):667-80. doi: 10.1021/cb100054m.


Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens.

Kim HY, Sohn J, Wijewickrama GT, Edirisinghe P, Gherezghiher T, Hemachandra M, Lu PY, Chandrasena RE, Molloy ME, Tonetti DA, Thatcher GR.

Bioorg Med Chem. 2010 Jan 15;18(2):809-21. doi: 10.1016/j.bmc.2009.11.046. Epub 2009 Nov 27.


Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention.

Hagos GK, Abdul-Hay SO, Sohn J, Edirisinghe PD, Chandrasena RE, Wang Z, Li Q, Thatcher GR.

Mol Pharmacol. 2008 Nov;74(5):1381-91. doi: 10.1124/mol.108.046664. Epub 2008 Aug 1.


Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase.

Chandrasena RE, Edirisinghe PD, Bolton JL, Thatcher GR.

Chem Res Toxicol. 2008 Jul;21(7):1324-9. doi: 10.1021/tx8000797. Epub 2008 Jun 28.


Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality.

Dunlap T, Abdul-Hay SO, Chandrasena RE, Hagos GK, Sinha V, Wang Z, Wang H, Thatcher GR.

Nitric Oxide. 2008 Sep;19(2):115-24. doi: 10.1016/j.niox.2008.04.013. Epub 2008 Apr 23.


Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection.

Dunlap T, Chandrasena RE, Wang Z, Sinha V, Wang Z, Thatcher GR.

Chem Res Toxicol. 2007 Dec;20(12):1903-12. Epub 2007 Nov 1.


Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.

Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR.

J Med Chem. 2007 May 31;50(11):2682-92. Epub 2007 May 10.


Products from enzyme-catalyzed oxidations of norcarenes.

Newcomb M, Lansakara-P DS, Kim HY, Chandrasena RE, Lippard SJ, Beauvais LG, Murray LJ, Izzo V, Hollenberg PF, Coon MJ.

J Org Chem. 2007 Feb 16;72(4):1128-33.


Desaturase reactions complicate the use of norcarane as a mechanistic probe. Unraveling the mixture of twenty-plus products formed in enzyme-catalyzed oxidations of norcarane.

Newcomb M, Chandrasena RE, Lansakara-P DS, Kim HY, Lippard SJ, Beauvais LG, Murray LJ, Izzo V, Hollenberg PF, Coon MJ.

J Org Chem. 2007 Feb 16;72(4):1121-7.


Cytochrome p450 compound I.

Newcomb M, Zhang R, Chandrasena RE, Halgrimson JA, Horner JH, Makris TM, Sligar SG.

J Am Chem Soc. 2006 Apr 12;128(14):4580-1.


Highly reactive electrophilic oxidants in cytochrome P450 catalysis.

Newcomb M, Chandrasena RE.

Biochem Biophys Res Commun. 2005 Dec 9;338(1):394-403. Epub 2005 Sep 6. Review.


Formation of compound I by photo-oxidation of compound II.

Zhang R, Chandrasena RE, Martinez E 2nd, Horner JH, Newcomb M.

Org Lett. 2005 Mar 17;7(6):1193-5.


Hydroxylation by the hydroperoxy-iron species in cytochrome P450 enzymes.

Chandrasena RE, Vatsis KP, Coon MJ, Hollenberg PF, Newcomb M.

J Am Chem Soc. 2004 Jan 14;126(1):115-26.


Kinetic isotope effects implicate two electrophilic oxidants in cytochrome p450-catalyzed hydroxylations.

Newcomb M, Aebisher D, Shen R, Chandrasena RE, Hollenberg PF, Coon MJ.

J Am Chem Soc. 2003 May 21;125(20):6064-5.


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