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Items: 39

1.

Plant-Microbe Interactions Drive Denitrification Rates, Dissolved Nitrogen Removal, and the Abundance of Denitrification Genes in Stormwater Control Measures.

Morse N, Payne E, Henry R, Hatt B, Chandrasena G, Shapleigh J, Cook P, Coutts S, Hathaway J, Walter MT, McCarthy D.

Environ Sci Technol. 2018 Aug 21;52(16):9320-9329. doi: 10.1021/acs.est.8b02133. Epub 2018 Aug 13.

PMID:
30059225
2.

Stormwater biofilter treatment model for faecal microorganisms.

Shen P, Deletic A, Urich C, Chandrasena GI, McCarthy DT.

Sci Total Environ. 2018 Jul 15;630:992-1002. doi: 10.1016/j.scitotenv.2018.02.193. Epub 2018 Mar 7.

PMID:
29554784
3.

Stormwater constructed wetlands: A source or a sink of Campylobacter spp.

Meng Z, Chandrasena G, Henry R, Deletic A, Kolotelo P, McCarthy D.

Water Res. 2018 Mar 15;131:218-227. doi: 10.1016/j.watres.2017.12.045. Epub 2017 Dec 21.

PMID:
29289923
4.

Quantitative analysis of lipids: a higher-throughput LC-MS/MS-based method and its comparison to ELISA.

Gandhi AS, Budac D, Khayrullina T, Staal R, Chandrasena G.

Future Sci OA. 2017 Jan 16;3(1):FSO157. doi: 10.4155/fsoa-2016-0067. eCollection 2017 Mar.

5.

Inhibition of the potassium channel KCa3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury.

Staal RGW, Khayrullina T, Zhang H, Davis S, Fallon SM, Cajina M, Nattini ME, Hu A, Zhou H, Poda SB, Zorn S, Chandrasena G, Dale E, Cambpell B, Biilmann Rønn LC, Munro G, Mӧller T.

Eur J Pharmacol. 2017 Jan 15;795:1-7. doi: 10.1016/j.ejphar.2016.11.031. Epub 2016 Nov 19.

PMID:
27876619
6.

Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods.

Jensen KG, Jacobsen AM, Bundgaard C, Nilausen DØ, Thale Z, Chandrasena G, Jørgensen M.

Drug Metab Dispos. 2017 Jan;45(1):68-75. Epub 2016 Oct 13.

7.

Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers.

Kumar JS, Walker M, Packiarajan M, Jubian V, Prabhakaran J, Chandrasena G, Pratap M, Parsey RV, Mann JJ.

ACS Chem Neurosci. 2016 May 18;7(5):540-5. doi: 10.1021/acschemneuro.5b00315. Epub 2016 Feb 22.

PMID:
26886507
8.

Environmental monitoring of waterborne Campylobacter: evaluation of the Australian standard and a hybrid extraction-free MPN-PCR method.

Henry R, Schang C, Chandrasena GI, Deletic A, Edmunds M, Jovanovic D, Kolotelo P, Schmidt J, Williamson R, McCarthy D.

Front Microbiol. 2015 Feb 9;6:74. doi: 10.3389/fmicb.2015.00074. eCollection 2015.

9.

Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist.

Cajina M, Nattini M, Song D, Smagin G, Jørgensen EB, Chandrasena G, Bundgaard C, Toft DB, Huang X, Acher F, Doller D.

ACS Med Chem Lett. 2013 Dec 12;5(2):119-23. doi: 10.1021/ml400338f. eCollection 2014 Feb 13.

10.

cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists.

Burns JF, Chen B, Chen CA, Doller D, Edelmenky E, Jiang Y, Peterson JM, Sabio M, Weiss J, White AD, Wu L, Bhardwaj R, Chandrasena G, Boyle NJ, Huang X.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1458-61. doi: 10.1016/j.bmcl.2014.02.023. Epub 2014 Feb 15.

PMID:
24582476
11.

Survival of Escherichia coli in stormwater biofilters.

Chandrasena GI, Deletic A, McCarthy DT.

Environ Sci Pollut Res Int. 2014 Apr;21(8):5391-401. doi: 10.1007/s11356-013-2430-2. Epub 2013 Dec 27.

PMID:
24371007
12.

Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.

Packiarajan M, Grenon M, Zorn S, Hopper AT, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4037-43. doi: 10.1016/j.bmcl.2013.05.070. Epub 2013 May 30.

PMID:
23770058
13.

Evaluating Escherichia coli removal performance in stormwater biofilters: a preliminary modelling approach.

Chandrasena GI, Deletic A, McCarthy DT.

Water Sci Technol. 2013;67(11):2467-75. doi: 10.2166/wst.2013.134.

PMID:
23752378
14.

Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.

Zhou H, Topiol SW, Grenon M, Jimenez HN, Uberti MA, Smith DG, Brodbeck RM, Chandrasena G, Pedersen H, Madsen JC, Doller D, Li G.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1398-406. doi: 10.1016/j.bmcl.2012.12.078. Epub 2013 Jan 5.

PMID:
23357634
15.

Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators.

Packiarajan M, Ferreira CG, Hong SP, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ.

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6469-74. doi: 10.1016/j.bmcl.2012.08.044. Epub 2012 Aug 25.

PMID:
22975301
16.

N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators.

Packiarajan M, Mazza Ferreira CG, Hong SP, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5658-62. doi: 10.1016/j.bmcl.2012.06.094. Epub 2012 Jul 6.

PMID:
22832311
17.

Evaluating Escherichia coli removal performance in stormwater biofilters: a laboratory-scale study.

Chandrasena GI, Deletic A, Ellerton J, McCarthy DT.

Water Sci Technol. 2012;66(5):1132-8. doi: 10.2166/wst.2012.283.

PMID:
22797244
18.

Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists.

Wu L, Lu K, Packiarajan M, Jubian V, Chandrasena G, Wolinsky TC, Walker MW.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2167-71. doi: 10.1016/j.bmcl.2012.01.117. Epub 2012 Feb 4.

PMID:
22361135
19.

5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists.

Packiarajan M, Coate H, Desai M, Jimenez HN, Reinhard EJ, Jubian VJ, Marzabadi MR, Chandrasena G, Wolinski TC, Walker MW, Andersen K.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6500-4. doi: 10.1016/j.bmcl.2011.08.072. Epub 2011 Aug 28.

PMID:
21924902
20.

Strategies to lower the Pgp efflux liability in a series of potent indole azetidine MCHR1 antagonists.

Lu K, Jiang Y, Chen B, Eldemenky EM, Ma G, Packiarajan M, Chandrasena G, White AD, Jones KA, Li B, Hong SP.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5310-4. doi: 10.1016/j.bmcl.2011.07.020. Epub 2011 Jul 14.

PMID:
21802292
21.

N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.

Wu L, Lu K, Desai M, Packiarajan M, Joshi A, Marzabadi MR, Jubian V, Andersen K, Chandrasena G, Boyle NJ, Walker MW.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5573-6. doi: 10.1016/j.bmcl.2011.06.078. Epub 2011 Jun 25.

PMID:
21782430
22.

Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.

Packiarajan M, Marzabadi MR, Desai M, Lu Y, Noble SA, Wong WC, Jubian V, Chandrasena G, Wolinsky TD, Zhong H, Walker MW, Wiborg O, Andersen K.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5436-41. doi: 10.1016/j.bmcl.2011.06.124. Epub 2011 Jul 2.

PMID:
21782428
23.

Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands.

Li G, Zhou H, Jiang Y, Keim H, Topiol SW, Poda SB, Ren Y, Chandrasena G, Doller D.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1236-42. doi: 10.1016/j.bmcl.2010.12.068. Epub 2010 Dec 19.

PMID:
21237644
24.

The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA.

J Pharmacol Exp Ther. 2009 Mar;328(3):900-11. doi: 10.1124/jpet.108.144634. Epub 2008 Dec 19.

25.

Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists.

Salvati ME, Balog A, Shan W, Rampulla R, Giese S, Mitt T, Furch JA, Vite GD, Attar RM, Jure-Kunkel M, Geng J, Rizzo CA, Gottardis MM, Krystek SR, Gougoutas J, Galella MA, Obermeier M, Fura A, Chandrasena G.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1910-5. doi: 10.1016/j.bmcl.2008.02.006. Epub 2008 Feb 8.

PMID:
18291644
26.

Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.

Devasthale PV, Chen S, Jeon Y, Qu F, Ryono DE, Wang W, Zhang H, Cheng L, Farrelly D, Golla R, Grover G, Ma Z, Moore L, Seethala R, Sun W, Doweyko AM, Chandrasena G, Sleph P, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2312-6. Epub 2007 Jan 25.

PMID:
17292606
27.

Pharmacokinetics of muraglitazar (BMS-298585), a dual peroxisome proliferator-activated receptors (PPAR) alpha and gamma activator, in mice, rats, dogs, and monkeys.

Hosagrahara VP, Chandrasena G, Chang SY, Koplowitz B, Hariharan N, Cheng PT, Humphreys WG.

Xenobiotica. 2006 Dec;36(12):1227-38.

PMID:
17162469
28.

Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.

Zhang D, Wang L, Chandrasena G, Ma L, Zhu M, Zhang H, Davis CD, Humphreys WG.

Drug Metab Dispos. 2007 Jan;35(1):139-49. Epub 2006 Oct 24.

29.

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.

Zhang D, Wang L, Raghavan N, Zhang H, Li W, Cheng PT, Yao M, Zhang L, Zhu M, Bonacorsi S, Yeola S, Mitroka J, Hariharan N, Hosagrahara V, Chandrasena G, Shyu WC, Humphreys WG.

Drug Metab Dispos. 2007 Jan;35(1):150-67. Epub 2006 Oct 24.

30.

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors.

Atwal KS, O'Neil SV, Ahmad S, Doweyko L, Kirby M, Dorso CR, Chandrasena G, Chen BC, Zhao R, Zahler R.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4796-9. Epub 2006 Jul 25.

PMID:
16870436
31.

3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.

Konkel MJ, Lagu B, Boteju LW, Jimenez H, Noble S, Walker MW, Chandrasena G, Blackburn TP, Nikam SS, Wright JL, Kornberg BE, Gregory T, Pugsley TA, Akunne H, Zoski K, Wise LD.

J Med Chem. 2006 Jun 29;49(13):3757-8.

PMID:
16789730
32.

A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series.

Vaz RJ, Nayeem A, Santone K, Chandrasena G, Gavai AV.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3816-20.

PMID:
15993593
33.

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R, Cheng L, Sleph P, Sun W, Tieman A, Wetterau JR, Doweyko A, Chandrasena G, Chang SY, Humphreys WG, Sasseville VG, Biller SA, Ryono DE, Selan F, Hariharan N, Cheng PT.

J Med Chem. 2005 Mar 24;48(6):2248-50.

PMID:
15771468
34.

Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1.

Ahmad S, Ngu K, Combs DW, Wu SC, Weinstein DS, Liu W, Chen BC, Chandrasena G, Dorso CR, Kirby M, Atwal KS.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):177-80.

PMID:
14684323
35.

Functional expression of human intestinal Na+-dependent and Na+-independent nucleoside transporters in Xenopus laevis oocytes.

Chandrasena G, Giltay R, Patil SD, Bakken A, Unadkat JD.

Biochem Pharmacol. 1997 Jun 15;53(12):1909-18.

PMID:
9256166
36.

Cloning and sequencing of a full-length rat sucrase-isomaltase-encoding cDNA.

Chandrasena G, Osterholm DE, Sunitha I, Henning SJ.

Gene. 1994 Dec 15;150(2):355-60.

PMID:
7821806
37.

Comparison of rates of intracellular metabolism of zidovudine in human and primate peripheral blood mononuclear cells.

Qian M, Chandrasena G, Ho RJ, Unadkat JD.

Antimicrob Agents Chemother. 1994 Oct;38(10):2398-403.

38.

Expression of sucrase-isomaltase mRNA along the villus-crypt axis in the rat small intestine.

Chandrasena G, Sunitha I, Lau C, Nanthakumar NN, Henning SJ.

Cell Mol Biol. 1992 May;38(3):243-54.

PMID:
1611655
39.

Radiation-induced recovery processes in cultured marsupial cells.

Overberg R, Chandrasena G, Rupert CS.

Mutat Res. 1988 Sep;194(2):83-92.

PMID:
3412365

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