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Items: 30


Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae.

McCullough LL, Pham TH, Parnell TJ, Connell Z, Chandrasekharan MB, Stillman DJ, Formosa T.

Genetics. 2019 Mar;211(3):877-892. doi: 10.1534/genetics.118.301853. Epub 2019 Jan 24.


A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.

Sdano MA, Fulcher JM, Palani S, Chandrasekharan MB, Parnell TJ, Whitby FG, Formosa T, Hill CP.

Elife. 2017 Aug 16;6. pii: e28723. doi: 10.7554/eLife.28723.


HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.

Tharkar-Promod S, Johnson DP, Bennett SE, Dennis EM, Banowsky BG, Jones SS, Shearstone JR, Quayle SN, Min C, Jarpe M, Mosbruger T, Pomicter AD, Miles RR, Chen WY, Bhalla KN, Zweidler-McKay PA, Shrieve DC, Deininger MW, Chandrasekharan MB, Bhaskara S.

Leukemia. 2018 Jan;32(1):49-60. doi: 10.1038/leu.2017.174. Epub 2017 Jun 5.


Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription.

Ramakrishnan S, Pokhrel S, Palani S, Pflueger C, Parnell TJ, Cairns BR, Bhaskara S, Chandrasekharan MB.

Nat Commun. 2016 Jun 21;7:11949. doi: 10.1038/ncomms11949.


SUMOylation Regulates Growth Factor Independence 1 in Transcriptional Control and Hematopoiesis.

Andrade D, Velinder M, Singer J, Maese L, Bareyan D, Nguyen H, Chandrasekharan MB, Lucente H, McClellan D, Jones D, Sharma S, Liu F, Engel ME.

Mol Cell Biol. 2016 May 2;36(10):1438-50. doi: 10.1128/MCB.01001-15. Print 2016 May 15.


Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination.

Huang F, Ramakrishnan S, Pokhrel S, Pflueger C, Parnell TJ, Kasten MM, Currie SL, Bhachech N, Horikoshi M, Graves BJ, Cairns BR, Bhaskara S, Chandrasekharan MB.

J Biol Chem. 2015 Nov 27;290(48):28760-77. doi: 10.1074/jbc.M115.693085. Epub 2015 Oct 8.


HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma.

Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, Chandrasekharan MB, Bhaskara S.

Oncotarget. 2015 Mar 10;6(7):4863-87.


Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression.

Bhaskara S, Jacques V, Rusche JR, Olson EN, Cairns BR, Chandrasekharan MB.

Epigenetics Chromatin. 2013 Aug 15;6(1):27. doi: 10.1186/1756-8935-6-27.


Decoding the trans-histone crosstalk: methods to analyze H2B ubiquitination, H3 methylation and their regulatory factors.

Chandrasekharan MB, Huang F, Sun ZW.

Methods. 2011 Jul;54(3):304-14. doi: 10.1016/j.ymeth.2011.02.010. Epub 2011 Mar 8. Review.


Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.

Joo HY, Jones A, Yang C, Zhai L, Smith AD 4th, Zhang Z, Chandrasekharan MB, Sun ZW, Renfrow MB, Wang Y, Chang C, Wang H.

J Biol Chem. 2011 Mar 4;286(9):7190-201. doi: 10.1074/jbc.M110.158311. Epub 2010 Dec 23.


Hdac3 is essential for the maintenance of chromatin structure and genome stability.

Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW.

Cancer Cell. 2010 Nov 16;18(5):436-47. doi: 10.1016/j.ccr.2010.10.022.


The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation.

Huang F, Chandrasekharan MB, Chen YC, Bhaskara S, Hiebert SW, Sun ZW.

J Biol Chem. 2010 Aug 6;285(32):24548-61. doi: 10.1074/jbc.M110.117333. Epub 2010 Jun 9.


Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation.

Chandrasekharan MB, Huang F, Sun ZW.

Epigenetics. 2010 Aug 16;5(6):460-8. doi: 10.4161/epi.5.6.12314. Epub 2010 Aug 16. Review.


Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination.

Chandrasekharan MB, Huang F, Chen YC, Sun ZW.

Mol Cell Biol. 2010 Jul;30(13):3216-32. doi: 10.1128/MCB.01008-09. Epub 2010 May 3.


Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability.

Chandrasekharan MB, Huang F, Sun ZW.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16686-91. doi: 10.1073/pnas.0907862106. Epub 2009 Sep 10.


Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.

Nakanishi S, Lee JS, Gardner KE, Gardner JM, Takahashi YH, Chandrasekharan MB, Sun ZW, Osley MA, Strahl BD, Jaspersen SL, Shilatifard A.

J Cell Biol. 2009 Aug 10;186(3):371-7. doi: 10.1083/jcb.200906005.


Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels.

Bhaskara S, Chandrasekharan MB, Ganguly R.

Gene. 2008 May 31;415(1-2):49-59. doi: 10.1016/j.gene.2008.02.017. Epub 2008 Mar 4.


Plant SET domain-containing proteins: structure, function and regulation.

Ng DW, Wang T, Chandrasekharan MB, Aramayo R, Kertbundit S, Hall TC.

Biochim Biophys Acta. 2007 May-Jun;1769(5-6):316-29. Epub 2007 Apr 12. Review.


Carcinogen-induced histone alteration in normal human mammary epithelial cells.

Bradley C, van der Meer R, Roodi N, Yan H, Chandrasekharan MB, Sun ZW, Mernaugh RL, Parl FF.

Carcinogenesis. 2007 Oct;28(10):2184-92. Epub 2007 Apr 29.


Ordered histone modifications are associated with transcriptional poising and activation of the phaseolin promoter.

Ng DW, Chandrasekharan MB, Hall TC.

Plant Cell. 2006 Jan;18(1):119-32. Epub 2005 Dec 2.


Interaction of PvALF and VP1 B3 domains with the beta -phaseolin promoter.

Carranco R, Chandrasekharan MB, Townsend JC, Hall TC.

Plant Mol Biol. 2004 May;55(2):221-37.


The 5' UTR negatively regulates quantitative and spatial expression from the ABI3 promoter.

Ng DW, Chandrasekharan MB, Hall TC.

Plant Mol Biol. 2004 Jan;54(1):25-38.


Sequence and spacing of TATA box elements are critical for accurate initiation from the beta-phaseolin promoter.

Grace ML, Chandrasekharan MB, Hall TC, Crowe AJ.

J Biol Chem. 2004 Feb 27;279(9):8102-10. Epub 2003 Dec 4.


Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus.

Teerawanichpan P, Chandrasekharan MB, Jiang Y, Narangajavana J, Hall TC.

Planta. 2004 Jan;218(3):337-49. Epub 2003 Sep 25.


S phase progression is required for transcriptional activation of the beta-phaseolin promoter.

Chandrasekharan MB, Li G, Bishop KJ, Hall TC.

J Biol Chem. 2003 Nov 14;278(46):45397-405. Epub 2003 Sep 5.


Module-specific regulation of the beta-phaseolin promoter during embryogenesis.

Chandrasekharan MB, Bishop KJ, Hall TC.

Plant J. 2003 Mar;33(5):853-66.


Kiddo, a new transposable element family closely associated with rice genes.

Yang G, Dong J, Chandrasekharan MB, Hall TC.

Mol Genet Genomics. 2001 Nov;266(3):417-24.


Chromatin structure and phaseolin gene regulation.

Li G, Chandrasekharan MB, Wolffe AP, Hall TC.

Plant Mol Biol. 2001 May;46(2):121-9. Review.


Transgene silencing in monocots.

Iyer LM, Kumpatla SP, Chandrasekharan MB, Hall TC.

Plant Mol Biol. 2000 Jun;43(2-3):323-46. Review.


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