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Items: 1 to 50 of 204

1.

Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function.

Fu Z, Ye J, Dean JW, Bostick JW, Weinberg SE, Xiong L, Oliff KN, Chen ZE, Avram D, Chandel NS, Zhou L.

Cell Rep. 2019 Jul 2;28(1):159-171.e4. doi: 10.1016/j.celrep.2019.06.024.

2.

Glucose Metabolism Linked to Antiviral Responses.

Stoolman JS, Chandel NS.

Cell. 2019 Jun 27;178(1):10-11. doi: 10.1016/j.cell.2019.05.057.

PMID:
31251910
3.

Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis.

Diebold LP, Gil HJ, Gao P, Martinez CA, Weinberg SE, Chandel NS.

Nat Metab. 2019 Jan;1(1):158-171. doi: 10.1038/s42255-018-0011-x. Epub 2019 Jan 7.

4.

Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate.

Yao Q, Khan MP, Merceron C, LaGory EL, Tata Z, Mangiavini L, Hu J, Vemulapalli K, Chandel NS, Giaccia AJ, Schipani E.

Dev Cell. 2019 Jun 3;49(5):748-763.e7. doi: 10.1016/j.devcel.2019.04.029. Epub 2019 May 16.

PMID:
31105007
5.

Immunometabolism of pro-repair cells.

Singer BD, Chandel NS.

J Clin Invest. 2019 May 13;130:2597-2607. doi: 10.1172/JCI124613. eCollection 2019 May 13. Review.

6.

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma.

Miska J, Lee-Chang C, Rashidi A, Muroski ME, Chang AL, Lopez-Rosas A, Zhang P, Panek WK, Cordero A, Han Y, Ahmed AU, Chandel NS, Lesniak MS.

Cell Rep. 2019 Apr 2;27(1):226-237.e4. doi: 10.1016/j.celrep.2019.03.029.

7.

NAD-biosynthetic pathways regulate innate immunity.

Billingham LK, Chandel NS.

Nat Immunol. 2019 Apr;20(4):380-382. doi: 10.1038/s41590-019-0353-x. No abstract available.

PMID:
30858621
8.

Serine Metabolism Supports Macrophage IL-1β Production.

Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS.

Cell Metab. 2019 Apr 2;29(4):1003-1011.e4. doi: 10.1016/j.cmet.2019.01.014. Epub 2019 Feb 14.

PMID:
30773464
9.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

10.

The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer.

Wen YA, Xiong X, Scott T, Li AT, Wang C, Weiss HL, Tan L, Bradford E, Fan TWM, Chandel NS, Barrett TA, Gao T.

Cell Death Differ. 2019 Jan 18. doi: 10.1038/s41418-018-0265-6. [Epub ahead of print]

PMID:
30659235
11.

Mitochondrial complex III is essential for suppressive function of regulatory T cells.

Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Martínez-Reyes I, Gao P, Helmin KA, Abdala-Valencia H, Sena LA, Schumacker PT, Turka LA, Chandel NS.

Nature. 2019 Jan;565(7740):495-499. doi: 10.1038/s41586-018-0846-z. Epub 2019 Jan 9.

12.

IDH3α regulates one-carbon metabolism in glioblastoma.

May JL, Kouri FM, Hurley LA, Liu J, Tommasini-Ghelfi S, Ji Y, Gao P, Calvert AE, Lee A, Chandel NS, Davuluri RV, Horbinski CM, Locasale JW, Stegh AH.

Sci Adv. 2019 Jan 2;5(1):eaat0456. doi: 10.1126/sciadv.aat0456. eCollection 2019 Jan.

13.

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.

Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB.

Cell Metab. 2019 Feb 5;29(2):443-456.e5. doi: 10.1016/j.cmet.2018.12.004. Epub 2018 Dec 27.

PMID:
30595481
14.

Probing mitochondrial metabolism in vivo.

McElroy GS, Chandel NS.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):20-22. doi: 10.1073/pnas.1819614116. Epub 2018 Dec 18. No abstract available.

15.

Hepatic HKDC1 Expression Contributes to Liver Metabolism.

Pusec CM, De Jesus A, Khan MW, Terry AR, Ludvik AE, Xu K, Giancola N, Pervaiz H, Daviau Smith E, Ding X, Harrison S, Chandel NS, Becker TC, Hay N, Ardehali H, Cordoba-Chacon J, Layden BT.

Endocrinology. 2019 Feb 1;160(2):313-330. doi: 10.1210/en.2018-00887.

PMID:
30517626
16.

There Is No Smoke without Mitochondria.

Han S, Chandel NS.

Am J Respir Cell Mol Biol. 2019 May;60(5):489-491. doi: 10.1165/rcmb.2018-0348ED. No abstract available.

17.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

PMID:
30318339
18.

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes.

Wei J, Yuan Y, Chen L, Xu Y, Zhang Y, Wang Y, Yang Y, Peek CB, Diebold L, Yang Y, Gao B, Jin C, Melo-Cardenas J, Chandel NS, Zhang DD, Pan H, Zhang K, Wang J, He F, Fang D.

Nat Commun. 2018 Sep 10;9(1):3659. doi: 10.1038/s41467-018-06091-7.

19.

Hexokinase 2 is dispensable for T cell-dependent immunity.

Mehta MM, Weinberg SE, Steinert EM, Chhiba K, Martinez CA, Gao P, Perlman HR, Bryce P, Hay N, Chandel NS.

Cancer Metab. 2018 Aug 17;6:10. doi: 10.1186/s40170-018-0184-5. eCollection 2018.

20.

ROS Promotes Cancer Cell Survival through Calcium Signaling.

Reczek CR, Chandel NS.

Cancer Cell. 2018 Jun 11;33(6):949-951. doi: 10.1016/j.ccell.2018.05.010.

21.

To Claim Growth Turf, mTOR Says SOD Off.

Kong H, Chandel NS.

Mol Cell. 2018 May 3;70(3):383-384. doi: 10.1016/j.molcel.2018.04.015.

22.

Acetyl-CoA-directed gene transcription in cancer cells.

Martínez-Reyes I, Chandel NS.

Genes Dev. 2018 Apr 1;32(7-8):463-465. doi: 10.1101/gad.315168.118. Review.

23.

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells.

Naguib A, Mathew G, Reczek CR, Watrud K, Ambrico A, Herzka T, Salas IC, Lee MF, El-Amine N, Zheng W, Di Francesco ME, Marszalek JR, Pappin DJ, Chandel NS, Trotman LC.

Cell Rep. 2018 Apr 3;23(1):58-67. doi: 10.1016/j.celrep.2018.03.032.

24.

Mitochondria-ER Pas de Deux Controls Memory T Cell Function.

Steinert EM, Chandel NS.

Immunity. 2018 Mar 20;48(3):479-481. doi: 10.1016/j.immuni.2018.03.002.

25.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

26.

E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells.

Xu S, Tao J, Yang L, Zhang E, Boriboun C, Zhou J, Sun T, Cheng M, Huang K, Shi J, Dong N, Liu Q, Zhao TC, Qiu H, Harris RA, Chandel NS, Losordo DW, Qin G.

Circ Res. 2018 Mar 2;122(5):701-711. doi: 10.1161/CIRCRESAHA.117.311814. Epub 2018 Jan 22.

27.

Regulation of redox balance in cancer and T cells.

Kong H, Chandel NS.

J Biol Chem. 2018 May 18;293(20):7499-7507. doi: 10.1074/jbc.TM117.000257. Epub 2017 Dec 27. Review.

28.

Mitochondria: back to the future.

Chandel NS.

Nat Rev Mol Cell Biol. 2018 Feb;19(2):76. doi: 10.1038/nrm.2017.133. Epub 2017 Dec 20. No abstract available.

PMID:
29259335
29.

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle.

Martínez-Reyes I, Chandel NS.

Cell Metab. 2017 Dec 5;26(6):803-804. doi: 10.1016/j.cmet.2017.11.005.

30.

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.

Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J.

J Biol Chem. 2018 Jan 5;293(1):271-284. doi: 10.1074/jbc.RA117.000440. Epub 2017 Nov 8.

31.

Reactive oxygen species as signaling molecules in the development of lung fibrosis.

Gonzalez-Gonzalez FJ, Chandel NS, Jain M, Budinger GRS.

Transl Res. 2017 Dec;190:61-68. doi: 10.1016/j.trsl.2017.09.005. Epub 2017 Oct 10. Review.

32.

A CRISPR screen identifies a pathway required for paraquat-induced cell death.

Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS.

Nat Chem Biol. 2017 Dec;13(12):1274-1279. doi: 10.1038/nchembio.2499. Epub 2017 Oct 23.

33.

Mitochondrial redox signaling enables repair of injured skeletal muscle cells.

Horn A, Van der Meulen JH, Defour A, Hogarth M, Sreetama SC, Reed A, Scheffer L, Chandel NS, Jaiswal JK.

Sci Signal. 2017 Sep 5;10(495). pii: eaaj1978. doi: 10.1126/scisignal.aaj1978.

34.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

35.

Mitochondrial control of immunity: beyond ATP.

Mehta MM, Weinberg SE, Chandel NS.

Nat Rev Immunol. 2017 Oct;17(10):608-620. doi: 10.1038/nri.2017.66. Epub 2017 Jul 3. Review.

PMID:
28669986
36.

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.

Calvert AE, Chalastanis A, Wu Y, Hurley LA, Kouri FM, Bi Y, Kachman M, May JL, Bartom E, Hua Y, Mishra RK, Schiltz GE, Dubrovskyi O, Mazar AP, Peter ME, Zheng H, James CD, Burant CF, Chandel NS, Davuluri RV, Horbinski C, Stegh AH.

Cell Rep. 2017 May 30;19(9):1858-1873. doi: 10.1016/j.celrep.2017.05.014.

37.

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.

Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J.

Nat Cell Biol. 2017 Jun;19(6):626-638. doi: 10.1038/ncb3527. Epub 2017 May 15.

38.

The mitochondrial respiratory chain is essential for haematopoietic stem cell function.

Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS.

Nat Cell Biol. 2017 Jun;19(6):614-625. doi: 10.1038/ncb3529. Epub 2017 May 15.

39.

Mitochondria control acute and chronic responses to hypoxia.

McElroy GS, Chandel NS.

Exp Cell Res. 2017 Jul 15;356(2):217-222. doi: 10.1016/j.yexcr.2017.03.034. Epub 2017 Mar 19. Review.

40.

Metabolism and Skeletal Muscle Homeostasis in Lung Disease.

Ceco E, Weinberg SE, Chandel NS, Sznajder JI.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):28-34. doi: 10.1165/rcmb.2016-0355TR. Review.

41.

Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI.

Dutta RK, Kondeti VK, Sharma I, Chandel NS, Quaggin SE, Kanwar YS.

J Am Soc Nephrol. 2017 May;28(5):1421-1436. doi: 10.1681/ASN.2016070744. Epub 2016 Nov 28.

42.

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM.

J Biol Chem. 2016 Dec 30;291(53):27239-27251. doi: 10.1074/jbc.M116.756247. Epub 2016 Nov 11.

43.

Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy.

Almassalha LM, Bauer GM, Chandler JE, Gladstein S, Cherkezyan L, Stypula-Cyrus Y, Weinberg S, Zhang D, Thusgaard Ruhoff P, Roy HK, Subramanian H, Chandel NS, Szleifer I, Backman V.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6372-E6381. Epub 2016 Oct 4.

44.

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy.

Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P.

Hum Mol Genet. 2016 Jun 1;25(11):2143-2157. Epub 2016 Mar 21.

45.

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

Chandel NS, Jasper H, Ho TT, Passegué E.

Nat Cell Biol. 2016 Aug;18(8):823-32. doi: 10.1038/ncb3385. Epub 2016 Jul 18. Review.

PMID:
27428307
46.

Fundamentals of cancer metabolism.

DeBerardinis RJ, Chandel NS.

Sci Adv. 2016 May 27;2(5):e1600200. doi: 10.1126/sciadv.1600200. eCollection 2016 May. Review.

47.

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics.

Navarro P, Bueno MJ, Zagorac I, Mondejar T, Sanchez J, Mourón S, Muñoz J, Gómez-López G, Jimenez-Renard V, Mulero F, Chandel NS, Quintela-Fandino M.

Cell Rep. 2016 Jun 21;15(12):2705-18. doi: 10.1016/j.celrep.2016.05.052. Epub 2016 Jun 9.

48.

Mitochondrial ROS regulation of proliferating cells.

Diebold L, Chandel NS.

Free Radic Biol Med. 2016 Nov;100:86-93. doi: 10.1016/j.freeradbiomed.2016.04.198. Epub 2016 May 3. Review.

PMID:
27154978
49.

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

Chandel NS, Avizonis D, Reczek CR, Weinberg SE, Menz S, Neuhaus R, Christian S, Haegebarth A, Algire C, Pollak M.

Cell Metab. 2016 Apr 12;23(4):569-70. doi: 10.1016/j.cmet.2016.03.010. No abstract available.

50.

The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia.

Hamanaka RB, Weinberg SE, Reczek CR, Chandel NS.

Cell Rep. 2016 Apr 19;15(3):451-459. doi: 10.1016/j.celrep.2016.03.044. Epub 2016 Apr 7.

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