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Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age.

Barbosa M, Maddess T, Ahn S, Chan-Ling T.

Sci Rep. 2019 Sep 17;9(1):13464. doi: 10.1038/s41598-019-49443-z.


P2X7 receptor signaling during adult hippocampal neurogenesis.

Leeson HC, Chan-Ling T, Lovelace MD, Brownlie JC, Gu BJ, Weible MW.

Neural Regen Res. 2019 Oct;14(10):1684-1694. doi: 10.4103/1673-5374.257510.


Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells.

Leeson HC, Chan-Ling T, Lovelace MD, Brownlie JD, Weible MW 2nd, Gu BJ.

J Vis Exp. 2019 Apr 3;(146). doi: 10.3791/59313.


Therapeutic regulation of VE-cadherin with a novel oligonucleotide drug for diabetic eye complications using retinopathy mouse models.

Ting KK, Zhao Y, Shen W, Coleman P, Yam M, Chan-Ling T, Li J, Moller T, Gillies M, Vadas MA, Gamble JR.

Diabetologia. 2019 Feb;62(2):322-334. doi: 10.1007/s00125-018-4770-4. Epub 2018 Nov 15.


P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis.

Leeson HC, Kasherman MA, Chan-Ling T, Lovelace MD, Brownlie JC, Toppinen KM, Gu BJ, Weible MW 2nd.

Stem Cells. 2018 Nov;36(11):1764-1777. doi: 10.1002/stem.2894. Epub 2018 Sep 17.


Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.

Hu P, Hunt NH, Arfuso F, Shaw LC, Uddin MN, Zhu M, Devasahayam R, Adamson SJ, Benson VL, Chan-Ling T, Grant MB.

Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5043-5055. doi: 10.1167/iovs.17-21654.


Pathophysiology, screening and treatment of ROP: A multi-disciplinary perspective.

Chan-Ling T, Gole GA, Quinn GE, Adamson SJ, Darlow BA.

Prog Retin Eye Res. 2018 Jan;62:77-119. doi: 10.1016/j.preteyeres.2017.09.002. Epub 2017 Sep 27. Review.


Insulin-like growth factor binding protein-3 links obesity and breast cancer progression.

Scully T, Firth SM, Scott CD, de Silva HC, Pintar JE, Chan-Ling T, Twigg SM, Baxter RC.

Oncotarget. 2016 Aug 23;7(34):55491-55505. doi: 10.18632/oncotarget.10675.


The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome.

Li SS, Qu Z, Haas M, Ngo L, Heo YJ, Kang HJ, Britto JM, Cullen HD, Vanyai HK, Tan SS, Chan-Ling T, Gunnersen JM, Heng JI.

Sci Rep. 2016 Jul 11;6:29514. doi: 10.1038/srep29514.


Author Response: Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid?

Chan-Ling T, Koina ME, Arfuso F, Adamson SJ, Baxter LC, Hu P, Madigan MC.

Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6711-3. doi: 10.1167/iovs.15-18011. No abstract available.


Differential expression of sirtuins in the aging rat brain.

Braidy N, Poljak A, Grant R, Jayasena T, Mansour H, Chan-Ling T, Smythe G, Sachdev P, Guillemin GJ.

Front Cell Neurosci. 2015 May 8;9:167. doi: 10.3389/fncel.2015.00167. eCollection 2015.


Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice.

Hu P, Thinschmidt JS, Caballero S, Adamson S, Cole L, Chan-Ling T, Grant MB.

Am J Physiol Endocrinol Metab. 2015 Apr 15;308(8):E688-98. doi: 10.1152/ajpendo.00504.2014. Epub 2015 Feb 24.


Evidence for lymphatics in the developing and adult human choroid.

Koina ME, Baxter L, Adamson SJ, Arfuso F, Hu P, Madigan MC, Chan-Ling T.

Invest Ophthalmol Vis Sci. 2015 Jan 13;56(2):1310-27. doi: 10.1167/iovs.14-15705.


P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts.

Lovelace MD, Gu BJ, Eamegdool SS, Weible MW 2nd, Wiley JS, Allen DG, Chan-Ling T.

Stem Cells. 2015 Feb;33(2):526-41. doi: 10.1002/stem.1864.


Ultrasmall superparamagnetic iron oxide nanoparticle prelabelling of human neural precursor cells.

Eamegdool SS, Weible MW 2nd, Pham BT, Hawkett BS, Grieve SM, Chan-ling T.

Biomaterials. 2014 Jul;35(21):5549-64. doi: 10.1016/j.biomaterials.2014.03.061. Epub 2014 Apr 13.


Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence.

Braidy N, Poljak A, Grant R, Jayasena T, Mansour H, Chan-Ling T, Guillemin GJ, Smythe G, Sachdev P.

Biogerontology. 2014 Apr;15(2):177-98. doi: 10.1007/s10522-013-9489-5. Epub 2013 Dec 17.


CNS inflammation and bone marrow neuropathy in type 1 diabetes.

Hu P, Thinschmidt JS, Yan Y, Hazra S, Bhatwadekar A, Caballero S, Salazar T, Miyan JA, Li W, Derbenev A, Zsombok A, Tikhonenko M, Dominguez JM 2nd, McGorray SP, Saban DR, Boulton ME, Busik JV, Raizada MK, Chan-Ling T, Grant MB.

Am J Pathol. 2013 Nov;183(5):1608-20. doi: 10.1016/j.ajpath.2013.07.009.


Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina.

Mansour H, McColm JR, Cole L, Weible M 2nd, Korlimbinis A, Chan-Ling T.

PLoS One. 2013;8(3):e57038. doi: 10.1371/journal.pone.0057038. Epub 2013 Mar 14.


Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.

Jarajapu YP, Cai J, Yan Y, Li Calzi S, Kielczewski JL, Hu P, Shaw LC, Firth SM, Chan-Ling T, Boulton ME, Baxter RC, Grant MB.

PLoS One. 2012;7(7):e39398. doi: 10.1371/journal.pone.0039398. Epub 2012 Jul 6.


The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes.

Combes V, Guillemin GJ, Chan-Ling T, Hunt NH, Grau GE.

Trends Parasitol. 2012 Aug;28(8):311-9. doi: 10.1016/ Epub 2012 Jun 22. Review.


Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease.

Kur J, Newman EA, Chan-Ling T.

Prog Retin Eye Res. 2012 Sep;31(5):377-406. doi: 10.1016/j.preteyeres.2012.04.004. Epub 2012 May 3. Review.


Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.

Braidy N, Guillemin GJ, Mansour H, Chan-Ling T, Grant R.

FEBS J. 2011 Nov;278(22):4425-34. doi: 10.1111/j.1742-4658.2011.08366.x.


Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase).

Kielczewski JL, Li Calzi S, Shaw LC, Cai J, Qi X, Ruan Q, Wu L, Liu L, Hu P, Chan-Ling T, Mames RN, Firth S, Baxter RC, Turowski P, Busik JV, Boulton ME, Grant MB.

Invest Ophthalmol Vis Sci. 2011 Oct 21;52(11):8278-86. doi: 10.1167/iovs.11-8167.


Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria.

Ampawong S, Combes V, Hunt NH, Radford J, Chan-Ling T, Pongponratn E, Grau GE.

Int J Clin Exp Pathol. 2011 Aug 15;4(6):566-74. Epub 2011 Jul 23.


Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats.

Braidy N, Guillemin GJ, Mansour H, Chan-Ling T, Poljak A, Grant R.

PLoS One. 2011 Apr 26;6(4):e19194. doi: 10.1371/journal.pone.0019194.


Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury.

Kielczewski JL, Hu P, Shaw LC, Li Calzi S, Mames RN, Gardiner TA, McFarland E, Chan-Ling T, Grant MB.

Am J Pathol. 2011 Apr;178(4):1517-28. doi: 10.1016/j.ajpath.2010.12.031.


Evidence of hematopoietic differentiation, vasculogenesis and angiogenesis in the formation of human choroidal blood vessels.

Chan-Ling T, Dahlstrom JE, Koina ME, McColm JR, Sterling RA, Bean EG, Adamson S, Hughes S, Baxter LC.

Exp Eye Res. 2011 May;92(5):361-76. doi: 10.1016/j.exer.2011.02.009. Epub 2011 Feb 24.


Role of CD44+ stem cells in mural cell formation in the human choroid: evidence of vascular instability due to limited pericyte ensheathment.

Chan-Ling T, Koina ME, McColm JR, Dahlstrom JE, Bean E, Adamson S, Yun S, Baxter L.

Invest Ophthalmol Vis Sci. 2011 Jan 21;52(1):399-410. doi: 10.1167/iovs.10-5403.


Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation.

Kielczewski JL, Jarajapu YP, McFarland EL, Cai J, Afzal A, Li Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Boulton ME, Mames RN, Chan-Ling T, Grant MB.

Circ Res. 2009 Oct 23;105(9):897-905. doi: 10.1161/CIRCRESAHA.109.199059. Epub 2009 Sep 17.


Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.

Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15489-94. doi: 10.1073/pnas.0904880106. Epub 2009 Aug 25.


MHC class II expression by beta2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina.

Huang W, Chamberlain CG, Sarafian RY, Chan-Ling T.

Neuron Glia Biol. 2008 Nov;4(4):285-94. doi: 10.1017/S1740925X0999007X. Epub 2009 Jul 6.


'When an old rat smells a cat': A decline in defense-related, but not accessory olfactory, Fos expression in aged rats.

Hunt GE, Van Nieuwenhuijzen PS, Chan-Ling T, McGregor IS.

Neurobiol Aging. 2011 Apr;32(4):737-49. doi: 10.1016/j.neurobiolaging.2009.03.014. Epub 2009 Apr 24.


Limited intravascular coupling in the rodent brainstem and retina supports a role for glia in regional blood flow.

Kuo IY, Chan-Ling T, Wojcikiewicz RJ, Hill CE.

J Comp Neurol. 2008 Dec 20;511(6):773-87. doi: 10.1002/cne.21873.


In vivo characterization of astrocyte precursor cells (APCs) and astrocytes in developing rat retinae: differentiation, proliferation, and apoptosis.

Chan-Ling T, Chu Y, Baxter L, Weible Ii M, Hughes S.

Glia. 2009 Jan 1;57(1):39-53. doi: 10.1002/glia.20733.


Aging-related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availability.

Mansour H, Chamberlain CG, Weible MW 2nd, Hughes S, Chu Y, Chan-Ling T.

Aging Cell. 2008 Aug;7(4):526-40. doi: 10.1111/j.1474-9726.2008.00402.x. Epub 2008 Jun 28.


Endometriosis of the inguinal region: magnetic resonance imaging (MRI) findings.

Low RS, Jones AO, Houang M, Newland L, Morey AL, Chan-Ling T.

Australas Radiol. 2007 Dec;51 Suppl:B272-5.


IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development.

Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Li Calzi S, Sullivan SM, Grant MB.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10595-600. Epub 2007 Jun 13.


Inflammation and breakdown of the blood-retinal barrier during "physiological aging" in the rat retina: a model for CNS aging.

Chan-Ling T, Hughes S, Baxter L, Rosinova E, McGregor I, Morcos Y, van Nieuwenhuyzen P, Hu P.

Microcirculation. 2007 Jan;14(1):63-76.


Changes in pericytes and smooth muscle cells in the kitten model of retinopathy of prematurity: implications for plus disease.

Hughes S, Gardiner T, Baxter L, Chan-Ling T.

Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1368-79.


Retinopathy of prematurity: two distinct mechanisms that underlie zone 1 and zone 2 disease.

Flynn JT, Chan-Ling T.

Am J Ophthalmol. 2006 Jul;142(1):46-59.


Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California).

Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton DR, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT.

Mol Vis. 2006 May 23;12:532-80.


Immunopathogenesis of cerebral malaria.

Hunt NH, Golenser J, Chan-Ling T, Parekh S, Rae C, Potter S, Medana IM, Miu J, Ball HJ.

Int J Parasitol. 2006 May 1;36(5):569-82. Epub 2006 Mar 20. Review.


Hematopoietic stem cells provide repair functions after laser-induced Bruch's membrane rupture model of choroidal neovascularization.

Chan-Ling T, Baxter L, Afzal A, Sengupta N, Caballero S, Rosinova E, Grant MB.

Am J Pathol. 2006 Mar;168(3):1031-44.


Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria.

Potter S, Chan-Ling T, Ball HJ, Mansour H, Mitchell A, Maluish L, Hunt NH.

Int J Parasitol. 2006 Apr;36(4):485-96. Epub 2006 Jan 19.


A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria.

Potter SM, Chan-Ling T, Rosinova E, Ball HJ, Mitchell AJ, Hunt NH.

J Neuroimmunol. 2006 Apr;173(1-2):96-107. Epub 2006 Jan 18.


Altered pericyte-endothelial relations in the rat retina during aging: implications for vessel stability.

Hughes S, Gardiner T, Hu P, Baxter L, Rosinova E, Chan-Ling T.

Neurobiol Aging. 2006 Dec;27(12):1838-47. Epub 2006 Jan 18.


Desmin ensheathment ratio as an indicator of vessel stability: evidence in normal development and in retinopathy of prematurity.

Chan-Ling T, Page MP, Gardiner T, Baxter L, Rosinova E, Hughes S.

Am J Pathol. 2004 Oct;165(4):1301-13.


Characterization of smooth muscle cell and pericyte differentiation in the rat retina in vivo.

Hughes S, Chan-Ling T.

Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2795-806.


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