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Experimental modeling of cornea wound healing in diabetes: clinical applications and beyond.

Bu Y, Shih KC, Kwok SS, Chan YK, Lo AC, Chan TCY, Jhanji V, Tong L.

BMJ Open Diabetes Res Care. 2019 Nov 27;7(1):e000779. doi: 10.1136/bmjdrc-2019-000779. eCollection 2019. Review.


Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity.

Riedl W, Acharya D, Lee JH, Liu G, Serman T, Chiang C, Chan YK, Diamond MS, Gack MU.

Cell Host Microbe. 2019 Oct 9;26(4):493-503.e6. doi: 10.1016/j.chom.2019.09.012.


On-Demand Droplet Collection for Capturing Single Cells.

Nan L, Lai MYA, Tang MYH, Chan YK, Poon LLM, Shum HC.

Small. 2019 Aug 25:e1902889. doi: 10.1002/smll.201902889. [Epub ahead of print]


Amphiphilic additives in silicone oil tamponade and emulsification: an eye-on-a-chip study.

Lu Y, Chan YK, Lau LH, Wong D, Wong JKW, Shih KC, Lai SM, Shum HC.

Acta Ophthalmol. 2019 Aug 6. doi: 10.1111/aos.14212. [Epub ahead of print]


Antecedent Carbapenem Exposure as a Risk Factor for Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae and Carbapenemase-Producing Enterobacteriaceae.

Marimuthu K, Ng OT, Cherng BPZ, Fong RKC, Pada SK, De PP, Ooi ST, Smitasin N, Thoon KC, Krishnan PU, Ang MLT, Chan DSG, Kwa ALH, Deepak RN, Chan YK, Chan YFZ, Huan X, Zaw Linn K, Tee NWS, Tan TY, Koh TH, Lin RTP, Hsu LY, Sengupta S, Paterson DL, Perencevich E, Harbarth S, Teo J, Venkatachalam I; CaPES Study Group.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00845-19. doi: 10.1128/AAC.00845-19. Print 2019 Oct.


Differential patterns of disease and injury in Mozambique: New perspectives from a pragmatic, multicenter, surveillance study of 7809 emergency presentations.

Mocumbi AO, Cebola B, Muloliwa A, Sebastião F, Sitefane SJ, Manafe N, Dobe I, Lumbandali N, Keates A, Stickland N, Chan YK, Stewart S.

PLoS One. 2019 Jul 10;14(7):e0219273. doi: 10.1371/journal.pone.0219273. eCollection 2019.


An in vitro pressure model towards studying the response of primary retinal ganglion cells to elevated hydrostatic pressures.

Wu J, Mak HK, Chan YK, Lin C, Kong C, Leung CKS, Shum HC.

Sci Rep. 2019 Jun 21;9(1):9057. doi: 10.1038/s41598-019-45510-7.


All-Aqueous Thin-Film-Flow-Induced Cell-Based Monolayers.

Chan YK, Yan WH, Hung LT, Chao Y, Wu J, Shum HC.

ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22869-22877. doi: 10.1021/acsami.9b06382. Epub 2019 Jun 12.


Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity.

Xiao Y, Muhuri M, Li S, Qin W, Xu G, Luo L, Li J, Letizia AJ, Wang SK, Chan YK, Wang C, Fuchs SP, Wang D, Su Q, Nahid MA, Church GM, Farzan M, Yang L, Wei Y, Desrosiers RC, Mueller C, Tai PW, Gao G.

JCI Insight. 2019 May 21;5. pii: 99052. doi: 10.1172/jci.insight.99052.


Light limitation selects for depth generalists in urbanised reef coral communities.

Chow GSE, Chan YKS, Jain SS, Huang D.

Mar Environ Res. 2019 May;147:101-112. doi: 10.1016/j.marenvres.2019.04.010. Epub 2019 Apr 19.


Gut Mucosal Proteins and Bacteriome Are Shaped by the Saturation Index of Dietary Lipids.

Abulizi N, Quin C, Brown K, Chan YK, Gill SK, Gibson DL.

Nutrients. 2019 Feb 16;11(2). pii: E418. doi: 10.3390/nu11020418.


Ciliochoroidal detachment after Ahmed glaucoma valve implantation: a retrospective study.

Fu L, Chan YK, Nie L, Dai Q, Qian Z, Shih KC, Lai JSM, Huang R, Pan W.

BMC Ophthalmol. 2019 Feb 6;19(1):46. doi: 10.1186/s12886-019-1060-y.


Adeno-associated Virus (AAV) versus Immune Response.

Rabinowitz J, Chan YK, Samulski RJ.

Viruses. 2019 Jan 25;11(2). pii: E102. doi: 10.3390/v11020102. Review.


Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up.

Loader J, Chan YK, Hawley JA, Moholdt T, McDonald CF, Jhund P, Petrie MC, McMurray JJ, Scuffham PA, Ramchand J, Burrell LM, Stewart S.

Int J Cardiol. 2019 Mar 15;279:126-132. doi: 10.1016/j.ijcard.2018.12.060. Epub 2019 Jan 2.


Malignant and Benign Phenotypes of Multimorbidity in Heart Failure: Implications for Clinical Practice.

Chen L, Chan YK, Busija L, Norekval TM, Riegel B, Stewart S.

J Cardiovasc Nurs. 2019 May/Jun;34(3):258-266. doi: 10.1097/JCN.0000000000000557.


[Robotic head and neck surgery at the Chinese University of Hong Kong].

Chan YK, Wong WY.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Jul;32(14):1056-1060. doi: 10.13201/j.issn.1001-1781.2018.14.004. Chinese.


Adhesion of silicone oil and emulsification: an in vitro assessment using a microfluidic device and 'Eye-on-a-Chip'.

Lu Y, Chan YK, Lau LH, Chao Y, Shih KC, Lai SM, Wong D, Shum HC.

Acta Ophthalmol. 2019 May;97(3):313-318. doi: 10.1111/aos.13982. Epub 2018 Nov 28.


Artificial Intelligence in Medical Applications.

Chan YK, Chen YF, Pham T, Chang W, Hsieh MY.

J Healthc Eng. 2018 Jul 15;2018:4827875. doi: 10.1155/2018/4827875. eCollection 2018. No abstract available.


Transcorneal Electrical Stimulation Inhibits Retinal Microglial Activation and Enhances Retinal Ganglion Cell Survival After Acute Ocular Hypertensive Injury.

Fu L, Fung FK, Lo AC, Chan YK, So KF, Wong IY, Shih KC, Lai JS.

Transl Vis Sci Technol. 2018 May 29;7(3):7. doi: 10.1167/tvst.7.3.7. eCollection 2018 May.


Prospective Study on Ex-PRESS Implantation Combined with Phacoemulsification in Primary Angle-Closure Glaucoma Coexisting Cataract: 3-Year Results.

Nie L, Fang A, Pan W, Ye H, Chan YK, Fu L, Qu J.

Curr Eye Res. 2018 Aug;43(8):1045-1051. doi: 10.1080/02713683.2018.1464196. Epub 2018 May 4.


Enabling multiplexed testing of pooled donor cells through whole-genome sequencing.

Chan Y, Chan YK, Goodman DB, Guo X, Chavez A, Lim ET, Church GM.

Genome Med. 2018 Apr 19;10(1):31. doi: 10.1186/s13073-018-0541-6.


Outcomes and morbidities of patients who survive haemoglobin Bart's hydrops fetalis syndrome: 20-year retrospective review.

Chan WY, Leung AW, Luk CW, Li RC, Ling AS, Ha SY.

Hong Kong Med J. 2018 Apr;24(2):107-118. doi: 10.12809/hkmj176336. Epub 2018 Apr 6.


Combined Phacoemulsification and Goniosynechialysis under an Endoscope for Chronic Primary Angle-Closure Glaucoma.

Nie L, Pan W, Fang A, Li Z, Qian Z, Fu L, Chan YK.

J Ophthalmol. 2018 Feb 8;2018:8160184. doi: 10.1155/2018/8160184. eCollection 2018.


Construction of diagnosis system and gene regulatory networks based on microarray analysis.

Hong CF, Chen YC, Chen WC, Tu KC, Tsai MH, Chan YK, Yu SS.

J Biomed Inform. 2018 May;81:61-73. doi: 10.1016/j.jbi.2018.03.008. Epub 2018 Mar 14.


Left Ventricular Dysfunction and Exercise Capacity Trajectory: Implications for Subclinical Heart Failure Staging Criteria.

Sacre JW, Wong C, Chan YK, Carrington MJ, Stewart S, Kingwell BA.

JACC Cardiovasc Imaging. 2019 May;12(5):798-806. doi: 10.1016/j.jcmg.2017.10.023. Epub 2018 Feb 14.


Applying Heart Failure Management to Improve Health Outcomes: But WHICH One?

Chan YK, David AM, Mainland C, Chen L, Stewart S.

Card Fail Rev. 2017 Nov;3(2):113-115. doi: 10.15420/cfr.2017:11:1.


Laws of physics help explain capillary non-perfusion in diabetic retinopathy.

Stefánsson E, Chan YK, Bek T, Hardarson SH, Wong D, Wilson DI.

Eye (Lond). 2018 Feb;32(2):210-212. doi: 10.1038/eye.2017.313. Epub 2018 Jan 19.


Intraocular currents, Bernoulli's principle and non-drainage scleral buckling for rhegmatogenous retinal detachment.

Wong D, Chan YK, Bek T, Wilson I, Stefánsson E.

Eye (Lond). 2018 Feb;32(2):213-221. doi: 10.1038/eye.2017.312. Epub 2018 Jan 19.


Correction to "Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues".

Peng T, Wong NK, Chen X, Chan YK, Sun Z, Hu JJ, Shen J, El-Nezami H, Yang D.

J Am Chem Soc. 2018 Jan 17;140(2):854. doi: 10.1021/jacs.7b13132. Epub 2018 Jan 2. No abstract available.


Economic evaluation of a nurse-led home and clinic-based secondary prevention programme to prevent progressive cardiac dysfunction in high-risk individuals: The Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomized controlled study.

Maru S, Byrnes J, Carrington MJ, Chan YK, Stewart S, Scuffham PA; NIL-CHF Trial Investigators.

Eur J Cardiovasc Nurs. 2018 Jun;17(5):439-445. doi: 10.1177/1474515117743979. Epub 2017 Nov 23.


Strategies for success: a multi-institutional study on robot-assisted partial nephrectomy for complex renal lesions.

Hennessey DB, Wei G, Moon D, Kinnear N, Bolton DM, Lawrentschuk N, Chan YK.

BJU Int. 2018 May;121 Suppl 3:40-47. doi: 10.1111/bju.14059. Epub 2017 Dec 21.


Mild cognitive impairment is associated with subclinical diastolic dysfunction in patients with chronic heart disease.

Sacre JW, Ball J, Wong C, Chan YK, Stewart S, Kingwell BA, Carrington MJ.

Eur Heart J Cardiovasc Imaging. 2018 Mar 1;19(3):285-292. doi: 10.1093/ehjci/jex169.


Comparison of the EQ-5D-3L and the SF-6D (SF-12) contemporaneous utility scores in patients with cardiovascular disease.

Kularatna S, Byrnes J, Chan YK, Ski CF, Carrington M, Thompson D, Stewart S, Scuffham PA.

Qual Life Res. 2017 Dec;26(12):3399-3408. doi: 10.1007/s11136-017-1666-6. Epub 2017 Aug 1.


A perfluorobutylpentane (F4H5)-based solution for the removal of residual emulsified silicone oil.

Chan YK, Cheng HC, Wu J, Tang YHM, Chan ST, Wong D, Shum HC.

Acta Ophthalmol. 2018 Feb;96(1):e38-e45. doi: 10.1111/aos.13465. Epub 2017 Jun 14.


Standard vs. intensified management of heart failure to reduce healthcare costs: results of a multicentre, randomized controlled trial.

Scuffham PA, Ball J, Horowitz JD, Wong C, Newton PJ, Macdonald P, McVeigh J, Rischbieth A, Emanuele N, Carrington MJ, Reid CM, Chan YK, Stewart S; WHICH? II Trial Investigators.

Eur Heart J. 2017 Aug 7;38(30):2340-2348. doi: 10.1093/eurheartj/ehx259.


An unbiased index to quantify participant's phenotypic contribution to an open-access cohort.

Chan Y, Tung M, Garruss AS, Zaranek SW, Chan YK, Lunshof JE, Zaranek AW, Ball MP, Chou MF, Lim ET, Church GM.

Sci Rep. 2017 Apr 7;7:46148. doi: 10.1038/srep46148.


Multimorbidity and the Risk of All-Cause 30-Day Readmission in the Setting of Multidisciplinary Management of Chronic Heart Failure: A Retrospective Analysis of 830 Hospitalized Patients in Australia.

Wiley JF, Chan YK, Ahamed Y, Ball J, Carrington MJ, Riegel B, Stewart S.

J Cardiovasc Nurs. 2018 Sep/Oct;33(5):437-445. doi: 10.1097/JCN.0000000000000391.


In vitro experiment to elucidate the mechanism of the 'soft shell technique' for preventing subretinal migration of perfluoro-octane.

Chan YK, Lu Y, Czanner G, Wu J, Cheng HC, Hussain R, Sakamoto T, Shum HC, Wong D.

Br J Ophthalmol. 2017 Mar;101(3):389-394. doi: 10.1136/bjophthalmol-2016-309856. Epub 2017 Jan 5.


Small particle size lipid emulsions, satiety and energy intake in lean men.

Chan YK, Budgett SC, MacGibbon AK, Quek SY, Kindleysides S, Poppitt SD.

Physiol Behav. 2017 Feb 1;169:98-105. doi: 10.1016/j.physbeh.2016.11.025. Epub 2016 Nov 24.


Comparison of contemporaneous responses for EQ-5D-3L and Minnesota Living with Heart Failure; a case for disease specific multiattribute utility instrument in cardiovascular conditions.

Kularatna S, Byrnes J, Chan YK, Carrington MJ, Stewart S, Scuffham PA.

Int J Cardiol. 2017 Jan 15;227:172-176. doi: 10.1016/j.ijcard.2016.11.030. Epub 2016 Nov 9.


Lipocalin-2 (NGAL) Attenuates Autophagy to Exacerbate Cardiac Apoptosis Induced by Myocardial Ischemia.

Sung HK, Chan YK, Han M, Jahng JWS, Song E, Danielson E, Berger T, Mak TW, Sweeney G.

J Cell Physiol. 2017 Aug;232(8):2125-2134. doi: 10.1002/jcp.25672. Epub 2017 Mar 24.


Towards better characterization and quantification of emulsification of silicone oil in vitro.

Chan YK, Czanner G, Shum HC, Williams RL, Cheung N, Wong D.

Acta Ophthalmol. 2017 Aug;95(5):e385-e392. doi: 10.1111/aos.13258. Epub 2016 Oct 24.


Economic outcomes of influenza in hospitalized elderly with and without ICU admission.

Chan YK, Wong RY, Ip M, Lee NL, You JH.

Antivir Ther. 2017;22(2):173-177. doi: 10.3851/IMP3102. Epub 2016 Oct 14.


Integrity of the Human Faecal Microbiota following Long-Term Sample Storage.

Kia E, Wagner Mackenzie B, Middleton D, Lau A, Waite DW, Lewis G, Chan YK, Silvestre M, Cooper GJ, Poppitt SD, Taylor MW.

PLoS One. 2016 Oct 4;11(10):e0163666. doi: 10.1371/journal.pone.0163666. eCollection 2016.


Current and projected burden of heart failure in the Australian adult population: a substantive but still ill-defined major health issue.

Chan YK, Tuttle C, Ball J, Teng TK, Ahamed Y, Carrington MJ, Stewart S.

BMC Health Serv Res. 2016 Sep 21;16(1):501.


Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE(-/-) mice.

Chan YK, El-Nezami H, Chen Y, Kinnunen K, Kirjavainen PV.

AMB Express. 2016 Dec;6(1):61. doi: 10.1186/s13568-016-0229-5. Epub 2016 Aug 30.


The impact of positron emission tomography on primary tumour delineation and dosimetric outcome in intensity modulated radiotherapy of early T-stage nasopharyngeal carcinoma.

Wu VW, Leung WS, Wong KL, Chan YK, Law WL, Leung WK, Yu YL.

Radiat Oncol. 2016 Aug 24;11(1):109. doi: 10.1186/s13014-016-0685-8.


Handedness in man: The energy availability hypothesis.

Chan YK, Loh PS.

Med Hypotheses. 2016 Sep;94:108-11. doi: 10.1016/j.mehy.2016.06.018. Epub 2016 Jun 15.


Epidemiology of Inflammatory Bowel Disease from 1981 to 2014: Results from a Territory-Wide Population-Based Registry in Hong Kong.

Ng SC, Leung WK, Shi HY, Li MK, Leung CM, Ng CK, Lo FH, Hui YT, Tsang SW, Chan YK, Loo CK, Chan KH, Hui AJ, Chow WH, Harbord M, Ching JY, Lee M, Chan V, Tang W, Hung IF, Ho J, Lao WC, Wong MT, Sze SF, Shan EH, Lam BC, Tong RW, Mak LY, Wong SH, Wu JC, Chan FK, Sung JJ.

Inflamm Bowel Dis. 2016 Aug;22(8):1954-60. doi: 10.1097/MIB.0000000000000846.


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