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MicroRNA-10a promotes granulosa cells tumor development via PTEN-AKT/Wnt regulatory axis.

Tu J, Cheung HH, Lu G, Chen Z, Chan WY.

Cell Death Dis. 2018 Oct 22;9(11):1076. doi: 10.1038/s41419-018-1117-5.


MicroRNA-26b promotes transition from Kit- to Kit+ mouse spermatogonia.

Tu J, Zhang P, Shui Luk AC, Liao JJ, Chan WY, Hoi-Hung AC, Lee TL.

Exp Cell Res. 2018 Sep 25. pii: S0014-4827(18)30585-8. doi: 10.1016/j.yexcr.2018.09.018. [Epub ahead of print]


Formulation Optimization of Chitosan-Stabilized Silver Nanoparticles Using In Vitro Antimicrobial Assay.

Pansara C, Chan WY, Parikh A, Trott DJ, Mehta T, Mishra R, Garg S.

J Pharm Sci. 2018 Sep 19. pii: S0022-3549(18)30538-0. doi: 10.1016/j.xphs.2018.09.011. [Epub ahead of print]


Indirubin-3'-oxime as an antiviral and immunomodulatory agent in treatment of severe human influenza virus infection.

Chan MC, Chan RW, Mok CK, Mak NK, Wong RN.

Hong Kong Med J. 2018 Oct;24 Suppl 6(5):45-47. No abstract available.


Mothers' preference and willingness to pay for human papillomavirus vaccination for their daughters: a discrete choice experiment.

Li X, Wong IC, McGhee SM, Kwan MY, Wong CK, Ip DK, Chau J, Chan EW.

Hong Kong Med J. 2018 Oct;24 Suppl 6(5):34-36. No abstract available.


Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming.

Ying Z, Xiang G, Zheng L, Tang H, Duan L, Lin X, Zhao Q, Chen K, Wu Y, Xing G, Lv Y, Li L, Yang L, Bao F, Long Q, Zhou Y, He X, Wang Y, Gao M, Pei D, Chan WY, Liu X.

Cell Metab. 2018 Aug 23. pii: S1550-4131(18)30502-3. doi: 10.1016/j.cmet.2018.08.001. [Epub ahead of print]


Bioelectrical impedance analysis (BIA)-derived phase angle (PA) is a practical aid to nutritional assessment in hospital in-patients.

Player EL, Morris P, Thomas T, Chan WY, Vyas R, Dutton J, Tang J, Alexandre L, Forbes A.

Clin Nutr. 2018 Aug 17. pii: S0261-5614(18)31345-1. doi: 10.1016/j.clnu.2018.08.003. [Epub ahead of print]


Melatonin as potential targets for delaying ovarian aging.

Yang Y, Cheung HH, Zhang C, Wu J, Chan WY.

Curr Drug Targets. 2018 Aug 28. doi: 10.2174/1389450119666180828144843. [Epub ahead of print]


Pattern-Dependent Mammalian Cell (Vero) Morphology on Tantalum/Silicon Oxide 3D Nanocomposites.

Moussa HI, Logan M, Chan WY, Wong K, Rao Z, Aucoin MG, Tsui TY.

Materials (Basel). 2018 Jul 28;11(8). pii: E1306. doi: 10.3390/ma11081306.


Randomized Phase II Study of Akt Blockade With or Without Ipatasertib in Abiraterone-Treated Patients With Metastatic Prostate Cancer With and Without PTEN Loss.

de Bono JS, De Giorgi U, Nava Rodrigues D, Massard C, Bracarda S, Font A, Arranz Arija JA, Shih KC, Radavoi GD, Xu N, Chan WY, Ma H, Gendreau S, Riisnaes R, Patel P, Maslyar DJ, Jinga V.

Clin Cancer Res. 2018 Jul 23. pii: clincanres.0981.2018. doi: 10.1158/1078-0432.CCR-18-0981. [Epub ahead of print]


In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa.

Chan WY, Hickey EE, Khazandi M, Page SW, Trott DJ, Hill PB.

Comp Immunol Microbiol Infect Dis. 2018 Apr;57:34-38. doi: 10.1016/j.cimid.2018.05.001. Epub 2018 May 12.


Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma.

Li T, Deng Y, Shi Y, Tian R, Chen Y, Zou L, Kazi JU, Rönnstrand L, Feng B, Chan SO, Chan WY, Sun J, Zhao H.

Oncogene. 2018 Jul 16. doi: 10.1038/s41388-018-0397-7. [Epub ahead of print]


Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing.

Ogunniyi AD, Kopecki Z, Hickey EE, Khazandi M, Peel E, Belov K, Boileau A, Garg S, Venter H, Chan WY, Hill PB, Page SW, Cowin AJ, Trott DJ.

PLoS One. 2018 Jul 16;13(7):e0200195. doi: 10.1371/journal.pone.0200195. eCollection 2018.


Comparison of multi-lineage differentiation of hiPSCs reveals novel miRNAs that regulate lineage specification.

Li L, Miu KK, Gu S, Cheung HH, Chan WY.

Sci Rep. 2018 Jun 25;8(1):9630. doi: 10.1038/s41598-018-27719-0.


Antifungal proteins with antiproliferative activity on cancer cells and HIV-1 enzyme inhibitory activity from medicinal plants and medicinal fungi.

Ng TB, Wang H, Cheung RCF, Wong JH, Ng CCW, Ye X, Yang J, Liu F, Ling C, Chan K, Ye X, Chan WY.

Curr Protein Pept Sci. 2018 Jun 12. doi: 10.2174/1389203719666180613085704. [Epub ahead of print]


The second generation tyrosine kinase inhibitor dasatinib induced eryptosis in human erythrocytes-An in vitro study.

Chan WY, Lau PM, Yeung KW, Kong SK.

Toxicol Lett. 2018 Oct 1;295:10-21. doi: 10.1016/j.toxlet.2018.05.030. Epub 2018 May 24.


Mechanical and Clinical Evaluation of a Shape Memory Alloy and Conventional Struts in a Flexible Scoliotic Brace.

Chan WY, Yip J, Yick KL, Ng SP, Lu L, Cheung KM, Kwan KY, Cheung JP, Yeung KW, Tse CY.

Ann Biomed Eng. 2018 Aug;46(8):1194-1205. doi: 10.1007/s10439-018-2016-8. Epub 2018 Apr 24.


Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats.

Li YH, Tai WC, Khan I, Lu C, Lu Y, Wong WY, Chan WY, Wendy Hsiao WL, Lin G.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2018 Apr 3;36(2):65-83. doi: 10.1080/10590501.2018.1450186.


Dietary and Physical Activity Interventions for Colorectal Cancer Survivors: A Randomized Controlled Trial.

Lee CF, Ho JWC, Fong DYT, Macfarlane DJ, Cerin E, Lee AM, Leung S, Chan WYY, Leung IPF, Lam SHS, Chu N, Taylor AJ, Cheng KK.

Sci Rep. 2018 Apr 10;8(1):5731. doi: 10.1038/s41598-018-24042-6.


MicroRNA profiling during directed differentiation of cortical interneurons from human-induced pluripotent stem cells.

Tu J, Cao D, Li L, Cheung HH, Chan WY.

FEBS Open Bio. 2018 Feb 17;8(4):502-512. doi: 10.1002/2211-5463.12377. eCollection 2018 Apr.


Outcomes and morbidities of patients who survive haemoglobin Bart's hydrops fetalis syndrome: 20-year retrospective review.

Chan WY, Leung AW, Luk CW, Li RC, Ling AS, Ha SY.

Hong Kong Med J. 2018 Apr;24(2):107-118. doi: 10.12809/hkmj176336. Epub 2018 Apr 6.


Corrigendum: Genome Data Provides High Support for Generic Boundaries in Burkholderia Sensu Lato.

Beukes CW, Palmer M, Manyaka P, Chan WY, Avontuur JR, van Zyl E, Huntemann M, Clum A, Pillay M, Palaniappan K, Varghese N, Mikhailova N, Stamatis D, Reddy TBK, Daum C, Shapiro N, Markowitz V, Ivanova N, Kyrpides N, Woyke T, Blom J, Whitman WB, Venter SN, Steenkamp ET.

Front Microbiol. 2018 Mar 2;9:373. doi: 10.3389/fmicb.2018.00373. eCollection 2018.


Mixta gen. nov., a new genus in the Erwiniaceae.

Palmer M, Steenkamp ET, Coetzee MPA, Avontuur JR, Chan WY, van Zyl E, Blom J, Venter SN.

Int J Syst Evol Microbiol. 2018 Apr;68(4):1396-1407. doi: 10.1099/ijsem.0.002540. Epub 2018 Feb 27.


In vitro antimicrobial activity of narasin against common clinical isolates associated with canine otitis externa.

Chan WY, Hickey EE, Khazandi M, Page SW, Trott DJ, Hill PB.

Vet Dermatol. 2018 Apr;29(2):149-e57. doi: 10.1111/vde.12516. Epub 2018 Jan 24.


Towards precision medicine: from quantitative imaging to radiomics.

Acharya UR, Hagiwara Y, Sudarshan VK, Chan WY, Ng KH.

J Zhejiang Univ Sci B. 2018 Jan.;19(1):6-24. doi: 10.1631/jzus.B1700260. Review.


Integrated microRNA and mRNA signatures in peripheral blood lymphocytes of familial epithelial ovarian cancer.

Dou YD, Huang T, Wang Q, Shu X, Zhao SG, Li L, Liu T, Lu G, Chan WY, Liu HB.

Biochem Biophys Res Commun. 2018 Jan 29;496(1):191-198. doi: 10.1016/j.bbrc.2018.01.023. Epub 2018 Jan 4.


Measurement of retropubic tissue thickness using intrapartum transperineal ultrasound to assess cephalopelvic disproportion.

Chor CM, Chan WYW, Tse WTA, Sahota DS.

Ultrasonography. 2018 Jul;37(3):211-216. doi: 10.14366/usg.17003. Epub 2017 Aug 11.


Anatomical Variants of Lister's Tubercle: A New Morphological Classification Based on Magnetic Resonance Imaging.

Chan WY, Chong LR.

Korean J Radiol. 2017 Nov-Dec;18(6):957-963. doi: 10.3348/kjr.2017.18.6.957. Epub 2017 Sep 21.


Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Kim SB, Dent R, Im SA, Espié M, Blau S, Tan AR, Isakoff SJ, Oliveira M, Saura C, Wongchenko MJ, Kapp AV, Chan WY, Singel SM, Maslyar DJ, Baselga J; LOTUS investigators.

Lancet Oncol. 2017 Oct;18(10):1360-1372. doi: 10.1016/S1470-2045(17)30450-3. Epub 2017 Aug 8.


Identification of reference genes for qRT-PCR in granulosa cells of healthy women and polycystic ovarian syndrome patients.

Lv Y, Zhao SG, Lu G, Leung CK, Xiong ZQ, Su XW, Ma JL, Chan WY, Liu HB.

Sci Rep. 2017 Jul 31;7(1):6961. doi: 10.1038/s41598-017-07346-x.


Genome Data Provides High Support for Generic Boundaries in Burkholderia Sensu Lato.

Beukes CW, Palmer M, Manyaka P, Chan WY, Avontuur JR, van Zyl E, Huntemann M, Clum A, Pillay M, Palaniappan K, Varghese N, Mikhailova N, Stamatis D, Reddy TBK, Daum C, Shapiro N, Markowitz V, Ivanova N, Kyrpides N, Woyke T, Blom J, Whitman WB, Venter SN, Steenkamp ET.

Front Microbiol. 2017 Jun 26;8:1154. doi: 10.3389/fmicb.2017.01154. eCollection 2017. Erratum in: Front Microbiol. 2018 Mar 02;9:373.


Survival of Staphylococcus pseudintermedius in modified Romanowsky staining solutions.

Misan A, Chan WY, Trott D, Hill PB.

Vet Dermatol. 2017 Aug;28(4):333-e71. doi: 10.1111/vde.12435. Epub 2017 May 3.


A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes.

Li Q, Hutchins AP, Chen Y, Li S, Shan Y, Liao B, Zheng D, Shi X, Li Y, Chan WY, Pan G, Wei S, Shu X, Pei D.

Nat Commun. 2017 May 3;8:15166. doi: 10.1038/ncomms15166.


Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage.

Lu G, Wong MS, Xiong MZQ, Leung CK, Su XW, Zhou JY, Poon WS, Zheng VZY, Chan WY, Wong GKC.

J Am Heart Assoc. 2017 Apr 25;6(4). pii: e005363. doi: 10.1161/JAHA.116.005363.


Practically delineating bacterial species with genealogical concordance.

Venter SN, Palmer M, Beukes CW, Chan WY, Shin G, van Zyl E, Seale T, Coutinho TA, Steenkamp ET.

Antonie Van Leeuwenhoek. 2017 Oct;110(10):1311-1325. doi: 10.1007/s10482-017-0869-8. Epub 2017 Apr 9.


From Moment to Movement: Empowerment and Resilience as a Framework for Collective Action in Hong Kong.

Chan WY, Cattaneo LB, Mak WW, Lin WY.

Am J Community Psychol. 2017 Mar;59(1-2):120-132. doi: 10.1002/ajcp.12130.


Role of transnasal flexible laryngo-oesophagoscopy (TNFLO) in investigating patients with globus symptoms.

Mohammed H, Coates M, Masterson L, Chan WY, Hassan Y, Nassif R.

Clin Otolaryngol. 2017 Dec;42(6):1311-1318. doi: 10.1111/coa.12872. Epub 2017 Apr 18.


Correction: Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens.

Wilson R, Cohen JM, Reglinski M, Jose RJ, Chan WY, Marshall H, de Vogel C, Gordon S, Goldblatt D, Petersen FC, Baxendale H, Brown JS.

PLoS Pathog. 2017 Mar 8;13(3):e1006259. doi: 10.1371/journal.ppat.1006259. eCollection 2017 Mar.


Phylogenomic resolution of the bacterial genus Pantoea and its relationship with Erwinia and Tatumella.

Palmer M, Steenkamp ET, Coetzee MPA, Chan WY, van Zyl E, De Maayer P, Coutinho TA, Blom J, Smits THM, Duffy B, Venter SN.

Antonie Van Leeuwenhoek. 2017 Oct;110(10):1287-1309. doi: 10.1007/s10482-017-0852-4. Epub 2017 Mar 2.


Shifting paradigms in restoration of the world's coral reefs.

van Oppen MJH, Gates RD, Blackall LL, Cantin N, Chakravarti LJ, Chan WY, Cormick C, Crean A, Damjanovic K, Epstein H, Harrison PL, Jones TA, Miller M, Pears RJ, Peplow LM, Raftos DA, Schaffelke B, Stewart K, Torda G, Wachenfeld D, Weeks AR, Putnam HM.

Glob Chang Biol. 2017 Sep;23(9):3437-3448. doi: 10.1111/gcb.13647. Epub 2017 Mar 1. Review.


The effect of co-trimoxazole on serum potassium concentration: safety evaluation of a randomized controlled trial.

Chan WY, Clark AB, Wilson AM, Loke YK; TIPAC investigators.

Br J Clin Pharmacol. 2017 Aug;83(8):1808-1814. doi: 10.1111/bcp.13263. Epub 2017 Mar 20.


Universal Health Coverage through Community Nursing Services: China vs. Hong Kong.

Chan WY, Fung IM, Chan E.

Rev Lat Am Enfermagem. 2017 Jan 30;25:e2838. doi: 10.1590/1518-8345.1664.2838. English, Portuguese, Spanish.


Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens.

Wilson R, Cohen JM, Reglinski M, Jose RJ, Chan WY, Marshall H, de Vogel C, Gordon S, Goldblatt D, Petersen FC, Baxendale H, Brown JS.

PLoS Pathog. 2017 Jan 30;13(1):e1006137. doi: 10.1371/journal.ppat.1006137. eCollection 2017 Jan. Erratum in: PLoS Pathog. 2017 Mar 8;13(3):e1006259.


Sharpness-induced energy shifts of quantum well states in Pb islands on Cu(111).

Chan WY, Lu SM, Su WB, Liao CC, Hoffmann G, Tsai TR, Chang CS.

Nanotechnology. 2017 Mar 3;28(9):095706. doi: 10.1088/1361-6528/aa583a. Epub 2017 Jan 30.


Icaritin enhances mESC self-renewal through upregulating core pluripotency transcription factors mediated by ERα.

Tsang WP, Zhang F, He Q, Cai W, Huang J, Chan WY, Shen Z, Wan C.

Sci Rep. 2017 Jan 16;7:40894. doi: 10.1038/srep40894.


Prevention and treatment of swine-origin influenza virus with interferon: an in vivo and ex vivo study.

Nicholls JM, Chan RW, Fish E.

Hong Kong Med J. 2016 Dec;22 Suppl 7(6):10-14. No abstract available.


A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors.

Saura C, Roda D, Roselló S, Oliveira M, Macarulla T, Pérez-Fidalgo JA, Morales-Barrera R, Sanchis-García JM, Musib L, Budha N, Zhu J, Nannini M, Chan WY, Sanabria Bohórquez SM, Meng RD, Lin K, Yan Y, Patel P, Baselga J, Tabernero J, Cervantes A.

Cancer Discov. 2017 Jan;7(1):102-113. doi: 10.1158/2159-8290.CD-16-0512. Epub 2016 Nov 21. Erratum in: Cancer Discov. 2018 Nov;8(11):1490.


CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development.

Liu Z, Guo J, Wang Y, Weng Z, Huang B, Yu MK, Zhang X, Yuan P, Zhao H, Chan WY, Jiang X, Chan HC.

Cell Death Differ. 2017 Jan;24(1):98-110. doi: 10.1038/cdd.2016.118. Epub 2016 Nov 11.


Time-resolved record of 236U and 239,240Pu isotopes from a coral growing during the nuclear testing program at Enewetak Atoll (Marshall Islands).

Froehlich MB, Chan WY, Tims SG, Fallon SJ, Fifield LK.

J Environ Radioact. 2016 Dec;165:197-205. doi: 10.1016/j.jenvrad.2016.09.015. Epub 2016 Oct 19.


Corrigendum: Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers.

Li L, Li C, Mao H, Du Z, Chan WY, Murray P, Luo B, Chan AT, Mok TS, Chan FK, Ambinder RF, Tao Q.

Sci Rep. 2016 Oct 6;6:34435. doi: 10.1038/srep34435. No abstract available.

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