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Performance of simple fibrosis scores in non-obese patients with nonalcoholic fatty liver disease.

Fu C, Wai JW, Nik Mustapha NR, Irles M, Lai-Hung Wong G, Mahadeva S, Shili S, Wing-Hung Chan A, Merrouche W, Lik-Yuen Chan H, Foucher J, Le Bail B, Wai-Sun Wong V, Chan WK, de Lédinghen V.

Clin Gastroenterol Hepatol. 2019 Sep 28. pii: S1542-3565(19)31076-6. doi: 10.1016/j.cgh.2019.09.027. [Epub ahead of print] No abstract available.


Precise modelling and interpretation of bioactivities of ligands targeting G protein-coupled receptors.

Wu J, Liu B, Chan WKB, Wu W, Pang T, Hu H, Yan S, Ke X, Zhang Y.

Bioinformatics. 2019 Jul 15;35(14):i324-i332. doi: 10.1093/bioinformatics/btz336.


Latent Tuberculosis Infection Testing Strategies for HIV-Positive Individuals in Hong Kong.

Wong NS, Chan KCW, Wong BCK, Leung CC, Chan WK, Lin AWC, Lui GCY, Mitchell KM, Lee SS.

JAMA Netw Open. 2019 Sep 4;2(9):e1910960. doi: 10.1001/jamanetworkopen.2019.10960.


Volumetric Liver Fat Fraction Determines Grade of Steatosis More Accurately Than Controlled Attenuation Parameter in Patients With Nonalcoholic Fatty Liver Disease.

Harry S, Lee Lai L, Nik Mustapha NR, Abdul Aziz YF, Vijayananthan A, Rahmat K, Mahadeva S, Chan WK.

Clin Gastroenterol Hepatol. 2019 Aug 20. pii: S1542-3565(19)30898-5. doi: 10.1016/j.cgh.2019.08.023. [Epub ahead of print]


Per urethral insertion of foreign body for erotism: case reports.

Mak CWH, Cho CL, Chan WKW, Chu RWH, Law IC.

Hong Kong Med J. 2019 Aug;25(4):320-322. doi: 10.12809/hkmj177044. No abstract available.


Predictive biomarkers and tumor microenvironment in female genital melanomas: a multi-institutional study of 55 cases.

Yu Y, Tse KY, Lee HHY, Chow KL, Tsang HW, Wong RWC, Cheung ETY, Cheuk W, Lee VWK, Chan WK, Wong AST, Loong HHF, Chan KKL, Ngan HYS, Cheung ANY, Ip PPC.

Mod Pathol. 2019 Aug 5. doi: 10.1038/s41379-019-0345-2. [Epub ahead of print]


A new bile acid treatment for non-alcoholic fatty liver disease.

Chan WK, Wong VW.

Lancet Gastroenterol Hepatol. 2019 Oct;4(10):747-749. doi: 10.1016/S2468-1253(19)30183-9. Epub 2019 Jul 22. No abstract available.


Suboptimal treatment of dyslipidemia in patients with nonalcoholic fatty liver disease.

Khoo S, Wong VW, Goh GB, Fan J, Chan WK, Seto WK, Chow WC.

J Gastroenterol Hepatol. 2019 Jul 23. doi: 10.1111/jgh.14794. [Epub ahead of print]


Comparing point shear wave elastography (ElastPQ) and transient elastography for diagnosis of fibrosis stage in non-alcoholic fatty liver disease.

Leong WL, Lai LL, Nik Mustapha NR, Vijayananthan A, Rahmat K, Mahadeva S, Chan WK.

J Gastroenterol Hepatol. 2019 Jul 16. doi: 10.1111/jgh.14782. [Epub ahead of print]


A longitudinal study on latent TB infection screening and its association with TB incidence in HIV patients.

Wong NS, Leung CC, Chan KCW, Chan WK, Lin AWC, Lee SS.

Sci Rep. 2019 Jul 12;9(1):10093. doi: 10.1038/s41598-019-46570-5.


NF-κB/NKILA signaling modulates the anti-cancerous effects of EZH2 inhibition.

Duan S, Chan WK, Oman A, Basile DP, Alvira CM, Buxton ILO, Iosef C.

J Cell Mol Med. 2019 Sep;23(9):6182-6192. doi: 10.1111/jcmm.14500. Epub 2019 Jul 7.


Contiguous gene deletion in a Chinese family with X-linked nephrogenic diabetes insipidus: challenges in early diagnosis and implications for affected families.

Leung MT, Sit JKK, Cheung HN, Iu YP, Chan WKY, Shek CC.

J Pediatr Endocrinol Metab. 2019 Aug 27;32(8):915-920. doi: 10.1515/jpem-2019-0028.


Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.

Chan WK, Horvath TD, Tan L, Link T, Harutyunyan KG, Pontikos MA, Anishkin A, Du D, Martin LA, Yin E, Rempe SB, Sukharev S, Konopleva M, Weinstein JN, Lorenzi PL.

Mol Cancer Ther. 2019 Sep;18(9):1587-1592. doi: 10.1158/1535-7163.MCT-18-1329. Epub 2019 Jun 17.


Reply to: CHAI and MACK-3 as noninvasive indices for nonalcoholic steatohepatitis.

Chuah KH, Chan WK.

Liver Int. 2019 Aug;39(8):1588. doi: 10.1111/liv.14139. Epub 2019 Jun 4. No abstract available.


Aryl hydrocarbon receptor acts as a tumor suppressor in a syngeneic MC38 colon carcinoma tumor model.

Yakkundi P, Gonsalves E, Galou-Lameyer M, Selby MJ, Chan WK.

Hypoxia (Auckl). 2019 Apr 10;7:1-16. doi: 10.2147/HP.S196301. eCollection 2019.


Association between non-alcoholic fatty liver disease evaluated by transient elastography with extracranial carotid atherosclerosis in a multiethnic Asian community.

Tan EC, Tai MS, Chan WK, Mahadeva S.

JGH Open. 2018 Dec 30;3(2):117-125. doi: 10.1002/jgh3.12114. eCollection 2019 Apr.


Measuring Enzymatic Stability by Isothermal Titration Calorimetry.

Chan WKD, Mason M, Hansen LD, Kenealey JD.

J Vis Exp. 2019 Mar 26;(145). doi: 10.3791/59302.


Optimizing Use of Nonalcoholic Fatty Liver Disease Fibrosis Score, Fibrosis-4 Score, and Liver Stiffness Measurement to Identify Patients With Advanced Fibrosis.

Chan WK, Treeprasertsuk S, Goh GB, Fan JG, Song MJ, Charatcharoenwitthaya P, Duseja A, Dan YY, Imajo K, Nakajima A, Ho KY, Goh KL, Wong VW.

Clin Gastroenterol Hepatol. 2019 Mar 12. pii: S1542-3565(19)30258-7. doi: 10.1016/j.cgh.2019.03.006. [Epub ahead of print]


Response envelope analysis for quantitative evaluation of drug combinations.

Du D, Chang CH, Wang Y, Tong P, Chan WK, Chiu Y, Peng B, Tan L, Weinstein JN, Lorenzi PL.

Bioinformatics. 2019 Oct 1;35(19):3761-3770. doi: 10.1093/bioinformatics/btz091.


MACK-3 (combination of hoMa, Ast and CK18): A promising novel biomarker for fibrotic non-alcoholic steatohepatitis.

Chuah KH, Wan Yusoff WNI, Sthaneshwar P, Nik Mustapha NR, Mahadeva S, Chan WK.

Liver Int. 2019 Jul;39(7):1315-1324. doi: 10.1111/liv.14084. Epub 2019 Mar 18.


Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation.

Molkentine JM, Fujimoto TN, Horvath TD, Grossberg AJ, Garcia CJG, Deorukhkar A, de la Cruz Bonilla M, Lin D, Samuel ELG, Chan WK, Lorenzi PL, Piwnica-Worms H, Dantzer R, Tour JM, Mason KA, Taniguchi CM.

Sci Rep. 2019 Feb 13;9(1):1949. doi: 10.1038/s41598-018-37147-9.


Empagliflozin for the Treatment of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus.

Lai LL, Vethakkan SR, Nik Mustapha NR, Mahadeva S, Chan WK.

Dig Dis Sci. 2019 Jan 25. doi: 10.1007/s10620-019-5477-1. [Epub ahead of print]


Unified interpretation of liver stiffness measurement by M and XL probes in non-alcoholic fatty liver disease.

Wong VW, Irles M, Wong GL, Shili S, Chan AW, Merrouche W, Shu SS, Foucher J, Le Bail B, Chan WK, Chan HL, de Ledinghen V.

Gut. 2019 Nov;68(11):2057-2064. doi: 10.1136/gutjnl-2018-317334. Epub 2019 Jan 18.


Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer.

Horvath TD, Chan WK, Pontikos MA, Martin LA, Du D, Tan L, Konopleva M, Weinstein JN, Lorenzi PL.

Metabolites. 2019 Jan 9;9(1). pii: E10. doi: 10.3390/metabo9010010.


Prospective observational cohort study on grading the severity of postoperative complications in global surgery research.

International Surgical Outcomes Study (ISOS) group.

Br J Surg. 2019 Jan;106(2):e73-e80. doi: 10.1002/bjs.11025.


Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography.

Lai LL, Wan Yusoff WNI, Vethakkan SR, Nik Mustapha NR, Mahadeva S, Chan WK.

J Gastroenterol Hepatol. 2019 Aug;34(8):1396-1403. doi: 10.1111/jgh.14577. Epub 2019 Jan 21.


Prevention of Pressure Injury by Using Silicone Foam Dressings: Experience at a University Hospital in Hong Kong.

Kuen Lee MW, Keung Lai PC, Boo MS, Chan WK, Hui YC, Sze Wan WW, Kwong WF.

Crit Care Nurs Q. 2019 Jan/Mar;42(1):117-126. doi: 10.1097/CNQ.0000000000000245.


Epidemiology of non-alcoholic fatty liver disease-related hepatocellular carcinoma and its implications.

Wong SW, Ting YW, Chan WK.

JGH Open. 2018 Jul 17;2(5):235-241. doi: 10.1002/jgh3.12070. eCollection 2018 Oct. Review.


What Is the Value of Continuous Monitoring Post-Transcatheter Aortic Valve Replacement?

Singh SM, Chan WK, Danon A.

JACC Cardiovasc Interv. 2018 Nov 12;11(21):2235. doi: 10.1016/j.jcin.2018.08.017. No abstract available.


Slip of fluid molecules on solid surfaces by surface diffusion.

Shu JJ, Teo JBM, Chan WK.

PLoS One. 2018 Oct 11;13(10):e0205443. doi: 10.1371/journal.pone.0205443. eCollection 2018.


Risk factors associated with 1-year mortality among patients with HIV-associated tuberculosis in areas with intermediate tuberculosis burden and low HIV prevalence.

Chan CK, Wong KH, Lee MP, Chan KC, Leung CC, Leung EC, Chan WK, Mak IK.

Hong Kong Med J. 2018 Oct;24(5):473-483. doi: 10.12809/hkmj187303. Review.


In Vivo Genome Editing as a Therapeutic Approach.

Ho BX, Loh SJH, Chan WK, Soh BS.

Int J Mol Sci. 2018 Sep 12;19(9). pii: E2721. doi: 10.3390/ijms19092721. Review.


Single Versus Dual Lead Atrioventricular Sequential Pacing for Acquired Atrioventricular Block During Transcatheter Aortic Valve Implantation Procedures.

Chan WK, Danon A, Wijeysundera HC, Singh SM.

Am J Cardiol. 2018 Aug 15;122(4):633-637. doi: 10.1016/j.amjcard.2018.04.043. Epub 2018 Jun 20.


Risk factors for damage in childhood-onset systemic lupus erythematosus in Asians: a case control study.

Sit JKK, Chan WKY.

Pediatr Rheumatol Online J. 2018 Sep 10;16(1):56. doi: 10.1186/s12969-018-0271-8.


CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway.

Chen L, Youssef Y, Robinson C, Ernst GF, Carson MY, Young KA, Scoville SD, Zhang X, Harris R, Sekhri P, Mansour AG, Chan WK, Nalin AP, Mao HC, Hughes T, Mace EM, Pan Y, Rustagi N, Chatterjee SS, Gunaratne PH, Behbehani GK, Mundy-Bosse BL, Caligiuri MA, Freud AG.

Immunity. 2018 Sep 18;49(3):464-476.e4. doi: 10.1016/j.immuni.2018.08.010. Epub 2018 Sep 4.


Competition of As and other Group 15 elements for surface binding sites of an extremophilic Acidomyces acidophilus isolated from a historical tin mining site.

Chan WK, Wildeboer D, Garelick H, Purchase D.

Extremophiles. 2018 Sep;22(5):795-809. doi: 10.1007/s00792-018-1039-2. Epub 2018 Jul 23.


Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development.

Iosef C, Liu M, Ying L, Rao SP, Concepcion KR, Chan WK, Oman A, Alvira CM.

J Cell Mol Med. 2018 Sep;22(9):4410-4422. doi: 10.1111/jcmm.13741. Epub 2018 Jul 11.


Hepatitis B virus infection among children of hepatitis B surface antigen positive mothers in a Malaysian hospital.

Chan WK, Yeoh KY, Lim CY, Lai SM, Lee JL, Leow AHR, Goh KL.

Med J Malaysia. 2018 Jun;73(3):137-140.


Control of Electron Flow Direction in Photoexcited Cycloplatinated Complex Containing Conjugated Polymer-Single-Walled Carbon Nanotube Hybrids.

Xiong W, Du L, Lo KC, Shi H, Takaya T, Iwata K, Chan WK, Phillips DL.

J Phys Chem Lett. 2018 Jul 19;9(14):3819-3824. doi: 10.1021/acs.jpclett.8b01713. Epub 2018 Jun 28.


A CS1-NKG2D Bispecific Antibody Collectively Activates Cytolytic Immune Cells against Multiple Myeloma.

Chan WK, Kang S, Youssef Y, Glankler EN, Barrett ER, Carter AM, Ahmed EH, Prasad A, Chen L, Zhang J, Benson DM Jr, Caligiuri MA, Yu J.

Cancer Immunol Res. 2018 Jul;6(7):776-787. doi: 10.1158/2326-6066.CIR-17-0649. Epub 2018 May 16.


Can the same controlled attenuation parameter cut-offs be used for M and XL probes for diagnosing hepatic steatosis?

Chan WK, Nik Mustapha NR, Mahadeva S, Wong VW, Cheng JY, Wong GL.

J Gastroenterol Hepatol. 2018 Oct;33(10):1787-1794. doi: 10.1111/jgh.14150. Epub 2018 May 7.


Photoconductivity enhancement and charge transport properties in ruthenium-containing block copolymer/carbon nanotube hybrids.

Lo KC, Hau KI, Chan WK.

Nanoscale. 2018 Apr 5;10(14):6474-6486. doi: 10.1039/C7NR09670D.


p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism.

Pappas B, Yang Y, Wang Y, Kim K, Chung HJ, Cheung M, Ngo K, Shinn A, Chan WK.

Biochem Pharmacol. 2018 Jun;152:34-44. doi: 10.1016/j.bcp.2018.03.015. Epub 2018 Mar 17.


Editorial: NAFLD in Asia-clinical associations with advanced disease become clearer. Authors' reply.

Chan WK, Dan YY, Wong VW; GO ASIA Initiative.

Aliment Pharmacol Ther. 2018 Apr;47(7):1037-1038. doi: 10.1111/apt.14572. No abstract available.


Impact of controlled attenuation parameter on detecting fibrosis using liver stiffness measurement.

Karlas T, Petroff D, Sasso M, Fan JG, Mi YQ, de Lédinghen V, Kumar M, Lupsor-Platon M, Han KH, Cardoso AC, Ferraioli G, Chan WK, Wong VW, Myers RP, Chayama K, Friedrich-Rust M, Beaugrand M, Shen F, Hiriart JB, Sarin SK, Badea R, Lee HW, Marcellin P, Filice C, Mahadeva S, Wong GL, Crotty P, Masaki K, Bojunga J, Bedossa P, Keim V, Wiegand J.

Aliment Pharmacol Ther. 2018 Apr;47(7):989-1000. doi: 10.1111/apt.14529. Epub 2018 Feb 15.


WDL-RF: predicting bioactivities of ligand molecules acting with G protein-coupled receptors by combining weighted deep learning and random forest.

Wu J, Zhang Q, Wu W, Pang T, Hu H, Chan WKB, Ke X, Zhang Y.

Bioinformatics. 2018 Jul 1;34(13):2271-2282. doi: 10.1093/bioinformatics/bty070.


The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis.

Abbott TEF, Ahmad T, Phull MK, Fowler AJ, Hewson R, Biccard BM, Chew MS, Gillies M, Pearse RM; International Surgical Outcomes Study (ISOS) group.

Br J Anaesth. 2018 Jan;120(1):146-155. doi: 10.1016/j.bja.2017.08.002. Epub 2017 Nov 23.


Repeated liver stiffness measurement compared with paired liver biopsy in patients with non-alcoholic fatty liver disease.

Kamarajah SK, Chan WK, Nik Mustapha NR, Mahadeva S.

Hepatol Int. 2018 Jan;12(1):44-55. doi: 10.1007/s12072-018-9843-4. Epub 2018 Jan 25.


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