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Items: 1 to 50 of 191

1.

Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors.

Chan KF, Sun N, Yan SC, Wong ILK, Lui HK, Cheung KC, Yuan J, Chan FY, Zheng Z, Chan EWC, Chen S, Leung YC, Chan TH, Wong KY.

ACS Omega. 2017 Oct 31;2(10):7281-7292. doi: 10.1021/acsomega.7b00701. Epub 2017 Oct 27.

2.

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.

Lee JB, Zgair A, Malec J, Kim TH, Kim MG, Ali J, Qin C, Feng W, Chiang M, Gao X, Voronin G, Garces AE, Lau CL, Chan TH, Hume A, McIntosh TM, Soukarieh F, Al-Hayali M, Cipolla E, Collins HM, Heery DM, Shin BS, Yoo SD, Kagan L, Stocks MJ, Bradshaw TD, Fischer PM, Gershkovich P.

J Control Release. 2018 Sep 28;286:10-19. doi: 10.1016/j.jconrel.2018.07.022. Epub 2018 Jul 18.

3.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.

Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.

PMID:
29976840
4.

Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1.

Jin WB, Xu C, Cheng Q, Qi XL, Gao W, Zheng Z, Chan EWC, Leung YC, Chan TH, Wong KY, Chen S, Chan KF.

Eur J Med Chem. 2018 Jul 15;155:285-302. doi: 10.1016/j.ejmech.2018.06.007. Epub 2018 Jun 6.

PMID:
29894943
5.

Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer.

Hong H, An O, Chan THM, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJT, Tang SJ, Yang H, Song Y, Bellido Molias F, Tenen DG, Chen L.

Nucleic Acids Res. 2018 Sep 6;46(15):7953-7969. doi: 10.1093/nar/gky396.

6.

Perspectives on the recent developments with green tea polyphenols in drug discovery.

Li F, Wang Y, Li D, Chen Y, Qiao X, Fardous R, Lewandowski A, Liu J, Chan TH, Dou QP.

Expert Opin Drug Discov. 2018 Jul;13(7):643-660. doi: 10.1080/17460441.2018.1465923. Epub 2018 Apr 24.

PMID:
29688074
7.

A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer.

Wang J, Man GCW, Chan TH, Kwong J, Wang CC.

Cancer Lett. 2018 Jan 1;412:10-20. doi: 10.1016/j.canlet.2017.09.054. Epub 2017 Oct 9.

PMID:
29024813
8.

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer.

Qi L, Song Y, Chan THM, Yang H, Lin CH, Tay DJT, Hong H, Tang SJ, Tan KT, Huang XX, Lin JS, Ng VHE, Maury JJP, Tenen DG, Chen L.

Nucleic Acids Res. 2017 Oct 13;45(18):10436-10451. doi: 10.1093/nar/gkx667.

9.

(-)-Epiafzelechin Protects against Ovariectomy-induced Bone Loss in Adult Mice and Modulate Osteoblastic and Osteoclastic Functions In Vitro.

Wong KC, Cao S, Dong X, Law MC, Chan TH, Wong MS.

Nutrients. 2017 May 22;9(5). pii: E530. doi: 10.3390/nu9050530.

10.

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation.

Jin K, Po KHL, Wang S, Reuven JA, Wai CN, Lau HT, Chan TH, Chen S, Li X.

Bioorg Med Chem. 2017 Sep 15;25(18):4990-4995. doi: 10.1016/j.bmc.2017.04.039. Epub 2017 Apr 29.

PMID:
28495382
11.

Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.

Dury L, Nasr R, Lorendeau D, Comsa E, Wong I, Zhu X, Chan KF, Chan TH, Chow L, Falson P, Di Pietro A, Baubichon-Cortay H.

Biochem Pharmacol. 2017 Jan 15;124:10-18. doi: 10.1016/j.bcp.2016.10.013. Epub 2016 Oct 28.

PMID:
27984000
12.

Perceived importance of childbearing and attitudes toward assisted reproductive technology among Chinese lesbians in Hong Kong: implications for psychological well-being.

Lo IP, Chan CH, Chan TH.

Fertil Steril. 2016 Oct;106(5):1221-1229. doi: 10.1016/j.fertnstert.2016.06.042. Epub 2016 Jul 26.

PMID:
27473352
13.

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

Chan TH, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VH, Song Y, Hong H, Tay ST, Liu Y, Lee J, Rha SY, Zhu F, So JB, Teh BT, Yeoh KG, Rozen S, Tenen DG, Tan P, Chen L.

Gastroenterology. 2016 Oct;151(4):637-650.e10. doi: 10.1053/j.gastro.2016.06.043. Epub 2016 Jul 1.

PMID:
27373511
14.

Restriction of Retrotransposon Mobilization in Schizosaccharomyces pombe by Transcriptional Silencing and Higher-Order Chromatin Organization.

Murton HE, Grady PJ, Chan TH, Cam HP, Whitehall SK.

Genetics. 2016 Aug;203(4):1669-78. doi: 10.1534/genetics.116.189118. Epub 2016 Jun 24.

15.

CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors.

Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY.

Hepatology. 2016 May;63(5):1544-59. doi: 10.1002/hep.28437. Epub 2016 Mar 4.

PMID:
27100146
16.

Biological and Mechanistic Characterization of Novel Prodrugs of Green Tea Polyphenol Epigallocatechin Gallate Analogs in Human Leiomyoma Cell Lines.

Ahmed RS, Liu G, Renzetti A, Farshi P, Yang H, Soave C, Saed G, El-Ghoneimy AA, El-Banna HA, Foldes R, Chan TH, Dou QP.

J Cell Biochem. 2016 Oct;117(10):2357-69. doi: 10.1002/jcb.25533. Epub 2016 Mar 28.

PMID:
26950525
17.

PCANet: A Simple Deep Learning Baseline for Image Classification?

Chan TH, Jia K, Gao S, Lu J, Zeng Z, Ma Y.

IEEE Trans Image Process. 2015 Dec;24(12):5017-32. doi: 10.1109/TIP.2015.2475625. Epub 2015 Sep 1.

PMID:
26340772
18.

Convex-Optimization-Based Compartmental Pharmacokinetic Analysis for Prostate Tumor Characterization Using DCE-MRI.

Ambikapathi A, Chan TH, Lin CH, Yang FS, Chi CY, Wang Y.

IEEE Trans Biomed Eng. 2016 Apr;63(4):707-20. doi: 10.1109/TBME.2015.2469601. Epub 2015 Aug 18.

PMID:
26292336
19.

A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.

Yan CS, Wong IL, Chan KF, Kan JW, Chong TC, Law MC, Zhao Y, Chan SW, Chan TH, Chow LM.

Mol Pharm. 2015 Oct 5;12(10):3507-17. doi: 10.1021/mp500770e. Epub 2015 Aug 27.

PMID:
26291333
20.

In Reply.

Echebiri NC, McDoom MM, Chan TH, Barnabei VM.

Obstet Gynecol. 2015 Jul;126(1):214-5. doi: 10.1097/AOG.0000000000000938. No abstract available.

PMID:
26241280
21.

Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).

Chiou J, Wan S, Chan KF, So PK, He D, Chan EW, Chan TH, Wong KY, Tao J, Chen S.

Chem Commun (Camb). 2015 Jun 11;51(46):9543-6. doi: 10.1039/c5cc02594j.

PMID:
25970101
22.

The need for uniform quality reporting across post-acute care rehabilitation settings: an examination of accidental falls.

Mallinson T, Leland NE, Chan TH.

J Am Geriatr Soc. 2015 Jan;63(1):195-7. doi: 10.1111/jgs.13221. No abstract available.

23.
24.

Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics.

Arkwright RT, Deshmukh R, Adapa N, Stevens R, Zonder E, Zhang Z, Farshi P, Ahmed RS, El-Banna HA, Chan TH, Dou QP.

Anticancer Agents Med Chem. 2015;15(5):657-71. Review.

25.

Intentions and attitudes towards parenthood and fertility awareness among Chinese university students in Hong Kong: a comparison with Western samples.

Chan CH, Chan TH, Peterson BD, Lampic C, Tam MY.

Hum Reprod. 2015 Feb;30(2):364-72. doi: 10.1093/humrep/deu324. Epub 2014 Dec 5.

26.

Determination of exogenous epigallocatechin gallate peracetate in mouse plasma using liquid chromatography with quadrupole time-of-flight mass spectrometry.

Chu KO, Man GC, Chan KP, Chu CY, Chan TH, Pang CP, Wang CC.

J Sep Sci. 2014 Dec;37(23):3473-80. doi: 10.1002/jssc.201400701. Epub 2014 Oct 18.

PMID:
25250898
27.

Development of a UPLC-MS/MS bioanalytical method for the pharmacokinetic study of (-)-epiafzelechin, a flavan-3-ol with osteoprotective activity, in C57BL/6J mice.

Wong KC, Law MC, Wong MS, Chan TH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:162-7. doi: 10.1016/j.jchromb.2014.07.028. Epub 2014 Jul 27.

PMID:
25108364
28.

ADAR1: a promising new biomarker for esophageal squamous cell carcinoma?

Qiao JJ, Chan TH, Qin YR, Chen L.

Expert Rev Anticancer Ther. 2014 Aug;14(8):865-8. doi: 10.1586/14737140.2014.928595. Epub 2014 Jun 13. Review.

PMID:
24928581
29.

Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity.

Sun N, Chan FY, Lu YJ, Neves MA, Lui HK, Wang Y, Chow KY, Chan KF, Yan SC, Leung YC, Abagyan R, Chan TH, Wong KY.

PLoS One. 2014 May 13;9(5):e97514. doi: 10.1371/journal.pone.0097514. eCollection 2014.

30.

In vitro and in vivo efficacy of novel flavonoid dimers against cutaneous leishmaniasis.

Wong IL, Chan KF, Chen YF, Lun ZR, Chan TH, Chow LM.

Antimicrob Agents Chemother. 2014 Jun;58(6):3379-88. doi: 10.1128/AAC.02425-13. Epub 2014 Mar 31.

31.

Experimental verification of the modified spring-mass theory of fiber Bragg grating accelerometers using transverse forces.

Li K, Chan TH, Yau MH, Thambiratnam DP, Tam HY.

Appl Opt. 2014 Feb 20;53(6):1200-11. doi: 10.1364/AO.53.001200.

PMID:
24663321
32.

Facebook and its effects on users' empathic social skills and life satisfaction: a double-edged sword effect.

Chan TH.

Cyberpsychol Behav Soc Netw. 2014 May;17(5):276-80. doi: 10.1089/cyber.2013.0466. Epub 2014 Mar 7.

PMID:
24606026
33.

RNA editome imbalance in hepatocellular carcinoma.

Qi L, Chan TH, Tenen DG, Chen L.

Cancer Res. 2014 Mar 1;74(5):1301-6. doi: 10.1158/0008-5472.CAN-13-3485. Epub 2014 Feb 20. Review.

34.

Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma.

Liu M, Li Y, Chen L, Chan TH, Song Y, Fu L, Zeng TT, Dai YD, Zhu YH, Li Y, Chen J, Yuan YF, Guan XY.

Gastroenterology. 2014 Apr;146(4):1084-96. doi: 10.1053/j.gastro.2013.12.041. Epub 2014 Jan 11.

PMID:
24417816
35.

Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma.

Qin YR, Qiao JJ, Chan TH, Zhu YH, Li FF, Liu H, Fei J, Li Y, Guan XY, Chen L.

Cancer Res. 2014 Feb 1;74(3):840-51. doi: 10.1158/0008-5472.CAN-13-2545. Epub 2013 Dec 3.

36.

Referral strategy for early recognition of axial spondyloarthritis: consensus recommendations from the Hong Kong Society of Rheumatology.

Mok CC, Tam LS, Leung MH, Ying KY, To CH, Lee KL, Ho LY, Yip ML, Tsui HS, Chan TH, Lee KW, Li EK; Hong Kong Society of Rheumatology.

Int J Rheum Dis. 2013 Oct;16(5):500-8. doi: 10.1111/1756-185X.12161.

PMID:
24164836
37.

Very sensitive fiber Bragg grating accelerometer using transverse forces with an easy over-range protection and low cross axial sensitivity.

Li K, Chan TH, Yau MH, Nguyen T, Thambiratnam DP, Tam HY.

Appl Opt. 2013 Sep 1;52(25):6401-10. doi: 10.1364/AO.52.006401.

PMID:
24085103
38.

The human microbiota: a new direction in the investigation of thoracic diseases.

Hui AW, Lau HW, Chan TH, Tsui SK.

J Thorac Dis. 2013 Aug;5 Suppl 2:S127-31. doi: 10.3978/j.issn.2072-1439.2013.07.41.

39.

From natural product-inspired pyrrolidine scaffolds to the development of new human Golgi α-mannosidase II inhibitors.

Cheng TJ, Chan TH, Tsou EL, Chang SY, Yun WY, Yang PJ, Wu YT, Cheng WC.

Chem Asian J. 2013 Nov;8(11):2600-4. doi: 10.1002/asia.201300680. Epub 2013 Aug 13. No abstract available.

PMID:
23943613
40.

Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening.

Chan FY, Sun N, Neves MA, Lam PC, Chung WH, Wong LK, Chow HY, Ma DL, Chan PH, Leung YC, Chan TH, Abagyan R, Wong KY.

J Chem Inf Model. 2013 Aug 26;53(8):2131-40. doi: 10.1021/ci400203f. Epub 2013 Jul 25.

PMID:
23848971
41.

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.

Chan TH, Lin CH, Qi L, Fei J, Li Y, Yong KJ, Liu M, Song Y, Chow RK, Ng VH, Yuan YF, Tenen DG, Guan XY, Chen L.

Gut. 2014 May;63(5):832-43. doi: 10.1136/gutjnl-2012-304037. Epub 2013 Jun 13.

42.

Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing.

Li Y, Chen L, Chan TH, Guan XY.

Int J Biochem Cell Biol. 2013 Aug;45(8):1843-8. doi: 10.1016/j.biocel.2013.05.033. Epub 2013 Jun 4. Review.

PMID:
23748106
43.

Fiber Bragg grating strain modulation based on nonlinear string transverse-force amplifier.

Li K, Yau MH, Chan TH, Thambiratnam D, Tam HY.

Opt Lett. 2013 Feb 1;38(3):311-3. doi: 10.1364/OL.38.000311.

PMID:
23381421
44.

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.

Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG, Guan XY.

Nat Med. 2013 Feb;19(2):209-16. doi: 10.1038/nm.3043. Epub 2013 Jan 6.

45.

Novel epigallocatechin gallate analogs as potential anticancer agents: a patent review (2009 - present).

Landis-Piwowar K, Chen D, Foldes R, Chan TH, Dou QP.

Expert Opin Ther Pat. 2013 Feb;23(2):189-202. doi: 10.1517/13543776.2013.743993. Epub 2012 Dec 12. Review.

46.

Incorporating spirituality in psychosocial group intervention for women undergoing in vitro fertilization: a prospective randomized controlled study.

Chan CH, Chan CL, Ng EH, Ho PC, Chan TH, Lee GL, Hui WH.

Psychol Psychother. 2012 Dec;85(4):356-73. doi: 10.1111/j.2044-8341.2011.02040.x. Epub 2011 Sep 22.

PMID:
23080528
47.

SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice.

Li Y, Chen L, Chan TH, Liu M, Kong KL, Qiu JL, Li Y, Yuan YF, Guan XY.

Gastroenterology. 2013 Jan;144(1):179-191.e4. doi: 10.1053/j.gastro.2012.09.042. Epub 2012 Sep 25.

PMID:
23022495
48.

Flavonoid dimers as novel, potent antileishmanial agents.

Wong IL, Chan KF, Chan TH, Chow LM.

J Med Chem. 2012 Oct 25;55(20):8891-902. doi: 10.1021/jm301172v. Epub 2012 Oct 3.

PMID:
22989363
49.

Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice.

Wang CC, Xu H, Man GC, Zhang T, Chu KO, Chu CY, Cheng JT, Li G, He YX, Qin L, Lau TS, Kwong J, Chan TH.

Angiogenesis. 2013 Jan;16(1):59-69. doi: 10.1007/s10456-012-9299-4. Epub 2012 Sep 5.

PMID:
22948799
50.

Role of translationally controlled tumor protein in cancer progression.

Chan TH, Chen L, Guan XY.

Biochem Res Int. 2012;2012:369384. doi: 10.1155/2012/369384. Epub 2012 Apr 17.

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