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Items: 1 to 50 of 203

1.

Transcription Factor Elf3 Modulates Vasopressin-Induced Aquaporin-2 Gene Expression in Kidney Collecting Duct Cells.

Lin ST, Ma CC, Kuo KT, Su YF, Wang WL, Chan TH, Su SH, Weng SC, Yang CH, Lin SL, Yu MJ.

Front Physiol. 2019 Oct 18;10:1308. doi: 10.3389/fphys.2019.01308. eCollection 2019.

2.

Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.

Zhu X, Wong ILK, Chan KF, Cui J, Law MC, Chong TC, Hu X, Chow LMC, Chan TH.

J Med Chem. 2019 Sep 26;62(18):8578-8608. doi: 10.1021/acs.jmedchem.9b00963. Epub 2019 Sep 12.

PMID:
31465686
3.

New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation.

Tan JL, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu GD, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG, Chai L.

Gastroenterology. 2019 Dec;157(6):1615-1629.e17. doi: 10.1053/j.gastro.2019.08.022. Epub 2019 Aug 22.

PMID:
31446059
4.

Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031.

Sarr A, Bré J, Um IH, Chan TH, Mullen P, Harrison DJ, Reynolds PA.

Sci Rep. 2019 May 21;9(1):7643. doi: 10.1038/s41598-019-44089-3.

5.

Correlated Eigenvalues of Multi-Soliton Optical Communications.

Zhang WQ, Gui T, Zhang Q, Lu C, Monro TM, Chan TH, Lau APT, Shahraam Afshar V.

Sci Rep. 2019 Apr 25;9(1):6399. doi: 10.1038/s41598-019-42510-5.

6.
7.

Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.

Lui HK, Gao W, Cheung KC, Jin WB, Sun N, Kan JWY, Wong ILK, Chiou J, Lin D, Chan EWC, Leung YC, Chan TH, Chen S, Chan KF, Wong KY.

Eur J Med Chem. 2019 Feb 1;163:95-115. doi: 10.1016/j.ejmech.2018.11.052. Epub 2018 Nov 24.

PMID:
30503946
8.

Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer.

Tsang JYS, Lee MA, Chan TH, Li J, Ni YB, Shao Y, Chan SK, Cheungc SY, Lau KF, Tse GMK.

EBioMedicine. 2018 Dec;38:89-99. doi: 10.1016/j.ebiom.2018.11.012. Epub 2018 Nov 20.

9.

Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells.

Heyza JR, Arora S, Zhang H, Conner KL, Lei W, Floyd AM, Deshmukh RR, Sarver J, Trabbic CJ, Erhardt P, Chan TH, Dou QP, Patrick SM.

Nutrients. 2018 Nov 3;10(11). pii: E1644. doi: 10.3390/nu10111644.

10.

Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".

Wong ILK, Zhu X, Chan KF, Law MC, Lo AMY, Hu X, Chow LMC, Chan TH.

J Med Chem. 2018 Nov 21;61(22):9931-9951. doi: 10.1021/acs.jmedchem.8b00834. Epub 2018 Nov 1.

PMID:
30351934
11.

Quasi-Spatially Periodic Signals for Optical Fibre Communications.

Zhang Q, Chan TH, Grant A.

Sci Rep. 2018 Oct 22;8(1):15596. doi: 10.1038/s41598-018-33589-3.

12.

Design, synthesis and antibacterial evaluation of 2,4-disubstituted-6-thiophenyl-pyrimidines.

Fang Z, Zheng S, Chan KF, Yuan W, Guo Q, Wu W, Lui HK, Lu Y, Leung YC, Chan TH, Wong KY, Sun N.

Eur J Med Chem. 2019 Jan 1;161:141-153. doi: 10.1016/j.ejmech.2018.10.039. Epub 2018 Oct 17.

PMID:
30347327
13.

Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors.

Chan KF, Sun N, Yan SC, Wong ILK, Lui HK, Cheung KC, Yuan J, Chan FY, Zheng Z, Chan EWC, Chen S, Leung YC, Chan TH, Wong KY.

ACS Omega. 2017 Oct 31;2(10):7281-7292. doi: 10.1021/acsomega.7b00701. Epub 2017 Oct 27.

14.

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.

Lee JB, Zgair A, Malec J, Kim TH, Kim MG, Ali J, Qin C, Feng W, Chiang M, Gao X, Voronin G, Garces AE, Lau CL, Chan TH, Hume A, McIntosh TM, Soukarieh F, Al-Hayali M, Cipolla E, Collins HM, Heery DM, Shin BS, Yoo SD, Kagan L, Stocks MJ, Bradshaw TD, Fischer PM, Gershkovich P.

J Control Release. 2018 Sep 28;286:10-19. doi: 10.1016/j.jconrel.2018.07.022. Epub 2018 Jul 18.

15.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.

Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.

16.

Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1.

Jin WB, Xu C, Cheng Q, Qi XL, Gao W, Zheng Z, Chan EWC, Leung YC, Chan TH, Wong KY, Chen S, Chan KF.

Eur J Med Chem. 2018 Jul 15;155:285-302. doi: 10.1016/j.ejmech.2018.06.007. Epub 2018 Jun 6.

PMID:
29894943
17.

Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer.

Hong H, An O, Chan THM, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJT, Tang SJ, Yang H, Song Y, Bellido Molias F, Tenen DG, Chen L.

Nucleic Acids Res. 2018 Sep 6;46(15):7953-7969. doi: 10.1093/nar/gky396.

18.

Perspectives on the recent developments with green tea polyphenols in drug discovery.

Li F, Wang Y, Li D, Chen Y, Qiao X, Fardous R, Lewandowski A, Liu J, Chan TH, Dou QP.

Expert Opin Drug Discov. 2018 Jul;13(7):643-660. doi: 10.1080/17460441.2018.1465923. Epub 2018 Apr 24. Review.

19.

A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer.

Wang J, Man GCW, Chan TH, Kwong J, Wang CC.

Cancer Lett. 2018 Jan 1;412:10-20. doi: 10.1016/j.canlet.2017.09.054. Epub 2017 Oct 9.

PMID:
29024813
20.

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer.

Qi L, Song Y, Chan THM, Yang H, Lin CH, Tay DJT, Hong H, Tang SJ, Tan KT, Huang XX, Lin JS, Ng VHE, Maury JJP, Tenen DG, Chen L.

Nucleic Acids Res. 2017 Oct 13;45(18):10436-10451. doi: 10.1093/nar/gkx667.

21.

(-)-Epiafzelechin Protects against Ovariectomy-induced Bone Loss in Adult Mice and Modulate Osteoblastic and Osteoclastic Functions In Vitro.

Wong KC, Cao S, Dong X, Law MC, Chan TH, Wong MS.

Nutrients. 2017 May 22;9(5). pii: E530. doi: 10.3390/nu9050530.

22.

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation.

Jin K, Po KHL, Wang S, Reuven JA, Wai CN, Lau HT, Chan TH, Chen S, Li X.

Bioorg Med Chem. 2017 Sep 15;25(18):4990-4995. doi: 10.1016/j.bmc.2017.04.039. Epub 2017 Apr 29.

PMID:
28495382
23.

Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.

Dury L, Nasr R, Lorendeau D, Comsa E, Wong I, Zhu X, Chan KF, Chan TH, Chow L, Falson P, Di Pietro A, Baubichon-Cortay H.

Biochem Pharmacol. 2017 Jan 15;124:10-18. doi: 10.1016/j.bcp.2016.10.013. Epub 2016 Oct 28.

PMID:
27984000
24.

Perceived importance of childbearing and attitudes toward assisted reproductive technology among Chinese lesbians in Hong Kong: implications for psychological well-being.

Lo IP, Chan CH, Chan TH.

Fertil Steril. 2016 Oct;106(5):1221-1229. doi: 10.1016/j.fertnstert.2016.06.042. Epub 2016 Jul 26.

PMID:
27473352
25.

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

Chan TH, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VH, Song Y, Hong H, Tay ST, Liu Y, Lee J, Rha SY, Zhu F, So JB, Teh BT, Yeoh KG, Rozen S, Tenen DG, Tan P, Chen L.

Gastroenterology. 2016 Oct;151(4):637-650.e10. doi: 10.1053/j.gastro.2016.06.043. Epub 2016 Jul 1.

PMID:
27373511
26.

Restriction of Retrotransposon Mobilization in Schizosaccharomyces pombe by Transcriptional Silencing and Higher-Order Chromatin Organization.

Murton HE, Grady PJ, Chan TH, Cam HP, Whitehall SK.

Genetics. 2016 Aug;203(4):1669-78. doi: 10.1534/genetics.116.189118. Epub 2016 Jun 24.

27.

CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors.

Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY.

Hepatology. 2016 May;63(5):1544-59. doi: 10.1002/hep.28437. Epub 2016 Mar 4.

PMID:
27100146
28.

Biological and Mechanistic Characterization of Novel Prodrugs of Green Tea Polyphenol Epigallocatechin Gallate Analogs in Human Leiomyoma Cell Lines.

Ahmed RS, Liu G, Renzetti A, Farshi P, Yang H, Soave C, Saed G, El-Ghoneimy AA, El-Banna HA, Foldes R, Chan TH, Dou QP.

J Cell Biochem. 2016 Oct;117(10):2357-69. doi: 10.1002/jcb.25533. Epub 2016 Mar 28.

PMID:
26950525
29.

PCANet: A Simple Deep Learning Baseline for Image Classification?

Chan TH, Jia K, Gao S, Lu J, Zeng Z, Ma Y.

IEEE Trans Image Process. 2015 Dec;24(12):5017-32. doi: 10.1109/TIP.2015.2475625. Epub 2015 Sep 1.

PMID:
26340772
30.

Convex-Optimization-Based Compartmental Pharmacokinetic Analysis for Prostate Tumor Characterization Using DCE-MRI.

Ambikapathi A, Chan TH, Lin CH, Yang FS, Chi CY, Wang Y.

IEEE Trans Biomed Eng. 2016 Apr;63(4):707-20. doi: 10.1109/TBME.2015.2469601. Epub 2015 Aug 18.

PMID:
26292336
31.

A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.

Yan CS, Wong IL, Chan KF, Kan JW, Chong TC, Law MC, Zhao Y, Chan SW, Chan TH, Chow LM.

Mol Pharm. 2015 Oct 5;12(10):3507-17. doi: 10.1021/mp500770e. Epub 2015 Aug 27.

PMID:
26291333
32.

In Reply.

Echebiri NC, McDoom MM, Chan TH, Barnabei VM.

Obstet Gynecol. 2015 Jul;126(1):214-5. doi: 10.1097/AOG.0000000000000938. No abstract available.

PMID:
26241280
33.

Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).

Chiou J, Wan S, Chan KF, So PK, He D, Chan EW, Chan TH, Wong KY, Tao J, Chen S.

Chem Commun (Camb). 2015 Jun 11;51(46):9543-6. doi: 10.1039/c5cc02594j.

PMID:
25970101
34.

The need for uniform quality reporting across post-acute care rehabilitation settings: an examination of accidental falls.

Mallinson T, Leland NE, Chan TH.

J Am Geriatr Soc. 2015 Jan;63(1):195-7. doi: 10.1111/jgs.13221. No abstract available.

35.
36.

Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics.

Arkwright RT, Deshmukh R, Adapa N, Stevens R, Zonder E, Zhang Z, Farshi P, Ahmed RS, El-Banna HA, Chan TH, Dou QP.

Anticancer Agents Med Chem. 2015;15(5):657-71. Review.

37.

Intentions and attitudes towards parenthood and fertility awareness among Chinese university students in Hong Kong: a comparison with Western samples.

Chan CH, Chan TH, Peterson BD, Lampic C, Tam MY.

Hum Reprod. 2015 Feb;30(2):364-72. doi: 10.1093/humrep/deu324. Epub 2014 Dec 5.

38.

Determination of exogenous epigallocatechin gallate peracetate in mouse plasma using liquid chromatography with quadrupole time-of-flight mass spectrometry.

Chu KO, Man GC, Chan KP, Chu CY, Chan TH, Pang CP, Wang CC.

J Sep Sci. 2014 Dec;37(23):3473-80. doi: 10.1002/jssc.201400701. Epub 2014 Oct 18.

PMID:
25250898
39.

Development of a UPLC-MS/MS bioanalytical method for the pharmacokinetic study of (-)-epiafzelechin, a flavan-3-ol with osteoprotective activity, in C57BL/6J mice.

Wong KC, Law MC, Wong MS, Chan TH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:162-7. doi: 10.1016/j.jchromb.2014.07.028. Epub 2014 Jul 27.

PMID:
25108364
40.

ADAR1: a promising new biomarker for esophageal squamous cell carcinoma?

Qiao JJ, Chan TH, Qin YR, Chen L.

Expert Rev Anticancer Ther. 2014 Aug;14(8):865-8. doi: 10.1586/14737140.2014.928595. Epub 2014 Jun 13. Review.

PMID:
24928581
41.

Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity.

Sun N, Chan FY, Lu YJ, Neves MA, Lui HK, Wang Y, Chow KY, Chan KF, Yan SC, Leung YC, Abagyan R, Chan TH, Wong KY.

PLoS One. 2014 May 13;9(5):e97514. doi: 10.1371/journal.pone.0097514. eCollection 2014.

42.

In vitro and in vivo efficacy of novel flavonoid dimers against cutaneous leishmaniasis.

Wong IL, Chan KF, Chen YF, Lun ZR, Chan TH, Chow LM.

Antimicrob Agents Chemother. 2014 Jun;58(6):3379-88. doi: 10.1128/AAC.02425-13. Epub 2014 Mar 31.

43.

Experimental verification of the modified spring-mass theory of fiber Bragg grating accelerometers using transverse forces.

Li K, Chan TH, Yau MH, Thambiratnam DP, Tam HY.

Appl Opt. 2014 Feb 20;53(6):1200-11. doi: 10.1364/AO.53.001200.

PMID:
24663321
44.

Facebook and its effects on users' empathic social skills and life satisfaction: a double-edged sword effect.

Chan TH.

Cyberpsychol Behav Soc Netw. 2014 May;17(5):276-80. doi: 10.1089/cyber.2013.0466. Epub 2014 Mar 7.

PMID:
24606026
45.

RNA editome imbalance in hepatocellular carcinoma.

Qi L, Chan TH, Tenen DG, Chen L.

Cancer Res. 2014 Mar 1;74(5):1301-6. doi: 10.1158/0008-5472.CAN-13-3485. Epub 2014 Feb 20. Review.

46.

Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma.

Liu M, Li Y, Chen L, Chan TH, Song Y, Fu L, Zeng TT, Dai YD, Zhu YH, Li Y, Chen J, Yuan YF, Guan XY.

Gastroenterology. 2014 Apr;146(4):1084-96. doi: 10.1053/j.gastro.2013.12.041. Epub 2014 Jan 11.

PMID:
24417816
47.

Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma.

Qin YR, Qiao JJ, Chan TH, Zhu YH, Li FF, Liu H, Fei J, Li Y, Guan XY, Chen L.

Cancer Res. 2014 Feb 1;74(3):840-51. doi: 10.1158/0008-5472.CAN-13-2545. Epub 2013 Dec 3.

48.

Referral strategy for early recognition of axial spondyloarthritis: consensus recommendations from the Hong Kong Society of Rheumatology.

Mok CC, Tam LS, Leung MH, Ying KY, To CH, Lee KL, Ho LY, Yip ML, Tsui HS, Chan TH, Lee KW, Li EK; Hong Kong Society of Rheumatology.

Int J Rheum Dis. 2013 Oct;16(5):500-8. doi: 10.1111/1756-185X.12161.

PMID:
24164836
49.

Very sensitive fiber Bragg grating accelerometer using transverse forces with an easy over-range protection and low cross axial sensitivity.

Li K, Chan TH, Yau MH, Nguyen T, Thambiratnam DP, Tam HY.

Appl Opt. 2013 Sep 1;52(25):6401-10. doi: 10.1364/AO.52.006401.

PMID:
24085103
50.

The human microbiota: a new direction in the investigation of thoracic diseases.

Hui AW, Lau HW, Chan TH, Tsui SK.

J Thorac Dis. 2013 Aug;5 Suppl 2:S127-31. doi: 10.3978/j.issn.2072-1439.2013.07.41.

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