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Items: 26


Performance Enhancements in Differential Ion Mobility Spectrometry-Mass Spectrometry (DMS-MS) by Using a Modified CaptiveSpray Source.

Wu R, Wu WJ, Wang Z, Wong YE, Hung YW, Wong HT, Chen X, Chan TD.

J Am Soc Mass Spectrom. 2018 Nov;29(11):2199-2207. doi: 10.1007/s13361-018-2041-8. Epub 2018 Aug 16.


Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

Burnett DL, Langley DB, Schofield P, Hermes JR, Chan TD, Jackson J, Bourne K, Reed JH, Patterson K, Porebski BT, Brink R, Christ D, Goodnow CC.

Science. 2018 Apr 13;360(6385):223-226. doi: 10.1126/science.aao3859.


Electron-ion reaction-based dissociation: A powerful ion activation method for the elucidation of natural product structures.

Chen X, Wang Z, Wong YE, Wu R, Zhang F, Chan TD.

Mass Spectrom Rev. 2018 Nov;37(6):793-810. doi: 10.1002/mas.21563. Epub 2018 Mar 30. Review.


Tissue imaging with in situ solid-phase extraction micro-funnel based spray ionization mass spectrometry.

Li W, Chen X, Wang Z, Wong YE, Wu R, Hung YW, Chan TD.

Eur J Mass Spectrom (Chichester). 2018 Feb;24(1):66-73. doi: 10.1177/1469066717731940. Epub 2017 Sep 14.


Structural Characterization of Intact Glycoconjugates by Tandem Mass Spectrometry Using Electron-Induced Dissociation.

Wong YLE, Chen X, Wu R, Hung YLW, Chan TD.

Anal Chem. 2017 Sep 19;89(18):10111-10117. doi: 10.1021/acs.analchem.7b03128. Epub 2017 Sep 7.


Generation and Characterization of Gas-Phase Doubly Charged Biradical Peptide Ions (M2+••).

Wong YLE, Chen X, Wu R, Hung YLW, Yeung HS, Chan TD.

Anal Chem. 2017 Jul 18;89(14):7773-7780. doi: 10.1021/acs.analchem.7b01808. Epub 2017 Jun 30.


Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells.

Kräutler NJ, Suan D, Butt D, Bourne K, Hermes JR, Chan TD, Sundling C, Kaplan W, Schofield P, Jackson J, Basten A, Christ D, Brink R.

J Exp Med. 2017 May 1;214(5):1259-1267. doi: 10.1084/jem.20161533. Epub 2017 Mar 31.


Magnetic porous carbon derived from a bimetallic metal-organic framework for magnetic solid-phase extraction of organochlorine pesticides from drinking and environmental water samples.

Liu Y, Gao Z, Wu R, Wang Z, Chen X, Chan TD.

J Chromatogr A. 2017 Jan 6;1479:55-61. doi: 10.1016/j.chroma.2016.12.014. Epub 2016 Dec 8.


Metal-Organic Framework@Microporous Organic Network as Adsorbent for Solid-Phase Microextraction.

Jia Y, Su H, Wang Z, Wong YE, Chen X, Wang M, Chan TD.

Anal Chem. 2016 Oct 4;88(19):9364-9367. Epub 2016 Sep 20.


A cadmium(II)-based metal-organic framework material for the dispersive solid-phase extraction of polybrominated diphenyl ethers in environmental water samples.

Su H, Wang Z, Jia Y, Deng L, Chen X, Zhao R, Chan TD.

J Chromatogr A. 2015 Nov 27;1422:334-339. doi: 10.1016/j.chroma.2015.10.039. Epub 2015 Oct 17.


IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses.

McGuire HM, Vogelzang A, Warren J, Loetsch C, Natividad KD, Chan TD, Brink R, Batten M, King C.

J Immunol. 2015 Dec 1;195(11):5123-35. doi: 10.4049/jimmunol.1501463. Epub 2015 Oct 21.


FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

Butt D, Chan TD, Bourne K, Hermes JR, Nguyen A, Statham A, O'Reilly LA, Strasser A, Price S, Schofield P, Christ D, Basten A, Ma CS, Tangye SG, Phan TG, Rao VK, Brink R.

Immunity. 2015 May 19;42(5):890-902. doi: 10.1016/j.immuni.2015.04.010. Epub 2015 May 12.


The SW(HEL) system for high-resolution analysis of in vivo antigen-specific T-dependent B cell responses.

Brink R, Paus D, Bourne K, Hermes JR, Gardam S, Phan TG, Chan TD.

Methods Mol Biol. 2015;1291:103-23. doi: 10.1007/978-1-4939-2498-1_9.


Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12.


Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

Chan TD, Wood K, Hermes JR, Butt D, Jolly CJ, Basten A, Brink R.

Immunity. 2012 Nov 16;37(5):893-904. doi: 10.1016/j.immuni.2012.07.017. Epub 2012 Nov 8.


Affinity-based selection and the germinal center response.

Chan TD, Brink R.

Immunol Rev. 2012 May;247(1):11-23. doi: 10.1111/j.1600-065X.2012.01118.x. Review.


B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells.

Lee SK, Rigby RJ, Zotos D, Tsai LM, Kawamoto S, Marshall JL, Ramiscal RR, Chan TD, Gatto D, Brink R, Yu D, Fagarasan S, Tarlinton DM, Cunningham AF, Vinuesa CG.

J Exp Med. 2011 Jul 4;208(7):1377-88. doi: 10.1084/jem.20102065. Epub 2011 Jun 27.


In vivo control of B-cell survival and antigen-specific B-cell responses.

Chan TD, Gardam S, Gatto D, Turner VM, Silke J, Brink R.

Immunol Rev. 2010 Sep;237(1):90-103. doi: 10.1111/j.1600-065X.2010.00942.x. Review.


B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.

Avery DT, Deenick EK, Ma CS, Suryani S, Simpson N, Chew GY, Chan TD, Palendira U, Bustamante J, Boisson-Dupuis S, Choo S, Bleasel KE, Peake J, King C, French MA, Engelhard D, Al-Hajjar S, Al-Muhsen S, Magdorf K, Roesler J, Arkwright PD, Hissaria P, Riminton DS, Wong M, Brink R, Fulcher DA, Casanova JL, Cook MC, Tangye SG.

J Exp Med. 2010 Jan 18;207(1):155-71. doi: 10.1084/jem.20091706. Epub 2010 Jan 4.


Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Randall KL, Lambe T, Johnson AL, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC.

Nat Immunol. 2009 Dec;10(12):1283-91. doi: 10.1038/ni.1820. Epub 2009 Nov 8. Erratum in: Nat Immunol. 2010 Jul;11(7):644. Johnson, Andy [corrected to Johnson, Andy L].


Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts.

Chan TD, Gatto D, Wood K, Camidge T, Basten A, Brink R.

J Immunol. 2009 Sep 1;183(5):3139-49. doi: 10.4049/jimmunol.0901690. Epub 2009 Aug 7.


Visualizing the effects of antigen affinity on T-dependent B-cell differentiation.

Brink R, Phan TG, Paus D, Chan TD.

Immunol Cell Biol. 2008 Jan;86(1):31-9. Epub 2007 Nov 20. Review.


High affinity germinal center B cells are actively selected into the plasma cell compartment.

Phan TG, Paus D, Chan TD, Turner ML, Nutt SL, Basten A, Brink R.

J Exp Med. 2006 Oct 30;203(11):2419-24. Epub 2006 Oct 9.


Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation.

Paus D, Phan TG, Chan TD, Gardam S, Basten A, Brink R.

J Exp Med. 2006 Apr 17;203(4):1081-91. Epub 2006 Apr 10.

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