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Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin.

Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD.

Genome Res. 2019 Mar;29(3):418-427. doi: 10.1101/gr.242719.118.


Angiogenic Factor Estimation as a Warning Sign of Preeclampsia-Related Peripartum Morbidity Among Hospitalized Patients.

Lopes Perdigao J, Chinthala S, Mueller A, Minhas R, Ramadan H, Nasim R, Naseem H, Young D, Shahul S, Chan SL, Yeo KJ, Rana S.

Hypertension. 2019 Apr;73(4):868-877. doi: 10.1161/HYPERTENSIONAHA.118.12205.


Genome-wide screening and functional analysis identifies tumor suppressor long non-coding RNAs epigenetically silenced in hepatocellular carcinoma.

Xu F, Li CH, Wong CH, Chen GG, Lai PBS, Shao S, Chan SL, Chen Y.

Cancer Res. 2019 Feb 4. pii: canres.1659.2018. doi: 10.1158/0008-5472.CAN-18-1659. [Epub ahead of print]


Embedding of Genes Using Cancer Gene Expression Data: Biological Relevance and Potential Application on Biomarker Discovery.

Choy CT, Wong CH, Chan SL.

Front Genet. 2019 Jan 4;9:682. doi: 10.3389/fgene.2018.00682. eCollection 2018.


Treatment of advanced hepatocellular carcinoma: immunotherapy from checkpoint blockade to potential of cellular treatment.

Siu EH, Chan AW, Chong CC, Chan SL, Lo KW, Cheung ST.

Transl Gastroenterol Hepatol. 2018 Nov 7;3:89. doi: 10.21037/tgh.2018.10.16. eCollection 2018. Review.


Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat.

Chan SL, Watchorn RE, Panagou E, Panou E, Ong EL, Heelan K, Haider A, Freeman A, Bunker CB.

Australas J Dermatol. 2018 Dec 25. doi: 10.1111/ajd.12981. [Epub ahead of print]


Association of antepartum blood pressure levels and angiogenic profile among women with chronic hypertension.

Minhas R, Young D, Naseem R, Mueller A, Chinthala S, Perdigao JL, Yeo KJ, Chan SL, Tung A, White JB, Shahul S, Rana S.

Pregnancy Hypertens. 2018 Oct;14:110-114. doi: 10.1016/j.preghy.2018.09.003. Epub 2018 Sep 5.


Novel biomarkers GEP/ABCB5 regulate response to adjuvant transarterial chemoembolization after curative hepatectomy for hepatocellular carcinoma.

Chong CC, Cheung ST, Cheung YS, Chan AW, Chan SL, Yu SC, Lai PB.

Hepatobiliary Pancreat Dis Int. 2018 Dec;17(6):524-530. doi: 10.1016/j.hbpd.2018.10.003. Epub 2018 Oct 29.


Economic burden of adverse drug reactions and potential for pharmacogenomic testing in Singaporean adults.

Chan SL, Ng HY, Sung C, Chan A, Winther MD, Brunham LR, Wee HL.

Pharmacogenomics J. 2018 Sep 24. doi: 10.1038/s41397-018-0053-1. [Epub ahead of print]


Reply to 'Comment on 'Circulating Neutrophils in patients with hepatocellular carcinoma".

Chan SL, McNally RJQ, Reeves HL.

Br J Cancer. 2018 Sep;119(6):781-782. doi: 10.1038/s41416-018-0250-3. Epub 2018 Sep 12. No abstract available.


The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation.

Cipolla MJ, Liebeskind DS, Chan SL.

J Cereb Blood Flow Metab. 2018 Dec;38(12):2129-2149. doi: 10.1177/0271678X18800589. Epub 2018 Sep 10.


ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib.

Niu LL, Cheng CL, Li MY, Yang SL, Hu BG, Chong CCN, Chan SL, Ren J, Chen GG, Lai PBS.

Cell Death Dis. 2018 Aug 28;9(9):852. doi: 10.1038/s41419-018-0926-x.


Transient receptor potential vanilloid-4 channels are involved in diminished myogenic tone in brain parenchymal arterioles in response to chronic hypoperfusion in mice.

Chan SL, Nelson MT, Cipolla MJ.

Acta Physiol (Oxf). 2019 Feb;225(2):e13181. doi: 10.1111/apha.13181. Epub 2018 Sep 16.


Inhibition of PAI (Plasminogen Activator Inhibitor)-1 Improves Brain Collateral Perfusion and Injury After Acute Ischemic Stroke in Aged Hypertensive Rats.

Chan SL, Bishop N, Li Z, Cipolla MJ.

Stroke. 2018 Aug;49(8):1969-1976. doi: 10.1161/STROKEAHA.118.022056.


Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma.

Abou-Alfa GK, Meyer T, Cheng AL, El-Khoueiry AB, Rimassa L, Ryoo BY, Cicin I, Merle P, Chen Y, Park JW, Blanc JF, Bolondi L, Klümpen HJ, Chan SL, Zagonel V, Pressiani T, Ryu MH, Venook AP, Hessel C, Borgman-Hagey AE, Schwab G, Kelley RK.

N Engl J Med. 2018 Jul 5;379(1):54-63. doi: 10.1056/NEJMoa1717002.


Association of serum folate level with toxicity of capecitabine in patients with colorectal cancers: a prospective cohort study.

Chan SL, Ma BB, Chan AK.

Hong Kong Med J. 2018 Jun;24 Suppl 3(3):29-31. No abstract available.


Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial.

Zhu AX, Finn RS, Edeline J, Cattan S, Ogasawara S, Palmer D, Verslype C, Zagonel V, Fartoux L, Vogel A, Sarker D, Verset G, Chan SL, Knox J, Daniele B, Webber AL, Ebbinghaus SW, Ma J, Siegel AB, Cheng AL, Kudo M; KEYNOTE-224 investigators.

Lancet Oncol. 2018 Jul;19(7):940-952. doi: 10.1016/S1470-2045(18)30351-6. Epub 2018 Jun 3. Erratum in: Lancet Oncol. 2018 Sep;19(9):e440.


Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer.

Chan SL, Chan AWH, Mo F, Ma BBY, Wong KCW, Lam D, Mok FST, Chan ATC, Mok T, Chan KCA.

Oncologist. 2018 Dec;23(12):1436-1445. doi: 10.1634/theoncologist.2017-0637. Epub 2018 May 25.


Transporter-mediated interaction of indican and methotrexate in rats.

Lin SP, Yu CP, Hou YC, Huang CY, Ho LC, Chan SL.

J Food Drug Anal. 2018 Apr;26(2S):S133-S140. doi: 10.1016/j.jfda.2017.11.006. Epub 2017 Dec 14.


Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features.

Li X, Xu W, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To KF, Chan SL, Chan MTV, Sung JJY, Wu WKK, Yu J.

Theranostics. 2018 Feb 12;8(6):1740-1751. doi: 10.7150/thno.22010. eCollection 2018.


Analytical validation of soluble fms-like tyrosine and placental growth factor assays on B·R·A·H·M·S KRYPTOR Compact Plus automated immunoassay platform.

Chan SL, Rana S, Chinthala S, Salahuddin S, Yeo KJ.

Pregnancy Hypertens. 2018 Jan;11:66-70. doi: 10.1016/j.preghy.2017.12.009. Epub 2018 Jan 2.


Time course and clinical characterization of cisplatin-induced ototoxicity after treatment for nasopharyngeal carcinoma in a South East Asian population.

Chan SL, Ng LS, Goh X, Siow CH, Goh HL, Goh BC, Cheo T, Loh KS, Brunham LR.

Head Neck. 2018 Jul;40(7):1425-1433. doi: 10.1002/hed.25112. Epub 2018 Feb 16.


Microwave ablation provides better survival than liver resection for hepatocellular carcinoma in patients with borderline liver function: application of ALBI score to patient selection.

Chong CCN, Lee KF, Chu CM, Chan AWH, Wong J, Chan SL, Lok HT, Fung AKY, Fong AKW, Cheung YS, Yu SCH, Johnson P, Lai PBS.

HPB (Oxford). 2018 Jun;20(6):546-554. doi: 10.1016/j.hpb.2017.12.001. Epub 2018 Jan 17.


Detection of Anterior Circulation Large Artery Occlusion in Ischemic Stroke Using Noninvasive Cerebral Oximetry.

Flint AC, Bhandari SG, Cullen SP, Reddy AV, Hsu DP, Rao VA, Patel M, Pombra J, Edwards NJ, Chan SL.

Stroke. 2018 Feb;49(2):458-460. doi: 10.1161/STROKEAHA.117.020140. Epub 2018 Jan 10.


Effect of TTC Treatment on Immunohistochemical Quantification of Collagen IV in Rat Brains after Stroke.

Li Z, Bishop N, Chan SL, Cipolla MJ.

Transl Stroke Res. 2018 Oct;9(5):499-505. doi: 10.1007/s12975-017-0604-9. Epub 2018 Jan 8.


Ablative Chemoembolization for Hepatocellular Carcinoma: A Prospective Phase I Case-Control Comparison with Conventional Chemoembolization.

Yu SCH, Chan SL, Lee KF, Hui JWY, Hui EP, Chu CM, Chan AW, Cheung S, Li L, Wong J, Yeo WMM.

Radiology. 2018 Apr;287(1):340-348. doi: 10.1148/radiol.2017170154. Epub 2017 Dec 22.


Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?

Margetts J, Ogle LF, Chan SL, Chan AWH, Chan KCA, Jamieson D, Willoughby CE, Mann DA, Wilson CL, Manas DM, Yeo W, Reeves HL.

Br J Cancer. 2018 Jan;118(2):248-257. doi: 10.1038/bjc.2017.386. Epub 2017 Nov 9.


Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients.

Chan SL, Chua APG, Aminkeng F, Chee CBE, Jin S, Loh M, Gan SH, Wang YT, Brunham LR.

PLoS One. 2017 Oct 16;12(10):e0186200. doi: 10.1371/journal.pone.0186200. eCollection 2017.


Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3β.

Lau WM, Teng E, Huang KK, Tan JW, Das K, Zang Z, Chia T, Teh M, Kono K, Yong WP, Shabbir A, Tay A, Phua NS, Tan P, Chan SL, So JBY.

Mol Cancer Ther. 2018 Jan;17(1):232-242. doi: 10.1158/1535-7163.MCT-17-0367. Epub 2017 Oct 4.


Higher order structures of Adalimumab, Infliximab and their complexes with TNFα revealed by electron microscopy.

Tran BN, Chan SL, Ng C, Shi J, Correia I, Radziejewski C, Matsudaira P.

Protein Sci. 2017 Dec;26(12):2392-2398. doi: 10.1002/pro.3306. Epub 2017 Nov 14.


Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.

Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY.

Nat Commun. 2017 Sep 21;8(1):653. doi: 10.1038/s41467-017-00413-x.


Luminescent Iridium(III) Pyridinium-Derived N-Heterocyclic Carbene Complexes as Versatile Photoredox Catalysts.

Lam TL, Lai J, Annapureddy RR, Xue M, Yang C, Guan Y, Zhou P, Chan SL.

Inorg Chem. 2017 Sep 18;56(18):10835-10839. doi: 10.1021/acs.inorgchem.7b00955. Epub 2017 Aug 28.


Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors.

Irving A, Abdulrazzaq G, Chan SLF, Penman J, Harvey J, Alexander SPH.

Adv Pharmacol. 2017;80:223-247. doi: 10.1016/bs.apha.2017.04.004. Epub 2017 Jun 12. Review.


Albumin-bilirubin grade predicts the outcomes of liver resection versus radiofrequency ablation for very early/early stage of hepatocellular carcinoma.

Chong CC, Chan AW, Wong J, Chu CM, Chan SL, Lee KF, Yu SC, To KF, Johnson P, Lai PB.

Surgeon. 2018 Jun;16(3):163-170. doi: 10.1016/j.surge.2017.07.003. Epub 2017 Aug 12.


Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.

Kasai N, Sasakawa A, Hosomi K, Poh TW, Chua BL, Yong WP, So J, Chan SL, Soong R, Kono K, Ishii T, Yamano K.

Am J Transl Res. 2017 Jul 15;9(7):3399-3410. eCollection 2017.


Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer.

Chan KCA, Woo JKS, King A, Zee BCY, Lam WKJ, Chan SL, Chu SWI, Mak C, Tse IOL, Leung SYM, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, van Hasselt AC, Chan ATC, Lo YMD.

N Engl J Med. 2017 Aug 10;377(6):513-522. doi: 10.1056/NEJMoa1701717. Erratum in: N Engl J Med. 2018 Mar 8;378(10 ):973.


Treatment with low dose fasudil for acute ischemic stroke in chronic hypertension.

Chan SL, Cipolla MJ.

J Cereb Blood Flow Metab. 2017 Sep;37(9):3262-3270. doi: 10.1177/0271678X17718665. Epub 2017 Jun 30.


A phase 2 study of the efficacy and biomarker on the combination of transarterial chemoembolization and axitinib in the treatment of inoperable hepatocellular carcinoma.

Chan SL, Yeo W, Mo F, Chan AWH, Koh J, Li L, Hui EP, Chong CCN, Lai PBS, Mok TSK, Yu SCH.

Cancer. 2017 Oct 15;123(20):3977-3985. doi: 10.1002/cncr.30825. Epub 2017 Jun 22.


Statin Adherence Is Associated With Reduced Recurrent Stroke Risk in Patients With or Without Atrial Fibrillation.

Flint AC, Conell C, Ren X, Kamel H, Chan SL, Rao VA, Johnston SC.

Stroke. 2017 Jul;48(7):1788-1794. doi: 10.1161/STROKEAHA.117.017343. Epub 2017 Jun 8.


Pharmacogenomics in Asia: a systematic review on current trends and novel discoveries.

Ang HX, Chan SL, Sani LL, Quah CB, Brunham LR, Tan BOP, Winther MD.

Pharmacogenomics. 2017 Jun;18(9):891-910. doi: 10.2217/pgs-2017-0009. Epub 2017 Jun 8. Review.


MolAlign: an algorithm for aligning multiple small molecules.

Chan SL.

J Comput Aided Mol Des. 2017 Jun;31(6):523-546. doi: 10.1007/s10822-017-0023-8. Epub 2017 Jun 1.


Targeting LRRK2 in Parkinson's disease: an update on recent developments.

Chan SL, Tan EK.

Expert Opin Ther Targets. 2017 Jun;21(6):601-610. doi: 10.1080/14728222.2017.1323881. Epub 2017 May 15. Review.


Pharmacologically increasing collateral perfusion during acute stroke using a carboxyhemoglobin gas transfer agent (Sanguinate™) in spontaneously hypertensive rats.

Cipolla MJ, Linfante I, Abuchowski A, Jubin R, Chan SL.

J Cereb Blood Flow Metab. 2018 May;38(5):755-766. doi: 10.1177/0271678X17705567. Epub 2017 Apr 24.


Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca2+ Entry and Ca2+-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation.

Chen J, Li Z, Hatcher JT, Chen QH, Chen L, Wurster RD, Chan SL, Cheng Z.

Front Neurosci. 2017 Mar 28;11:138. doi: 10.3389/fnins.2017.00138. eCollection 2017.


BCL6 promotes glioma and serves as a therapeutic target.

Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3981-3986. doi: 10.1073/pnas.1609758114. Epub 2017 Mar 29. Erratum in: Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4317.


Transarterial chemo-embolisation of hepatocellular carcinoma: impact of liver function and vascular invasion.

Waked I, Berhane S, Toyoda H, Chan SL, Stern N, Palmer D, Tada T, Yeo W, Mo F, Bettinger D, Kirstein MM, Iñarrairaegui M, Gomaa A, Vogel A, Meyer T, Sangro B, Lai P, Kumada T, Johnson PJ.

Br J Cancer. 2017 Feb 14;116(4):448-454. doi: 10.1038/bjc.2016.423. Epub 2017 Jan 26.


Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: Importance of physico-chemical characteristics.

Adomako-Bonsu AG, Chan SL, Pratten M, Fry JR.

Toxicol In Vitro. 2017 Apr;40:248-255. doi: 10.1016/j.tiv.2017.01.016. Epub 2017 Jan 22.


Wheel-to-rhomboid isomerization as well as nitrene transfer catalysis of ruthenium-thiolate wheels.

Tso KC, Chan SL, Huang JS, Che CM.

Chem Commun (Camb). 2017 Feb 21;53(16):2419-2422. doi: 10.1039/c6cc09903c.


Treatment of chronic subdural hematomas with subdural evacuating port system placement in the intensive care unit: evolution of practice and comparison with bur hole evacuation in the operating room.

Flint AC, Chan SL, Rao VA, Efron AD, Kalani MA, Sheridan WF.

J Neurosurg. 2017 Dec;127(6):1443-1448. doi: 10.3171/2016.9.JNS161166. Epub 2017 Jan 20.


Impact of disease stage and aetiology on survival in hepatocellular carcinoma: implications for surveillance.

Johnson P, Berhane S, Kagebayashi C, Satomura S, Teng M, Fox R, Yeo W, Mo F, Lai P, Chan SL, Tada T, Toyoda H, Kumada T.

Br J Cancer. 2017 Feb 14;116(4):441-447. doi: 10.1038/bjc.2016.422. Epub 2017 Jan 12.

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