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Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma.

Sangro B, Chan SL, Meyer T, Reig M, El-Khoueiry A, Galle PR.

J Hepatol. 2020 Feb;72(2):320-341. doi: 10.1016/j.jhep.2019.10.021. Review.


Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma.

Cheng AL, Hsu C, Chan SL, Choo SP, Kudo M.

J Hepatol. 2020 Feb;72(2):307-319. doi: 10.1016/j.jhep.2019.09.025. Review.


A phase II study of the efficacy and safety of the MET inhibitor capmatinib (INC280) in patients with advanced hepatocellular carcinoma.

Qin S, Chan SL, Sukeepaisarnjaroen W, Han G, Choo SP, Sriuranpong V, Pan H, Yau T, Guo Y, Chen M, Ren Z, Xu J, Yen CJ, Lin ZZ, Manenti L, Gu Y, Sun Y, Tiedt R, Hao L, Song W, Tanwandee T.

Ther Adv Med Oncol. 2019 Dec 11;11:1758835919889001. doi: 10.1177/1758835919889001. eCollection 2019.


Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial.

Finn RS, Ryoo BY, Merle P, Kudo M, Bouattour M, Lim HY, Breder V, Edeline J, Chao Y, Ogasawara S, Yau T, Garrido M, Chan SL, Knox J, Daniele B, Ebbinghaus SW, Chen E, Siegel AB, Zhu AX, Cheng AL; KEYNOTE-240 investigators.

J Clin Oncol. 2020 Jan 20;38(3):193-202. doi: 10.1200/JCO.19.01307. Epub 2019 Dec 2.


A Field Study Into Hong Kong's Wet Markets: Raised Questions Into the Hygienic Maintenance of Meat Contact Surfaces and the Dissemination of Microorganisms Associated With Nosocomial Infections.

Lo MY, Ngan WY, Tsun SM, Hsing HL, Lau KT, Hung HP, Chan SL, Lai YY, Yao Y, Pu Y, Habimana O.

Front Microbiol. 2019 Nov 12;10:2618. doi: 10.3389/fmicb.2019.02618. eCollection 2019.


Prediction of Survival Among Patients Receiving Transarterial Chemoembolization for Hepatocellular Carcinoma: A Response-Based Approach.

Han G, Berhane S, Toyoda H, Bettinger D, Elshaarawy O, Chan AWH, Kirstein M, Mosconi C, Hucke F, Palmer D, Pinato DJ, Sharma R, Ottaviani D, Jang JW, Labeur TA, van Delden OM, Pirisi M, Stern N, Sangro B, Meyer T, Fateen W, García-Fiñana M, Gomaa A, Waked I, Rewisha E, Aithal GP, Travis S, Kudo M, Cucchetti A, Peck-Radosavljevic M, Takkenberg RB, Chan SL, Vogel A, Johnson PJ.

Hepatology. 2019 Nov 7. doi: 10.1002/hep.31022. [Epub ahead of print]


First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma.

Kim RD, Sarker D, Meyer T, Yau T, Macarulla T, Park JW, Choo SP, Hollebecque A, Sung MW, Lim HY, Mazzaferro V, Trojan J, Zhu AX, Yoon JH, Sharma S, Lin ZZ, Chan SL, Faivre S, Feun LG, Yen CJ, Dufour JF, Palmer DH, Llovet JM, Manoogian M, Tugnait M, Stransky N, Hagel M, Kohl NE, Lengauer C, Sherwin CA, Schmidt-Kittler O, Hoeflich KP, Shi H, Wolf BB, Kang YK.

Cancer Discov. 2019 Dec;9(12):1696-1707. doi: 10.1158/2159-8290.CD-19-0555. Epub 2019 Oct 1.


Efficacy of Ear Molding in Infants using the EarWell Infant Correction System and Factors Affecting Outcome.

Chan SLS, Lim GJS, Por YC, Chiang MF, Ho S, Saffari SE, Chia HL.

Plast Reconstr Surg. 2019 Oct;144(4):648e-658e. doi: 10.1097/PRS.0000000000006057.


Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas.

Ding X, He M, Chan AWH, Song QX, Sze SC, Chen H, Man MKH, Man K, Chan SL, Lai PBS, Wang X, Wong N.

Gastroenterology. 2019 Dec;157(6):1630-1645.e6. doi: 10.1053/j.gastro.2019.09.005. Epub 2019 Sep 24.


Tenofovir disoproxil fumarate reduces hepatocellular carcinoma, decompensation and death in chronic hepatitis B patients with cirrhosis.

Liu K, Choi J, Le A, Yip TC, Wong VW, Chan SL, Chan HL, Nguyen MH, Lim YS, Wong GL.

Aliment Pharmacol Ther. 2019 Nov;50(9):1037-1048. doi: 10.1111/apt.15499. Epub 2019 Sep 16.


Biology and significance of alpha-fetoprotein in hepatocellular carcinoma.

Galle PR, Foerster F, Kudo M, Chan SL, Llovet JM, Qin S, Schelman WR, Chintharlapalli S, Abada PB, Sherman M, Zhu AX.

Liver Int. 2019 Dec;39(12):2214-2229. doi: 10.1111/liv.14223. Epub 2019 Sep 11. Review.


Development of a Nonradioactive Platelet Serotonin Uptake and Release Assay by Micro-Liquid Chromatography Tandem Mass Spectrometry Using Minimal Blood Volume.

Chan SL, Yi X, Wysocki E, Bridgman R, Gutierrez J, Mikrut K, Leung EK, Yeo KJ, Miller JL.

Am J Clin Pathol. 2019 Nov 4;152(6):718-724. doi: 10.1093/ajcp/aqz094.


Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes.

Flint AC, Conell C, Ren X, Banki NM, Chan SL, Rao VA, Melles RB, Bhatt DL.

N Engl J Med. 2019 Jul 18;381(3):243-251. doi: 10.1056/NEJMoa1803180.


Age, race/ethnicity, and comorbidities predict statin adherence after ischemic stroke or myocardial infarction.

Chan SL, Edwards NJ, Conell C, Ren X, Banki NM, Rao VA, Flint AC.

Eur J Prev Cardiol. 2019 Jul 11:2047487319861219. doi: 10.1177/2047487319861219. [Epub ahead of print] No abstract available.


A comparability study of immunohistochemical assays for PD-L1 expression in hepatocellular carcinoma.

Shi L, Zhang SJ, Chen J, Lu SX, Fan XJ, Tong JH, Chow C, Tin EK, Chan SL, Chong CC, Lai PB, To KF, Wong N, Chan AW.

Mod Pathol. 2019 Nov;32(11):1646-1656. doi: 10.1038/s41379-019-0307-8. Epub 2019 Jun 23.


The ATP-binding cassette transporter ABCF1 is a hepatic oncofetal protein that promotes chemoresistance, EMT and cancer stemness in hepatocellular carcinoma.

Fung SW, Cheung PF, Yip CW, Ng LW, Cheung TT, Chong CC, Lee C, Lai PB, Chan AW, Tsao GS, Wong CH, Chan SL, Lo KW, Cheung ST.

Cancer Lett. 2019 Aug 10;457:98-109. doi: 10.1016/j.canlet.2019.05.010. Epub 2019 May 14.


Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma.

Liu M, Zhou J, Liu X, Feng Y, Yang W, Wu F, Cheung OK, Sun H, Zeng X, Tang W, Mok MTS, Wong J, Yeung PC, Lai PBS, Chen Z, Jin H, Chen J, Chan SL, Chan AWH, To KF, Sung JJY, Chen M, Cheng AS.

Gut. 2020 Feb;69(2):365-379. doi: 10.1136/gutjnl-2018-317257. Epub 2019 May 10.


Impact of Weight Loss During Chemotherapy in Chinese Patients with Unresectable Pancreatic Cancer.

Wong HCY, Lam KY, Chong CCN, Chan AWH, Chan SL.

Nutr Cancer. 2019;71(6):954-970. doi: 10.1080/01635581.2019.1595047. Epub 2019 May 6.


The association of liver function and quality of life of patients with liver cancer.

Li L, Mo F, Hui EP, Chan SL, Koh J, Tang NLS, Yu SCH, Yeo W.

BMC Gastroenterol. 2019 May 2;19(1):66. doi: 10.1186/s12876-019-0984-2.


Correlations of health-related quality of life with serum inflammatory indicators IL-8 and mIBI in patients with hepatocellular carcinoma.

Li L, Chan SL, Mo F, Hui EP, Koh J, Chan AKC, Tang NLS, Lee KF, Lai PBS, Yu SCH, Yeo W.

Cancer Manag Res. 2019 Apr 4;11:2719-2727. doi: 10.2147/CMAR.S178482. eCollection 2019.


Status of inflammation in relation to health related quality of life in hepatocellular carcinoma patients.

Li L, Chan SL, Mo F, Hui EP, Koh J, Chan AK, Tang NL, Chu CM, Hui J, Lee KF, Yu S, Yeo W.

Qual Life Res. 2019 Sep;28(9):2597-2607. doi: 10.1007/s11136-019-02190-0. Epub 2019 Apr 29.


A comparison between Caucasian and Asian superficial venous anatomy and reflux patterns - Implications for potential precision endovenous ablation therapy.

Lee Q, Gibson K, Chan SL, Rathnaweera HP, Chong TT, Tang TY.

Phlebology. 2020 Feb;35(1):39-45. doi: 10.1177/0268355519845984. Epub 2019 Apr 29. No abstract available.


Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin.

Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD.

Genome Res. 2019 Mar;29(3):418-427. doi: 10.1101/gr.242719.118.


Angiogenic Factor Estimation as a Warning Sign of Preeclampsia-Related Peripartum Morbidity Among Hospitalized Patients.

Lopes Perdigao J, Chinthala S, Mueller A, Minhas R, Ramadan H, Nasim R, Naseem H, Young D, Shahul S, Chan SL, Yeo KJ, Rana S.

Hypertension. 2019 Apr;73(4):868-877. doi: 10.1161/HYPERTENSIONAHA.118.12205.


Genome-Wide Screening and Functional Analysis Identifies Tumor Suppressor Long Noncoding RNAs Epigenetically Silenced in Hepatocellular Carcinoma.

Xu F, Li CH, Wong CH, Chen GG, Lai PBS, Shao S, Chan SL, Chen Y.

Cancer Res. 2019 Apr 1;79(7):1305-1317. doi: 10.1158/0008-5472.CAN-18-1659. Epub 2019 Feb 4.


Embedding of Genes Using Cancer Gene Expression Data: Biological Relevance and Potential Application on Biomarker Discovery.

Choy CT, Wong CH, Chan SL.

Front Genet. 2019 Jan 4;9:682. doi: 10.3389/fgene.2018.00682. eCollection 2018.


Treatment of advanced hepatocellular carcinoma: immunotherapy from checkpoint blockade to potential of cellular treatment.

Siu EH, Chan AW, Chong CC, Chan SL, Lo KW, Cheung ST.

Transl Gastroenterol Hepatol. 2018 Nov 7;3:89. doi: 10.21037/tgh.2018.10.16. eCollection 2018. Review.


Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat.

Chan SL, Watchorn RE, Panagou E, Panou E, Ong EL, Heelan K, Haider A, Freeman A, Bunker CB.

Australas J Dermatol. 2019 Aug;60(3):e201-e207. doi: 10.1111/ajd.12981. Epub 2018 Dec 25.


Association of antepartum blood pressure levels and angiogenic profile among women with chronic hypertension.

Minhas R, Young D, Naseem R, Mueller A, Chinthala S, Perdigao JL, Yeo KJ, Chan SL, Tung A, White JB, Shahul S, Rana S.

Pregnancy Hypertens. 2018 Oct;14:110-114. doi: 10.1016/j.preghy.2018.09.003. Epub 2018 Sep 5.


Novel biomarkers GEP/ABCB5 regulate response to adjuvant transarterial chemoembolization after curative hepatectomy for hepatocellular carcinoma.

Chong CC, Cheung ST, Cheung YS, Chan AW, Chan SL, Yu SC, Lai PB.

Hepatobiliary Pancreat Dis Int. 2018 Dec;17(6):524-530. doi: 10.1016/j.hbpd.2018.10.003. Epub 2018 Oct 29.


Economic burden of adverse drug reactions and potential for pharmacogenomic testing in Singaporean adults.

Chan SL, Ng HY, Sung C, Chan A, Winther MD, Brunham LR, Wee HL.

Pharmacogenomics J. 2019 Aug;19(4):401-410. doi: 10.1038/s41397-018-0053-1. Epub 2018 Sep 24.


Reply to 'Comment on 'Circulating Neutrophils in patients with hepatocellular carcinoma".

Chan SL, McNally RJQ, Reeves HL.

Br J Cancer. 2018 Sep;119(6):781-782. doi: 10.1038/s41416-018-0250-3. Epub 2018 Sep 12. No abstract available.


The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation.

Cipolla MJ, Liebeskind DS, Chan SL.

J Cereb Blood Flow Metab. 2018 Dec;38(12):2129-2149. doi: 10.1177/0271678X18800589. Epub 2018 Sep 10. Review.


ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib.

Niu LL, Cheng CL, Li MY, Yang SL, Hu BG, Chong CCN, Chan SL, Ren J, Chen GG, Lai PBS.

Cell Death Dis. 2018 Aug 28;9(9):852. doi: 10.1038/s41419-018-0926-x.


Transient receptor potential vanilloid-4 channels are involved in diminished myogenic tone in brain parenchymal arterioles in response to chronic hypoperfusion in mice.

Chan SL, Nelson MT, Cipolla MJ.

Acta Physiol (Oxf). 2019 Feb;225(2):e13181. doi: 10.1111/apha.13181. Epub 2018 Sep 16.


Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma.

Abou-Alfa GK, Meyer T, Cheng AL, El-Khoueiry AB, Rimassa L, Ryoo BY, Cicin I, Merle P, Chen Y, Park JW, Blanc JF, Bolondi L, Klümpen HJ, Chan SL, Zagonel V, Pressiani T, Ryu MH, Venook AP, Hessel C, Borgman-Hagey AE, Schwab G, Kelley RK.

N Engl J Med. 2018 Jul 5;379(1):54-63. doi: 10.1056/NEJMoa1717002.


Association of serum folate level with toxicity of capecitabine in patients with colorectal cancers: a prospective cohort study.

Chan SL, Ma BB, Chan AK.

Hong Kong Med J. 2018 Jun;24 Suppl 3(3):29-31. No abstract available.


Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial.

Zhu AX, Finn RS, Edeline J, Cattan S, Ogasawara S, Palmer D, Verslype C, Zagonel V, Fartoux L, Vogel A, Sarker D, Verset G, Chan SL, Knox J, Daniele B, Webber AL, Ebbinghaus SW, Ma J, Siegel AB, Cheng AL, Kudo M; KEYNOTE-224 investigators.

Lancet Oncol. 2018 Jul;19(7):940-952. doi: 10.1016/S1470-2045(18)30351-6. Epub 2018 Jun 3. Erratum in: Lancet Oncol. 2018 Sep;19(9):e440.


Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer.

Chan SL, Chan AWH, Mo F, Ma BBY, Wong KCW, Lam D, Mok FST, Chan ATC, Mok T, Chan KCA.

Oncologist. 2018 Dec;23(12):1436-1445. doi: 10.1634/theoncologist.2017-0637. Epub 2018 May 25.


Transporter-mediated interaction of indican and methotrexate in rats.

Lin SP, Yu CP, Hou YC, Huang CY, Ho LC, Chan SL.

J Food Drug Anal. 2018 Apr;26(2S):S133-S140. doi: 10.1016/j.jfda.2017.11.006. Epub 2017 Dec 14.


Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features.

Li X, Xu W, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To KF, Chan SL, Chan MTV, Sung JJY, Wu WKK, Yu J.

Theranostics. 2018 Feb 12;8(6):1740-1751. doi: 10.7150/thno.22010. eCollection 2018.


Analytical validation of soluble fms-like tyrosine and placental growth factor assays on B·R·A·H·M·S KRYPTOR Compact Plus automated immunoassay platform.

Chan SL, Rana S, Chinthala S, Salahuddin S, Yeo KJ.

Pregnancy Hypertens. 2018 Jan;11:66-70. doi: 10.1016/j.preghy.2017.12.009. Epub 2018 Jan 2.


Time course and clinical characterization of cisplatin-induced ototoxicity after treatment for nasopharyngeal carcinoma in a South East Asian population.

Chan SL, Ng LS, Goh X, Siow CH, Goh HL, Goh BC, Cheo T, Loh KS, Brunham LR.

Head Neck. 2018 Jul;40(7):1425-1433. doi: 10.1002/hed.25112. Epub 2018 Feb 16.


Microwave ablation provides better survival than liver resection for hepatocellular carcinoma in patients with borderline liver function: application of ALBI score to patient selection.

Chong CCN, Lee KF, Chu CM, Chan AWH, Wong J, Chan SL, Lok HT, Fung AKY, Fong AKW, Cheung YS, Yu SCH, Johnson P, Lai PBS.

HPB (Oxford). 2018 Jun;20(6):546-554. doi: 10.1016/j.hpb.2017.12.001. Epub 2018 Jan 17.


Detection of Anterior Circulation Large Artery Occlusion in Ischemic Stroke Using Noninvasive Cerebral Oximetry.

Flint AC, Bhandari SG, Cullen SP, Reddy AV, Hsu DP, Rao VA, Patel M, Pombra J, Edwards NJ, Chan SL.

Stroke. 2018 Feb;49(2):458-460. doi: 10.1161/STROKEAHA.117.020140. Epub 2018 Jan 10.


Effect of TTC Treatment on Immunohistochemical Quantification of Collagen IV in Rat Brains after Stroke.

Li Z, Bishop N, Chan SL, Cipolla MJ.

Transl Stroke Res. 2018 Oct;9(5):499-505. doi: 10.1007/s12975-017-0604-9. Epub 2018 Jan 8.


Ablative Chemoembolization for Hepatocellular Carcinoma: A Prospective Phase I Case-Control Comparison with Conventional Chemoembolization.

Yu SCH, Chan SL, Lee KF, Hui JWY, Hui EP, Chu CM, Chan AW, Cheung S, Li L, Wong J, Yeo WMM.

Radiology. 2018 Apr;287(1):340-348. doi: 10.1148/radiol.2017170154. Epub 2017 Dec 22.


Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?

Margetts J, Ogle LF, Chan SL, Chan AWH, Chan KCA, Jamieson D, Willoughby CE, Mann DA, Wilson CL, Manas DM, Yeo W, Reeves HL.

Br J Cancer. 2018 Jan;118(2):248-257. doi: 10.1038/bjc.2017.386. Epub 2017 Nov 9.


Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients.

Chan SL, Chua APG, Aminkeng F, Chee CBE, Jin S, Loh M, Gan SH, Wang YT, Brunham LR.

PLoS One. 2017 Oct 16;12(10):e0186200. doi: 10.1371/journal.pone.0186200. eCollection 2017.

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