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Determinants of life satisfaction and self-perception of ageing among elderly people in China: An exploratory study in comparison between physical and social functioning.

Pan Y, Chan SHW, Xu Y, Yeung KC.

Arch Gerontol Geriatr. 2019 Jul 8;84:103910. doi: 10.1016/j.archger.2019.103910. [Epub ahead of print]


Megapixel photon-counting color imaging using quanta image sensor.

Gnanasambandam A, Elgendy O, Ma J, Chan SH.

Opt Express. 2019 Jun 10;27(12):17298-17310. doi: 10.1364/OE.27.017298.


Health-related quality of life in Chinese boys with Duchenne muscular dystrophy and their families.

Liang R, Chan SHS, Ho FKW, Tang OC, Cherk SWW, Ip P, Lau EYY.

J Child Health Care. 2019 Jun 20:1367493519857423. doi: 10.1177/1367493519857423. [Epub ahead of print]


Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation.

Chan SH, Tang Y, Miao L, Darwich-Codore H, Vejnar CE, Beaudoin JD, Musaev D, Fernandez JP, Benitez MDJ, Bazzini AA, Moreno-Mateos MA, Giraldez AJ.

Dev Cell. 2019 Jun 17;49(6):867-881.e8. doi: 10.1016/j.devcel.2019.05.037.


6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels.

Li H, Ericsson M, Rabasha B, Budnik B, Chan SH, Freinkman E, Lewis CA, Doench JG, Wagner BK, Garraway LA, Schreiber SL.

Cell Chem Biol. 2019 Jun 4. pii: S2451-9456(19)30175-8. doi: 10.1016/j.chembiol.2019.05.006. [Epub ahead of print]


The yeast scavenger decapping enzyme DcpS and its application for in vitro RNA recapping.

Wulf MG, Buswell J, Chan SH, Dai N, Marks K, Martin ER, Tzertzinis G, Whipple JM, Corrêa IR Jr, Schildkraut I.

Sci Rep. 2019 Jun 13;9(1):8594. doi: 10.1038/s41598-019-45083-5.


Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions.

Mukda S, Tsai CY, Leu S, Yang JL, Chan SHH.

J Biomed Sci. 2019 Jun 5;26(1):43. doi: 10.1186/s12929-019-0538-5.


Differential impacts of brain stem oxidative stress and nitrosative stress on sympathetic vasomotor tone.

Chan JYH, Chan SHH.

Pharmacol Ther. 2019 May 31. pii: S0163-7258(19)30098-1. doi: 10.1016/j.pharmthera.2019.05.015. [Epub ahead of print] Review.


Systems Biology - A Guide for Understanding and Developing Improved Strains of Lactic Acid Bacteria.

Liu J, Chan SHJ, Chen J, Solem C, Jensen PR.

Front Microbiol. 2019 Apr 30;10:876. doi: 10.3389/fmicb.2019.00876. eCollection 2019. Review.


Congenital muscular dystrophies in China.

Ge L, Zhang C, Wang Z, Chan SHS, Zhu W, Han C, Zhang X, Zheng H, Wu L, Jin B, Shan J, Mao B, Zhong J, Peng X, Cheng Y, Hu J, Sun Y, Lu J, Hua Y, Zhu S, Wei C, Wang S, Jiao H, Yang H, Fu X, Fan Y, Chang X, Wang S, Bao X, Zhang Y, Wang J, Wu Y, Jiang Y, Yuan Y, Rutkowski A, Bönnemann CG, Wei W, Wu X, Xiong H.

Clin Genet. 2019 May 8. doi: 10.1111/cge.13560. [Epub ahead of print]


Isotopic dilution assay development of nisin A in cream cheese, mascarpone, processed cheese and ripened cheese by LC-MS/MS method.

Lim CW, Lai KY, Ho WT, Chan SH.

Food Chem. 2019 Sep 15;292:58-65. doi: 10.1016/j.foodchem.2019.04.040. Epub 2019 Apr 10.


Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.

Sullivan MR, Danai LV, Lewis CA, Chan SH, Gui DY, Kunchok T, Dennstedt EA, Vander Heiden MG, Muir A.

Elife. 2019 Apr 16;8. pii: e44235. doi: 10.7554/eLife.44235.


Galectin-3 aggravates ox-LDL-induced endothelial dysfunction through LOX-1 mediated signaling pathway.

Ou HC, Chou WC, Hung CH, Chu PM, Hsieh PL, Chan SH, Tsai KL.

Environ Toxicol. 2019 Jul;34(7):825-835. doi: 10.1002/tox.22750. Epub 2019 Apr 9.


Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy.

Yen CJ, Hung CH, Kao CL, Tsai WM, Chan SH, Cheng HC, Jheng WT, Lu YJ, Tsai KL.

Support Care Cancer. 2019 Apr 4. doi: 10.1007/s00520-019-04786-1. [Epub ahead of print]


Initiation-specific alleles of the Cdc45 helicase-activating protein.

Rios-Morales RY, Chan SH, Bell SP.

PLoS One. 2019 Mar 26;14(3):e0214426. doi: 10.1371/journal.pone.0214426. eCollection 2019.


Relationship Between Body Mass Index, Antidiabetic Agents, and Midterm Mortality in Patients With Both Type 2 Diabetes Mellitus and Acute Coronary Syndrome.

Jong CB, Li HY, Pan SL, Hsieh MY, Su FY, Chen KC, Yin WH, Chan SH, Wu YW, Wang KY, Chang KC, Hwang JJ, Wu CC.

J Am Heart Assoc. 2019 Apr 2;8(7):e011215. doi: 10.1161/JAHA.118.011215.


Optimal Combination of Image Denoisers.

Choi JH, Elgendy OA, Chan SH.

IEEE Trans Image Process. 2019 Aug;28(8):4016-4031. doi: 10.1109/TIP.2019.2903321. Epub 2019 Mar 8.


Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0.

Heirendt L, Arreckx S, Pfau T, Mendoza SN, Richelle A, Heinken A, Haraldsdóttir HS, Wachowiak J, Keating SM, Vlasov V, Magnusdóttir S, Ng CY, Preciat G, Žagare A, Chan SHJ, Aurich MK, Clancy CM, Modamio J, Sauls JT, Noronha A, Bordbar A, Cousins B, El Assal DC, Valcarcel LV, Apaolaza I, Ghaderi S, Ahookhosh M, Ben Guebila M, Kostromins A, Sompairac N, Le HM, Ma D, Sun Y, Wang L, Yurkovich JT, Oliveira MAP, Vuong PT, El Assal LP, Kuperstein I, Zinovyev A, Hinton HS, Bryant WA, Aragón Artacho FJ, Planes FJ, Stalidzans E, Maass A, Vempala S, Hucka M, Saunders MA, Maranas CD, Lewis NE, Sauter T, Palsson BØ, Thiele I, Fleming RMT.

Nat Protoc. 2019 Mar;14(3):639-702. doi: 10.1038/s41596-018-0098-2.


A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway.

Huang WC, Jang TH, Tung SL, Yen TC, Chan SH, Wang LH.

J Exp Clin Cancer Res. 2019 Feb 19;38(1):89. doi: 10.1186/s13046-019-1091-5.


Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.

Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, Birsoy K.

Nature. 2019 Mar;567(7746):118-122. doi: 10.1038/s41586-019-0945-5. Epub 2019 Feb 13.


Knowledge, attitude and ethical consideration of Chinese couples requesting preimplantation genetic testing in Hong Kong.

Chan SHS, Li RHW, Lee VCY, Tang MHY, Ng EHY.

J Obstet Gynaecol Res. 2019 Jun;45(6):1096-1105. doi: 10.1111/jog.13940. Epub 2019 Feb 11.


Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.

Chang JF, Hsu JL, Sheng YH, Leu WJ, Yu CC, Chan SH, Chan ML, Hsu LC, Liu SP, Guh JH.

Front Oncol. 2019 Jan 17;8:681. doi: 10.3389/fonc.2018.00681. eCollection 2018.


Reliability of the Maximal Step Length Test and Its Correlation with Motor Function in Chronic Stroke Survivors.

Ng SSM, Tse MMY, Kwong PWH, Fong ICK, Chan SH, Cheung TCH, Ko HL, Yan DMH, Lai CYY.

Biomed Res Int. 2018 Dec 20;2018:6985963. doi: 10.1155/2018/6985963. eCollection 2018.


A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35.

Fung JLF, Tsang MHY, Leung GKC, Yeung KS, Mak CCY, Fung CW, Chan SHS, Yu MHC, Chung BHY.

Parkinsonism Relat Disord. 2019 Jan 17. pii: S1353-8020(19)30013-6. doi: 10.1016/j.parkreldis.2019.01.013. [Epub ahead of print]


MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.

Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):303-312. doi: 10.1073/pnas.1816656115. Epub 2018 Dec 12.


Activation of spinal nociceptin receptors induces cardiovascular depression and antinociception in an independent manner in mice.

Tsai CY, Poon YY, Huang YH, Chan SH.

J Pain Res. 2018 Nov 1;11:2699-2708. doi: 10.2147/JPR.S175259. eCollection 2018.


Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors.

Tso WWY, Liu APY, Lee TMC, Cheuk KL, Shing MK, Luk CW, Ling SC, Ku DTL, Li K, Yung AWY, Fung CW, Chan SHS, Ho ACC, Ho FKW, Ip P, Chan GCF.

J Neurooncol. 2019 Jan;141(2):393-401. doi: 10.1007/s11060-018-03045-3. Epub 2018 Nov 20.


Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours.

Chan SH, Chew W, Ishak NDB, Lim WK, Li ST, Tan SH, Teo JX, Shaw T, Chang K, Chen Y, Iyer P, Tan EEK, Seng MS, Chan MY, Tan AM, Low SYY, Soh SY, Loh AHP, Ngeow J.

NPJ Genom Med. 2018 Nov 15;3:30. doi: 10.1038/s41525-018-0070-7. eCollection 2018.


SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.

Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM.

Science. 2018 Nov 16;362(6416). pii: eaat9528. doi: 10.1126/science.aat9528.


Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma.

Chan JY, Ng AYJ, Cheng CL, Nairismägi ML, Venkatesh B, Cheah DMZ, Li ST, Chan SH, Ngeow J, Laurensia Y, Lim JQ, Pang JWL, Nagarajan S, Song T, Chia B, Tan J, Huang D, Goh YT, Poon E, Somasundaram N, Tao M, Quek RHH, Farid M, Khor CC, Bei JX, Tan SY, Lim ST, Ong CK, Tang T.

Blood Cancer J. 2018 Nov 12;8(11):111. doi: 10.1038/s41408-018-0149-5. No abstract available.


Identification of the Novel Role of CD24 as an Oncogenesis Regulator and Therapeutic Target for Triple-Negative Breast Cancer.

Chan SH, Tsai KW, Chiu SY, Kuo WH, Chen HY, Jiang SS, Chang KJ, Hung WC, Wang LH.

Mol Cancer Ther. 2019 Jan;18(1):147-161. doi: 10.1158/1535-7163.MCT-18-0292. Epub 2018 Oct 31.


Baroreflex functionality in the eye of diffusion tensor imaging.

Tsai CY, Poon YY, Chan JYH, Chan SHH.

J Physiol. 2019 Jan;597(1):41-55. doi: 10.1113/JP277008. Epub 2018 Nov 2.


Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis.

Waudby CA, Wlodarski T, Karyadi ME, Cassaignau AME, Chan SHS, Wentink AS, Schmidt-Engler JM, Camilloni C, Vendruscolo M, Cabrita LD, Christodoulou J.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9744-9749. doi: 10.1073/pnas.1716252115. Epub 2018 Sep 10.


An explorative study on coping flexibility with behavioral approach system-activating stimuli: A comparison of people with and without bipolar disorder.

Chan SHW, Tse S.

Psychiatry Res. 2018 Nov;269:399-407. doi: 10.1016/j.psychres.2018.08.084. Epub 2018 Aug 28.


NEK2 Promotes Hepatoma Metastasis and Serves as Biomarker for High Recurrence Risk after Hepatic Resection.

Chang YY, Yen CJ, Chan SH, Chou YW, Lee YP, Bao CY, Huang CJ, Huang W.

Ann Hepatol. 2018 Aug 24;17(5):843-856. doi: 10.5604/01.3001.0012.3146.


A recurrent de novo DYNC1H1 tail domain mutation causes spinal muscular atrophy with lower extremity predominance, learning difficulties and mild brain abnormality.

Chan SHS, van Alfen N, Thuestad IJ, Ip J, Chan AO, Mak C, Chung BH, Verrips A, Kamsteeg EJ.

Neuromuscul Disord. 2018 Sep;28(9):750-756. doi: 10.1016/j.nmd.2018.07.002. Epub 2018 Jul 20.


Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey.

Mak CC, Leung GK, Mok GT, Yeung KS, Yang W, Fung CW, Chan SH, Lee SL, Lee NC, Pfundt R, Lau YL, Chung BH.

NPJ Genom Med. 2018 Aug 6;3:19. doi: 10.1038/s41525-018-0056-5. eCollection 2018.


Coping with amplified emotionality among people with bipolar disorder: A longitudinal study.

Chan SHW, Tse S.

J Affect Disord. 2018 Oct 15;239:303-312. doi: 10.1016/j.jad.2018.07.025. Epub 2018 Jul 18.


PTEN/FLJ10540/PI3K/Akt cascade in experimental brain stem death: A newfound role for a classical tumorigenic signaling pathway.

Tsai CY, Dai KY, Fang C, Wu JCC, Chan SHH.

Biochem Pharmacol. 2018 Sep;155:207-212. doi: 10.1016/j.bcp.2018.07.002. Epub 2018 Jul 3. Review.


Histidine catabolism is a major determinant of methotrexate sensitivity.

Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM.

Nature. 2018 Jul;559(7715):632-636. doi: 10.1038/s41586-018-0316-7. Epub 2018 Jul 11.


RES complex is associated with intron definition and required for zebrafish early embryogenesis.

Fernandez JP, Moreno-Mateos MA, Gohr A, Miao L, Chan SH, Irimia M, Giraldez AJ.

PLoS Genet. 2018 Jul 3;14(7):e1007473. doi: 10.1371/journal.pgen.1007473. eCollection 2018 Jul.


A novel co-processing method to manufacture an API for extended release formulation via formation of agglomerates of active ingredient and hydroxypropyl methylcellulose during crystallization.

Rosenbaum T, Erdemir D, Chang SY, Kientzler D, Wang S, Chan SH, Brown J, Hanley S, Kiang S.

Drug Dev Ind Pharm. 2018 Oct;44(10):1606-1612. doi: 10.1080/03639045.2018.1483386. Epub 2018 Aug 14.


Accelerating flux balance calculations in genome-scale metabolic models by localizing the application of loopless constraints.

Chan SHJ, Wang L, Dash S, Maranas CD.

Bioinformatics. 2018 Dec 15;34(24):4248-4255. doi: 10.1093/bioinformatics/bty446.


In-Hospital Implementation of Evidence-Based Medications is Associated with Improved Survival in Diabetic Patients with Acute Coronary Syndrome - Data from TSOC ACS-DM Registry.

Chen KC, Yin WH, Wu CC, Chan SH, Wu YW, Yang Wang K, Chang KC, Hwang JJ, Voon WC, Hsieh IC, Chong JT, Lin WS, Hsu CN, Ueng KC, Hsia CP, Liu JC, Yeh JS, Mar GY, Shih JY, Kuo JY, Tsao HM, Tseng WK, Yang CH, Chang CC, Chiang CE, Lei MH, Lin JF, Shyu KG.

Acta Cardiol Sin. 2018 May;34(3):211-223. doi: 10.6515/ACS.201805_34(3).20180207B.


Spinal Muscular Atrophy With Respiratory Distress Type 1-A Child With Atypical Presentation.

Chiu ATG, Chan SHS, Wu SP, Ting SH, Chung BHY, Chan AOK, Wong VCN.

Child Neurol Open. 2018 Apr 19;5:2329048X18769811. doi: 10.1177/2329048X18769811. eCollection 2018.


Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway.

Chang JW, Kuo WH, Lin CM, Chen WL, Chan SH, Chiu MF, Chang IS, Jiang SS, Tsai FY, Chen CH, Huang PH, Chang KJ, Lin KT, Lin SC, Wang MY, Uen YH, Tu CW, Hou MF, Tsai SF, Shen CY, Tung SL, Wang LH.

Oncogene. 2018 Jul;37(30):4137-4150. doi: 10.1038/s41388-018-0253-9. Epub 2018 Apr 30.


NUFIP1 is a ribosome receptor for starvation-induced ribophagy.

Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM.

Science. 2018 May 18;360(6390):751-758. doi: 10.1126/science.aar2663. Epub 2018 Apr 26.


Isocitrate dehydrogenase 1-snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability.

Liu WS, Chan SH, Chang HT, Li GC, Tu YT, Tseng HH, Fu TY, Chang HY, Liou HH, Ger LP, Tsai KW.

Breast Cancer Res. 2018 Apr 16;20(1):25. doi: 10.1186/s13058-018-0953-7.


Chlorogenic Acid Protects Against oxLDL-Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells.

Tsai KL, Hung CH, Chan SH, Hsieh PL, Ou HC, Cheng YH, Chu PM.

Mol Nutr Food Res. 2018 Jun;62(11):e1700928. doi: 10.1002/mnfr.201700928. Epub 2018 May 10.


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