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Understanding molecular surface doping of large bandgap organic semiconductors and overcoming the contact/access resistance in organic field-effect transistors.

Pei K, Lau AHY, Chan PKL.

Phys Chem Chem Phys. 2020 Mar 23. doi: 10.1039/d0cp00487a. [Epub ahead of print]


Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer's disease mouse model.

Ng RC, Jian M, Ma OK, Bunting M, Kwan JS, Zhou GJ, Senthilkumar K, Iyaswamy A, Chan PK, Li M, Leung KM, Kumar Durairajan SS, Lam KS, Chu LW, Festenstein R, Chung SK, Chan KH.

Mol Psychiatry. 2020 Mar 4. doi: 10.1038/s41380-020-0701-0. [Epub ahead of print]


The Medial Collateral Ligament in Primary Total Knee Arthroplasty: Anatomy, Biomechanics, and Injury.

Cheung A, Yan CH, Chan PK, Chiu KY.

J Am Acad Orthop Surg. 2020 Feb 24. doi: 10.5435/JAAOS-D-19-00355. [Epub ahead of print]


Southern Chinese populations harbour non-nucleatum Fusobacteria possessing homologues of the colorectal cancer-associated FadA virulence factor.

Yeoh YK, Chen Z, Wong MCS, Hui M, Yu J, Ng SC, Sung JJY, Chan FKL, Chan PKS.

Gut. 2020 Feb 12. pii: gutjnl-2019-319635. doi: 10.1136/gutjnl-2019-319635. [Epub ahead of print]


Cost-effectiveness analysis of fecal microbiota transplantation for recurrent Clostridium difficile infection in patients with inflammatory bowel disease.

You JHS, Jiang X, Lee WH, Chan PKS, Ng SC.

J Gastroenterol Hepatol. 2020 Feb 3. doi: 10.1111/jgh.15002. [Epub ahead of print]


Human papillomavirus 58E7 T20I/G63S variant isolated from an East Asian population possesses high oncogenicity.

Boon SS, Xia C, Lim JY, Chen Z, Law PTY, Yeung ACM, Thomas M, Banks L, Chan PKS.

J Virol. 2020 Jan 29. pii: JVI.00090-20. doi: 10.1128/JVI.00090-20. [Epub ahead of print]


Human cardiac ventricular organoid chambers and tissue strips from pluripotent stem cells as a two-tiered assay for inotropic responses: A blinded validation.

Keung W, Chan PK, Backeris P, Lee EK, Wong N, Wong GK, Chan CW, Fermini B, Costa KD, Li RA.

J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106595. doi: 10.1016/j.vascn.2019.05.174. Epub 2019 Oct 17. No abstract available.


Automated drug classification by machine learning analysis of drug screening data from human pluripotent stem cell-derived engineered cardiac tissue assays.

Lee EK, Tran DD, Keung W, Chan PK, Wong GK, Chan CW, Costa KD, Khine M, Li RA.

J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106595. doi: 10.1016/j.vascn.2019.05.177. Epub 2019 Oct 17. No abstract available.


"Human heart-in-a-Jar": An electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

Li RA, Keung W, Cashman T, Backeris P, Johnson BV, Bardot ES, Wong AO, Chan PK, Chan CW, Costa KD.

J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106595. doi: 10.1016/j.vascn.2019.05.178. Epub 2019 Oct 17. No abstract available.


Systematic review of human gut resistome studies revealed variable definitions and approaches.

Ho J, Yeoh YK, Barua N, Chen Z, Lui G, Wong SH, Yang X, Chan MC, Chan PK, Hawkey PM, Ip M.

Gut Microbes. 2020 Jan 16:1-12. doi: 10.1080/19490976.2019.1700755. [Epub ahead of print]


Surveillance of biologic sources of hepatitis E viruses in community.

Chan MCW, Chan PKS.

Hong Kong Med J. 2019 Dec;25 Suppl 9(6):17-20. No abstract available.


Correction to: Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly.

Boon SS, Chen Z, Li J, Lee KYC, Cai L, Zhong R, Chan PKS.

BMC Cancer. 2019 Dec 29;19(1):1255. doi: 10.1186/s12885-019-6493-4.


Synergistic Effect between Human Papillomavirus 18 and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone on Malignant Transformation of Immortalized SHEE Cells.

Zhuang Z, Li J, Sun G, Cui X, Zhang N, Zhao L, Chan PKS, Zhong R.

Chem Res Toxicol. 2020 Feb 17;33(2):470-481. doi: 10.1021/acs.chemrestox.9b00371. Epub 2020 Jan 9.


Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly.

Boon SS, Chen Z, Li J, Lee KYC, Cai L, Zhong R, Chan PKS.

BMC Cancer. 2019 Dec 12;19(1):1211. doi: 10.1186/s12885-019-6413-7. Erratum in: BMC Cancer. 2019 Dec 29;19(1):1255.


The human oral cavity microbiota composition during acute tonsillitis: a cross-sectional survey.

Yeoh YK, Chan MH, Chen Z, Lam EWH, Wong PY, Ngai CM, Chan PKS, Hui M.

BMC Oral Health. 2019 Dec 5;19(1):275. doi: 10.1186/s12903-019-0956-5.


Review article: fungal alterations in inflammatory bowel diseases.

Lam S, Zuo T, Ho M, Chan FKL, Chan PKS, Ng SC.

Aliment Pharmacol Ther. 2019 Dec;50(11-12):1159-1171. doi: 10.1111/apt.15523. Epub 2019 Oct 24. Review.


Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma.

Sun X, Hou T, Cheung E, Iu TN, Tam VW, Chu IM, Tsang MS, Chan PK, Lam CW, Wong CK.

Cell Mol Immunol. 2019 Oct 23. doi: 10.1038/s41423-019-0300-7. [Epub ahead of print]


Paget disease of bone in an elderly patient with chronic renal disease and weight loss: A case report.

Chan PK, Lyu SY, Lu CC.

Medicine (Baltimore). 2019 Oct;98(42):e17458. doi: 10.1097/MD.0000000000017458.


Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE).

Ng SC, Kamm MA, Yeoh YK, Chan PKS, Zuo T, Tang W, Sood A, Andoh A, Ohmiya N, Zhou Y, Ooi CJ, Mahachai V, Wu CY, Zhang F, Sugano K, Chan FKL.

Gut. 2020 Jan;69(1):83-91. doi: 10.1136/gutjnl-2019-319407. Epub 2019 Oct 14.


Field-Effect Transistors Based on 2D Organic Semiconductors Developed by a Hybrid Deposition Method.

Zhou Z, Wu Q, Wang S, Huang YT, Guo H, Feng SP, Chan PKL.

Adv Sci (Weinh). 2019 Aug 1;6(19):1900775. doi: 10.1002/advs.201900775. eCollection 2019 Oct 2.


Association between meteorological variations and activities of influenza A and B across different climate zones: a multi-region modelling analysis across the globe.

Chong KC, Lee TC, Bialasiewicz S, Chen J, Smith DW, Choy WSC, Krajden M, Jalal H, Jennings L, Alexander B, Lee HK, Fraaij P, Levy A, Yeung ACM, Tozer S, Lau SYF, Jia KM, Tang JWT, Hui DSC, Chan PKS.

J Infect. 2020 Jan;80(1):84-98. doi: 10.1016/j.jinf.2019.09.013. Epub 2019 Oct 1.


Non-human Primate Papillomaviruses Share Similar Evolutionary Histories and Niche Adaptation as the Human Counterparts.

Chen Z, Long T, Wong PY, Ho WCS, Burk RD, Chan PKS.

Front Microbiol. 2019 Sep 10;10:2093. doi: 10.3389/fmicb.2019.02093. eCollection 2019.


Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease.

Ko FW, Chan PK, Chan RWY, Chan KP, Ip A, Kwok A, Ngai JC, Ng SS, On CT, Hui DS.

Respir Res. 2019 Sep 13;20(1):210. doi: 10.1186/s12931-019-1181-0.


Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.

Ye J, Yang X, Xu M, Chan PK, Ma C.

Eur J Med Chem. 2019 Nov 15;182:111635. doi: 10.1016/j.ejmech.2019.111635. Epub 2019 Aug 22.


Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota.

Lyu Y, Zhang Y, Yang M, Lin L, Yang X, Cheung SCK, Shaw PC, Chan PKS, Kong APS, Zuo Z.

Life Sci. 2019 Oct 15;235:116818. doi: 10.1016/j.lfs.2019.116818. Epub 2019 Aug 29.


Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteins.

Qiu Y, Chan ST, Lin L, Shek TL, Tsang TF, Zhang Y, Ip M, Chan PK, Blanchard N, Hanquet G, Zuo Z, Yang X, Ma C.

Bioorg Chem. 2019 Nov;92:103203. doi: 10.1016/j.bioorg.2019.103203. Epub 2019 Aug 16.


Use of Human Intestinal Enteroids to Detect 
Human Norovirus Infectivity.

Chan MC, Cheung SKC, Mohammad KN, Chan JCM, Estes MK, Chan PKS.

Emerg Infect Dis. 2019 Sep;25(9):1730-1735. doi: 10.3201/eid2509.190205.


Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7.

McComb S, Chan PK, Guinot A, Hartmannsdottir H, Jenni S, Dobay MP, Bourquin JP, Bornhauser BC.

Sci Adv. 2019 Jul 31;5(7):eaau9433. doi: 10.1126/sciadv.aau9433. eCollection 2019 Jul.


Randomized Controlled Trial on Adjunctive Lavage for Severe Peritonitis.

Wong SS, Lau WY, Tse YY, Chan PK, Wan CK, Cheng YL, Yu AW.

Perit Dial Int. 2019 Sep-Oct;39(5):447-454. doi: 10.3747/pdi.2018.00111. Epub 2019 Jul 23.


Comparative global epidemiology of influenza, respiratory syncytial and parainfluenza viruses, 2010-2015.

Lam TT, Tang JW, Lai FY, Zaraket H, Dbaibo G, Bialasiewicz S, Tozer S, Heraud JM, Drews SJ, Hachette T, Chan PK, Koay ES, Lee HK, Tee KK, Liu Y, Fraaij P, Jennings L, Waris M, Krajden M, Corriveau A, Jalal H, Nishimura H, Nymadawa P, Badarch D, Watanabe A, Kabanda A, Sloots T, Kok J, Dwyer DE, Koopmans M; INSPIRE (International Network for the Sequencing of Respiratory Viruses).

J Infect. 2019 Oct;79(4):373-382. doi: 10.1016/j.jinf.2019.07.008. Epub 2019 Jul 16.


Achieving Ultralow Turn-On Voltages in Organic Thin-Film Transistors: Investigating Fluoroalkylphosphonic Acid Self-Assembled Monolayer Hybrid Dielectrics.

Acharya R, Peng B, Chan PKL, Schmitz G, Klauk H.

ACS Appl Mater Interfaces. 2019 Jul 31;11(30):27104-27111. doi: 10.1021/acsami.9b04361. Epub 2019 Jul 16.


Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.

Qiu Y, Chan ST, Lin L, Shek TL, Tsang TF, Barua N, Zhang Y, Ip M, Chan PK, Blanchard N, Hanquet G, Zuo Z, Yang X, Ma C.

Eur J Med Chem. 2019 Sep 15;178:214-231. doi: 10.1016/j.ejmech.2019.05.090. Epub 2019 Jun 3.


Faecal microbiota transplantation for treatment of recurrent or refractory Clostridioides difficile infection in Hong Kong.

Lui RN, Wong SH, Lau LHS, Chan TT, Cheung KCY, Li A, Chin ML, Tang W, Ching JYL, Lam KLY, Chan PKS, Wu JCY, Sung JJY, Chan FKL, Ng SC.

Hong Kong Med J. 2019 Jun;25(3):178-182. doi: 10.12809/hkmj197855. Epub 2019 May 29.


Unicompartmental knee arthroplasties in Hong Kong: 15 years of experience in a teaching hospital.

Yung CS, Cheung MH, Fu HCH, Chan PK, Yan CH, Chiu KY.

J Orthop Surg (Hong Kong). 2019 May-Aug;27(2):2309499019850364. doi: 10.1177/2309499019850364.


Ten- to Sixteen-Year Follow-Up of Highly Cross-Linked Polyethylene in Total Hip Arthroplasty: What Factors Affect Wear?

Cheung A, Yan CH, Fu H, Cheung MH, Chan PK, Chiu KY.

J Arthroplasty. 2019 Sep;34(9):2016-2021. doi: 10.1016/j.arth.2019.04.041. Epub 2019 May 6.


Solution-Phase Epitaxial Growth of Perovskite Films on 2D Material Flakes for High-Performance Solar Cells.

Tang G, You P, Tai Q, Yang A, Cao J, Zheng F, Zhou Z, Zhao J, Chan PKL, Yan F.

Adv Mater. 2019 Jun;31(24):e1807689. doi: 10.1002/adma.201807689. Epub 2019 Apr 29.


Non-surgical treatment of knee osteoarthritis.

Kan HS, Chan PK, Chiu KY, Yan CH, Yeung SS, Ng YL, Shiu KW, Ho T.

Hong Kong Med J. 2019 Apr;25(2):127-133. doi: 10.12809/hkmj187600. Epub 2019 Mar 28. Review.


Liquid biopsy of HPV DNA in cervical cancer.

Cheung TH, Yim SF, Yu MY, Worley MJ Jr, Fiascone SJ, Chiu RWK, Lo KWK, Siu NSS, Wong MCS, Yeung ACM, Wong RRY, Chen ZG, Elias KM, Chung TKH, Berkowitz RS, Wong YF, Chan PKS.

J Clin Virol. 2019 May;114:32-36. doi: 10.1016/j.jcv.2019.03.005. Epub 2019 Mar 12.


Extended Experience in the Use of Antibiotic Lock for Eradication of Biofilm Bacteria on Tenckhoff Catheter.

Wong SS, Lau WY, Chan PK, Wan CK, Cheng YL.

Perit Dial Int. 2019 Mar-Apr;39(2):187-190. doi: 10.3747/pdi.2018.00098.


Small contact resistance and high-frequency operation of flexible low-voltage inverted coplanar organic transistors.

Borchert JW, Peng B, Letzkus F, Burghartz JN, Chan PKL, Zojer K, Ludwigs S, Klauk H.

Nat Commun. 2019 Mar 8;10(1):1119. doi: 10.1038/s41467-019-09119-8.


Gut mucosal virome alterations in ulcerative colitis.

Zuo T, Lu XJ, Zhang Y, Cheung CP, Lam S, Zhang F, Tang W, Ching JYL, Zhao R, Chan PKS, Sung JJY, Yu J, Chan FKL, Cao Q, Sheng JQ, Ng SC.

Gut. 2019 Jul;68(7):1169-1179. doi: 10.1136/gutjnl-2018-318131. Epub 2019 Mar 6.


Impact of Preservation Method and 16S rRNA Hypervariable Region on Gut Microbiota Profiling.

Chen Z, Hui PC, Hui M, Yeoh YK, Wong PY, Chan MCW, Wong MCS, Ng SC, Chan FKL, Chan PKS.

mSystems. 2019 Feb 26;4(1). pii: e00271-18. doi: 10.1128/mSystems.00271-18. eCollection 2019 Jan-Feb.


The Extended C-Terminal Region of Influenza C Virus Nucleoprotein Is Important for Nuclear Import and Ribonucleoprotein Activity.

Tang YS, Lo CY, Mok CK, Chan PK, Shaw PC.

J Virol. 2019 Apr 17;93(9). pii: e02048-18. doi: 10.1128/JVI.02048-18. Print 2019 May 1.


Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis.

Zhang C, Luo Y, Zhong R, Law PTY, Boon SS, Chen Z, Wong CH, Chan PKS.

BMC Cancer. 2019 Feb 11;19(1):138. doi: 10.1186/s12885-019-5347-4.


Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses.

Keung W, Chan PKW, Backeris PC, Lee EK, Wong N, Wong AOT, Wong GKY, Chan CWY, Fermini B, Costa KD, Li RA.

Clin Pharmacol Ther. 2019 Aug;106(2):402-414. doi: 10.1002/cpt.1385. Epub 2019 Mar 28.


Are reusable blood collection tube holders the culprit for nosocomial hepatitis C virus transmission?

Tsang DNC, Ip M, Chan PKS, Ching PTY, Lam HS, Seto WH.

Infect Control Hosp Epidemiol. 2019 Feb;40(2):250-251. doi: 10.1017/ice.2018.302. No abstract available.


Oncogenicitiy Comparison of Human Papillomavirus Type 52 E6 Variants.

Lai TO, Boon SS, Law PT, Chen Z, Thomas M, Banks L, Chan PK.

J Gen Virol. 2019 Mar;100(3):484-496. doi: 10.1099/jgv.0.001222. Epub 2019 Jan 24.


Economic Analysis of Herpes Zoster in a Hospital Setting in Hong Kong.

Ming WK, Yu WY, Tsang OT, Chan PK, You JH.

Acta Derm Venereol. 2019 May 1;99(6):616-617. doi: 10.2340/00015555-3118. No abstract available.

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