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Items: 40

1.

Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV.

Gibson EG, Oviatt AA, Cacho M, Neuman KC, Chan PF, Osheroff N.

Biochemistry. 2019 Nov 5;58(44):4447-4455. doi: 10.1021/acs.biochem.9b00805. Epub 2019 Oct 28.

PMID:
31617352
2.

Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.

Thalji RK, Raha K, Andreotti D, Checchia A, Cui H, Meneghelli G, Profeta R, Tonelli F, Tommasi S, Bakshi T, Donovan BT, Howells A, Jain S, Nixon C, Quinque G, McCloskey L, Bax BD, Neu M, Chan PF, Stavenger RA.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1407-1412. doi: 10.1016/j.bmcl.2019.03.029. Epub 2019 Mar 22.

PMID:
30962087
3.

Sudden-onset rash on the trunk and limbs · morbid obesity · family history of diabetes mellitus · Dx?

Chan KS, Lai LKP, Chan PF, Chao DVK.

J Fam Pract. 2019 Mar;68(2):109-112. No abstract available.

PMID:
30870536
4.

Evaluation of the applicability of deep breathing test in the diagnosis of hypertension with white-coat effect in Chinese patients in primary care.

Chan KS, Lai KPL, Chan PF, Luk MHM, Chao VKD.

Clin Hypertens. 2019 Feb 1;25:2. doi: 10.1186/s40885-018-0106-4. eCollection 2019.

5.

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.

Gibson EG, Bax B, Chan PF, Osheroff N.

ACS Infect Dis. 2019 Apr 12;5(4):570-581. doi: 10.1021/acsinfecdis.8b00315. Epub 2019 Feb 28.

6.

Left atrial appendage mass.

Chan PF, Kofidis T, Tan KB, Yip JW, Ling LH.

Echocardiography. 2018 Dec;35(12):2106-2108. doi: 10.1111/echo.14168. Epub 2018 Oct 30.

PMID:
30376594
7.

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Fern Toh M, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G.

Nat Commun. 2018 Jul 13;9:16227. doi: 10.1038/ncomms16227.

8.

Effects of whole-body vibration on balance and mobility in institutionalized older adults: a randomized controlled trial.

Lam FM, Chan PF, Liao LR, Woo J, Hui E, Lai CW, Kwok TC, Pang MY.

Clin Rehabil. 2018 Apr;32(4):462-472. doi: 10.1177/0269215517733525. Epub 2017 Oct 11.

PMID:
29019274
9.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Toh MF, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G.

Nat Commun. 2017 Jul 17;8:16081. doi: 10.1038/ncomms16081. Erratum in: Nat Commun. 2018 Jul 13;9:16227.

10.

Mondor's disease: sclerosing thrombophlebitis of subcutaneous veins in a patient with occult carcinoma of the breast.

Wong SN, Lai LK, Chan PF, Chao DV.

Hong Kong Med J. 2017 Jun;23(3):311-2. doi: 10.12809/hkmj154699. No abstract available.

11.

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.

Chan PF, Germe T, Bax BD, Huang J, Thalji RK, Bacqué E, Checchia A, Chen D, Cui H, Ding X, Ingraham K, McCloskey L, Raha K, Srikannathasan V, Maxwell A, Stavenger RA.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4492-E4500. doi: 10.1073/pnas.1700721114. Epub 2017 May 15.

12.

Declining Trends of Cardiovascular-Renal Complications and Mortality in Type 2 Diabetes: The Hong Kong Diabetes Database.

Luk AOY, Hui EMT, Sin MC, Yeung CY, Chow WS, Ho AYY, Hung HF, Kan E, Ng CM, So WY, Yeung CK, Chan KS, Chan KW, Chan PF, Siu SC, Tiu SC, Yeung VTF, Chan JCN, Chan FWK, Cheung C, Cheung NT, Ho ST, Lam KSL, Yu LWL, Chao D, Lau IT.

Diabetes Care. 2017 Jul;40(7):928-935. doi: 10.2337/dc16-2354. Epub 2017 May 10.

PMID:
28490423
13.

Sleep Patterns and Dysfunctions in Children with Learning Problems.

Aishworiya R, Chan PF, Kiing JS, Chong SC, Tay SK.

Ann Acad Med Singapore. 2016 Nov;45(11):507-512.

14.

Obstructive Sleep Apnea and Cardiovascular Events After Percutaneous Coronary Intervention.

Lee CH, Sethi R, Li R, Ho HH, Hein T, Jim MH, Loo G, Koo CY, Gao XF, Chandra S, Yang XX, Furlan SF, Ge Z, Mundhekar A, Zhang WW, Uchôa CH, Kharwar RB, Chan PF, Chen SL, Chan MY, Richards AM, Tan HC, Ong TH, Roldan G, Tai BC, Drager LF, Zhang JJ.

Circulation. 2016 May 24;133(21):2008-17. doi: 10.1161/CIRCULATIONAHA.115.019392. Epub 2016 May 13.

PMID:
27178625
15.

Fever in a Patient with a Previous Gastrectomy.

Seow DG, Chan PF, Chia BL, Loh JP.

Ann Acad Med Singapore. 2016 Mar;45(3):117-20. No abstract available.

16.

Optimal Body Mass Index Cut-offs for Identification of Patients with Coronary Artery Disease at High Risk of Obstructive Sleep Apnoea.

Chan PF, Tai BC, Loo G, Koo CY, Ong TH, Yeo TC, Lee CH.

Heart Lung Circ. 2016 Aug;25(8):847-54. doi: 10.1016/j.hlc.2016.02.010. Epub 2016 Mar 14.

PMID:
27067667
17.

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.

Chan PF, Srikannathasan V, Huang J, Cui H, Fosberry AP, Gu M, Hann MM, Hibbs M, Homes P, Ingraham K, Pizzollo J, Shen C, Shillings AJ, Spitzfaden CE, Tanner R, Theobald AJ, Stavenger RA, Bax BD, Gwynn MN.

Nat Commun. 2015 Dec 7;6:10048. doi: 10.1038/ncomms10048.

18.

Linear rash from shoulder to wrist.

Chow KL, Chan PF, Lai LK, Chao DV.

J Fam Pract. 2015 Oct;64(10):E1-2. No abstract available.

PMID:
26551479
19.

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.

Srikannathasan V, Wohlkonig A, Shillings A, Singh O, Chan PF, Huang J, Gwynn MN, Fosberry AP, Homes P, Hibbs M, Theobald AJ, Spitzfaden C, Bax BD.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1242-6. doi: 10.1107/S2053230X15015290. Epub 2015 Sep 23.

20.

Spontaneous adrenal haemorrhage after catheter ablation of supraventricular tachycardia.

Kristanto W, Chan PF, Yeong SS, Kojodjojo P.

BMJ Case Rep. 2015 Sep 23;2015. pii: bcr2015209754. doi: 10.1136/bcr-2015-209754.

21.

Echocardiographic quantification of pulmonary artery systolic pressure in ventricular septal defect: Do calculations from Doppler interrogation across tricuspid regurgitation and ventricular septal defect correlate?

Panday V, Tay EL, Chan PF, Yip JW, Poh KK.

Int J Cardiol. 2016 Jan 1;202:100-2. doi: 10.1016/j.ijcard.2015.08.181. Epub 2015 Aug 29. No abstract available.

PMID:
26386934
22.

Acquired localised hypertrichosis in a Chinese child after cast immobilisation.

Yuen MW, Lai LK, Chan PF, Chao DV.

Hong Kong Med J. 2015 Aug;21(4):369-71. doi: 10.12809/hkmj144414.

23.

End-of-life characteristics and palliative care provision for elderly patients suffering from acute myeloid leukemia.

Cheng HW, Li CW, Chan KY, Au HY, Chan PF, Sin YC, Szeto Y, Sham MK.

Support Care Cancer. 2015 Jan;23(1):111-6. doi: 10.1007/s00520-014-2333-x. Epub 2014 Jul 5.

PMID:
24996833
24.

Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity.

Abbate V, Liang W, Patel J, Lan Y, Capriotti L, Iacobucci V, Bui TT, Chaudhuri P, Kudsiova L, Vermeer LS, Chan PF, Kong X, Drake AF, Lam JK, Bansal SS, Mason AJ.

J Control Release. 2013 Dec 28;172(3):929-38. doi: 10.1016/j.jconrel.2013.09.033. Epub 2013 Oct 18.

25.

Authors' reply.

Chan PF, Lai LK, Wong SN, Chao DV, Lau IT.

Hong Kong Med J. 2013 Apr;19(2):189. No abstract available.

PMID:
23535684
26.

Review on the use of insulin in primary care.

Chan PF, Lai LK, Wong SN, Chao DV, Lau IT.

Hong Kong Med J. 2013 Feb;19(1):52-60. Review.

27.

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance.

Wohlkonig A, Chan PF, Fosberry AP, Homes P, Huang J, Kranz M, Leydon VR, Miles TJ, Pearson ND, Perera RL, Shillings AJ, Gwynn MN, Bax BD.

Nat Struct Mol Biol. 2010 Sep;17(9):1152-3. doi: 10.1038/nsmb.1892. Epub 2010 Aug 29.

PMID:
20802486
28.

High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay.

Singh PK, Chan PF, Hibbs MJ, Vazquez MJ, Segura DC, Thomas DA, Theobald AJ, Gallagher KT, Hassan NJ.

Protein Expr Purif. 2011 Apr;76(2):165-72. doi: 10.1016/j.pep.2010.08.001. Epub 2010 Aug 13.

PMID:
20709174
29.

Type IIA topoisomerase inhibition by a new class of antibacterial agents.

Bax BD, Chan PF, Eggleston DS, Fosberry A, Gentry DR, Gorrec F, Giordano I, Hann MM, Hennessy A, Hibbs M, Huang J, Jones E, Jones J, Brown KK, Lewis CJ, May EW, Saunders MR, Singh O, Spitzfaden CE, Shen C, Shillings A, Theobald AJ, Wohlkonig A, Pearson ND, Gwynn MN.

Nature. 2010 Aug 19;466(7309):935-40. doi: 10.1038/nature09197. Epub 2010 Aug 4.

PMID:
20686482
30.

Characterization of a novel fucose-regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae.

Chan PF, O'Dwyer KM, Palmer LM, Ambrad JD, Ingraham KA, So C, Lonetto MA, Biswas S, Rosenberg M, Holmes DJ, Zalacain M.

J Bacteriol. 2003 Mar;185(6):2051-8.

31.

Novel antibacterials: a genomics approach to drug discovery.

Chan PF, Macarron R, Payne DJ, Zalacain M, Holmes DJ.

Curr Drug Targets Infect Disord. 2002 Dec;2(4):291-308. Review.

PMID:
12570737
32.

Staphylococcus aureus accessory regulators: expression within biofilms and effect on adhesion.

Pratten J, Foster SJ, Chan PF, Wilson M, Nair SP.

Microbes Infect. 2001 Jul;3(8):633-7.

PMID:
11445449
35.
36.

Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator.

McGowan S, Sebaihia M, Jones S, Yu B, Bainton N, Chan PF, Bycroft B, Stewart GS, Williams P, Salmond GP.

Microbiology. 1995 Mar;141 ( Pt 3):541-50. Erratum in: Microbiology 1995 May;141(Pt 5):1268.

PMID:
7711893
37.

Small molecule mediated autoinduction of antibiotic biosynthesis in the plant pathogen Erwinia carotovora.

Chan PF, Bainton NJ, Daykin MM, Winson MK, Chhabra SR, Stewart GS, Salmond GP, Bycroft BW, Williams P.

Biochem Soc Trans. 1995 Feb;23(1):127S. No abstract available.

PMID:
7758689
38.

A novel strategy for the isolation of luxI homologues: evidence for the widespread distribution of a LuxR:LuxI superfamily in enteric bacteria.

Swift S, Winson MK, Chan PF, Bainton NJ, Birdsall M, Reeves PJ, Rees CE, Chhabra SR, Hill PJ, Throup JP, et al.

Mol Microbiol. 1993 Nov;10(3):511-20.

PMID:
7968529
39.

[Transcervical resection of endometrium and submucous myomas].

Li YT, Tsui MS, Lin HM, Sun LS, Tu FC, Chen PC, Chan PF, Yang CH.

Zhonghua Yi Xue Za Zhi (Taipei). 1992 Nov;50(5):434-8. Chinese.

PMID:
1338017
40.

The selection of buffer salts for the high-performance liquid chromatography of basic compounds.

Law B, Chan PF.

J Pharm Biomed Anal. 1991;9(3):271-4. No abstract available.

PMID:
1873323

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