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Critically ill patients with COVID-19 in Hong Kong: a multicentre retrospective observational cohort study

Ling L, So C, Shum HP, Chan PKS, Lai CKC, Kandamby DH, Ho E, So D, Yan WW, Lui G, Leung WS, Chan MC, Gomersall CD.

Crit Care Resusc. 2020 Apr 6. [Epub ahead of print]


Stepping Forward: Urologists' Efforts During the COVID-19 Outbreak in Singapore.

Chan MC, Yeo SEK, Chong YL, Lee YM.

Eur Urol. 2020 Mar 17. pii: S0302-2838(20)30145-7. doi: 10.1016/j.eururo.2020.03.004. [Epub ahead of print] No abstract available.


Heterosubtypic Protection Induced by a Live Attenuated Influenza Virus Vaccine Expressing Galactose-α-1,3-Galactose Epitopes in Infected Cells.

Yan LM, Lau SPN, Poh CM, Chan VSF, Chan MCW, Peiris M, Poon LLM.

mBio. 2020 Mar 3;11(2). pii: e00027-20. doi: 10.1128/mBio.00027-20.


Impact of corticosteroid treatment on clinical outcomes of influenza-associated ARDS: a nationwide multicenter study.

Tsai MJ, Yang KY, Chan MC, Kao KC, Wang HC, Perng WC, Wu CL, Liang SJ, Fang WF, Tsai JR, Chang WA, Chien YC, Chen WC, Hu HC, Lin CY, Chao WC, Sheu CC; for Taiwan Severe Influenza Research Consortium (TSIRC) Investigators.

Ann Intensive Care. 2020 Feb 27;10(1):26. doi: 10.1186/s13613-020-0642-4.


Cost-effectiveness analysis of chromosomal microarray as a primary test for prenatal diagnosis in Hong Kong.

Chung CCY, Chan KYK, Hui PW, Au PKC, Tam WK, Li SKM, Leung GKC, Fung JLF, Chan MCY, Luk HM, Mak ASL, Leung KY, Tang MHY, Chung BHY, Kan ASY.

BMC Pregnancy Childbirth. 2020 Feb 14;20(1):109. doi: 10.1186/s12884-020-2772-y.


Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis.

Chao WC, Tseng CH, Wu CL, Shih SJ, Yi CY, Chan MC.

Ann Intensive Care. 2020 Feb 7;10(1):17. doi: 10.1186/s13613-020-0635-3.


Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.

Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C; Autism Sequencing Consortium; iPSYCH-Broad Consortium, Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Børglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JD.

Cell. 2020 Feb 6;180(3):568-584.e23. doi: 10.1016/j.cell.2019.12.036. Epub 2020 Jan 23.


Genome Sequence of a Human Norovirus GII.4 Hong Kong[P31] Variant in Hong Kong, China.

Tse EHY, Zhang LY, Lau SL, Chan MC.

Microbiol Resour Announc. 2020 Jan 16;9(3). pii: e01391-19. doi: 10.1128/MRA.01391-19.


Systematic review of human gut resistome studies revealed variable definitions and approaches.

Ho J, Yeoh YK, Barua N, Chen Z, Lui G, Wong SH, Yang X, Chan MC, Chan PK, Hawkey PM, Ip M.

Gut Microbes. 2020 Jan 16:1-12. doi: 10.1080/19490976.2019.1700755. [Epub ahead of print]


Quantitative MS-Based Proteomics: Comparing the MCF-7 Cellular Response to Hypoxia and a 2-Oxoglutarate Analogue.

Bush JT, Chan MC, Mohammed S, Schofield CJ.

Chembiochem. 2020 Jan 10. doi: 10.1002/cbic.201900719. [Epub ahead of print]


Surveillance of biologic sources of hepatitis E viruses in community.

Chan MCW, Chan PKS.

Hong Kong Med J. 2019 Dec;25 Suppl 9(6):17-20. No abstract available.


Macrophages protect mycoplasma-infected chronic myeloid leukemia cells from natural killer cell killing.

Choo QWW, Koean RAG, Chang SC, Chng WJ, Chan MC, Wang W, Er JZ, Ding JL.

Immunol Cell Biol. 2020 Feb;98(2):138-151. doi: 10.1111/imcb.12309. Epub 2020 Jan 13.


Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser.

Wang TA, Chan MC, Lee HC, Lee CY, Tsai MT.

Biomed Opt Express. 2019 Oct 11;10(11):5687-5702. doi: 10.1364/BOE.10.005687. eCollection 2019 Nov 1.


Antiplatelet agents and anticoagulants increased the bleeding risk of bedside percutaneous dilational tracheostomy in critically ill patients.

Huang YH, Tseng CH, Chan MC, Lee BJ, Lin CH, Chang GC.

J Formos Med Assoc. 2019 Nov 2. pii: S0929-6646(19)30459-0. doi: 10.1016/j.jfma.2019.10.014. [Epub ahead of print]


Slipped capital femoral epiphysis and Blount disease as indicators for early metabolic surgical intervention.

Griggs CL, Perez NP, Chan MC, Pratt JS.

Surg Obes Relat Dis. 2019 Oct;15(10):1836-1841. doi: 10.1016/j.soard.2019.06.024. Epub 2019 Jul 2.


Updated classification of norovirus genogroups and genotypes.

Chhabra P, de Graaf M, Parra GI, Chan MC, Green K, Martella V, Wang Q, White PA, Katayama K, Vennema H, Koopmans MPG, Vinjé J.

J Gen Virol. 2019 Oct;100(10):1393-1406. doi: 10.1099/jgv.0.001318.


Use of Human Intestinal Enteroids to Detect 
Human Norovirus Infectivity.

Chan MC, Cheung SKC, Mohammad KN, Chan JCM, Estes MK, Chan PKS.

Emerg Infect Dis. 2019 Sep;25(9):1730-1735. doi: 10.3201/eid2509.190205.


Endobronchial one-way valve for persistent air leak and lung volume reduction.

Yu WC, Kwok HC, Chan YH, Ho MY, Chan MC, Yeung YC.

Respirol Case Rep. 2019 Jul 15;7(7):e00461. doi: 10.1002/rcr2.461. eCollection 2019 Oct.


Ilizarov reconstruction of chronic bilateral calcaneovalgus deformities.

Chan MC, Khan SA.

Chin J Traumatol. 2019 Aug;22(4):202-206. doi: 10.1016/j.cjtee.2019.04.001. Epub 2019 Apr 20.


Tropism of influenza B viruses in human respiratory tract explants and airway organoids.

Bui CHT, Chan RWY, Ng MMT, Cheung MC, Ng KC, Chan MPK, Chan LLY, Fong JHM, Nicholls JM, Peiris JSM, Chan MCW.

Eur Respir J. 2019 Aug 15;54(2). pii: 1900008. doi: 10.1183/13993003.00008-2019. Print 2019 Aug.


Risk Assessment of the Tropism and Pathogenesis of the Highly Pathogenic Avian Influenza A/H7N9 Virus Using Ex Vivo and In Vitro Cultures of Human Respiratory Tract.

Chan LLY, Hui KPY, Kuok DIT, Bui CHT, Ng KC, Mok CKP, Yang ZF, Guan W, Poon LLM, Zhong N, Peiris JSM, Nicholls JM, Chan MCW.

J Infect Dis. 2019 Jul 19;220(4):578-588. doi: 10.1093/infdis/jiz165.


Impact of Preservation Method and 16S rRNA Hypervariable Region on Gut Microbiota Profiling.

Chen Z, Hui PC, Hui M, Yeoh YK, Wong PY, Chan MCW, Wong MCS, Ng SC, Chan FKL, Chan PKS.

mSystems. 2019 Feb 26;4(1). pii: e00271-18. doi: 10.1128/mSystems.00271-18. eCollection 2019 Jan-Feb.


What Are the Clinical Factors That Are Predictive of Persistent Pessary Use at 12 Months?

Chan MC, Hyakutake M, Yaskina M, Schulz JA.

J Obstet Gynaecol Can. 2019 Sep;41(9):1276-1281. doi: 10.1016/j.jogc.2018.11.015. Epub 2019 Feb 1.


Kuskaya: a training program for collaboration and innovation in global health.

Chan MC, Bayer AM, Zunt JR, Blas MM, Garcia PJ.

J Multidiscip Healthc. 2018 Dec 27;12:31-42. doi: 10.2147/JMDH.S173165. eCollection 2019.


Higher Viral Load of Emerging Norovirus GII.P16-GII.2 than Pandemic GII.4 and Epidemic GII.17, Hong Kong, China.

Cheung SKC, Kwok K, Zhang LY, Mohammad KN, Lui GCY, Lee N, Nelson EAS, Lai RWM, Leung TF, Chan PKS, Chan MC.

Emerg Infect Dis. 2019 Jan;25(1):119-122. doi: 10.3201/eid2501.180395.


Diversity of macaque microbiota compared to the human counterparts.

Chen Z, Yeoh YK, Hui M, Wong PY, Chan MCW, Ip M, Yu J, Burk RD, Chan FKL, Chan PKS.

Sci Rep. 2018 Oct 22;8(1):15573. doi: 10.1038/s41598-018-33950-6.


Recommendations on prevention and screening for colorectal cancer in Hong Kong.

Lam TH, Wong KH, Chan KK, Chan MC, Chao DV, Cheung AN, Fan CY, Ho J, Hui EP, Lam KO, Law CK, Law WL, Loong HH, Ngan RK, Tsang TH, Wong MC, Yeung RM, Ying AC, Ching R.

Hong Kong Med J. 2018 Oct;24(5):521-526. doi: 10.12809/hkmj177095.


Melioidosis in Hong Kong.

Lui G, Tam A, Tso EYK, Wu AKL, Zee J, Choi KW, Lam W, Chan MC, Ting WM, Hung IFN.

Trop Med Infect Dis. 2018 Aug 25;3(3). pii: E91. doi: 10.3390/tropicalmed3030091. Review.


Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning.

Kao KC, Chang KW, Chan MC, Liang SJ, Chien YC, Hu HC, Chiu LC, Chen WC, Fang WF, Chen YM, Sheu CC, Tsai MJ, Perng WC, Peng CK, Wu CL, Wang HC, Yang KY; TSIRC (Taiwan Severe Influenza Research Consortium).

Ann Intensive Care. 2018 Sep 24;8(1):94. doi: 10.1186/s13613-018-0440-4.


Indirubin-3'-oxime as an antiviral and immunomodulatory agent in treatment of severe human influenza virus infection.

Chan MC, Chan RW, Mok CK, Mak NK, Wong RN.

Hong Kong Med J. 2018 Oct;24 Suppl 6(5):45-47. No abstract available.


Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996-2012.

Chan MCW, Wang MH, Chen Z, Hui DSC, Kwok AK, Yeung ACM, Liu KM, Yeoh YK, Lee N, Chan PKS.

Emerg Infect Dis. 2018 Oct;24(10):1825-1834. doi: 10.3201/eid2410.180652.


Comparison between COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) dyspnea scores for evaluation of clinical symptoms, comorbidities and medical resources utilization in COPD patients.

Cheng SL, Lin CH, Wang CC, Chan MC, Hsu JY, Hang LW, Perng DW, Yu CJ, Wang HC; Taiwan Clinical Trial Consortium for Respiratory Disease (TCORE).

J Formos Med Assoc. 2019 Jan;118(1 Pt 3):429-435. doi: 10.1016/j.jfma.2018.06.018. Epub 2018 Aug 25.


Using Objective Fluid Balance Data to Identify Pulmonary Edema in Subjects With Ventilator-Associated Events.

Chao WC, Chang WL, Wu CL, Chan MC.

Respir Care. 2018 Nov;63(11):1413-1420. doi: 10.4187/respcare.06221. Epub 2018 Aug 7.


Therapeutic Implications of Human Umbilical Cord Mesenchymal Stromal Cells in Attenuating Influenza A(H5N1) Virus-Associated Acute Lung Injury.

Loy H, Kuok DIT, Hui KPY, Choi MHL, Yuen W, Nicholls JM, Peiris JSM, Chan MCW.

J Infect Dis. 2019 Jan 7;219(2):186-196. doi: 10.1093/infdis/jiy478. Erratum in: J Infect Dis. 2019 Jan 7;219(2):339.


First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome.

Chan MC, Chao WC, Liang SJ, Tseng CH, Wang HC, Chien YC, Yang KY, Chen WC, Perng WC, Kao KC, Hu HC, Sheu CC, Chang WA, Fang WF, Chen YM, Slutsky AS, Wu CL; for Taiwan Severe Influenza Research Consortium (TSIRC) Investigators.

J Formos Med Assoc. 2019 Jan;118(1 Pt 2):378-385. doi: 10.1016/j.jfma.2018.06.010. Epub 2018 Jul 3.


Production of amphiregulin and recovery from influenza is greater in males than females.

Vermillion MS, Ursin RL, Kuok DIT, Vom Steeg LG, Wohlgemuth N, Hall OJ, Fink AL, Sasse E, Nelson A, Ndeh R, McGrath-Morrow S, Mitzner W, Chan MCW, Pekosz A, Klein SL.

Biol Sex Differ. 2018 Jul 17;9(1):24. doi: 10.1186/s13293-018-0184-8.


Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures.

Hui KPY, Ching RHH, Chan SKH, Nicholls JM, Sachs N, Clevers H, Peiris JSM, Chan MCW.

Lancet Respir Med. 2018 Nov;6(11):846-854. doi: 10.1016/S2213-2600(18)30236-4. Epub 2018 Jul 11.


Recommendations on prevention and screening for breast cancer in Hong Kong.

Lam TH, Wong KH, Chan KK, Chan MC, Chao DV, Cheung AN, Fan CY, Ho J, Hui EP, Lam KO, Law CK, Law WL, Loong HH, Ngan RK, Tsang TH, Wong MC, Yeung RM, Ying AC, Ching R.

Hong Kong Med J. 2018 Jun;24(3):298-306. doi: 10.12809/hkmj177037.


Carbapenem Nonsusceptible Klebsiella pneumoniae in Taiwan: Dissemination and Increasing Resistance of Carbapenemase Producers During 2012-2015.

Chiu SK, Ma L, Chan MC, Lin YT, Fung CP, Wu TL, Chuang YC, Lu PL, Wang JT, Lin JC, Yeh KM.

Sci Rep. 2018 May 31;8(1):8468. doi: 10.1038/s41598-018-26691-z.


Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model.

Li HS, Kuok DIT, Cheung MC, Ng MMT, Ng KC, Hui KPY, Peiris JSM, Chan MCW, Nicholls JM.

Antiviral Res. 2018 Jul;155:89-96. doi: 10.1016/j.antiviral.2018.05.007. Epub 2018 May 17.


Age-specific seroprevalence of dengue infection in Hong Kong.

Lee P, Yeung ACM, Chen Z, Chan MCW, Sze KH, Chan PKS.

J Med Virol. 2018 Sep;90(9):1427-1430. doi: 10.1002/jmv.25216. Epub 2018 May 25.


Cost-effectiveness analysis of a fixed-dose combination of indacaterol and glycopyrronium as maintenance treatment for COPD.

Chan MC, Tan EC, Yang MC.

Int J Chron Obstruct Pulmon Dis. 2018 Apr 4;13:1079-1088. doi: 10.2147/COPD.S159103. eCollection 2018.


Tuning the Color Temperature of White-Light-Emitting Electrochemical Cells by Laser-Scanning Perovskite-Nanocrystal Color Conversion Layers.

Wu WK, Wang CM, Chan MC, Lien JY, Su YM, Sarma M, Yang ZP, Su HC, Wong KT, Wang SL.

Chempluschem. 2018 Apr;83(4):239-245. doi: 10.1002/cplu.201700422. Epub 2017 Dec 12.


MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

Chu DKW, Hui KPY, Perera RAPM, Miguel E, Niemeyer D, Zhao J, Channappanavar R, Dudas G, Oladipo JO, Traoré A, Fassi-Fihri O, Ali A, Demissié GF, Muth D, Chan MCW, Nicholls JM, Meyerholz DK, Kuranga SA, Mamo G, Zhou Z, So RTY, Hemida MG, Webby RJ, Roger F, Rambaut A, Poon LLM, Perlman S, Drosten C, Chevalier V, Peiris M.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3144-3149. doi: 10.1073/pnas.1718769115. Epub 2018 Mar 5.


Bimodal Seasonality and Alternating Predominance of Norovirus GII.4 and Non-GII.4, Hong Kong, China, 2014-20171.

Chan MC, Kwok K, Zhang LY, Mohammad KN, Lee N, Lui GCY, Nelson EAS, Lai RWM, Leung TF, Chan PKS.

Emerg Infect Dis. 2018 Apr 17;24(4). doi: 10.3201/eid2404.171791. [Epub ahead of print]


Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan.

Chao WC, Tseng CH, Chien YC, Sheu CC, Tsai MJ, Fang WF, Chen YM, Kao KC, Hu HC, Perng WC, Yang KY, Chen WC, Liang SJ, Wu CL, Wang HC, Chan MC; TSIRC (Taiwan Severe Influenza Research Consortium).

PLoS One. 2018 Jan 9;13(1):e0190952. doi: 10.1371/journal.pone.0190952. eCollection 2018.


Optimising the utility of pleural fluid adenosine deaminase for the diagnosis of adult tuberculous pleural effusion in Hong Kong.

Chang KC, Chan MC, Leung WM, Kong FY, Mak CM, Chen SP, Yu WC.

Hong Kong Med J. 2018 Feb;24(1):38-47. doi: 10.12809/hkmj176238. Epub 2017 Dec 22.


[Improving the Accuracy Rate of Analgesics and Sedatives Administration in an Intensive Care Unit].

Lai HC, Chen YH, Li YJ, Huang HM, Tseng CH, Chan MC.

Hu Li Za Zhi. 2017 Dec;64(6):77-84. doi: 10.6224/JN.000085. Chinese.


Increased Detection of Emergent Recombinant Norovirus GII.P16-GII.2 Strains in Young Adults, Hong Kong, China, 2016-2017.

Kwok K, Niendorf S, Lee N, Hung TN, Chan LY, Jacobsen S, Nelson EAS, Leung TF, Lai RWM, Chan PKS, Chan MCW.

Emerg Infect Dis. 2017 Nov;23(11):1852-1855. doi: 10.3201/eid2311.170561.

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