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Items: 1 to 50 of 319


Self-administered acupressure for knee osteoarthritis in middle-aged and older adults: a pilot randomized controlled trial.

Cheung DST, Yeung WF, Suen LK, Chong TC, Ho YS, Yu BY, Chan LY, Chen HY, Lao LX.

Acupunct Med. 2019 Nov 13:964528419883269. doi: 10.1177/0964528419883269. [Epub ahead of print]


Exploration of the antibiotic resistome in a wastewater treatment plant by a nine-year longitudinal metagenomic study.

Yin X, Deng Y, Ma L, Wang Y, Chan LYL, Zhang T.

Environ Int. 2019 Dec;133(Pt B):105270. doi: 10.1016/j.envint.2019.105270. Epub 2019 Nov 1.


Gamma Radiation-Induced Disruption of Cellular Junctions in HUVECs Is Mediated through Affecting MAPK/NF-κB Inflammatory Pathways.

Wang H, Segaran RC, Chan LY, Aladresi AAM, Chinnathambi A, Alharbi SA, Sethi G, Tang FR.

Oxid Med Cell Longev. 2019 Aug 4;2019:1486232. doi: 10.1155/2019/1486232. eCollection 2019.


Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties.

Oshiro KGN, Cândido ES, Chan LY, Torres MDT, Monges BED, Rodrigues SG, Porto WF, Ribeiro SM, Henriques ST, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL, Cardoso MH.

J Med Chem. 2019 Sep 12;62(17):8140-8151. doi: 10.1021/acs.jmedchem.9b00915. Epub 2019 Aug 26.


Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury.

Li B, Leung JCK, Chan LYY, Yiu WH, Li Y, Lok SWY, Liu WH, Chan KW, Tse HF, Lai KN, Tang SCW.

Stem Cells Transl Med. 2019 Sep;8(9):898-910. doi: 10.1002/sctm.18-0265. Epub 2019 May 3.


Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential.

Cândido ES, Cardoso MH, Chan LY, Torres MDT, Oshiro KGN, Porto WF, Ribeiro SM, Haney EF, Hancock REW, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL.

ACS Infect Dis. 2019 Jul 12;5(7):1081-1086. doi: 10.1021/acsinfecdis.9b00073. Epub 2019 May 1.


Sulfasalazine-Induced Connective Tissue Disease.

Chan LY, Chung HY.

J Clin Rheumatol. 2019 Mar 20. doi: 10.1097/RHU.0000000000001028. [Epub ahead of print] No abstract available.


Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells.

Hollerer I, Barker JC, Jorgensen V, Tresenrider A, Dugast-Darzacq C, Chan LY, Darzacq X, Tjian R, Ünal E, Brar GA.

G3 (Bethesda). 2019 Apr 9;9(4):1045-1053. doi: 10.1534/g3.118.200802.


Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica.

Du J, Chan LY, Poth AG, Craik DJ.

J Nat Prod. 2019 Feb 22;82(2):293-300. doi: 10.1021/acs.jnatprod.8b00716. Epub 2019 Jan 23.


Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate.

Cheng Z, Mugler CF, Keskin A, Hodapp S, Chan LY, Weis K, Mertins P, Regev A, Jovanovic M, Brar GA.

Mol Cell. 2019 Jan 3;73(1):36-47.e10. doi: 10.1016/j.molcel.2018.10.032. Epub 2018 Nov 29.


Discovery and Characterization of Cyclotides from Rinorea Species.

Niyomploy P, Chan LY, Harvey PJ, Poth AG, Colgrave ML, Craik DJ.

J Nat Prod. 2018 Nov 26;81(11):2512-2520. doi: 10.1021/acs.jnatprod.8b00572. Epub 2018 Nov 2.


A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies.

Cardoso MH, Cândido ES, Chan LY, Der Torossian Torres M, Oshiro KGN, Rezende SB, Porto WF, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL.

ACS Infect Dis. 2018 Dec 14;4(12):1727-1736. doi: 10.1021/acsinfecdis.8b00219. Epub 2018 Nov 1.


18-month follow-up of randomized controlled trial of parent and child enhancement program.

Leung C, Tsang S, Chan LY.

J Evid Inf Soc Work. 2018 Nov-Dec;15(6):676-694. doi: 10.1080/23761407.2018.1528195.


Near Infrared Fluorophore-Tagged Chloroquine in Plasmodium falciparum Diagnostic Imaging.

Chan LY, Teo JDW, Tan KS, Sou K, Kwan WL, Lee CK.

Molecules. 2018 Oct 14;23(10). pii: E2635. doi: 10.3390/molecules23102635.


Effects of Zero-time Exercise on inactive adults with insomnia disorder: a pilot randomized controlled trial.

Yeung WF, Lai AY, Ho FY, Suen LK, Chung KF, Ho JY, Ho LM, Yu BY, Chan LY, Lam TH.

Sleep Med. 2018 Dec;52:118-127. doi: 10.1016/j.sleep.2018.07.025. Epub 2018 Aug 24.


Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability.

Chan LY, Mugler CF, Heinrich S, Vallotton P, Weis K.

Elife. 2018 Sep 7;7. pii: e32536. doi: 10.7554/eLife.32536.


Ictal intracranial electroencephalography using wavelet analysis of high-frequency oscillations in Chinese patients with refractory epilepsy.

Leung HW, Poon WS, Kwan PK, Lui CH, Poon TL, Chan EL, Yuen SC.

Hong Kong Med J. 2018 Jun;24 Suppl 3(3):21-23. No abstract available.


Electroconvulsive therapy for new-onset super-refractory status epilepticus.

Chan EL, Lee WC, Koo CK, King HS, Woo CT, Ng SH.

Hong Kong Med J. 2018 Jun;24(3):307-310. doi: 10.12809/hkmj154501. No abstract available.


Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases.

Jackson MA, Gilding EK, Shafee T, Harris KS, Kaas Q, Poon S, Yap K, Jia H, Guarino R, Chan LY, Durek T, Anderson MA, Craik DJ.

Nat Commun. 2018 Jun 20;9(1):2411. doi: 10.1038/s41467-018-04669-9.


Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria.

Wong DWL, Yiu WH, Chan KW, Li Y, Li B, Lok SWY, Taketo MM, Igarashi P, Chan LYY, Leung JCK, Lai KN, Tang SCW.

Kidney Int. 2018 Jun;93(6):1367-1383. doi: 10.1016/j.kint.2017.12.017. Epub 2018 Mar 28.


Establishment of Signaling Interactions with Cellular Resolution for Every Cell Cycle of Embryogenesis.

Chen L, Ho VWS, Wong MK, Huang X, Chan LY, Ng HCK, Ren X, Yan H, Zhao Z.

Genetics. 2018 May;209(1):37-49. doi: 10.1534/genetics.118.300820. Epub 2018 Mar 22.


Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy.

Yiu WH, Li RX, Wong DWL, Wu HJ, Chan KW, Chan LYY, Leung JCK, Lai KN, Sacks SH, Zhou W, Tang SCW.

Nephrol Dial Transplant. 2018 Aug 1;33(8):1323-1332. doi: 10.1093/ndt/gfx336.


Human induced pluripotent stem cell-derived mesenchymal stem cells prevent adriamycin nephropathy in mice.

Wu HJ, Yiu WH, Wong DWL, Li RX, Chan LYY, Leung JCK, Zhang Y, Lian Q, Lai KN, Tse HF, Tang SCW.

Oncotarget. 2017 Oct 10;8(61):103640-103656. doi: 10.18632/oncotarget.21760. eCollection 2017 Nov 28.


Thrombolytic Therapy in Acute Ischemic Stroke in Patients Not Fulfilling Conventional Criteria.

Chi MS, Chan LY.

Neurologist. 2017 Nov;22(6):219-226. doi: 10.1097/NRL.0000000000000149.


Increased Detection of Emergent Recombinant Norovirus GII.P16-GII.2 Strains in Young Adults, Hong Kong, China, 2016-2017.

Kwok K, Niendorf S, Lee N, Hung TN, Chan LY, Jacobsen S, Nelson EAS, Leung TF, Lai RWM, Chan PKS, Chan MCW.

Emerg Infect Dis. 2017 Nov;23(11):1852-1855. doi: 10.3201/eid2311.170561.


Natively Unfolded FG Repeats Stabilize the Structure of the Nuclear Pore Complex.

Onischenko E, Tang JH, Andersen KR, Knockenhauer KE, Vallotton P, Derrer CP, Kralt A, Mugler CF, Chan LY, Schwartz TU, Weis K.

Cell. 2017 Nov 2;171(4):904-917.e19. doi: 10.1016/j.cell.2017.09.033. Epub 2017 Oct 12.


Liver fibrosis progression in patients with chronic hepatitis B: a prospective study with paired transient elastography.

Wong VW, Chan HL, Wong GL.

Hong Kong Med J. 2017 Aug;23 Suppl 5(4):23-26. No abstract available.


Self-administered acupressure for insomnia disorder: a pilot randomized controlled trial.

Yeung WF, Ho FY, Chung KF, Zhang ZJ, Yu BY, Suen LK, Chan LY, Chen HY, Ho LM, Lao LX.

J Sleep Res. 2018 Apr;27(2):220-231. doi: 10.1111/jsr.12597. Epub 2017 Sep 8.


Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties.

Troeira Henriques S, Lawrence N, Chaousis S, Ravipati AS, Cheneval O, Benfield AH, Elliott AG, Kavanagh AM, Cooper MA, Chan LY, Huang YH, Craik DJ.

ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. Epub 2017 Aug 8.


Complete Genome Sequence of an Emergent Recombinant GII.P16-GII.2 Norovirus Strain Associated with an Epidemic Spread in the Winter of 2016-2017 in Hong Kong, China.

Chan MCW, Kwok K, Hung TN, Chan LY, Chan PKS.

Genome Announc. 2017 May 18;5(20). pii: e00343-17. doi: 10.1128/genomeA.00343-17.


An update of the Hong Kong Epilepsy Guideline: consensus statement on the use of antiepileptic drugs in Hong Kong.

Fong JK, Chan EL, Leung H, Chan I, Chang RS, Fong GC, Fung EL, Lui CH, Fung BB, Poon TL, Siu D, Wong HT, Yeung E, Yung AW, Zhu CX; Subcommittee on the Consensus Statement of The Hong Kong Epilepsy Society.

Hong Kong Med J. 2017 Feb;23(1):74-88. doi: 10.12809/hkmj166027. Review.


Recurrent Infections of Emergent Norovirus GII.17 in an Elderly.

Chan MC, Lee N, Hung TN, Chan LY, Kwok K, Wong RY, Chan PK.

Clin Infect Dis. 2017 Mar 1;64(5):697-699. Epub 2016 Dec 12. No abstract available.


ATPase activity of the DEAD-box protein Dhh1 controls processing body formation.

Mugler CF, Hondele M, Heinrich S, Sachdev R, Vallotton P, Koek AY, Chan LY, Weis K.

Elife. 2016 Oct 3;5. pii: e18746. doi: 10.7554/eLife.18746.


Asymmetric Acute Motor Axonal Neuropathy With Unilateral Tongue Swelling Mimicking Stroke.

Chi MS, Ng SH, Chan LY.

Neurologist. 2016 Nov;21(6):106-108.


Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy.

Chan LY, Craik DJ, Daly NL.

Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347.


Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial.

Chan KW, Ip TP, Kwong AS, Lui SL, Chan GC, Cowling BJ, Yiu WH, Wong DW, Liu Y, Feng Y, Tan KC, Chan LY, Leung JC, Lai KN, Tang SC.

BMJ Open. 2016 Aug 5;6(8):e010741. doi: 10.1136/bmjopen-2015-010741.


Discovery, isolation, and structural characterization of cyclotides from Viola sumatrana Miq.

Niyomploy P, Chan LY, Poth AG, Colgrave ML, Sangvanich P, Craik DJ.

Biopolymers. 2016 Nov;106(6):796-805. doi: 10.1002/bip.22914.


Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy.

Wong DW, Yiu WH, Wu HJ, Li RX, Liu Y, Chan KW, Leung JC, Chan LY, Lai KN, Tang SC.

Cell Death Dis. 2016 Mar 24;7:e2155. doi: 10.1038/cddis.2016.62.


Localized topical steroid use and central serous retinopathy.

Chan LY, Adam RS, Adam DN.

J Dermatolog Treat. 2016 Oct;27(5):425-6. doi: 10.3109/09546634.2015.1136049. Epub 2016 Jan 29.


Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer.

D'Souza C, Henriques ST, Wang CK, Cheneval O, Chan LY, Bokil NJ, Sweet MJ, Craik DJ.

Biochemistry. 2016 Jan 19;55(2):396-405. doi: 10.1021/acs.biochem.5b00529. Epub 2016 Jan 6.


Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress.

Yiu WH, Wong DW, Wu HJ, Li RX, Yam I, Chan LY, Leung JC, Lan HY, Lai KN, Tang SC.

Kidney Int. 2016 Feb;89(2):386-98.


Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia.

Smout MJ, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta RN, Chan LY, Johnson MS, Turnbull L, Whitchurch CB, Giacomin PR, Moran CS, Golledge J, Daly N, Sripa B, Mulvenna JP, Brindley PJ, Loukas A.

PLoS Pathog. 2015 Oct 20;11(10):e1005209. doi: 10.1371/journal.ppat.1005209. eCollection 2015 Oct.


Measurements of electron density and temperature profiles in plasma produced by Nike KrF laser for laser plasma instability research.

Oh J, Weaver JL, Karasik M, Chan LY.

Rev Sci Instrum. 2015 Aug;86(8):083501. doi: 10.1063/1.4927452.


Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium.

Himeno K, Rosengren KJ, Inoue T, Perez RH, Colgrave ML, Lee HS, Chan LY, Henriques ST, Fujita K, Ishibashi N, Zendo T, Wilaipun P, Nakayama J, Leelawatcharamas V, Jikuya H, Craik DJ, Sonomoto K.

Biochemistry. 2015 Aug 11;54(31):4863-76. doi: 10.1021/acs.biochem.5b00196. Epub 2015 Jul 31.


Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells.

Leung JC, Chan LY, Saleem MA, Mathieson PW, Tang SC, Lai KN.

Apoptosis. 2015 Jul;20(7):907-20. doi: 10.1007/s10495-015-1117-1.


Dichoptic training improves contrast sensitivity in adults with amblyopia.

Li J, Spiegel DP, Hess RF, Chen Z, Chan LY, Deng D, Yu M, Thompson B.

Vision Res. 2015 Sep;114:161-72. doi: 10.1016/j.visres.2015.01.017. Epub 2015 Feb 9.


In vivo efficacy of anuran trypsin inhibitory peptides against staphylococcal skin infection and the impact of peptide cyclization.

Malik U, Silva ON, Fensterseifer IC, Chan LY, Clark RJ, Franco OL, Daly NL, Craik DJ.

Antimicrob Agents Chemother. 2015 Apr;59(4):2113-21. doi: 10.1128/AAC.04324-14. Epub 2015 Jan 26.

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