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Cardiovascular Risk Reduction with Icosapent Ethyl.

Chan LN.

N Engl J Med. 2019 Apr 25;380(17):1677. doi: 10.1056/NEJMc1902165. No abstract available.


Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus Paper.

Blaauw R, Osland E, Sriram K, Ali A, Allard JP, Ball P, Chan LN, Jurewitsch B, Logan Coughlin K, Manzanares W, Menéndez AM, Mutiara R, Rosenfeld R, Sioson M, Visser J, Berger MM.

JPEN J Parenter Enteral Nutr. 2019 Mar;43 Suppl 1:S5-S23. doi: 10.1002/jpen.1525.


Effects of a nurse-led post-discharge advance care planning programme for community-dwelling patients nearing the end of life and their family members: A randomised controlled trial.

Chan HY, Ng JS, Chan KS, Ko PS, Leung DY, Chan CW, Chan LN, Lee IF, Lee DT.

Int J Nurs Stud. 2018 Nov;87:26-33. doi: 10.1016/j.ijnurstu.2018.07.008. Epub 2018 Jul 23.


Significant Published Articles for Pharmacy Nutrition Support Practice in 2017.

Dickerson RN, Kumpf VJ, Bingham AL, Blackmer AB, Canada TW, Chan LN, Cogle SV, Tucker AM.

Hosp Pharm. 2018 Jul;53(4):239-246. doi: 10.1177/0018578718779006. Epub 2018 May 30.


Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M.

Nature. 2018 Jun;558(7711):E5. doi: 10.1038/s41586-018-0164-5.


B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.

Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M.

Cell. 2018 Apr 5;173(2):470-484.e18. doi: 10.1016/j.cell.2018.02.048. Epub 2018 Mar 15.


Loss of Pax5 Exploits Sca1-BCR-ABLp190 Susceptibility to Confer the Metabolic Shift Essential for pB-ALL.

Martín-Lorenzo A, Auer F, Chan LN, García-Ramírez I, González-Herrero I, Rodríguez-Hernández G, Bartenhagen C, Dugas M, Gombert M, Ginzel S, Blanco O, Orfao A, Alonso-López D, Rivas JL, García-Cenador MB, García-Criado FJ, Müschen M, Sánchez-García I, Borkhardt A, Vicente-Dueñas C, Hauer J.

Cancer Res. 2018 May 15;78(10):2669-2679. doi: 10.1158/0008-5472.CAN-17-3262. Epub 2018 Feb 28.


Significant Published Articles for Pharmacy Nutrition Support Practice in 2016.

Dickerson RN, Kumpf VJ, Bingham AL, Cogle SV, Blackmer AB, Tucker AM, Chan LN, Canada TW.

Hosp Pharm. 2017 Jun;52(6):412-421. doi: 10.1177/0018578717720313. Epub 2017 Jul 21.


B-cell identity as a metabolic barrier against malignant transformation.

Chan LN, Müschen M.

Exp Hematol. 2017 Sep;53:1-6. doi: 10.1016/j.exphem.2017.06.004. Epub 2017 Jun 24. Review.


When Is Parenteral Nutrition Appropriate?

Worthington P, Balint J, Bechtold M, Bingham A, Chan LN, Durfee S, Jevenn AK, Malone A, Mascarenhas M, Robinson DT, Holcombe B.

JPEN J Parenter Enteral Nutr. 2017 Mar;41(3):324-377. doi: 10.1177/0148607117695251. Epub 2017 Feb 1.


Metabolic gatekeeper function of B-lymphoid transcription factors.

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M.

Nature. 2017 Feb 23;542(7642):479-483. doi: 10.1038/nature21076. Epub 2017 Feb 13. Erratum in: Nature. 2018 Jun;558(7711):E5.


Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.

Anderson GD, Chan LN.

Clin Pharmacokinet. 2016 Nov;55(11):1353-1368. Review.


PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M.

Nat Med. 2016 Apr;22(4):379-87. doi: 10.1038/nm.4062. Epub 2016 Mar 14.


Impact of Death Work on Self: Existential and Emotional Challenges and Coping of Palliative Care Professionals.

Chan WC, Tin AF, Wong KL, Tse DM, Lau KS, Chan LN.

Health Soc Work. 2016 Feb;41(1):33-41. Erratum in: Health Soc Work. 2016 May;41(2):73. Fong, Agnes [corrected to Tin, Agnes Fong].


Response to Letter Regarding Article, "Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia".

Iriyama T, Sun K, Parchim NF, Li J, Zhao C, Song A, Hart LA, Blackwell SC, Sibai BM, Chan LN, Chan TS, Hicks JM, Blackburn MR, Kellems RE, Xia Y.

Circulation. 2015 Nov 3;132(18):e222-3. doi: 10.1161/CIRCULATIONAHA.115.017262. No abstract available.


Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.

Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, Koeffler HP, Willman CL, Hunger SP, Melnick A, Kornblau SM, Müschen M.

Cancer Cell. 2015 Jul 13;28(1):114-28. doi: 10.1016/j.ccell.2015.05.008. Epub 2015 Jun 11.


Optimization of Vitamin D Status After Roux-en-Y Gastric Bypass Surgery in Obese Patients Living in Northern Climate.

Chan LN, Neilson CH, Kirk EA, Colovos TF, Javelli DR, Khandelwal S.

Obes Surg. 2015 Dec;25(12):2321-7. doi: 10.1007/s11695-015-1685-8.


Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.

Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M.

Cancer Cell. 2015 Mar 9;27(3):409-25. doi: 10.1016/j.ccell.2015.02.003.


Proximal Roux-en-Y gastric bypass alters drug absorption pattern but not systemic exposure of CYP3A4 and P-glycoprotein substrates.

Chan LN, Lin YS, Tay-Sontheimer JC, Trawick D, Oelschlager BK, Flum DR, Patton KK, Shen DD, Horn JR.

Pharmacotherapy. 2015 Apr;35(4):361-9. doi: 10.1002/phar.1560. Epub 2015 Mar 10.


Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia.

Iriyama T, Sun K, Parchim NF, Li J, Zhao C, Song A, Hart LA, Blackwell SC, Sibai BM, Chan LN, Chan TS, Hicks MJ, Blackburn MR, Kellems RE, Xia Y.

Circulation. 2015 Feb 24;131(8):730-41. doi: 10.1161/CIRCULATIONAHA.114.013740. Epub 2014 Dec 23.


Probiotics for neonates: safety for prime time questioned without regulatory changes.

Chan LN, Soltani H, Hazlet TK.

J Pediatr. 2015 Feb;166(2):502. doi: 10.1016/j.jpeds.2014.10.041. Epub 2014 Dec 2. No abstract available.


Hangover and hydration therapy in the time of intravenous drug shortages: an ethical dilemma and a safety concern.

Chan LN, Seres DS, Malone A, Holcombe B, Guenter P, Plogsted S, Teitelbaum DH.

JPEN J Parenter Enteral Nutr. 2014 Nov;38(8):921-3. doi: 10.1177/0148607114553233. No abstract available.


Pharmacokinetic and pharmacodynamic drug interactions with ethanol (alcohol).

Chan LN, Anderson GD.

Clin Pharmacokinet. 2014 Dec;53(12):1115-36. doi: 10.1007/s40262-014-0190-x. Review.


The effect of patient education with telephone follow-up on wound healing in adult patients with clean wounds: a randomized controlled trial.

Chan LN, Lai CK.

J Wound Ostomy Continence Nurs. 2014 Jul-Aug;41(4):345-55. doi: 10.1097/WON.0000000000000047.


The science and practice of micronutrient supplementations in nutritional anemia: an evidence-based review.

Chan LN, Mike LA.

JPEN J Parenter Enteral Nutr. 2014 Aug;38(6):656-72. doi: 10.1177/0148607114533726. Epub 2014 May 20. Review.


Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.

Kharabi Masouleh B, Geng H, Hurtz C, Chan LN, Logan AC, Chang MS, Huang C, Swaminathan S, Sun H, Paietta E, Melnick AM, Koeffler P, Müschen M.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2219-28. doi: 10.1073/pnas.1400958111. Epub 2014 May 12.


Using plasma vitamin D concentration as a surrogate marker to predict drug response: a new chapter in the management of inflammatory bowel disease and beyond?

Chan LN, Paski SC.

JPEN J Parenter Enteral Nutr. 2014 Mar-Apr;38(3):279-80. doi: 10.1177/0148607114525470. No abstract available.


American Society for Parenteral and Enteral Nutrition research agenda.

Chan LN, Compher C, DiBaise JK, Dimaria-Ghalili RA, Guenter P, Resnick HE, Ziegler TR; Research Committee; American Society for Parenteral and Enteral Nutrition.

JPEN J Parenter Enteral Nutr. 2014 Jan;38(1):13-8. doi: 10.1177/0148607113508783. Epub 2013 Nov 4. No abstract available.


Iatrogenic malnutrition: a serious public health issue caused by drug shortages.

Chan LN.

JPEN J Parenter Enteral Nutr. 2013 Nov;37(6):702-4. doi: 10.1177/0148607113509282. No abstract available.


Drug-nutrient interactions.

Chan LN.

JPEN J Parenter Enteral Nutr. 2013 Jul;37(4):450-9. doi: 10.1177/0148607113488799. Epub 2013 May 14.


In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells.

Zimonjic DB, Chan LN, Tripathi V, Lu J, Kwon O, Popescu NC, Lowy DR, Tamanoi F.

BMC Cancer. 2013 Apr 22;13:198. doi: 10.1186/1471-2407-13-198.


SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia.

Ramezani-Rad P, Geng H, Hurtz C, Chan LN, Chen Z, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, Müschen M.

Blood. 2013 Jan 3;121(1):148-55. doi: 10.1182/blood-2012-05-428938. Epub 2012 Nov 14.


Pharmacokinetics of the etonogestrel contraceptive implant in obese women.

Mornar S, Chan LN, Mistretta S, Neustadt A, Martins S, Gilliam M.

Am J Obstet Gynecol. 2012 Aug;207(2):110.e1-6. doi: 10.1016/j.ajog.2012.05.002. Epub 2012 May 8.


Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I.

Chan LN, Fiji HD, Watanabe M, Kwon O, Tamanoi F.

PLoS One. 2011;6(10):e26135. doi: 10.1371/journal.pone.0026135. Epub 2011 Oct 18.


Aberrant transcription and post-transcriptional processing of hepatitis C virus non-structural genes in transgenic mice.

Desai MM, Tumurbataar B, Zhang Y, Chan LN, Sun J, Chan TS.

Transgenic Res. 2011 Dec;20(6):1273-84. doi: 10.1007/s11248-011-9494-x. Epub 2011 Feb 24.


The meaning of hope from the perspective of Chinese advanced cancer patients in Hong Kong.

Mok E, Lam WM, Chan LN, Lau KP, Ng JS, Chan KS.

Int J Palliat Nurs. 2010 Jun;16(6):298-305.


Postoperative acquired coagulopathy: a pilot study to determine the impact on clinical and economic outcomes.

Devine EB, Chan LN, Babigumira J, Kao H, Drysdale T, Reilly D, Sullivan S.

Pharmacotherapy. 2010 Oct;30(10):994-1003. doi: 10.1592/phco.30.10.994.


Health-care professionals' perspective on hope in the palliative care setting.

Mok E, Lau KP, Lam WM, Chan LN, Ng J, Chan KS.

J Palliat Med. 2010 Jul;13(7):877-83. doi: 10.1089/jpm.2009.0393.


Healthcare professionals' perceptions of existential distress in patients with advanced cancer.

Mok E, Lau KP, Lam WM, Chan LN, Ng JS, Chan KS.

J Adv Nurs. 2010 Jul;66(7):1510-22. doi: 10.1111/j.1365-2648.2010.05330.x. Epub 2010 May 13.


Effects of oral clotrimazole troches on the pharmacokinetics of oral and intravenous midazolam.

Shord SS, Chan LN, Camp JR, Vasquez EM, Jeong HY, Molokie RE, Baum CL, Xie H.

Br J Clin Pharmacol. 2010 Feb;69(2):160-6. doi: 10.1111/j.1365-2125.2009.03559.x.


Critical illness, gastrointestinal complications, and medication therapy during enteral feeding in critically ill adult patients.

Btaiche IF, Chan LN, Pleva M, Kraft MD.

Nutr Clin Pract. 2010 Feb;25(1):32-49. doi: 10.1177/0884533609357565. Review.


A "gutsy move": tackling enteral feeding intolerance in critically ill patients.

Chan LN.

Nutr Clin Pract. 2010 Feb;25(1):10-2. doi: 10.1177/0884533609357434. No abstract available.


A novel approach to tag and identify geranylgeranylated proteins.

Chan LN, Hart C, Guo L, Nyberg T, Davies BS, Fong LG, Young SG, Agnew BJ, Tamanoi F.

Electrophoresis. 2009 Oct;30(20):3598-606. doi: 10.1002/elps.200900259.


The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.

Ghiani CA, Starcevic M, Rodriguez-Fernandez IA, Nazarian R, Cheli VT, Chan LN, Malvar JS, de Vellis J, Sabatti C, Dell'Angelica EC.

Mol Psychiatry. 2010 Feb;15(2):115, 204-15. doi: 10.1038/mp.2009.58. Epub 2009 Jun 23.


Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor.

Wang R, Wei Z, Jin H, Wu H, Yu C, Wen W, Chan LN, Wen Z, Zhang M.

Mol Cell. 2009 Mar 27;33(6):692-703. doi: 10.1016/j.molcel.2009.02.016.


ACCP white paper: Essential components of a faculty development program for pharmacy practice faculty.

American College of Clinical Pharmacy, Boyce EG, Burkiewicz JS, Haase MR, MacLaughlin EJ, Segal AR, Chung EP, Chan LN, Rospond RM, Barone JA, Durst SW, Wells BG.

Pharmacotherapy. 2009 Jan;29(1):127. doi: 10.1592/phco.29.1.127.


ACCP position statement: Clinical faculty development.

American College of Clinical Pharmacy, Boyce EG, Burkiewicz JS, Haase MR, MacLaughlin EJ, Segal AR, Chung EP, Chan LN, Rospond RM, Barone JA, Durst SW, Wells BG.

Pharmacotherapy. 2009 Jan;29(1):124-6. doi: 10.1592/phco.29.1.124. No abstract available.


Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment.

Feng W, Wu H, Chan LN, Zhang M.

J Biol Chem. 2008 Aug 22;283(34):23440-9. doi: 10.1074/jbc.M802482200. Epub 2008 Jun 10.


Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase.

Yan J, Wen W, Chan LN, Zhang M.

J Mol Biol. 2008 Apr 25;378(2):425-35. doi: 10.1016/j.jmb.2008.02.052. Epub 2008 Mar 4.


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