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CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.

Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC.

Nat Commun. 2019 Nov 8;10(1):5114. doi: 10.1038/s41467-019-13105-5.


The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species.

Shefchek KA, Harris NL, Gargano M, Matentzoglu N, Unni D, Brush M, Keith D, Conlin T, Vasilevsky N, Zhang XA, Balhoff JP, Babb L, Bello SM, Blau H, Bradford Y, Carbon S, Carmody L, Chan LE, Cipriani V, Cuzick A, Rocca MD, Dunn N, Essaid S, Fey P, Grove C, Gourdine JP, Hamosh A, Harris M, Helbig I, Hoatlin M, Joachimiak M, Jupp S, Lett KB, Lewis SE, McNamara C, Pendlington ZM, Pilgrim C, Putman T, Ravanmehr V, Reese J, Riggs E, Robb S, Roncaglia P, Seager J, Segerdell E, Similuk M, Storm AL, Thaxon C, Thessen A, Jacobsen JOB, McMurry JA, Groza T, Köhler S, Smedley D, Robinson PN, Mungall CJ, Haendel MA, Munoz-Torres MC, Osumi-Sutherland D.

Nucleic Acids Res. 2019 Nov 8. pii: gkz997. doi: 10.1093/nar/gkz997. [Epub ahead of print]


Does Curve Regression Occur During Underarm Bracing in Patients with Adolescent Idiopathic Scoliosis?

Cheung JPY, Cheung PWH, Yeng WC, Chan LCK.

Clin Orthop Relat Res. 2019 Oct 31. doi: 10.1097/CORR.0000000000000989. [Epub ahead of print]


Strain relaxation of InGaN/GaN multi-quantum well light emitters via nanopatterning.

Ley R, Chan L, Shapturenka P, Wong M, DenBaars S, Gordon M.

Opt Express. 2019 Oct 14;27(21):30081-30089. doi: 10.1364/OE.27.030081.


Exploration of the antibiotic resistome in a wastewater treatment plant by a nine-year longitudinal metagenomic study.

Yin X, Deng Y, Ma L, Wang Y, Chan LYL, Zhang T.

Environ Int. 2019 Dec;133(Pt B):105270. doi: 10.1016/j.envint.2019.105270. Epub 2019 Nov 1.


Targeting the Immune Microenvironment in the Treatment of Head and Neck Squamous Cell Carcinoma.

Wang HC, Chan LP, Cho SF.

Front Oncol. 2019 Oct 15;9:1084. doi: 10.3389/fonc.2019.01084. eCollection 2019. Review.


Intravenous Thrombolysis Administration 3-4.5 h After Acute Ischemic Stroke: A Retrospective, Multicenter Study.

Chen YW, Sung SF, Chen CH, Tang SC, Tsai LK, Lin HJ, Huang HY, Po HL, Sun Y, Chen PL, Chan L, Wei CY, Lee JT, Hsieh CY, Lin YY, Yeh SJ, Lien LM, Jeng JS.

Front Neurol. 2019 Oct 15;10:1038. doi: 10.3389/fneur.2019.01038. eCollection 2019.


3-year freedom from progression following 68GaPSMA PET CT triaged management in men with biochemical recurrence post radical prostatectomy. Results of a prospective multi-center trial.

Emmett L, Tang R, Nandurkar RH, Hruby G, Roach PJ, Watts JA, Cusick T, Kneebone A, Ho B, Chan L, van Leeuwen P, Scheltema M, Nguyen A, Yin C, Scott A, Tang C, McCarthy M, Fullard K, Roberts M, Francis R, Stricker P.

J Nucl Med. 2019 Nov 1. pii: jnumed.119.235028. doi: 10.2967/jnumed.119.235028. [Epub ahead of print]


Mechanisms Controlling PD-L1 Expression in Cancer.

Cha JH, Chan LC, Li CW, Hsu JL, Hung MC.

Mol Cell. 2019 Nov 7;76(3):359-370. doi: 10.1016/j.molcel.2019.09.030. Epub 2019 Oct 24. Review.


SCGN deficiency results in colitis susceptibility.

Sifuentes-Dominguez LF, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, Venuprasad K, Baker LA, Jia D, Burstein E.

Elife. 2019 Oct 30;8. pii: e49910. doi: 10.7554/eLife.49910.


A prospective clinical study assessing the presence of exfoliated cancer cells and rectal washout including tumors in patients who receive neoadjuvant chemoradiotherapy for rectal cancer.

Okada K, Sadahiro S, Kamei Y, Chan LF, Ogimi T, Miyakita H, Saito G, Tanaka A, Suzuki T.

Surg Today. 2019 Oct 21. doi: 10.1007/s00595-019-01883-w. [Epub ahead of print]


Exercise is medicine in oncology: Engaging clinicians to help patients move through cancer.

Schmitz KH, Campbell AM, Stuiver MM, Pinto BM, Schwartz AL, Morris GS, Ligibel JA, Cheville A, Galvão DA, Alfano CM, Patel AV, Hue T, Gerber LH, Sallis R, Gusani NJ, Stout NL, Chan L, Flowers F, Doyle C, Helmrich S, Bain W, Sokolof J, Winters-Stone KM, Campbell KL, Matthews CE.

CA Cancer J Clin. 2019 Nov;69(6):468-484. doi: 10.3322/caac.21579. Epub 2019 Oct 16.


New Approaches on Cancer Immunotherapy.

Cha JH, Chan LC, Song MS, Hung MC.

Cold Spring Harb Perspect Med. 2019 Oct 15. pii: a036863. doi: 10.1101/cshperspect.a036863. [Epub ahead of print]


Broadening horizons: the case for capturing function and the role of health informatics in its use.

Newman-Griffis D, Porcino J, Zirikly A, Thieu T, Camacho Maldonado J, Ho PS, Ding M, Chan L, Rasch E.

BMC Public Health. 2019 Oct 15;19(1):1288. doi: 10.1186/s12889-019-7630-3.


Quality of life after amputation in patients with advanced complex regional pain syndrome: a systematic review.

Ayyaswamy B, Saeed B, Anand A, Chan L, Shetty V.

EFORT Open Rev. 2019 Sep 3;4(9):533-540. doi: 10.1302/2058-5241.4.190008. eCollection 2019 Sep. Review.


National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support.

Miller PE, Patel S, Saha A, Guha A, Pawar S, Poojary P, Ratnani P, Chan L, Kamholz SL, Alviar CL, van Diepen S, Nasir K, Ahmad T, Nadkarni GN, Desai NR.

Am J Cardiol. 2019 Sep 6. pii: S0002-9149(19)30999-3. doi: 10.1016/j.amjcard.2019.08.033. [Epub ahead of print]


Domain Generalization via Multidomain Discriminant Analysis.

Hu S, Zhang K, Chen Z, Chan L.

Uncertain Artif Intell. 2019 Jul;35. pii: 101.


Significant Published Articles for Pharmacy Nutrition Support Practice in 2018.

Dickerson RN, Kumpf VJ, Bingham AL, Blackmer AB, Canada TW, Chan LN, Cogle SV, Tucker AM.

Hosp Pharm. 2019 Oct;54(5):285-293. doi: 10.1177/0018578719851727. Epub 2019 May 25.


Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.

Mba Medie F, Sharma-Kuinkel BK, Ruffin F, Chan LC, Rossetti M, Chang YL, Park LP, Bayer AS, Filler SG, Ahn R, Reed EF, Gjertson D, Yeaman MR, Fowler VG Jr; MRSA Systems Immunobiology Group.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20087-20096. doi: 10.1073/pnas.1909849116. Epub 2019 Sep 16.


A Novel Tool to Evaluate the Accuracy of Predicting Survival and Guiding Lung Transplantation in Cystic Fibrosis.

Bansal A, Mayer-Hamblett N, Goss CH, Chan LN, Heagerty PJ.

Epidemiology (Sunnyvale). 2019;9(2). pii: 375. doi: 10.4172/2161-1165.1000375. Epub 2019 Jun 17.


Estimating premorbid intelligence in persons with traumatic brain injury: an examination of the Test of Premorbid Functioning.

Joseph AC, Lippa SM, McNally SM, Garcia KM, Leary JB, Dsurney J, Chan L.

Appl Neuropsychol Adult. 2019 Sep 13:1-9. doi: 10.1080/23279095.2019.1661247. [Epub ahead of print]


Effects of Drug Particle Size and Lipid Additives on Drug Release from Paraffin Wax Formulations Prepared by Spray Congealing Technique.

Ouyang H, Ang CY, Heng PWS, Chan LW.

AAPS PharmSciTech. 2019 Sep 9;20(7):303. doi: 10.1208/s12249-019-1519-4.


Are migrant workers in Singapore receiving adequate healthcare? A survey of doctors working in public tertiary healthcare institutions.

Ang JW, Koh CJ, Chua BW, Narayanaswamy S, Wijaya L, Chan LG, Soh LL, Goh WL, Vasoo S.

Singapore Med J. 2019 Sep 6. doi: 10.11622/smedj.2019101. [Epub ahead of print]


Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma.

Ho AS, Ochoa A, Jayakumaran G, Zehir A, Valero Mayor C, Tepe J, Makarov V, Dalin MG, He J, Bailey M, Montesion M, Ross JS, Miller VA, Chan L, Ganly I, Dogan S, Katabi N, Tsipouras P, Ha P, Agrawal N, Solit DB, Futreal PA, El Naggar AK, Reis-Filho JS, Weigelt B, Ho AL, Schultz N, Chan TA, Morris LG.

J Clin Invest. 2019 Oct 1;129(10):4276-4289. doi: 10.1172/JCI128227.


Haematopoietic stem cell transplantation for inborn errors of immunity: 25-year experience from University of Malaya Medical Centre, Malaysia.

Ariffin H, Ab Rahman S, Jawin V, Foo JC, Amram NF, Mahmood NM, Yap TY, Rajagopal R, Lum SH, Chan LL, Lin HP.

J Paediatr Child Health. 2019 Sep 3. doi: 10.1111/jpc.14621. [Epub ahead of print]


Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes.

Chan LJ, Dietrich MH, Nguitragool W, Tham WH.

Cell Microbiol. 2019 Aug 30:e13110. doi: 10.1111/cmi.13110. [Epub ahead of print] Review.


CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.

Wong TL, Ng KY, Tan KV, Chan LH, Zhou L, Che N, Hoo RL, Lee TK, Richard S, Lo CM, Man K, Khong PL, Ma S.

Hepatology. 2019 Aug 30. doi: 10.1002/hep.30923. [Epub ahead of print]


Gamma Radiation-Induced Disruption of Cellular Junctions in HUVECs Is Mediated through Affecting MAPK/NF-κB Inflammatory Pathways.

Wang H, Segaran RC, Chan LY, Aladresi AAM, Chinnathambi A, Alharbi SA, Sethi G, Tang FR.

Oxid Med Cell Longev. 2019 Aug 4;2019:1486232. doi: 10.1155/2019/1486232. eCollection 2019.


Aspirin better than clopidogrel on major adverse cardiovascular events reduction after ischemic stroke: A retrospective nationwide cohort study.

Vidyanti AN, Chan L, Lin CL, Muo CH, Hsu CY, Chen YC, Wu D, Hu CJ.

PLoS One. 2019 Aug 29;14(8):e0221750. doi: 10.1371/journal.pone.0221750. eCollection 2019.


Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

Pech MF, Fong LE, Villalta JE, Chan LJ, Kharbanda S, O'Brien JJ, McAllister FE, Firestone AJ, Jan CH, Settleman J.

Elife. 2019 Aug 27;8. pii: e47362. doi: 10.7554/eLife.47362.


Augmented intelligence with natural language processing applied to electronic health records for identifying patients with non-alcoholic fatty liver disease at risk for disease progression.

Van Vleck TT, Chan L, Coca SG, Craven CK, Do R, Ellis SB, Kannry JL, Loos RJF, Bonis PA, Cho J, Nadkarni GN.

Int J Med Inform. 2019 Sep;129:334-341. doi: 10.1016/j.ijmedinf.2019.06.028. Epub 2019 Jul 6.


Automated "Cells-To-Peptides" Sample Preparation Workflow for High-Throughput, Quantitative Proteomic Assays of Microbes.

Chen Y, Guenther JM, Gin JW, Chan LJG, Costello Z, Ogorzalek TL, Tran HM, Blake-Hedges JM, Keasling JD, Adams PD, García Martín H, Hillson NJ, Petzold CJ.

J Proteome Res. 2019 Oct 4;18(10):3752-3761. doi: 10.1021/acs.jproteome.9b00455. Epub 2019 Aug 30.


The applications of big data in molecular diagnostics.

Wong YKE, Lam KW, Ho KY, Yu CSA, Cho WC, Tsang HF, Chu MKM, Ng PWL, Tai CSW, Chan LWC, Wong EYL, Wong SCC.

Expert Rev Mol Diagn. 2019 Oct;19(10):905-917. doi: 10.1080/14737159.2019.1657834. Epub 2019 Aug 29.


Determining the validity of the visual field principle for designing control/display arrangements.

Hoffmann ER, Chan AHS, Man SS, Chan LCM.

Appl Ergon. 2019 Nov;81:102887. doi: 10.1016/j.apergo.2019.102887. Epub 2019 Jul 1.


Prenatal diagnosis of pathogenic genomic imbalance in fetuses with increased nuchal translucency but normal karyotyping using chromosomal microarray.

Leung TY, Au Yeung KC, Leung WC, Leung KY, Lo TK, To WWK, Lau WL, Chan LW, Sahota DS, Choy RKW.

Hong Kong Med J. 2019 Aug;25 Suppl 5(4):30-32. No abstract available.


The applications of metabolomics in the molecular diagnostics of cancer.

Cheung PK, Ma MH, Tse HF, Yeung KF, Tsang HF, Chu MKM, Kan CM, Cho WCS, Ng LBW, Chan LWC, Wong SCC.

Expert Rev Mol Diagn. 2019 Sep;19(9):785-793. doi: 10.1080/14737159.2019.1656530. Epub 2019 Aug 21.


Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties.

Oshiro KGN, Cândido ES, Chan LY, Torres MDT, Monges BED, Rodrigues SG, Porto WF, Ribeiro SM, Henriques ST, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL, Cardoso MH.

J Med Chem. 2019 Sep 12;62(17):8140-8151. doi: 10.1021/acs.jmedchem.9b00915. Epub 2019 Aug 26.


The Association of Fenofibrate with Kidney Tubular Injury in a Subgroup of Participants in the ACCORD Trial.

Chauhan K, Nadkarni GN, Debnath N, Chan L, Saha A, Garg AX, Parikh CR, Coca SG.

Clin J Am Soc Nephrol. 2019 Oct 7;14(10):1521-1523. doi: 10.2215/CJN.00370119. Epub 2019 Aug 13. No abstract available.


Causative Factors for Complications in Transpalatal Advancement.

Chan L, Kitpornchai L, Mackay S.

Ann Otol Rhinol Laryngol. 2019 Aug 13:3489419867969. doi: 10.1177/0003489419867969. [Epub ahead of print]


Stability and Turnover of the ACTH Receptor Complex.

Clark AJL, Chan L.

Front Endocrinol (Lausanne). 2019 Jul 26;10:491. doi: 10.3389/fendo.2019.00491. eCollection 2019. Review.


Socio-ecological influences on political ideology.

Conway LG 3rd, Chan L, Woodard SR.

Curr Opin Psychol. 2019 Jul 15;32:76-80. doi: 10.1016/j.copsyc.2019.06.034. [Epub ahead of print] Review.


Resilience: insights from medical educators.

Chan L, Dennis AA.

Clin Teach. 2019 Aug;16(4):384-389. doi: 10.1111/tct.13058.


Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.

Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M.

Genes Dev. 2019 Sep 1;33(17-18):1265-1279. doi: 10.1101/gad.327593.119. Epub 2019 Aug 8.


Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis.

Chen L, Chan LS, Lung HL, Yip TTC, Ngan RKC, Wong JWC, Lo KW, Ng WT, Lee AWM, Tsao GSW, Lung ML, Mak NK.

Phytomedicine. 2019 Jul 29;63:153058. doi: 10.1016/j.phymed.2019.153058. [Epub ahead of print]


Distribution of Neuroendocrine Marker-Positive Cells in Colorectal Cancer Tissue and Normal Mucosal Tissue: Consideration of Histogenesis of Neuroendocrine Cancer.

Ogimi T, Sadahiro S, Kamei Y, Chan LF, Miyakita H, Saito G, Okada K, Suzuki T, Kajiwara H.

Oncology. 2019;97(5):294-300. doi: 10.1159/000501521. Epub 2019 Aug 7.


Copper Deficiency in Liver Diseases: A Case Series and Pathophysiological Considerations.

Yu L, Liou IW, Biggins SW, Yeh M, Jalikis F, Chan LN, Burkhead J.

Hepatol Commun. 2019 Jun 26;3(8):1159-1165. doi: 10.1002/hep4.1393. eCollection 2019 Aug.


Trends and Racial Disparities of Palliative Care Use among Hospitalized Patients with ESKD on Dialysis.

Wen Y, Jiang C, Koncicki HM, Horowitz CR, Cooper RS, Saha A, Coca SG, Nadkarni GN, Chan L.

J Am Soc Nephrol. 2019 Sep;30(9):1687-1696. doi: 10.1681/ASN.2018121256. Epub 2019 Aug 6.


Electrochemical characteristics of microelectrode designed for electrical stimulation.

Cui H, Xie X, Xu S, Chan LLH, Hu Y.

Biomed Eng Online. 2019 Aug 1;18(1):86. doi: 10.1186/s12938-019-0704-8.


The Association between Mortality-to-Incidence Ratios and Health Expenditures in Brain and Nervous System Cancers.

Lee TH, Sung WW, Chan L, Lee HL, Chen SL, Huang YH, Kwan AL.

Int J Environ Res Public Health. 2019 Jul 31;16(15). pii: E2739. doi: 10.3390/ijerph16152739.

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