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NF-E2 mutation as a novel cause for inherited thrombocytopenia.

Luk ADW, Yang X, Alcasabas AP, Hao RC, Chan KW, Lee PP, Yang J, Chan GC, So JC, Yang W, Lau YL.

Br J Haematol. 2020 Jan 17. doi: 10.1111/bjh.16438. [Epub ahead of print] No abstract available.


Anti-Tumor Activity of Atractylenolide I in Human Colon Adenocarcinoma In Vitro.

Chan KWK, Chung HY, Ho WS.

Molecules. 2020 Jan 4;25(1). pii: E212. doi: 10.3390/molecules25010212.


Sub-genomic RNA from dengue virus type 2 suppresses replication of dengue virus genomes and interacts with virus-encoded NS3 and NS5 proteins.

Wang S, Chan KWK, Naripogu K, Swarbrick C, Aaskov J, Vasudevan SG.

ACS Infect Dis. 2020 Jan 10. doi: 10.1021/acsinfecdis.9b00384. [Epub ahead of print]


Probiotic Properties of Bacillus Strains Isolated from Stingless Bee (Heterotrigona itama) Honey Collected across Malaysia.

Zulkhairi Amin FA, Sabri S, Ismail M, Chan KW, Ismail N, Mohd Esa N, Mohd Lila MA, Zawawi N.

Int J Environ Res Public Health. 2019 Dec 31;17(1). pii: E278. doi: 10.3390/ijerph17010278.


Single-spin qubits in isotopically enriched silicon at low magnetic field.

Zhao R, Tanttu T, Tan KY, Hensen B, Chan KW, Hwang JCC, Leon RCC, Yang CH, Gilbert W, Hudson FE, Itoh KM, Kiselev AA, Ladd TD, Morello A, Laucht A, Dzurak AS.

Nat Commun. 2019 Dec 3;10(1):5500. doi: 10.1038/s41467-019-13416-7.


The Potential Role of the ZIKV NS5 Nuclear Spherical-Shell Structures in Cell Type-Specific Host Immune Modulation during ZIKV Infection.

Tan MJA, Chan KWK, Ng IHW, Kong SYZ, Gwee CP, Watanabe S, Vasudevan SG.

Cells. 2019 Nov 26;8(12). pii: E1519. doi: 10.3390/cells8121519. Review.


Platelet-derived alpha-granules are associated with inflammation in patients with NK/T-cell lymphoma-associated hemophagocytic syndrome.

Ren Q, Chan KW, Huang H, Wang Z, Fang X, Guo C, Li F, Zhang L, Yao Y, Chen Z, Tian Y, Lin T.

Cytokine. 2020 Feb;126:154878. doi: 10.1016/j.cyto.2019.154878. Epub 2019 Nov 15.


Guideline-Based Critical Care Pathway Improves Long-Term Clinical Outcomes in Patients with Acute Coronary Syndrome.

Hai JJ, Wong CK, Un KC, Wong KL, Zhang ZY, Chan PH, Lam YM, Chan WS, Lam CC, Tam CC, Wong YT, Yung SY, Chan KW, Siu CW, Lau CP, Tse HF.

Sci Rep. 2019 Nov 14;9(1):16814. doi: 10.1038/s41598-019-53348-2.


Effect of non-surgical periodontal therapy on renal function in chronic kidney disease patients with periodontitis: a systematic review and meta-analysis of interventional studies.

Zhao D, Khawaja AT, Jin L, Chan KW, Tonetti M, Tang SCW, Pelekos G.

Clin Oral Investig. 2019 Nov 12. doi: 10.1007/s00784-019-03066-w. [Epub ahead of print]


Cost-utility analysis of 21-gene assay for node-positive early breast cancer.

Masucci L, Torres S, Eisen A, Trudeau M, Tyono I, Saunders H, Chan KW, Isaranuwatchai W.

Curr Oncol. 2019 Oct;26(5):307-318. doi: 10.3747/co.26.4769. Epub 2019 Oct 1.


Genetic Approaches for Definitive Diagnosis of Agammaglobulinemia in Consanguineous Families.

Ben-Ali M, Kechout N, Mekki N, Yang J, Chan KW, Barakat A, Aadam Z, Gamara J, Gargouri L, Largueche B, BelHadj-Hmida N, Nedri A, Ameur HB, Mellouli F, Boukari R, Bejaoui M, Bousfiha A, Ben-Mustapha I, Lau YL, Barbouche MR.

J Clin Immunol. 2019 Nov 6. doi: 10.1007/s10875-019-00706-4. [Epub ahead of print]


CT and CEST MRI bimodal imaging of the intratumoral distribution of iodinated liposomes.

Chen Z, Li Y, Airan R, Han Z, Xu J, Chan KWY, Xu Y, Bulte JWM, van Zijl PCM, McMahon MT, Zhou S, Liu G.

Quant Imaging Med Surg. 2019 Sep;9(9):1579-1591. doi: 10.21037/qims.2019.06.10.


MicroRNA-338-5p reverses chemoresistance and inhibits invasion of esophageal squamous cell carcinoma cells by targeting Id-1.

Han L, Cui D, Li B, Xu WW, Lam AKY, Chan KT, Zhu Y, Lee NPY, Law SYK, Guan XY, Qin YR, Chan KW, Ma S, Tsao SW, Cheung ALM.

Cancer Sci. 2019 Dec;110(12):3677-3688. doi: 10.1111/cas.14220. Epub 2019 Nov 17.


Well-Defined Silica-Supported Tungsten(IV)-Oxo Complex: Olefin Metathesis Activity, Initiation, and Role of Brønsted Acid Sites.

Chan KW, Mance D, Safonova OV, Copéret C.

J Am Chem Soc. 2019 Nov 13;141(45):18286-18292. doi: 10.1021/jacs.9b09493. Epub 2019 Nov 4.


Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells.

Zhou Y, Chung PY, Ma JY, Lam AK, Law S, Chan KW, Chan AS, Li X, Lam KH, Chui CH, Tang JC.

Biology (Basel). 2019 Oct 1;8(4). pii: E75. doi: 10.3390/biology8040075.


Application of Flow Cytometry in the Diagnostics Pipeline of Primary Immunodeficiencies Underlying Disseminated Talaromyces marneffei Infection in HIV-Negative Children.

Lee PP, Lao-Araya M, Yang J, Chan KW, Ma H, Pei LC, Kui L, Mao H, Yang W, Zhao X, Trakultivakorn M, Lau YL.

Front Immunol. 2019 Sep 13;10:2189. doi: 10.3389/fimmu.2019.02189. eCollection 2019.


A clinical prediction score using age at diagnosis and saline infusion test parameters can predict aldosterone-producing adenoma from idiopathic adrenal hyperplasia.

Leung HT, Woo YC, Fong CHY, Tan KCB, Lau EYF, Chan KW, Leung JYY.

J Endocrinol Invest. 2019 Sep 16. doi: 10.1007/s40618-019-01114-6. [Epub ahead of print]


Silica-Supported MnII Sites as Efficient Catalysts for Carbonyl Hydroboration, Hydrosilylation, and Transesterification.

Ghaffari B, Mendes-Burak J, Chan KW, Copéret C.

Chemistry. 2019 Nov 4;25(61):13869-13873. doi: 10.1002/chem.201903638. Epub 2019 Oct 11.


Clinical considerations when adding a sodium-glucose co-transporter-2 inhibitor to insulin therapy in patients with diabetes mellitus.

Tan K, Chow WS, Leung J, Ho A, Ozaki R, Kam G, Li J, Choi CH, Tsang MW, Chan N, Lee KK, Chan KW.

Hong Kong Med J. 2019 Aug;25(4):312-319. doi: 10.12809/hkmj197802. No abstract available.


Effect of mycophenolate and rapamycin on renal fibrosis in lupus nephritis.

Zhang C, Chan CCY, Cheung KF, Chau MKM, Yap DYH, Ma MKM, Chan KW, Yung S, Chan TM.

Clin Sci (Lond). 2019 Aug 5;133(15):1721-1744. doi: 10.1042/CS20190536. Print 2019 Aug 15.


Incidence of dual antiplatelet therapy interruption within 1 year after primary percutaneous coronary intervention in patients with acute ST elevation myocardial infarction.

Tam CC, Lee J, Chan KW, Lam CC, Wong YT, Chan E, Sze M, Lam YM, Chan C, Tse HF, Siu CW.

Postgrad Med J. 2020 Jan;96(1131):9-13. doi: 10.1136/postgradmedj-2019-136760. Epub 2019 Jul 19.


Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells.

Zhang Q, Liu RX, Chan KW, Hu J, Zhang J, Wei L, Tan H, Yang X, Liu H.

J Exp Clin Cancer Res. 2019 Jul 19;38(1):320. doi: 10.1186/s13046-019-1314-9.


A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice.

Chan KWK, Watanabe S, Jin JY, Pompon J, Teng D, Alonso S, Vijaykrishna D, Halstead SB, Marzinek JK, Bond PJ, Burla B, Torta F, Wenk MR, Ooi EE, Vasudevan SG.

Sci Transl Med. 2019 Jun 26;11(498). pii: eaat7726. doi: 10.1126/scitranslmed.aat7726.


Vascular age is associated with the risk of dialysis or death in chronic kidney disease.

Lin M, Chan GC, Chan KW, Lai KN, Tang SC.

Nephrology (Carlton). 2019 Jun 21. doi: 10.1111/nep.13624. [Epub ahead of print]


TIMI risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-non-ST-elevation myocardial infarction patients.

Huang D, Cheng YY, Wong YT, Yung SY, Chan KW, Lam CC, Hai J, Lau CP, Wong KL, Feng YQ, Tan N, Chen JY, Wu MX, Su X, Yan H, Song D, Tse HF, Chan PH, Siu CW, Tam CC.

Postgrad Med J. 2019 Jul;95(1125):372-377. doi: 10.1136/postgradmedj-2019-136404. Epub 2019 May 23.


Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity.

Saw WG, Chan KW, Vasudevan SG, Grüber G.

FEBS Lett. 2019 Jun;593(12):1272-1291. doi: 10.1002/1873-3468.13437. Epub 2019 May 31.


Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure.

Jallow S, Wilmshurst JM, Howard W, Copelyn J, Seakamela L, Chan KW, Sebunya R, Sibiya R, Du Plessis H, Jacobs C, Berkowitz N, Blumberg L, McCarthy K, Maseti E, Kamupira M, Dlamini N, Gumede N, Diop OM, Lau YL, Moonsamy S, Eley B, Suchard M.

Clin Infect Dis. 2020 Jan 1;70(1):132-135. doi: 10.1093/cid/ciz361.


Fidelity benchmarks for two-qubit gates in silicon.

Huang W, Yang CH, Chan KW, Tanttu T, Hensen B, Leon RCC, Fogarty MA, Hwang JCC, Hudson FE, Itoh KM, Morello A, Laucht A, Dzurak AS.

Nature. 2019 May;569(7757):532-536. doi: 10.1038/s41586-019-1197-0. Epub 2019 May 13.


Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury.

Li B, Leung JCK, Chan LYY, Yiu WH, Li Y, Lok SWY, Liu WH, Chan KW, Tse HF, Lai KN, Tang SCW.

Stem Cells Transl Med. 2019 Sep;8(9):898-910. doi: 10.1002/sctm.18-0265. Epub 2019 May 3.


Assessing the utility of antivirals for preventing maternal-fetal transmission of zika virus in pregnant mice.

Watanabe S, Tan NWW, Chan KWK, Vasudevan SG.

Antiviral Res. 2019 Jul;167:104-109. doi: 10.1016/j.antiviral.2019.04.013. Epub 2019 Apr 30.


Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance.

Li B, Hong P, Zheng CC, Dai W, Chen WY, Yang QS, Han L, Tsao SW, Chan KT, Lee NPY, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, Lung ML, He QY, Xu WW, Cheung AL.

Theranostics. 2019 Feb 28;9(6):1599-1613. doi: 10.7150/thno.30372. eCollection 2019.


Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells.

Ng IHW, Chan KW, Tan MJA, Gwee CP, Smith KM, Jeffress SJ, Saw WG, Swarbrick CMD, Watanabe S, Jans DA, Grüber G, Forwood JK, Vasudevan SG.

ACS Infect Dis. 2019 Jun 14;5(6):932-948. doi: 10.1021/acsinfecdis.8b00373. Epub 2019 Mar 19.


The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma.

Xu X, Xu J, Knutsson L, Liu J, Liu H, Li Y, Lal B, Laterra J, Artemov D, Liu G, van Zijl PCM, Chan KWY.

Magn Reson Med. 2019 Jun;81(6):3798-3807. doi: 10.1002/mrm.27683. Epub 2019 Feb 22.


Extended early intervention versus standard psychiatric care for adults with first-episode psychosis.

Chang WC, Chan SK, Lee EH, Hui CL, Chen EY.

Hong Kong Med J. 2019 Feb;25 Suppl 3(1):4-8. No abstract available.


Prebiotic reduction of brain histone deacetylase (HDAC) activity and olanzapine-mediated weight gain in rats, are acetate independent.

Kao AC, Chan KW, Anthony DC, Lennox BR, Burnet PW.

Neuropharmacology. 2019 May 15;150:184-191. doi: 10.1016/j.neuropharm.2019.02.014. Epub 2019 Feb 11.


Therapeutic Properties of Stingless Bee Honey in Comparison with European Bee Honey.

Zulkhairi Amin FA, Sabri S, Mohammad SM, Ismail M, Chan KW, Ismail N, Norhaizan ME, Zawawi N.

Adv Pharmacol Sci. 2018 Dec 26;2018:6179596. doi: 10.1155/2018/6179596. eCollection 2018. Review.


Duration of early intervention for psychosis: 2 years versus 3 years.

Chen EY, Chang WC, Hui CL, Chan SK, Lee EH, Wong GH.

Hong Kong Med J. 2019 Feb;25 Suppl 2(1):10-14. No abstract available.


Circulating Transforming Growth Factor-β and Aortic Dilation in Patients with Repaired Congenital Heart Disease.

Cheung YF, Chow PC, So EK, Chan KW.

Sci Rep. 2019 Jan 17;9(1):162. doi: 10.1038/s41598-018-36458-1.


Microwave synthesis, crystal structure, antioxidant, and antimicrobial study of new 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline compound.

Hasan HA, Abdulmalek E, Rahman MBA, Shaari KB, Yamin BM, Chan KW.

Chem Cent J. 2018 Dec 20;12(1):145. doi: 10.1186/s13065-018-0509-z.


Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI.

Chen L, Wei Z, Chan KWY, Cai S, Liu G, Lu H, Wong PC, van Zijl PCM, Li T, Xu J.

Neuroimage. 2019 Mar;188:380-390. doi: 10.1016/j.neuroimage.2018.12.018. Epub 2018 Dec 13.


Integrated silicon qubit platform with single-spin addressability, exchange control and single-shot singlet-triplet readout.

Fogarty MA, Chan KW, Hensen B, Huang W, Tanttu T, Yang CH, Laucht A, Veldhorst M, Hudson FE, Itoh KM, Culcer D, Ladd TD, Morello A, Dzurak AS.

Nat Commun. 2018 Oct 30;9(1):4370. doi: 10.1038/s41467-018-06039-x.


Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients.

Bhatt ST, Bednarski JJ, Berg J, Trinkaus K, Murray L, Hayashi R, Schulz G, Hente M, Grimley M, Chan KW, Kamani N, Jacobsohn D, Nieder M, Hale G, Yu L, Adams R, Dalal J, Pulsipher MA, Haut P, Chaudhury S, Davis J, Jaroscak J, Andreansky M, Willert J, Shenoy S.

Biol Blood Marrow Transplant. 2019 Mar;25(3):556-561. doi: 10.1016/j.bbmt.2018.10.008. Epub 2018 Oct 12.


Ten-Year Native Liver Survival Rate After Laparoscopic and Open Kasai Portoenterostomy for Biliary Atresia.

Chan KWE, Lee KH, Wong HYV, Tsui SYB, Mou JWC, Tam YHP.

J Laparoendosc Adv Surg Tech A. 2019 Jan;29(1):121-125. doi: 10.1089/lap.2018.0350. Epub 2018 Sep 14.


WITHDRAWN: Correlation of SPINK1 gene polymorphisms in canine pancreatitis.

Fan MH, Chou SJ, Zheng ZJ, Wu JT, Chan KW.

J Vet Sci. 2018 Aug 30. [Epub ahead of print]


Chemotherapeutic Treatments Increase PD-L1 Expression in Esophageal Squamous Cell Carcinoma through EGFR/ERK Activation.

Ng HY, Li J, Tao L, Lam AK, Chan KW, Ko JMY, Yu VZ, Wong M, Li B, Lung ML.

Transl Oncol. 2018 Dec;11(6):1323-1333. doi: 10.1016/j.tranon.2018.08.005. Epub 2018 Aug 31.


Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus.

Luk ADW, Ni K, Wu Y, Lam KT, Chan KW, Lee PP, Tu W, Mao H, Lau YL.

Front Immunol. 2018 Aug 10;9:1826. doi: 10.3389/fimmu.2018.01826. eCollection 2018.


Highly Productive Propane Dehydrogenation Catalyst Using Silica-Supported Ga-Pt Nanoparticles Generated from Single-Sites.

Searles K, Chan KW, Mendes Burak JA, Zemlyanov D, Safonova O, Copéret C.

J Am Chem Soc. 2018 Sep 19;140(37):11674-11679. doi: 10.1021/jacs.8b05378. Epub 2018 Sep 11.


C-H Activation and Proton Transfer Initiate Alkene Metathesis Activity of the Tungsten(IV)-Oxo Complex.

Chan KW, Lam E, D'Anna V, Allouche F, Michel C, Safonova OV, Sautet P, Copéret C.

J Am Chem Soc. 2018 Sep 12;140(36):11395-11401. doi: 10.1021/jacs.8b06603. Epub 2018 Aug 29.


Dengue Virus and Zika Virus Serological Cross-reactivity and Their Impact on Pathogenesis in Mice.

Watanabe S, Tan NWW, Chan KWK, Vasudevan SG.

J Infect Dis. 2019 Jan 7;219(2):223-233. doi: 10.1093/infdis/jiy482.


Scalable Generation of Multi-mode NOON States for Quantum Multiple-phase Estimation.

Zhang L, Chan KWC.

Sci Rep. 2018 Jul 30;8(1):11440. doi: 10.1038/s41598-018-29828-2.

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