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Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.

AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, Vergara IA, Papenfuss AT, Lau P, Ghosh P, Haupt S, Haupt Y, Sanij E, Poortinga G, Pearson RB, Falk H, Curtis DJ, Stupple P, Devlin M, Street I, Davies MA, McArthur GA, Sheppard KE.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17990-18000. doi: 10.1073/pnas.1901323116. Epub 2019 Aug 22.


BRCA2 loss-of-function germline mutations are associated with esophageal squamous cell carcinoma risk in Chinese.

Ko JM, Ning L, Zhao XK, Chai AWY, Lei LC, Choi SSA, Tao L, Law S, Kwong A, Lee NP, Chan KT, Lo A, Song X, Chen PN, Chang YL, Wang LD, Lung ML.

Int J Cancer. 2019 Aug 9. doi: 10.1002/ijc.32619. [Epub ahead of print]


Strongly Luminescent Tungsten Emitters with Emission Quantum Yields of up to 84 %: TADF and High-Efficiency Molecular Tungsten OLEDs.

Chan KT, Lam TL, Yu D, Du L, Phillips DL, Kwong CL, Tong GSM, Cheng G, Che CM.

Angew Chem Int Ed Engl. 2019 Oct 14;58(42):14896-14900. doi: 10.1002/anie.201906698. Epub 2019 Sep 5.


A functional genetic screen defines the AKT-induced senescence signaling network.

Chan KT, Blake S, Zhu H, Kang J, Trigos AS, Madhamshettiwar PB, Diesch J, Paavolainen L, Horvath P, Hannan RD, George AJ, Sanij E, Hannan KM, Simpson KJ, Pearson RB.

Cell Death Differ. 2019 Jul 8. doi: 10.1038/s41418-019-0384-8. [Epub ahead of print]


Diabetes and Diabetes Care among Nonobese Japanese-Americans: Findings from a Population-Based Study.

Kobayashi K, Chan KT, Roy A, Khan MM, Fuller-Thomson E.

Adv Prev Med. 2019 Jun 2;2019:3650649. doi: 10.1155/2019/3650649. eCollection 2019.


Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance.

Li B, Hong P, Zheng CC, Dai W, Chen WY, Yang QS, Han L, Tsao SW, Chan KT, Lee NPY, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, Lung ML, He QY, Xu WW, Cheung AL.

Theranostics. 2019 Feb 28;9(6):1599-1613. doi: 10.7150/thno.30372. eCollection 2019.


De-escalation from ticagrelor to clopidogrel in acute coronary syndrome patients: a systematic review and meta-analysis.

Angiolillo DJ, Patti G, Chan KT, Han Y, Huang WC, Yakovlev A, Paek D, Del Aguila M, Girotra S, Sibbing D.

J Thromb Thrombolysis. 2019 Jul;48(1):1-10. doi: 10.1007/s11239-019-01860-7.


Age differences in the association of nonmedical prescription opioid use and suicidality.

Chan KT, Winston P, Jennings R, Trant J, Moller M.

J Opioid Manag. 2019 Jan/Feb;15(1):5-10. doi: 10.5055/jom.2019.0480.


Diabetes Care of Non-obese Korean Americans: Considerable Room for Improvement.

Chan KT, Kobayashi KM, Roy A, Fuller-Thomson E.

Korean J Fam Med. 2019 Mar;40(2):72-79. doi: 10.4082/kjfm.18.0002. Epub 2018 Dec 19.


Cystathionine β-Synthase in Physiology and Cancer.

Zhu H, Blake S, Chan KT, Pearson RB, Kang J.

Biomed Res Int. 2018 Jun 28;2018:3205125. doi: 10.1155/2018/3205125. eCollection 2018. Review.


Inactivation of Planktonic Escherichia coli by Focused 1-MHz Ultrasound Pulses with Shocks: Efficacy and Kinetics Upon Volume Scale-Up.

Brayman AA, MacConaghy BE, Wang YN, Chan KT, Monsky WL, Chernikov VP, Buravkov SV, Khokhlova VA, Matula TJ.

Ultrasound Med Biol. 2018 Sep;44(9):1996-2008. doi: 10.1016/j.ultrasmedbio.2018.05.010. Epub 2018 Jun 23.


Hepatotoxic Dose Thresholds by Positron-Emission Tomography After Yttrium-90 Radioembolization of Liver Tumors: A Prospective Single-Arm Observational Study.

Chan KT, Alessio AM, Johnson GE, Vaidya S, Kwan SW, Monsky W, Wilson AE, Lewis DH, Padia SA.

Cardiovasc Intervent Radiol. 2018 Sep;41(9):1363-1372. doi: 10.1007/s00270-018-1949-5. Epub 2018 Apr 12.


Prospective Trial Using Internal Pair-Production Positron Emission Tomography to Establish the Yttrium-90 Radioembolization Dose Required for Response of Hepatocellular Carcinoma.

Chan KT, Alessio AM, Johnson GE, Vaidya S, Kwan SW, Monsky W, Wilson AE, Lewis DH, Padia SA.

Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):358-365. doi: 10.1016/j.ijrobp.2018.01.116. Epub 2018 Feb 9.


Serum microRNA-193b as a promising biomarker for prediction of chemoradiation sensitivity in esophageal squamous cell carcinoma patients.

Chan CM, Lai KKY, Ng EKO, Kiang MN, Kwok TWH, Wang HK, Chan KW, Law TT, Tong DK, Chan KT, Lee NP, Law S.

Oncol Lett. 2018 Mar;15(3):3273-3280. doi: 10.3892/ol.2017.7698. Epub 2017 Dec 27.


Preclinical Study of Novel Curcumin Analogue SSC-5 Using Orthotopic Tumor Xenograft Model for Esophageal Squamous Cell Carcinoma.

Tung LN, Song S, Chan KT, Choi MY, Lam HY, Chan CM, Chen Z, Wang HK, Leung HT, Law S, Huang Y, Song H, Lee NP.

Cancer Res Treat. 2018 Oct;50(4):1362-1377. doi: 10.4143/crt.2017.353. Epub 2018 Jan 24.


Elevated levels of serum nidogen-2 in esophageal squamous cell carcinoma.

Chai AWY, Cheung AKL, Dai W, Ko JMY, Lee NPY, Chan KT, Law SY, Lung ML.

Cancer Biomark. 2018 Feb 14;21(3):583-590. doi: 10.3233/CBM-170484.


Diabetes among asian americans with BMI less than or equal to 23.

Kobayashi KM, Chan KT, Fuller-Thomson E.

Diabetes Metab Syndr. 2018 Apr - Jun;12(2):169-173. doi: 10.1016/j.dsx.2017.12.011. Epub 2017 Dec 16.


Transcatheter aortic valve implantation: initial experience in Hong Kong.

Lee MK, Chui SF, Chan AK, Chan JL, Wong EC, Chan KT, Cheung HL, Chiang CS.

Hong Kong Med J. 2017 Aug;23(4):349-55. doi: 10.12809/hkmj166030. Epub 2017 Jun 28.


Applying Rasch model analysis in the development of the cantonese tone identification test (CANTIT).

Lee KYS, Lam JHS, Chan KTY, van Hasselt CA, Tong MCF.

Int J Audiol. 2017;56(sup2):S60-S73. doi: 10.1080/14992027.2017.1294766. Epub 2017 Mar 1.


Mindfulness-based interventions with youth: A comprehensive meta-analysis of group-design studies.

Klingbeil DA, Renshaw TL, Willenbrink JB, Copek RA, Chan KT, Haddock A, Yassine J, Clifton J.

J Sch Psychol. 2017 Aug;63:77-103. doi: 10.1016/j.jsp.2017.03.006. Epub 2017 Apr 11.


Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/β-catenin axis in hepatocellular carcinoma.

Shek FH, Luo R, Lam BYH, Sung WK, Lam TW, Luk JM, Leung MS, Chan KT, Wang HK, Chan CM, Poon RT, Lee NP.

Cell Oncol (Dordr). 2017 Oct;40(5):443-456. doi: 10.1007/s13402-017-0332-x. Epub 2017 Jun 19.


Whole-exome sequencing reveals critical genes underlying metastasis in oesophageal squamous cell carcinoma.

Dai W, Ko JMY, Choi SSA, Yu Z, Ning L, Zheng H, Gopalan V, Chan KT, Lee NP, Chan KW, Law SY, Lam AK, Lung ML.

J Pathol. 2017 Aug;242(4):500-510. doi: 10.1002/path.4925. Epub 2017 Jul 12.


Strongly Luminescent Cyclometalated Gold(III) Complexes Supported by Bidentate Ligands Displaying Intermolecular Interactions and Tunable Emission Energy.

Chan KT, Tong GSM, Wan Q, Cheng G, Yang C, Che CM.

Chem Asian J. 2017 Aug 17;12(16):2104-2120. doi: 10.1002/asia.201700686. Epub 2017 Jul 27.


Inactivation of Planktonic Escherichia coli by Focused 2-MHz Ultrasound.

Brayman AA, MacConaghy BE, Wang YN, Chan KT, Monsky WL, McClenny AJ, Matula TJ.

Ultrasound Med Biol. 2017 Jul;43(7):1476-1485. doi: 10.1016/j.ultrasmedbio.2017.03.009. Epub 2017 Apr 26.


The interplay between fluorescence and phosphorescence with luminescent gold(i) and gold(iii) complexes bearing heterocyclic arylacetylide ligands.

Chan KT, Tong GSM, To WP, Yang C, Du L, Phillips DL, Che CM.

Chem Sci. 2017 Mar 1;8(3):2352-2364. doi: 10.1039/c6sc03775e. Epub 2016 Dec 5.


Diabetes among non-obese Filipino Americans: Findings from a large population-based study.

Fuller-Thomson E, Roy A, Chan KT, Kobayashi KM.

Can J Public Health. 2017 Apr 20;108(1):e36-e42. doi: 10.17269/cjph.108.5761.


MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF.

Li B, Xu WW, Han L, Chan KT, Tsao SW, Lee NPY, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, He QY, Cheung ALM.

Oncogene. 2017 Jul 13;36(28):3986-4000. doi: 10.1038/onc.2017.29. Epub 2017 Mar 13.


Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.

Xu WW, Li B, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Lee NP, Chan KW, Xu LY, Li EM, Tsao SW, He QY, Cheung AL.

Nat Commun. 2017 Feb 10;8:14399. doi: 10.1038/ncomms14399.


The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.

Yan S, Frank D, Son J, Hannan KM, Hannan RD, Chan KT, Pearson RB, Sanij E.

Int J Mol Sci. 2017 Jan 20;18(1). pii: E210. doi: 10.3390/ijms18010210. Review.


Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

Chan KT, Paavolainen L, Hannan KM, George AJ, Hannan RD, Simpson KJ, Horvath P, Pearson RB.

Assay Drug Dev Technol. 2016 Sep;14(7):416-28. doi: 10.1089/adt.2016.739.


Improving outpatient phlebotomy service efficiency and patient experience using discrete-event simulation.

Yip K, Pang SK, Chan KT, Chan CK, Lee TL.

Int J Health Care Qual Assur. 2016 Aug 8;29(7):733-43. doi: 10.1108/IJHCQA-08-2015-0093.


Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.

Quin J, Chan KT, Devlin JR, Cameron DP, Diesch J, Cullinane C, Ahern J, Khot A, Hein N, George AJ, Hannan KM, Poortinga G, Sheppard KE, Khanna KK, Johnstone RW, Drygin D, McArthur GA, Pearson RB, Sanij E, Hannan RD.

Oncotarget. 2016 Aug 2;7(31):49800-49818. doi: 10.18632/oncotarget.10452.


Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation.

Fung TM, Ng KY, Tong M, Chen JN, Chai S, Chan KT, Law S, Lee NP, Choi MY, Li B, Cheung AL, Tsao SW, Qin YR, Guan XY, Chan KW, Ma S.

J Pathol. 2016 Jul;239(3):309-19. doi: 10.1002/path.4728. Epub 2016 May 5.


Dual-energy CT Aortography with 50% Reduced Iodine Dose Versus Single-energy CT Aortography with Standard Iodine Dose.

Shuman WP, Chan KT, Busey JM, Mitsumori LM, Koprowicz KM.

Acad Radiol. 2016 May;23(5):611-8. doi: 10.1016/j.acra.2015.12.019. Epub 2016 Feb 17.


Predictors for Paravalvular Regurgitation After TAVR With the Self-Expanding Prosthesis: Quantitative Measurement of MDCT Analysis.

Yoon SH, Ahn JM, Ohno Y, Barbanti M, Chan J, Lin MS, Kim YH, Yang DH, Sugiyama D, Chan KT, Immé S, Tamburino CI, Sgroi C, Park DW, Kang SJ, Lee SW, Lee CW, Park SW, Lee M, Kao HL, Tamburino C, Park SJ.

JACC Cardiovasc Imaging. 2016 Oct;9(10):1233-1234. doi: 10.1016/j.jcmg.2015.10.011. Epub 2016 Jan 6. No abstract available.


The 12-Month Incidence and Predictors of PHQ-9-Screened Depressive Symptoms in Chinese Primary Care Patients.

Chin WY, Wan EY, Choi EP, Chan KT, Lam CL.

Ann Fam Med. 2016 Jan-Feb;14(1):47-53. doi: 10.1370/afm.1854.


Building Mobile Apps for Underrepresented Mental Health care Consumers: A Grounded Theory Approach.

Leung R, Hastings JF, Keefe RH, Brownstein-Evans C, Chan KT, Mullick R.

Soc Work Ment Health. 2016;14(6):625-636. doi: 10.1080/15332985.2015.1130010. Epub 2016 Feb 22.


Tri-band spectroscopic optical coherence tomography based on optical parametric amplification for lipid and vessel visualization.

Yu L, Kang J, Jinata C, Wang X, Wei X, Chan KT, Lee NP, Wong KK.

J Biomed Opt. 2015;20(12):126006. doi: 10.1117/1.JBO.20.12.126006.


Metal-organic framework composites with luminescent gold(iii) complexes. Strongly emissive and long-lived excited states in open air and photo-catalysis.

Sun CY, To WP, Wang XL, Chan KT, Su ZM, Che CM.

Chem Sci. 2015 Dec 1;6(12):7105-7111. doi: 10.1039/c5sc02216a. Epub 2015 Sep 21.


β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.

Creed SJ, Le CP, Hassan M, Pon CK, Albold S, Chan KT, Berginski ME, Huang Z, Bear JE, Lane JR, Halls ML, Ferrari D, Nowell CJ, Sloan EK.

Breast Cancer Res. 2015 Nov 25;17(1):145. doi: 10.1186/s13058-015-0655-3.


Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma.

Li J, Li B, Xu WW, Chan KW, Guan XY, Qin YR, Lee NP, Chan KT, Law S, Tsao SW, Cheung AL.

Expert Opin Ther Targets. 2016;20(1):7-18. doi: 10.1517/14728222.2016.1121236. Epub 2015 Dec 15.


Oxygen carrier YQ23 can enhance the chemotherapeutic drug responses of chemoresistant esophageal tumor xenografts.

Lee NP, Chan KT, Choi MY, Lam HY, Tung LN, Tzang FC, Han H, Lam IP, Kwok SY, Lau SH, Man C, Tong DK, Wong BL, Law S.

Cancer Chemother Pharmacol. 2015 Dec;76(6):1199-207. doi: 10.1007/s00280-015-2897-2. Epub 2015 Nov 9.


Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance.

Li B, Xu WW, Guan XY, Qin YR, Law S, Lee NP, Chan KT, Tam PY, Li YY, Chan KW, Yuen HF, Tsao SW, He QY, Cheung AL.

Clin Cancer Res. 2016 Mar 1;22(5):1243-55. doi: 10.1158/1078-0432.CCR-15-1196. Epub 2015 Oct 16.


Improving newborn hearing screening: Are automated auditory brainstem response ear inserts an effective option?

Chan KT, Wong EC, Law CW, Chong HM, McPherson B.

Int J Pediatr Otorhinolaryngol. 2015 Nov;79(11):1920-5. doi: 10.1016/j.ijporl.2015.09.008. Epub 2015 Sep 24.


14-3-3σ confers cisplatin resistance in esophageal squamous cell carcinoma cells via regulating DNA repair molecules.

Lai KK, Chan KT, Choi MY, Wang HK, Fung EY, Lam HY, Tan W, Tung LN, Tong DK, Sun RW, Lee NP, Law S.

Tumour Biol. 2016 Feb;37(2):2127-36. doi: 10.1007/s13277-015-4018-6. Epub 2015 Sep 8.


Expectations Among Academic Clinicians of Inpatient Imaging Turnaround Time: Does it Correlate with Satisfaction?

Chan KT, Carroll T, Linnau KF, Lehnert B.

Acad Radiol. 2015 Nov;22(11):1449-56. doi: 10.1016/j.acra.2015.06.019. Epub 2015 Aug 24.


Oxidative Stress and Plasma Membrane Repair in Single Myoblasts After Femtosecond Laser Photoporation.

Duan X, Chan KT, Lee KK, Mak AF.

Ann Biomed Eng. 2015 Nov;43(11):2735-44. doi: 10.1007/s10439-015-1341-4. Epub 2015 May 27.


IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.

Carson CC, Moschos SJ, Edmiston SN, Darr DB, Nikolaishvili-Feinberg N, Groben PA, Zhou X, Kuan PF, Pandey S, Chan KT, Jordan JL, Hao H, Frank JS, Hopkinson DA, Gibbs DC, Alldredge VD, Parrish E, Hanna SC, Berkowitz P, Rubenstein DS, Miller CR, Bear JE, Ollila DW, Sharpless NE, Conway K, Thomas NE.

Clin Cancer Res. 2015 May 1;21(9):2167-76. doi: 10.1158/1078-0432.CCR-14-1826.

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