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Active generation and magnetic actuation of microrobotic swarms in bio-fluids.

Yu J, Jin D, Chan KF, Wang Q, Yuan K, Zhang L.

Nat Commun. 2019 Dec 10;10(1):5631. doi: 10.1038/s41467-019-13576-6.


Imaging and quantifying drug delivery in skin - Part 1: Autoradiography and mass spectrometry imaging.

Grégoire S, Luengo GS, Hallegot P, Pena AM, Chen X, Bornschlögl T, Chan KF, Pence I, Obeidy P, Feizpour A, Jeong S, Evans CL.

Adv Drug Deliv Rev. 2019 Nov 26. pii: S0169-409X(19)30207-8. doi: 10.1016/j.addr.2019.11.004. [Epub ahead of print] Review.


Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs.

Xia X, Chan KF, Wong GTY, Wang P, Liu L, Yeung BPM, Ng EKW, Lau JYW, Chiu PWY.

Sci Transl Med. 2019 Oct 30;11(516). pii: eaat7455. doi: 10.1126/scitranslmed.aat7455.


Topical minocycline formulations: Evaluation and comparison of dermal uptake efficacy.

Lac D, Hermsmeier M, Chen X, Yam N, Yamamoto A, Huang S, Sawant T, Chan KF, Nagavarapu U.

Int J Pharm X. 2019 Mar 1;1:100009. doi: 10.1016/j.ijpx.2019.100009. eCollection 2019 Dec.


Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.

Zhu X, Wong ILK, Chan KF, Cui J, Law MC, Chong TC, Hu X, Chow LMC, Chan TH.

J Med Chem. 2019 Sep 26;62(18):8578-8608. doi: 10.1021/acs.jmedchem.9b00963. Epub 2019 Sep 12.


Phenol-Soluble-Modulin-Inspired Amphipathic Peptides Have Bactericidal Activity against Multidrug-Resistant Bacteria.

Zeng P, Xu C, Cheng Q, Liu J, Gao W, Yang X, Wong KY, Chen S, Chan KF.

ChemMedChem. 2019 Aug 20;14(16):1547-1559. doi: 10.1002/cmdc.201900364. Epub 2019 Jul 30.


First Use of Optical Coherence Tomography on In Vivo Inflammatory Acne-Like Lesions: A Murine Model.

Hermsmeier M, Sawant T, Chowdhury K, Nagavarapu U, Chan KF.

Lasers Surg Med. 2019 Jul 25. doi: 10.1002/lsm.23140. [Epub ahead of print]


On-Demand Coalescence and Splitting of Liquid Marbles and Their Bioapplications.

Wang B, Chan KF, Ji F, Wang Q, Chiu PWY, Guo Z, Zhang L.

Adv Sci (Weinh). 2019 Mar 14;6(10):1802033. doi: 10.1002/advs.201802033. eCollection 2019 May 17.


Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics.

Lin PC, Chan KF, Kiess IA, Tan J, Shahreel W, Wong SY, Song Z.

MAbs. 2019 Jul;11(5):965-976. doi: 10.1080/19420862.2019.1612690. Epub 2019 Jun 4.


Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing.

Tsang CC, Tang JYM, Chan KF, Lee CY, Chan JFW, Ngan AHY, Cheung M, Lau ECL, Li X, Ng RHY, Lai CKC, Fung KSC, Lau SKP, Woo PCY.

Emerg Microbes Infect. 2019;8(1):531-541. doi: 10.1080/22221751.2019.1598781.


Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of C. diff toxins.

Zhang Y, Zhang L, Yang L, Vong CI, Chan KF, Wu WKK, Kwong TNY, Lo NWS, Ip M, Wong SH, Sung JJY, Chiu PWY, Zhang L.

Sci Adv. 2019 Jan 11;5(1):eaau9650. doi: 10.1126/sciadv.aau9650. eCollection 2019 Jan.


Perspective: The promises of a holistic view of proteins-impact on antibody engineering and drug discovery.

Phua SX, Chan KF, Su CT, Poh JJ, Gan SK.

Biosci Rep. 2019 Jan 30;39(1). pii: BSR20181958. doi: 10.1042/BSR20181958. Print 2019 Jan 31.


Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.

Lui HK, Gao W, Cheung KC, Jin WB, Sun N, Kan JWY, Wong ILK, Chiou J, Lin D, Chan EWC, Leung YC, Chan TH, Chen S, Chan KF, Wong KY.

Eur J Med Chem. 2019 Feb 1;163:95-115. doi: 10.1016/j.ejmech.2018.11.052. Epub 2018 Nov 24.


Characterization of human cutaneous tissue autofluorescence: implications in topical drug delivery studies with fluorescence microscopy.

Hermsmeier M, Jeong S, Yamamoto A, Chen X, Nagavarapu U, Evans CL, Chan KF.

Biomed Opt Express. 2018 Oct 12;9(11):5400-5418. doi: 10.1364/BOE.9.005400. eCollection 2018 Nov 1.


Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".

Wong ILK, Zhu X, Chan KF, Law MC, Lo AMY, Hu X, Chow LMC, Chan TH.

J Med Chem. 2018 Nov 21;61(22):9931-9951. doi: 10.1021/acs.jmedchem.8b00834. Epub 2018 Nov 1.


Design, synthesis and antibacterial evaluation of 2,4-disubstituted-6-thiophenyl-pyrimidines.

Fang Z, Zheng S, Chan KF, Yuan W, Guo Q, Wu W, Lui HK, Lu Y, Leung YC, Chan TH, Wong KY, Sun N.

Eur J Med Chem. 2019 Jan 1;161:141-153. doi: 10.1016/j.ejmech.2018.10.039. Epub 2018 Oct 17.


Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors.

Chan KF, Sun N, Yan SC, Wong ILK, Lui HK, Cheung KC, Yuan J, Chan FY, Zheng Z, Chan EWC, Chen S, Leung YC, Chan TH, Wong KY.

ACS Omega. 2017 Oct 31;2(10):7281-7292. doi: 10.1021/acsomega.7b00701. Epub 2017 Oct 27.


Visualization of drug distribution of a topical minocycline gel in human facial skin.

Jeong S, Hermsmeier M, Osseiran S, Yamamoto A, Nagavarapu U, Chan KF, Evans CL.

Biomed Opt Express. 2018 Jun 27;9(7):3434-3448. doi: 10.1364/BOE.9.003434. eCollection 2018 Jul 1.


Safety, immunogenicity and protection of A(H3N2) live attenuated influenza vaccines containing wild-type nucleoprotein in a ferret model.

Korenkov DA, Laurie KL, Reading PC, Carolan LA, Chan KF, Isakova-Sivak II, Smolonogina TA, Subbarao K, Barr IG, Villanueva J, Shcherbik S, Bousse T, Rudenko LG.

Infect Genet Evol. 2018 Oct;64:95-104. doi: 10.1016/j.meegid.2018.06.019. Epub 2018 Jun 19.


Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1.

Jin WB, Xu C, Cheng Q, Qi XL, Gao W, Zheng Z, Chan EWC, Leung YC, Chan TH, Wong KY, Chen S, Chan KF.

Eur J Med Chem. 2018 Jul 15;155:285-302. doi: 10.1016/j.ejmech.2018.06.007. Epub 2018 Jun 6.


Investigating Viral Interference Between Influenza A Virus and Human Respiratory Syncytial Virus in a Ferret Model of Infection.

Chan KF, Carolan LA, Korenkov D, Druce J, McCaw J, Reading PC, Barr IG, Laurie KL.

J Infect Dis. 2018 Jul 2;218(3):406-417. doi: 10.1093/infdis/jiy184.


The "less-is-more" in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity.

Pereira NA, Chan KF, Lin PC, Song Z.

MAbs. 2018 Jul;10(5):693-711. doi: 10.1080/19420862.2018.1466767. Review.


Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells.

Kang H, Jung HJ, Wong DSH, Kim SK, Lin S, Chan KF, Zhang L, Li G, Dravid VP, Bian L.

J Am Chem Soc. 2018 May 9;140(18):5909-5913. doi: 10.1021/jacs.8b03001. Epub 2018 Apr 27.


Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay.

Wernery U, Tsang CC, Hebel C, Damerau A, Kinne J, Cai JP, Küspert H, Chan KF, Joseph M, Xue S, Raghavan R, Tang JYM, Syriac G, Lau SKP, Jose S, Woo PCY.

Mycoses. 2018 Aug;61(8):600-609. doi: 10.1111/myc.12776. Epub 2018 Jun 20.


Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.

Chan KF, Gully BS, Gras S, Beringer DX, Kjer-Nielsen L, Cebon J, McCluskey J, Chen W, Rossjohn J.

Nat Commun. 2018 Mar 12;9(1):1026. doi: 10.1038/s41467-018-03321-w.


Tumor budding and poorly-differentiated cluster in prognostication in Stage II colon cancer.

Lee VWK, Chan KF.

Pathol Res Pract. 2018 Mar;214(3):402-407. doi: 10.1016/j.prp.2017.12.019. Epub 2018 Jan 2.


Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages.

Laurie KL, Horman W, Carolan LA, Chan KF, Layton D, Bean A, Vijaykrishna D, Reading PC, McCaw JM, Barr IG.

J Infect Dis. 2018 Jan 30;217(4):548-559. doi: 10.1093/infdis/jix509.


Pathogenesis, Humoral Immune Responses, and Transmission between Cohoused Animals in a Ferret Model of Human Respiratory Syncytial Virus Infection.

Chan KF, Carolan LA, Druce J, Chappell K, Watterson D, Young P, Korenkov D, Subbarao K, Barr IG, Laurie KL, Reading PC.

J Virol. 2018 Jan 30;92(4). pii: e01322-17. doi: 10.1128/JVI.01322-17. Print 2018 Feb 15.


Modified Penicillin Molecule with Carbapenem-Like Stereochemistry Specifically Inhibits Class C β-Lactamases.

Pan X, He Y, Chen T, Chan KF, Zhao Y.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01288-17. doi: 10.1128/AAC.01288-17. Print 2017 Dec.


PD-L1 expression and tumor infiltrating PD-1+ lymphocytes associated with outcome in HER2+ breast cancer patients.

Tsang JY, Au WL, Lo KY, Ni YB, Hlaing T, Hu J, Chan SK, Chan KF, Cheung SY, Tse GM.

Breast Cancer Res Treat. 2017 Feb;162(1):19-30. doi: 10.1007/s10549-016-4095-2. Epub 2017 Jan 5.


Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.

Dury L, Nasr R, Lorendeau D, Comsa E, Wong I, Zhu X, Chan KF, Chan TH, Chow L, Falson P, Di Pietro A, Baubichon-Cortay H.

Biochem Pharmacol. 2017 Jan 15;124:10-18. doi: 10.1016/j.bcp.2016.10.013. Epub 2016 Oct 28.


Comprehensive characterization of the patient-derived xenograft and the paralleled primary hepatocellular carcinoma cell line.

Cheung PF, Yip CW, Ng LW, Lo KW, Chow C, Chan KF, Cheung TT, Cheung ST.

Cancer Cell Int. 2016 Jun 8;16:41. doi: 10.1186/s12935-016-0322-5. eCollection 2016.


Hyaluronan synthase 2 is an adverse prognostic marker in androgen receptor-negative breast cancer.

Zhang H, Tsang JY, Ni YB, Chan SK, Chan KF, Cheung SY, Tse GM.

J Clin Pathol. 2016 Dec;69(12):1055-1062. doi: 10.1136/jclinpath-2016-203617. Epub 2016 May 11.


A randomized controlled trial of a Return-to-Work Coordinator model of care in a general hospital to facilitate return to work of injured workers.

Tan HS, Yeo DS, Giam JY, Cheong FW, Chan KF.

Work. 2016 Apr 7;54(1):209-22. doi: 10.3233/WOR-162288.


FGFR1 is an adverse outcome indicator for luminal A breast cancers.

Shi YJ, Tsang JY, Ni YB, Chan SK, Chan KF, Tse GM.

Oncotarget. 2016 Jan 26;7(4):5063-73. doi: 10.18632/oncotarget.6563.


Doublecortin-like kinase 1 expression associates with breast cancer with neuroendocrine differentiation.

Liu YH, Tsang JY, Ni YB, Hlaing T, Chan SK, Chan KF, Ko CW, Mujtaba SS, Tse GM.

Oncotarget. 2016 Jan 12;7(2):1464-76. doi: 10.18632/oncotarget.6386.


Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast.

Chen LY, Tsang JY, Ni YB, Chan SK, Chan KF, Zhang S, Tse GM.

J Clin Pathol. 2016 Jun;69(6):527-32. doi: 10.1136/jclinpath-2015-203334. Epub 2015 Nov 18.


Fabrication of graphene/gold-modified screen-printed electrode for detection of carcinoembryonic antigen.

Chan KF, Lim HN, Shams N, Jayabal S, Pandikumar A, Huang NM.

Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:666-74. doi: 10.1016/j.msec.2015.09.010. Epub 2015 Sep 7.


Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies.

Chan KF, Shahreel W, Wan C, Teo G, Hayati N, Tay SJ, Tong WH, Yang Y, Rudd PM, Zhang P, Song Z.

Biotechnol J. 2016 Mar;11(3):399-414. doi: 10.1002/biot.201500331. Epub 2015 Dec 11.


A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.

Yan CS, Wong IL, Chan KF, Kan JW, Chong TC, Law MC, Zhao Y, Chan SW, Chan TH, Chow LM.

Mol Pharm. 2015 Oct 5;12(10):3507-17. doi: 10.1021/mp500770e. Epub 2015 Aug 27.


IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling.

Phoon YP, Cheung AK, Cheung FM, Chan KF, Wong S, Wong BW, Tung SY, Yau CC, Ng WT, Lung ML.

Int J Cancer. 2016 Jan 1;138(1):160-70. doi: 10.1002/ijc.29702. Epub 2015 Aug 10.


Production of Highly Sialylated Recombinant Glycoproteins Using Ricinus communis Agglutinin-I-Resistant CHO Glycosylation Mutants.

Goh JS, Chan KF, Song Z.

Methods Mol Biol. 2015;1321:323-33. doi: 10.1007/978-1-4939-2760-9_22.


Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).

Chiou J, Wan S, Chan KF, So PK, He D, Chan EW, Chan TH, Wong KY, Tao J, Chen S.

Chem Commun (Camb). 2015 Jun 11;51(46):9543-6. doi: 10.1039/c5cc02594j.


Elucidating the prognostic significance of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese patients with metastatic colorectal cancer.

Ma BB, Mo F, Tong JH, Wong A, Wong SC, Ho WM, Wu C, Lam PW, Chan KF, Chan TS, Tsui WM, Tsang AK, Fung MN, Chan AT, To KF.

Asia Pac J Clin Oncol. 2015 Jun;11(2):160-9. doi: 10.1111/ajco.12342. Epub 2015 Apr 13.


Bcl2 and Ki67 refine prognostication in luminal breast cancers.

Chen LY, Tsang JY, Ni YB, Chan SK, Chan KF, Zhang S, Tse GM.

Breast Cancer Res Treat. 2015 Feb;149(3):631-43. doi: 10.1007/s10549-015-3288-4. Epub 2015 Feb 4.


Establishment and characterization of a novel primary hepatocellular carcinoma cell line with metastatic ability in vivo.

Cheung PF, Yip CW, Ng LW, Lo KW, Wong N, Choy KW, Chow C, Chan KF, Cheung TT, Poon RT, Fan ST, Cheung ST.

Cancer Cell Int. 2014 Oct 9;14(1):103. doi: 10.1186/s12935-014-0103-y. eCollection 2014.


Antibody against granulin-epithelin precursor sensitizes hepatocellular carcinoma to chemotherapeutic agents.

Wong NC, Cheung PF, Yip CW, Chan KF, Ng IO, Fan ST, Cheung ST.

Mol Cancer Ther. 2014 Dec;13(12):3001-12. doi: 10.1158/1535-7163.MCT-14-0012. Epub 2014 Sep 24.


Producing recombinant therapeutic glycoproteins with enhanced sialylation using CHO-gmt4 glycosylation mutant cells.

Goh JS, Liu Y, Chan KF, Wan C, Teo G, Zhang P, Zhang Y, Song Z.

Bioengineered. 2014 Jul-Aug;5(4):269–73. doi: 10.4161/bioe.29490. Epub 2014 Jun 9.


Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors.

Wang Y, Chan FY, Sun N, Lui HK, So PK, Yan SC, Chan KF, Chiou J, Chen S, Abagyan R, Leung YC, Wong KY.

Chem Biol Drug Des. 2014 Dec;84(6):685-96. doi: 10.1111/cbdd.12361. Epub 2014 Aug 14.


Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity.

Sun N, Chan FY, Lu YJ, Neves MA, Lui HK, Wang Y, Chow KY, Chan KF, Yan SC, Leung YC, Abagyan R, Chan TH, Wong KY.

PLoS One. 2014 May 13;9(5):e97514. doi: 10.1371/journal.pone.0097514. eCollection 2014.

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