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Items: 1 to 50 of 100

1.

Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.

Bradshaw EL, Spilker ME, Zang R, Bansal L, He H, DO Jones R, Le K, Penney M, Schuck E, Topp B, Tsai A, Xu C, J M A Nijsen M, Chan JR.

CPT Pharmacometrics Syst Pharmacol. 2019 Sep 19. doi: 10.1002/psp4.12463. [Epub ahead of print]

2.

Breaking Molecular Nitrogen under Mild Conditions with an Atomically Clean Lanthanide Surface.

Ullstad F, Bioletti G, Chan JR, Proust A, Bodin C, Ruck BJ, Trodahl J, Natali F.

ACS Omega. 2019 Mar 28;4(3):5950-5954. doi: 10.1021/acsomega.9b00293. eCollection 2019 Mar 31.

3.

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7.

Harty BL, Coelho F, Pease-Raissi SE, Mogha A, Ackerman SD, Herbert AL, Gereau RW 4th, Golden JP, Lyons DA, Chan JR, Monk KR.

Nat Commun. 2019 Jul 5;10(1):2976. doi: 10.1038/s41467-019-10881-y.

4.

A surprising role for myelin in Williams syndrome.

Osso LA, Chan JR.

Nat Neurosci. 2019 May;22(5):681-683. doi: 10.1038/s41593-019-0368-5. No abstract available.

PMID:
31011225
5.

Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.

Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ.

Nat Neurosci. 2019 May;22(5):709-718. doi: 10.1038/s41593-019-0369-4. Epub 2019 Apr 15.

6.

A Flexible Approach for Context-Dependent Assessment of Quantitative Systems Pharmacology Models.

Ramanujan S, Chan JR, Friedrich CM, Thalhauser CJ.

CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):340-343. doi: 10.1002/psp4.12409. Epub 2019 May 14. No abstract available.

7.

Incorporating Placebo Response in Quantitative Systems Pharmacology Models.

Wang EB, Shen L, Heathman M, Chan JR.

CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):344-346. doi: 10.1002/psp4.12412. Epub 2019 Jun 9. No abstract available.

8.

Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors.

Rankin KA, Mei F, Kim K, Shen YA, Mayoral SR, Desponts C, Lorrain DS, Green AJ, Baranzini SE, Chan JR, Bove R.

J Neurosci. 2019 Mar 20;39(12):2184-2194. doi: 10.1523/JNEUROSCI.1530-18.2019. Epub 2019 Jan 29.

9.

Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber.

Mayoral SR, Etxeberria A, Shen YA, Chan JR.

Cell Rep. 2018 Oct 16;25(3):544-550.e3. doi: 10.1016/j.celrep.2018.09.052.

10.

Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia.

Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ, Xiao L, Chan JR, Mei F.

Neuron. 2018 Aug 22;99(4):689-701.e5. doi: 10.1016/j.neuron.2018.07.017. Epub 2018 Aug 2.

11.

The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner.

Jiang M, Rao R, Wang J, Wang J, Xu L, Wu LM, Chan JR, Wang H, Lu QR.

Glia. 2018 Sep;66(9):1947-1959. doi: 10.1002/glia.23449. Epub 2018 May 3.

12.

Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand.

Almeida RG, Pan S, Cole KLH, Williamson JM, Early JJ, Czopka T, Klingseisen A, Chan JR, Lyons DA.

Curr Biol. 2018 Apr 23;28(8):1296-1305.e5. doi: 10.1016/j.cub.2018.02.068. Epub 2018 Apr 5.

13.

Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.

Nijsen MJMA, Wu F, Bansal L, Bradshaw-Pierce E, Chan JR, Liederer BM, Mettetal JT, Schroeder P, Schuck E, Tsai A, Xu C, Chimalakonda A, Le K, Penney M, Topp B, Yamada A, Spilker ME.

CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):135-146. doi: 10.1002/psp4.12282. Epub 2018 Feb 1. Review.

14.

Micro(glial)-managing executive function: white matter inflammation drives catatonia.

Pease-Raissi SE, Chan JR.

J Clin Invest. 2018 Feb 1;128(2):564-566. doi: 10.1172/JCI98761. Epub 2017 Dec 18.

15.

Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.

Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ.

Brain. 2018 Jan 1;141(1):85-98. doi: 10.1093/brain/awx312.

16.

Regulation and dysregulation of axon infrastructure by myelinating glia.

Pan S, Chan JR.

J Cell Biol. 2017 Dec 4;216(12):3903-3916. doi: 10.1083/jcb.201702150. Epub 2017 Nov 7. Review.

17.

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K.

Neuron. 2017 Dec 6;96(5):1003-1012.e7. doi: 10.1016/j.neuron.2017.10.008. Epub 2017 Nov 2.

18.

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial.

Green AJ, Gelfand JM, Cree BA, Bevan C, Boscardin WJ, Mei F, Inman J, Arnow S, Devereux M, Abounasr A, Nobuta H, Zhu A, Friessen M, Gerona R, von Büdingen HC, Henry RG, Hauser SL, Chan JR.

Lancet. 2017 Dec 2;390(10111):2481-2489. doi: 10.1016/S0140-6736(17)32346-2. Epub 2017 Oct 10.

19.

Mechanical plasticity during oligodendrocyte differentiation and myelination.

Domingues HS, Cruz A, Chan JR, Relvas JB, Rubinstein B, Pinto IM.

Glia. 2018 Jan;66(1):5-14. doi: 10.1002/glia.23206. Epub 2017 Sep 21. Review.

20.

Architecting the myelin landscape.

Osso LA, Chan JR.

Curr Opin Neurobiol. 2017 Dec;47:1-7. doi: 10.1016/j.conb.2017.06.005. Epub 2017 Jul 11. Review.

21.

Regulatory T cells promote myelin regeneration in the central nervous system.

Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC.

Nat Neurosci. 2017 May;20(5):674-680. doi: 10.1038/nn.4528. Epub 2017 Mar 13.

22.

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery.

Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR.

Elife. 2016 Sep 27;5. pii: e18246. doi: 10.7554/eLife.18246.

23.

Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.

Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E, Chan JR.

Neuron. 2016 Aug 17;91(4):824-836. doi: 10.1016/j.neuron.2016.07.021. Epub 2016 Aug 4.

24.

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.

Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR.

J Neurosci. 2016 Jul 27;36(30):7925-35. doi: 10.1523/JNEUROSCI.1493-16.2016.

25.

Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity.

Etxeberria A, Hokanson KC, Dao DQ, Mayoral SR, Mei F, Redmond SA, Ullian EM, Chan JR.

J Neurosci. 2016 Jun 29;36(26):6937-48. doi: 10.1523/JNEUROSCI.0908-16.2016.

26.

Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.

Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ.

Neuron. 2016 Jul 6;91(1):41-55. doi: 10.1016/j.neuron.2016.05.021. Epub 2016 Jun 16.

27.

Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination.

Wu LM, Wang J, Conidi A, Zhao C, Wang H, Ford Z, Zhang L, Zweier C, Ayee BG, Maurel P, Zwijsen A, Chan JR, Jankowski MP, Huylebroeck D, Lu QR.

Nat Neurosci. 2016 Aug;19(8):1060-72. doi: 10.1038/nn.4322. Epub 2016 Jun 13.

28.

The environment rules: spatiotemporal regulation of oligodendrocyte differentiation.

Mayoral SR, Chan JR.

Curr Opin Neurobiol. 2016 Aug;39:47-52. doi: 10.1016/j.conb.2016.04.002. Epub 2016 Apr 26. Review.

29.

Remodeling myelination: implications for mechanisms of neural plasticity.

Chang KJ, Redmond SA, Chan JR.

Nat Neurosci. 2016 Feb;19(2):190-7. doi: 10.1038/nn.4200. Review.

30.

Oligodendrocyte precursors migrate along vasculature in the developing nervous system.

Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP.

Science. 2016 Jan 22;351(6271):379-84. doi: 10.1126/science.aad3839.

31.

Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes.

Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, Casaccia P.

J Neurosci. 2016 Jan 20;36(3):806-13. doi: 10.1523/JNEUROSCI.2873-15.2016.

32.

Astrocytes Underlie Neuroinflammatory Memory Impairment.

Osso LA, Chan JR.

Cell. 2015 Dec 17;163(7):1574-6. doi: 10.1016/j.cell.2015.12.001.

33.

Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor.

Burns ML, Malott TM, Metcalf KJ, Puguh A, Chan JR, Shusta EV.

Biotechnol J. 2016 Mar;11(3):425-36. doi: 10.1002/biot.201500360. Epub 2015 Dec 9.

PMID:
26580314
34.

The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.

von Büdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan JR.

J Cell Biol. 2015 Sep 14;210(6):891-8.

35.

Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent.

Shen YA, Chen Y, Dao DQ, Mayoral SR, Wu L, Meijer D, Ullian EM, Chan JR, Lu QR.

Nat Commun. 2014 Sep 26;5:4991. doi: 10.1038/ncomms5991.

36.

Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae.

Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan JR, Shusta EV.

Appl Environ Microbiol. 2014 Sep;80(18):5732-42. doi: 10.1128/AEM.01466-14. Epub 2014 Jul 11.

37.

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.

Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJM, Green A, Hauser SL, Chan JR.

Nat Med. 2014 Aug;20(8):954-960. doi: 10.1038/nm.3618. Epub 2014 Jul 6.

38.

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.

Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH.

Nature. 2014 May 8;509(7499):189-94. doi: 10.1038/nature13161. Epub 2014 Apr 28.

39.

Multiple sclerosis: Prospects and promise.

Hauser SL, Chan JR, Oksenberg JR.

Ann Neurol. 2013 Sep;74(3):317-27. doi: 10.1002/ana.24009. Review.

PMID:
23955638
40.

Alternate virtual populations elucidate the type I interferon signature predictive of the response to rituximab in rheumatoid arthritis.

Schmidt BJ, Casey FP, Paterson T, Chan JR.

BMC Bioinformatics. 2013 Jul 10;14:221. doi: 10.1186/1471-2105-14-221.

41.

Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes.

Mei F, Wang H, Liu S, Niu J, Wang L, He Y, Etxeberria A, Chan JR, Xiao L.

J Neurosci. 2013 May 8;33(19):8454-62. doi: 10.1523/JNEUROSCI.2453-12.2013.

42.

A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers.

Lee S, Chong SY, Tuck SJ, Corey JM, Chan JR.

Nat Protoc. 2013 Apr;8(4):771-82.

43.

Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration.

Mei F, Christin Chong SY, Chan JR.

Neurosci Bull. 2013 Apr;29(2):177-88. doi: 10.1007/s12264-013-1319-x. Epub 2013 Mar 20. Review.

44.

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.

Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR.

Cell. 2013 Jan 17;152(1-2):248-61. doi: 10.1016/j.cell.2012.12.006.

45.

Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.

Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan JR, Tsujimoto G, Tanoue A.

Sci Signal. 2012 Sep 25;5(243):ra69.

46.

A culture system to study oligodendrocyte myelination processes using engineered nanofibers.

Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR.

Nat Methods. 2012 Sep;9(9):917-22. doi: 10.1038/nmeth.2105. Epub 2012 Jul 15.

47.

Neuroscience. Revitalizing remyelination--the answer is circulating.

Redmond SA, Chan JR.

Science. 2012 Apr 13;336(6078):161-2. doi: 10.1126/science.1221689. No abstract available.

PMID:
22499927
48.

Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3.

Mamchak AA, Manenkova Y, Leconet W, Zheng Y, Chan JR, Stokes CL, Shoda LK, von Herrath M, Bresson D.

Diabetes. 2012 Jun;61(6):1490-9. doi: 10.2337/db11-1304. Epub 2012 Feb 23.

49.

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.

Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1299-304. doi: 10.1073/pnas.1113540109. Epub 2011 Dec 12.

50.

Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.

Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO.

J Biol Chem. 2012 Jan 6;287(2):1600-8. doi: 10.1074/jbc.M111.312736. Epub 2011 Nov 29.

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