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Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial.

Mullane KM, Morrison VA, Camacho LH, Arvin A, McNeil SA, Durrand J, Campbell B, Su SC, Chan ISF, Parrino J, Kaplan SS, Popmihajlov Z, Annunziato PW; V212 Protocol 011 Trial Team.

Lancet Infect Dis. 2019 Sep;19(9):1001-1012. doi: 10.1016/S1473-3099(19)30310-X. Epub 2019 Aug 6. Erratum in: Lancet Infect Dis. 2019 Aug 23;:.


Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial.

Winston DJ, Mullane KM, Cornely OA, Boeckh MJ, Brown JW, Pergam SA, Trociukas I, Žák P, Craig MD, Papanicolaou GA, Velez JD, Panse J, Hurtado K, Fernsler DA, Stek JE, Pang L, Su SC, Zhao Y, Chan ISF, Kaplan SS, Parrino J, Lee I, Popmihajlov Z, Annunziato PW, Arvin A; V212 Protocol 001 Trial Team.

Lancet. 2018 May 26;391(10135):2116-2127. doi: 10.1016/S0140-6736(18)30631-7. Epub 2018 May 24.


Immunotherapy for Merkel cell carcinoma: a turning point in patient care.

Chan IS, Bhatia S, Kaufman HL, Lipson EJ.

J Immunother Cancer. 2018 Mar 23;6(1):23. doi: 10.1186/s40425-018-0335-9.


Perspective of Taiwan's experience in the management of meconium peritonitis.

Lin YS, Yeh CC, Chang WH, Chan IS, Lin CY, Wang PH.

Taiwan J Obstet Gynecol. 2017 Oct;56(5):709-710. doi: 10.1016/j.tjog.2017.08.024. No abstract available.


Safety and immunogenicity of inactivated varicella-zoster virus vaccine in adults with hematologic malignancies receiving treatment with anti-CD20 monoclonal antibodies.

Parrino J, McNeil SA, Lawrence SJ, Kimby E, Pagnoni MF, Stek JE, Zhao Y, Chan IS, Kaplan SS.

Vaccine. 2017 Mar 27;35(14):1764-1769. doi: 10.1016/j.vaccine.2016.10.055. Epub 2017 Mar 3.


An Acquired Factor X Inhibitor: The Importance of Understanding Coagulation.

Chan IS, Ogunsile FJ.

Am J Med. 2017 Jul;130(7):e307-e308. doi: 10.1016/j.amjmed.2017.01.046. Epub 2017 Feb 24. No abstract available.


Delayed Diagnosis of Disseminated Cryptococcosis with Associated Meningoencephalitis in an Immunocompetent Septuagenarian Host.

Chan IS, Chudasama R, Burrows AB.

Am J Med. 2017 Jan;130(1):e31-e32. doi: 10.1016/j.amjmed.2016.05.044. Epub 2016 Aug 24. No abstract available.


Surrogate Endpoint Evaluation: Principal Stratification Criteria and the Prentice Definition.

Gilbert PB, Gabriel EE, Huang Y, Chan IS.

J Causal Inference. 2015 Sep 1;3(2):157-175. Epub 2015 Feb 1.


Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Pereira TA, Syn WK, Machado MV, Vidigal PV, Resende V, Voieta I, Xie G, Otoni A, Souza MM, Santos ET, Chan IS, Trindade GV, Choi SS, Witek RP, Pereira FE, Secor WE, Andrade ZA, Lambertucci JR, Diehl AM.

Clin Sci (Lond). 2015 Nov;129(10):875-83. doi: 10.1042/CS20150117. Epub 2015 Jul 21.


Reply to Dunning.

Gilbert PB, Gabriel EE, Hudgens MG, Miao X, Li X, Su SC, Parrino J, Chan IS.

J Infect Dis. 2015 Nov 1;212(9):1521-3. doi: 10.1093/infdis/jiv287. Epub 2015 May 17. No abstract available.


A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women.

Joura EA, Giuliano AR, Iversen OE, Bouchard C, Mao C, Mehlsen J, Moreira ED Jr, Ngan Y, Petersen LK, Lazcano-Ponce E, Pitisuttithum P, Restrepo JA, Stuart G, Woelber L, Yang YC, Cuzick J, Garland SM, Huh W, Kjaer SK, Bautista OM, Chan IS, Chen J, Gesser R, Moeller E, Ritter M, Vuocolo S, Luxembourg A; Broad Spectrum HPV Vaccine Study.

N Engl J Med. 2015 Feb 19;372(8):711-23. doi: 10.1056/NEJMoa1405044.


Modeling the durability of ZOSTAVAX® vaccine efficacy in people ≥60 years of age.

Li X, Zhang JH, Betts RF, Morrison VA, Xu R, Itzler RF, Acosta CJ, Dasbach EJ, Pellissier JM, Johnson GR, Chan IS.

Vaccine. 2015 Mar 17;33(12):1499-505. doi: 10.1016/j.vaccine.2014.10.039. Epub 2014 Nov 6.


Long-term persistence of zoster vaccine efficacy.

Morrison VA, Johnson GR, Schmader KE, Levin MJ, Zhang JH, Looney DJ, Betts R, Gelb L, Guatelli JC, Harbecke R, Pachucki C, Keay S, Menzies B, Griffin MR, Kauffman CA, Marques A, Toney J, Boardman K, Su SC, Li X, Chan IS, Parrino J, Annunziato P, Oxman MN; Shingles Prevention Study Group.

Clin Infect Dis. 2015 Mar 15;60(6):900-9. doi: 10.1093/cid/ciu918. Epub 2014 Nov 20.


Soft wearable contact lens sensor for continuous intraocular pressure monitoring.

Chen GZ, Chan IS, Leung LK, Lam DC.

Med Eng Phys. 2014 Sep;36(9):1134-9. doi: 10.1016/j.medengphy.2014.06.005. Epub 2014 Jul 15.


Fold rise in antibody titers by measured by glycoprotein-based enzyme-linked immunosorbent assay is an excellent correlate of protection for a herpes zoster vaccine, demonstrated via the vaccine efficacy curve.

Gilbert PB, Gabriel EE, Miao X, Li X, Su SC, Parrino J, Chan IS.

J Infect Dis. 2014 Nov 15;210(10):1573-81. doi: 10.1093/infdis/jiu279. Epub 2014 May 13.


Confidence-interval construction for rate ratio in matched-pair studies with incomplete data.

Li HQ, Chan IS, Tang ML, Tian GL, Tang NS.

J Biopharm Stat. 2014;24(3):546-68. doi: 10.1080/10543406.2014.888438.


Continuing bonds, attachment style, and adjustment in the conjugal bereavement among Hong Kong Chinese.

Ho SM, Chan IS, Ma EP, Field NP.

Death Stud. 2013 Mar;37(3):248-68.


Issues about home computer workstations and primary school children in Hong Kong: a pilot study.

Py Szeto G, Tsui MM, Sze WW, Chan IS, Chung CC, Lee FW.

Work. 2014;48(4):485-93. doi: 10.3233/WOR-131810.


Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.

Chan IS, Guy CD, Machado MV, Wank A, Kadiyala V, Michelotti G, Choi S, Swiderska-Syn M, Karaca G, Pereira TA, Yip-Schneider MT, Max Schmidt C, Diehl AM.

Alcohol Clin Exp Res. 2014 Mar;38(3):787-800. doi: 10.1111/acer.12279. Epub 2013 Oct 24.


Varicella-zoster virus-specific antibody responses in 50-59-year-old recipients of zoster vaccine.

Levin MJ, Schmader KE, Gnann JW, McNeil SA, Vesikari T, Betts RF, Keay S, Stek JE, Bundick ND, Su SC, Zhao Y, Li X, Chan IS, Annunziato PW, Parrino J.

J Infect Dis. 2013 Nov 1;208(9):1386-90. doi: 10.1093/infdis/jit342. Epub 2013 Aug 1.


Safety of zoster vaccine in elderly adults following documented herpes zoster.

Morrison VA, Oxman MN, Levin MJ, Schmader KE, Guatelli JC, Betts RF, Gelb LD, Pachucki CT, Keay SK, Menzies B, Griffin MR, Kauffman CA, Marques AR, Toney JF, Simberkoff MS, Serrao R, Arbeit RD, Gnann JW, Greenberg RN, Holodniy M, Keitel WA, Yeh SS, Davis LE, Crawford GE, Neuzil KM, Johnson GR, Zhang JH, Harbecke R, Chan IS, Keller PM, Williams HM, Boardman KD, Silber JL, Annunziato PW; Shingles Prevention Study Group.

J Infect Dis. 2013 Aug 15;208(4):559-63. doi: 10.1093/infdis/jit182. Epub 2013 Apr 30.


Determining the cutoff based on a continuous variable to define two populations with application to vaccines.

Li S, Parnes M, Chan IS.

J Biopharm Stat. 2013 May;23(3):662-80. doi: 10.1080/10543406.2012.756502.


Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial.

Fowler VG, Allen KB, Moreira ED, Moustafa M, Isgro F, Boucher HW, Corey GR, Carmeli Y, Betts R, Hartzel JS, Chan IS, McNeely TB, Kartsonis NA, Guris D, Onorato MT, Smugar SS, DiNubile MJ, Sobanjo-ter Meulen A.

JAMA. 2013 Apr 3;309(13):1368-78. doi: 10.1001/jama.2013.3010.


Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications.

Irwin MR, Levin MJ, Laudenslager ML, Olmstead R, Lucko A, Lang N, Carrillo C, Stanley HA, Caulfield MJ, Weinberg A, Chan IS, Clair J, Smith JG, Marchese RD, Williams HM, Beck DJ, McCook PT, Zhang JH, Johnson G, Oxman MN.

Clin Infect Dis. 2013 Apr;56(8):1085-93. doi: 10.1093/cid/cis1208. Epub 2013 Feb 13.


Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni.

Pereira TA, Xie G, Choi SS, Syn WK, Voieta I, Lu J, Chan IS, Swiderska M, Amaral KB, Antunes CM, Secor WE, Witek RP, Lambertucci JR, Pereira FL, Diehl AM.

Liver Int. 2013 Jan;33(1):149-61. doi: 10.1111/liv.12016. Epub 2012 Nov 1.


Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.

Chan IS, Guy CD, Chen Y, Lu J, Swiderska-Syn M, Michelotti GA, Karaca G, Xie G, Krüger L, Syn WK, Anderson BR, Pereira TA, Choi SS, Baldwin AS, Diehl AM.

Cancer Res. 2012 Dec 15;72(24):6344-50. doi: 10.1158/0008-5472.CAN-12-1068. Epub 2012 Oct 12.


Hedgehog controls hepatic stellate cell fate by regulating metabolism.

Chen Y, Choi SS, Michelotti GA, Chan IS, Swiderska-Syn M, Karaca GF, Xie G, Moylan CA, Garibaldi F, Premont R, Suliman HB, Piantadosi CA, Diehl AM.

Gastroenterology. 2012 Nov;143(5):1319-1329.e11. doi: 10.1053/j.gastro.2012.07.115. Epub 2012 Aug 8.


The bZIP dimer localizes at DNA full-sites where each basic region can alternately translocate and bind to subsites at the half-site.

Chan IS, Al-Sarraj T, Shahravan SH, Fedorova AV, Shin JA.

Biochemistry. 2012 Aug 21;51(33):6632-43. doi: 10.1021/bi300718f. Epub 2012 Aug 10.


Persistence of the efficacy of zoster vaccine in the shingles prevention study and the short-term persistence substudy.

Schmader KE, Oxman MN, Levin MJ, Johnson G, Zhang JH, Betts R, Morrison VA, Gelb L, Guatelli JC, Harbecke R, Pachucki C, Keay S, Menzies B, Griffin MR, Kauffman C, Marques A, Toney J, Keller PM, Li X, Chan IS, Annunziato P; Shingles Prevention Study Group.

Clin Infect Dis. 2012 Nov 15;55(10):1320-8. doi: 10.1093/cid/cis638. Epub 2012 Jul 24.


Varicella-zoster virus-specific enzyme-linked immunospot assay responses and zoster-associated pain in herpes zoster subjects.

Tyring SK, Stek JE, Smith JG, Xu J, Pagnoni M, Chan IS, Silber JL, Parrino J, Levin MJ.

Clin Vaccine Immunol. 2012 Sep;19(9):1411-5. doi: 10.1128/CVI.00095-12. Epub 2012 Jul 11.


NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.

Syn WK, Agboola KM, Swiderska M, Michelotti GA, Liaskou E, Pang H, Xie G, Philips G, Chan IS, Karaca GF, Pereira Tde A, Chen Y, Mi Z, Kuo PC, Choi SS, Guy CD, Abdelmalek MF, Diehl AM.

Gut. 2012 Sep;61(9):1323-9. doi: 10.1136/gutjnl-2011-301857. Epub 2012 Mar 17.


Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation.

Xie G, Choi SS, Syn WK, Michelotti GA, Swiderska M, Karaca G, Chan IS, Chen Y, Diehl AM.

Gut. 2013 Feb;62(2):299-309. doi: 10.1136/gutjnl-2011-301494. Epub 2012 Feb 23.


Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years.

Schmader KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, Betts RF, Keay S, Stek JE, Bundick ND, Su SC, Zhao Y, Li X, Chan IS, Annunziato PW, Parrino J.

Clin Infect Dis. 2012 Apr;54(7):922-8. doi: 10.1093/cid/cir970. Epub 2012 Jan 30.


Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults ≥60 years of age.

Vermeulen JN, Lange JM, Tyring SK, Peters PH, Nunez M, Poland G, Levin MJ, Freeman C, Chalikonda I, Li J, Smith JG, Caulfield MJ, Stek JE, Chan IS, Vessey R, Schödel FP, Annunziato PW, Schlienger K, Silber JL.

Vaccine. 2012 Jan 20;30(5):904-10. doi: 10.1016/j.vaccine.2011.11.096. Epub 2011 Dec 7.


Safety and tolerability of zoster vaccine in adults ≥60 years old.

Murray AV, Reisinger KS, Kerzner B, Stek JE, Sausser TA, Xu J, Wang WW, Chan IS, Annunziato PW, Parrino J.

Hum Vaccin. 2011 Nov;7(11):1130-6. doi: 10.4161/hv.7.11.17982. Epub 2011 Nov 1.


Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.

Philips GM, Chan IS, Swiderska M, Schroder VT, Guy C, Karaca GF, Moylan C, Venkatraman T, Feuerlein S, Syn WK, Jung Y, Witek RP, Choi S, Michelotti GA, Rangwala F, Merkle E, Lascola C, Diehl AM.

PLoS One. 2011;6(9):e23943. doi: 10.1371/journal.pone.0023943. Epub 2011 Sep 2.


Coping flexibility and complicated grief: a comparison of American and Chinese samples.

Burton CL, Yan OH, Pat-Horenczyk R, Chan IS, Ho S, Bonanno GA.

Depress Anxiety. 2012 Jan;29(1):16-22. doi: 10.1002/da.20888. Epub 2011 Sep 2.


Personalized medicine: progress and promise.

Chan IS, Ginsburg GS.

Annu Rev Genomics Hum Genet. 2011;12:217-44. doi: 10.1146/annurev-genom-082410-101446. Review.


Handling missing data in vaccine clinical trials for immunogenicity and safety evaluation.

Li X, Wang WW, Liu GF, Chan IS.

J Biopharm Stat. 2011 Mar;21(2):294-310. doi: 10.1080/10543406.2011.550111.


Major depressive disorder and immunity to varicella-zoster virus in the elderly.

Irwin MR, Levin MJ, Carrillo C, Olmstead R, Lucko A, Lang N, Caulfield MJ, Weinberg A, Chan IS, Clair J, Smith JG, Marchese RD, Williams HM, Beck DJ, McCook PT, Johnson G, Oxman MN.

Brain Behav Immun. 2011 May;25(4):759-66. doi: 10.1016/j.bbi.2011.02.001. Epub 2011 Feb 15.


Concomitant administration of zoster and pneumococcal vaccines in adults ≥60 years old.

MacIntyre CR, Egerton T, McCaughey M, Parrino J, Campbell BV, Su SC, Pagnoni MF, Stek JE, Xu J, Annunziato PW, Chan IS, Silber JL.

Hum Vaccin. 2010 Nov;6(11):894-902. Epub 2010 Nov 1.


Effect of a zoster vaccine on herpes zoster-related interference with functional status and health-related quality-of-life measures in older adults.

Schmader KE, Johnson GR, Saddier P, Ciarleglio M, Wang WW, Zhang JH, Chan IS, Yeh SS, Levin MJ, Harbecke RM, Oxman MN; Shingles Prevention Study Group.

J Am Geriatr Soc. 2010 Sep;58(9):1634-41. doi: 10.1111/j.1532-5415.2010.03021.x.


Safety, tolerability, and immunogenicity of zoster vaccine in subjects with a history of herpes zoster.

Mills R, Tyring SK, Levin MJ, Parrino J, Li X, Coll KE, Stek JE, Schlienger K, Chan IS, Silber JL.

Vaccine. 2010 Jun 7;28(25):4204-9. doi: 10.1016/j.vaccine.2010.04.003. Epub 2010 Apr 21.


Influence of age and nature of primary infection on varicella-zoster virus-specific cell-mediated immune responses.

Weinberg A, Lazar AA, Zerbe GO, Hayward AR, Chan IS, Vessey R, Silber JL, MacGregor RR, Chan K, Gershon AA, Levin MJ.

J Infect Dis. 2010 Apr 1;201(7):1024-30. doi: 10.1086/651199.


Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine.

Weinberg A, Zhang JH, Oxman MN, Johnson GR, Hayward AR, Caulfield MJ, Irwin MR, Clair J, Smith JG, Stanley H, Marchese RD, Harbecke R, Williams HM, Chan IS, Arbeit RD, Gershon AA, Schödel F, Morrison VA, Kauffman CA, Straus SE, Schmader KE, Davis LE, Levin MJ; US Department of Veterans Affairs (VA) Cooperative Studies Program Shingles Prevention Study Investigators.

J Infect Dis. 2009 Oct 1;200(7):1068-77. doi: 10.1086/605611.


Comparison of the levels of immunogenicity and safety of Zostavax in adults 50 to 59 years old and in adults 60 years old or older.

Sutradhar SC, Wang WW, Schlienger K, Stek JE, Xu J, Chan IS, Silber JL.

Clin Vaccine Immunol. 2009 May;16(5):646-52. doi: 10.1128/CVI.00407-08. Epub 2009 Mar 4.


The bZIP targets overlapping DNA subsites within a half-site, resulting in increased binding affinities.

Chan IS, Shahravan SH, Fedorova AV, Shin JA.

Biochemistry. 2008 Sep 9;47(36):9646-52. doi: 10.1021/bi800355t. Epub 2008 Aug 15.


Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine.

Levin MJ, Oxman MN, Zhang JH, Johnson GR, Stanley H, Hayward AR, Caulfield MJ, Irwin MR, Smith JG, Clair J, Chan IS, Williams H, Harbecke R, Marchese R, Straus SE, Gershon A, Weinberg A; Veterans Affairs Cooperative Studies Program Shingles Prevention Study Investigators.

J Infect Dis. 2008 Mar 15;197(6):825-35. doi: 10.1086/528696.


Enhancing the specificity of the enterokinase cleavage reaction to promote efficient cleavage of a fusion tag.

Shahravan SH, Qu X, Chan IS, Shin JA.

Protein Expr Purif. 2008 Jun;59(2):314-9. doi: 10.1016/j.pep.2008.02.015. Epub 2008 Mar 5.


A double-blind, randomized, controlled, multicenter safety and immunogenicity study of a refrigerator-stable formulation of Zostavax.

Gilderman LI, Lawless JF, Nolen TM, Sterling T, Rutledge RZ, Fernsler DA, Azrolan N, Sutradhar SC, Wang WW, Chan IS, Schlienger K, Schödel F, Silber JL; Zostavax Protocol 010 Study Group.

Clin Vaccine Immunol. 2008 Feb;15(2):314-9. Epub 2007 Dec 12.

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