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Nuclear receptor ERRα contributes to castration-resistant growth of prostate cancer via its regulation of intratumoral androgen biosynthesis.

Xu Z, Ma T, Zhou J, Gao W, Li Y, Yu S, Wang Y, Chan FL.

Theranostics. 2020 Mar 4;10(9):4201-4216. doi: 10.7150/thno.35589. eCollection 2020.


Targeting prostate cancer stem-like cells by an immunotherapeutic platform based on immunogenic peptide-sensitized dendritic cells-cytokine-induced killer cells.

Wang Z, Li Y, Wang Y, Wu D, Lau AHY, Zhao P, Zou C, Dai Y, Chan FL.

Stem Cell Res Ther. 2020 Mar 17;11(1):123. doi: 10.1186/s13287-020-01634-6.


Adipose-derived stem cells and cancer cells fuse to generate cancer stem cell-like cells with increased tumorigenicity.

Chan YW, So C, Yau KL, Chiu KC, Wang X, Chan FL, Tsang SY.

J Cell Physiol. 2020 Jan 29. doi: 10.1002/jcp.29574. [Epub ahead of print]


Implementation of Genetic Screening to Prevent Severe Cutaneous Adverse Drug Reactions Is Crucial-Rebuttal From the Devil's Antagonist.

Chan FL, Dodiuk-Gad RP.

JAMA Dermatol. 2019 Dec 18. doi: 10.1001/jamadermatol.2019.3950. [Epub ahead of print] No abstract available.


New Discoveries and Updates on Cutaneous Adverse Drug Reactions Presented at the 24th World Congress of Dermatology, Milan, Italy, 2019.

Chan FL, Shear NH, Shah N, Olteanu C, Hashimoto R, Dodiuk-Gad RP.

Drug Saf. 2020 Feb;43(2):179-187. doi: 10.1007/s40264-019-00880-9. No abstract available.


Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.

Zhu Y, Xie M, Meng Z, Leung LK, Chan FL, Hu X, Chi K, Liu C, Yao X.

Oncogene. 2019 Jul;38(29):5778-5791. doi: 10.1038/s41388-019-0846-y. Epub 2019 Jun 27.


Chlorhexidine skin symptoms and allergy in dialysis patients and nurses.

Chan FL, Merchant AA, Breede N, Lipszyc JC, House R, Tarlo SM.

Clin Exp Allergy. 2019 Aug;49(8):1158-1162. doi: 10.1111/cea.13440. Epub 2019 Jun 27. No abstract available.


Chromogranin A is a predictor of prognosis in patients with prostate cancer: a systematic review and meta-analysis.

Guo Z, Wang Y, Xiang S, Wang S, Chan FL.

Cancer Manag Res. 2019 Apr 5;11:2747-2758. doi: 10.2147/CMAR.S190678. eCollection 2019.


Knowledge and opinions among Canadian academic physicians regarding genetic screening to prevent severe cutaneous adverse drug reactions.

Chan FL, Shear NH, Maharaj A, Olteanu C, Hashimoto R, Ziv M, Dodiuk-Gad RP.

J Am Acad Dermatol. 2019 Dec;81(6):1401-1405. doi: 10.1016/j.jaad.2019.04.040. Epub 2019 Apr 19. No abstract available.


The utility of ESR, CRP and platelets in the diagnosis of GCA.

Chan FLY, Lester S, Whittle SL, Hill CL.

BMC Rheumatol. 2019 Apr 10;3:14. doi: 10.1186/s41927-019-0061-z. eCollection 2019.


Determination of the complexity and diversity of the TCR β-chain CDR3 repertoire in bladder cancer using high-throughput sequencing.

Ma J, Sun G, Zhu P, Liu S, Ou M, Chen Z, Zou C, Chan FL, Dai Y, Sui W.

Oncol Lett. 2019 Apr;17(4):3808-3816. doi: 10.3892/ol.2019.10015. Epub 2019 Feb 5.


Development of a novel and economical agar-based non-adherent three-dimensional culture method for enrichment of cancer stem-like cells.

Gao W, Wu D, Wang Y, Wang Z, Zou C, Dai Y, Ng CF, Teoh JY, Chan FL.

Stem Cell Res Ther. 2018 Sep 26;9(1):243. doi: 10.1186/s13287-018-0987-x.


LRH-1 drives hepatocellular carcinoma partially through induction of c-myc and cyclin E1, and suppression of p21.

Xiao L, Wang Y, Liang W, Liu L, Pan N, Deng H, Li L, Zou C, Chan FL, Zhou Y.

Cancer Manag Res. 2018 Aug 1;10:2389-2400. doi: 10.2147/CMAR.S162887. eCollection 2018.


Incidence and risk factors of suicide after a prostate cancer diagnosis: a meta-analysis of observational studies.

Guo Z, Gan S, Li Y, Gu C, Xiang S, Zhou J, Gong L, Chan FL, Wang S.

Prostate Cancer Prostatic Dis. 2018 Nov;21(4):499-508. doi: 10.1038/s41391-018-0073-6. Epub 2018 Aug 14.


Serum C-peptide concentration and prostate cancer: A meta-analysis of observational studies.

Guo ZL, Weng XT, Chan FL, Gong LL, Xiang ST, Gan S, Gu CM, Wang SS.

Medicine (Baltimore). 2018 Aug;97(31):e11771. doi: 10.1097/MD.0000000000011771.


Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer.

Xu Z, Wang Y, Xiao ZG, Zou C, Zhang X, Wang Z, Wu D, Yu S, Chan FL.

Oncogene. 2018 Nov;37(48):6259-6274. doi: 10.1038/s41388-018-0409-7. Epub 2018 Jul 24.


Association of androgen deprivation therapy with thromboembolic events in patients with prostate cancer: a systematic review and meta-analysis.

Guo Z, Huang Y, Gong L, Gan S, Chan FL, Gu C, Xiang S, Wang S.

Prostate Cancer Prostatic Dis. 2018 Nov;21(4):451-460. doi: 10.1038/s41391-018-0059-4. Epub 2018 Jul 9.


Fatal Strongyloides hyperinfection syndrome in an immunocompetent adult with review of the literature.

Chan FLY, Kennedy B, Nelson R.

Intern Med J. 2018 Jul;48(7):872-875. doi: 10.1111/imj.13940. Review.


Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.

Udugama M, Sanij E, Voon HPJ, Son J, Hii L, Henson JD, Chan FL, Chang FTM, Liu Y, Pearson RB, Kalitsis P, Mann JR, Collas P, Hannan RD, Wong LH.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4737-4742. doi: 10.1073/pnas.1720391115. Epub 2018 Apr 18.


Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.

Jia L, Wu D, Wang Y, You W, Wang Z, Xiao L, Cai G, Xu Z, Zou C, Wang F, Teoh JY, Ng CF, Yu S, Chan FL.

Oncogene. 2018 Jun;37(25):3340-3355. doi: 10.1038/s41388-018-0198-z. Epub 2018 Mar 20.


Health survey of employees regularly using 3D printers.

Chan FL, House R, Kudla I, Lipszyc JC, Rajaram N, Tarlo SM.

Occup Med (Lond). 2018 May 17;68(3):211-214. doi: 10.1093/occmed/kqy042.


Nuclear Receptor LRH-1 Functions to Promote Castration-Resistant Growth of Prostate Cancer via Its Promotion of Intratumoral Androgen Biosynthesis.

Xiao L, Wang Y, Xu K, Hu H, Xu Z, Wu D, Wang Z, You W, Ng CF, Yu S, Chan FL.

Cancer Res. 2018 May 1;78(9):2205-2218. doi: 10.1158/0008-5472.CAN-17-2341. Epub 2018 Feb 8.


Morphological changes of the optic lobe from late embryonic to adult stages in oval squids Sepioteuthis lessoniana.

Liu YC, Chung WS, Yu CC, Hsu ST, Chan FL, Liu TH, Su CH, Hwu Y, Marshall NJ, Chiao CC.

J Morphol. 2018 Jan;279(1):75-85. doi: 10.1002/jmor.20755. Epub 2017 Oct 17.


Nuclear receptor profiling in prostatospheroids and castration-resistant prostate cancer.

Wang Z, Wu D, Ng CF, Teoh JY, Yu S, Wang Y, Chan FL.

Endocr Relat Cancer. 2018 Jan;25(1):35-50. doi: 10.1530/ERC-17-0280. Epub 2017 Oct 17.


Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity.

Chan FL, Vinod B, Novy K, Schittenhelm RB, Huang C, Udugama M, Nunez-Iglesias J, Lin JI, Hii L, Chan J, Pickett HA, Daly RJ, Wong LH.

Nucleic Acids Res. 2017 Dec 1;45(21):12340-12353. doi: 10.1093/nar/gkx904.


1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21.

Li M, Li L, Zhang L, Hu W, Shen J, Xiao Z, Wu X, Chan FL, Cho CH.

Life Sci. 2017 Jun 15;179:88-97. doi: 10.1016/j.lfs.2017.04.021. Epub 2017 Apr 29.


The emerging roles of orphan nuclear receptors in prostate cancer.

Wu D, Cheung A, Wang Y, Yu S, Chan FL.

Biochim Biophys Acta. 2016 Aug;1866(1):23-36. doi: 10.1016/j.bbcan.2016.06.001. Epub 2016 Jun 2. Review.


Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres.

Udugama M, M Chang FT, Chan FL, Tang MC, Pickett HA, R McGhie JD, Mayne L, Collas P, Mann JR, Wong LH.

Nucleic Acids Res. 2015 Dec 2;43(21):10227-37. doi: 10.1093/nar/gkv847. Epub 2015 Aug 24.


Correction: FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells.

Ren SX, Shen J, Cheng AS, Lu L, Chan RL, Li ZJ, Wang XJ, Wong CC, Zhang L, Ng SS, Chan FL, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH.

PLoS One. 2015 Jun 25;10(6):e0131750. doi: 10.1371/journal.pone.0131750. eCollection 2015. No abstract available.


CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells.

Chang FT, Chan FL, R McGhie JD, Udugama M, Mayne L, Collas P, Mann JR, Wong LH.

Nucleic Acids Res. 2015 Mar 11;43(5):2603-14. doi: 10.1093/nar/gkv104. Epub 2015 Feb 17.


Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.

Wu D, Yu S, Jia L, Zou C, Xu Z, Xiao L, Wong KB, Ng CF, Chan FL.

J Pathol. 2015 May;236(1):103-15. doi: 10.1002/path.4505. Epub 2015 Feb 2.


Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration.

Sailland J, Tribollet V, Forcet C, Billon C, Barenton B, Carnesecchi J, Bachmann A, Gauthier KC, Yu S, Giguère V, Chan FL, Vanacker JM.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15108-13. doi: 10.1073/pnas.1402094111. Epub 2014 Oct 6.


Coadministrating luteolin minimizes the side effects of the aromatase inhibitor letrozole.

Li F, Wong TY, Lin SM, Chow S, Cheung WH, Chan FL, Chen S, Leung LK.

J Pharmacol Exp Ther. 2014 Nov;351(2):270-7. doi: 10.1124/jpet.114.216754. Epub 2014 Aug 19.


Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2 -independent and RACK1-mediated mechanism of HIF-1α stabilization.

Yu S, Xu Z, Zou C, Wu D, Wang Y, Yao X, Ng CF, Chan FL.

J Pathol. 2014 Dec;234(4):514-25. doi: 10.1002/path.4413. Epub 2014 Sep 15.


Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice.

Wong TY, Li F, Lin SM, Chan FL, Chen S, Leung LK.

BMC Cancer. 2014 Jun 12;14:426. doi: 10.1186/1471-2407-14-426.


Assessing the effect of food mycotoxins on aromatase by using a cell-based system.

Wang Y, Wong TY, Chan FL, Chen S, Leung LK.

Toxicol In Vitro. 2014 Jun;28(4):640-6. doi: 10.1016/j.tiv.2014.01.012. Epub 2014 Feb 7.


ERRα augments HIF-1 signalling by directly interacting with HIF-1α in normoxic and hypoxic prostate cancer cells.

Zou C, Yu S, Xu Z, Wu D, Ng CF, Yao X, Yew DT, Vanacker JM, Chan FL.

J Pathol. 2014 May;233(1):61-73. doi: 10.1002/path.4329. Epub 2014 Feb 5.


FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells.

Ren SX, Shen J, Cheng AS, Lu L, Chan RL, Li ZJ, Wang XJ, Wong CC, Zhang L, Ng SS, Chan FL, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH.

PLoS One. 2013 May 20;8(5):e63641. doi: 10.1371/journal.pone.0063641. Print 2013. Erratum in: PLoS One. 2015;10(6):e0131750.


PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.

Chang FT, McGhie JD, Chan FL, Tang MC, Anderson MA, Mann JR, Andy Choo KH, Wong LH.

Nucleic Acids Res. 2013 Apr;41(8):4447-58. doi: 10.1093/nar/gkt114. Epub 2013 Feb 26.


The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer.

Li F, Chow S, Cheung WH, Chan FL, Chen S, Leung LK.

J Nutr Biochem. 2013 Jun;24(6):1112-6. doi: 10.1016/j.jnutbio.2012.08.010. Epub 2012 Dec 11.


Transcription in the maintenance of centromere chromatin identity.

Chan FL, Wong LH.

Nucleic Acids Res. 2012 Dec;40(22):11178-88. doi: 10.1093/nar/gks921. Epub 2012 Oct 11. Review.


Increased expression of activated endothelial nitric oxide synthase contributes to antiandrogen resistance in prostate cancer cells by suppressing androgen receptor transactivation.

Yu S, Jia L, Zhang Y, Wu D, Xu Z, Ng CF, To KK, Huang Y, Chan FL.

Cancer Lett. 2013 Jan 1;328(1):83-94. doi: 10.1016/j.canlet.2012.09.006. Epub 2012 Sep 18.


Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells.

Ma X, Cai Y, He D, Zou C, Zhang P, Lo CY, Xu Z, Chan FL, Yu S, Chen Y, Zhu R, Lei J, Jin J, Yao X.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16282-7. doi: 10.1073/pnas.1202989109. Epub 2012 Sep 17.


Active transcription and essential role of RNA polymerase II at the centromere during mitosis.

Chan FL, Marshall OJ, Saffery R, Kim BW, Earle E, Choo KH, Wong LH.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1979-84. doi: 10.1073/pnas.1108705109. Epub 2012 Jan 20.


The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.

Ye L, Chan FL, Chen S, Leung LK.

J Nutr Biochem. 2012 Oct;23(10):1230-7. doi: 10.1016/j.jnutbio.2011.07.003. Epub 2011 Dec 30.


Lessons from neocentromeres.

Chan FL, Wong LH.

Epigenomics. 2011 Jun;3(3):251-4. doi: 10.2217/epi.11.60. No abstract available.


Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population.

Luk SU, Lee TK, Liu J, Lee DT, Chiu YT, Ma S, Ng IO, Wong YC, Chan FL, Ling MT.

PLoS One. 2011;6(5):e19804. doi: 10.1371/journal.pone.0019804. Epub 2011 May 16. Erratum in: PLoS One. 2011;6(6). doi:10.1371/annotation/0f6309be-936c-4974-97bf-ed3a98289cd9. PLoS One. 2011;6(6). doi:10.1371/annotation/b0312c4c-e06a-47ef-9e9c-b044dbfa3d6a.


17-Beta-estradiol induces neoplastic transformation in prostatic epithelial cells.

Yu S, Zhang Y, Yuen MT, Zou C, Danielpour D, Chan FL.

Cancer Lett. 2011 May 1;304(1):8-20. doi: 10.1016/j.canlet.2011.01.003. Epub 2011 Feb 25.


Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells.

Kwong J, Chan FL, Wong KK, Birrer MJ, Archibald KM, Balkwill FR, Berkowitz RS, Mok SC.

Neoplasia. 2009 Jun;11(6):529-41.

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