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Cancer risk and chemoprevention in Chinese inflammatory bowel disease patients: a population-based cohort study.

Mak JWY, So J, Tang W, Yip TCF, Leung WK, Li M, Lo FH, Ng KM, Sze SF, Leung CM, Tsang SWC, Shan EHS, Chan KH, Lam BCY, Hui AJ, Chow WH, Chan FKL, Ng SC.

Scand J Gastroenterol. 2020 Mar 2:1-8. doi: 10.1080/00365521.2020.1731760. [Epub ahead of print]


Interpretation and application of Sponge City guidelines in China.

Griffiths J, Chan FKS, Shao M, Zhu F, Higgitt DL.

Philos Trans A Math Phys Eng Sci. 2020 Apr 3;378(2168):20190222. doi: 10.1098/rsta.2019.0222. Epub 2020 Feb 17.


Southern Chinese populations harbour non-nucleatum Fusobacteria possessing homologues of the colorectal cancer-associated FadA virulence factor.

Yeoh YK, Chen Z, Wong MCS, Hui M, Yu J, Ng SC, Sung JJY, Chan FKL, Chan PKS.

Gut. 2020 Feb 12. pii: gutjnl-2019-319635. doi: 10.1136/gutjnl-2019-319635. [Epub ahead of print]


Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations.

Szeto CC, Sugano K, Wang JG, Fujimoto K, Whittle S, Modi GK, Chen CH, Park JB, Tam LS, Vareesangthip K, Tsoi KKF, Chan FKL.

Gut. 2020 Apr;69(4):617-629. doi: 10.1136/gutjnl-2019-319300. Epub 2020 Jan 14.


Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review.

Watanabe T, Fujiwara Y, Chan FKL.

J Gastroenterol. 2019 Dec 21. doi: 10.1007/s00535-019-01657-8. [Epub ahead of print] Review.


Management of Gastroesophageal Reflux Disease in Asian Countries: Results of a Questionnaire Survey.

Hojo M, Nagahara A, Hahm KB, Iwakiri R, Watanabe T, Rani AA, Zhu Q, Chan FKL, Sollano JD, Kamiya T, Yamaguchi S, Motoya S, Fock KM, Fukudo S, Kachintorn U, Suzuki H, Murakami K; The International Gastroenterology Consensus Symposium Study Group.

Digestion. 2020;101(1):66-79. doi: 10.1159/000504749. Epub 2019 Dec 4.


Endoscopic management of nonvariceal upper gastrointestinal bleeding.

Cañamares-Orbís P, Chan FKL.

Best Pract Res Clin Gastroenterol. 2019 Oct - Dec;42-43:101608. doi: 10.1016/j.bpg.2019.04.001. Epub 2019 Apr 17. Review.


A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer.

Liang JQ, Li T, Nakatsu G, Chen YX, Yau TO, Chu E, Wong S, Szeto CH, Ng SC, Chan FKL, Fang JY, Sung JJY, Yu J.

Gut. 2019 Nov 27. pii: gutjnl-2019-318532. doi: 10.1136/gutjnl-2019-318532. [Epub ahead of print]


Impact of brand drug discount cards on private insurer, government and patient expenditures.

Law MR, Chan FKI, Harrison M, Worthington HC.

CMAJ. 2019 Nov 11;191(45):E1237-E1241. doi: 10.1503/cmaj.190098.


Review article: fungal alterations in inflammatory bowel diseases.

Lam S, Zuo T, Ho M, Chan FKL, Chan PKS, Ng SC.

Aliment Pharmacol Ther. 2019 Dec;50(11-12):1159-1171. doi: 10.1111/apt.15523. Epub 2019 Oct 24. Review.


Modeling and simulation of complex dynamic musculoskeletal architectures.

Zhang X, Chan FK, Parthasarathy T, Gazzola M.

Nat Commun. 2019 Oct 23;10(1):4825. doi: 10.1038/s41467-019-12759-5.


Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group.

Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M.

Ann Intern Med. 2019 Oct 22. doi: 10.7326/M19-1795. [Epub ahead of print]


Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE).

Ng SC, Kamm MA, Yeoh YK, Chan PKS, Zuo T, Tang W, Sood A, Andoh A, Ohmiya N, Zhou Y, Ooi CJ, Mahachai V, Wu CY, Zhang F, Sugano K, Chan FKL.

Gut. 2020 Jan;69(1):83-91. doi: 10.1136/gutjnl-2019-319407. Epub 2019 Oct 14.


Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity.

Long X, Wong CC, Tong L, Chu ESH, Ho Szeto C, Go MYY, Coker OO, Chan AWH, Chan FKL, Sung JJY, Yu J.

Nat Microbiol. 2019 Dec;4(12):2319-2330. doi: 10.1038/s41564-019-0541-3. Epub 2019 Sep 9.


Early prolonged ambulatory cardiac monitoring in stroke (EPACS): an open-label randomised controlled trial.

Kaura A, Sztriha L, Chan FK, Aeron-Thomas J, Gall N, Piechowski-Jozwiak B, Teo JT.

Eur J Med Res. 2019 Jul 26;24(1):25. doi: 10.1186/s40001-019-0383-8.


Rofecoxib and Clinically Significant Gastrointestinal Events: Response.

Graham DY, Jewell NP, Chan FKL.

Am J Med Sci. 2019 Sep;358(3):e9-e10. doi: 10.1097/MAJ.0000000000000222. Epub 2019 Jul 10. No abstract available.



Chan FKL, Kyaw MH.

Gastroenterology. 2019 Aug;157(2):581-582. doi: 10.1053/j.gastro.2019.06.008. Epub 2019 Jun 13. No abstract available.


Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial.

Wong GLH, Lau LHS, Ching JYL, Tse YK, Ling RHY, Wong VWS, Chiu PWY, Lau JYW, Chan FKL.

Gut. 2020 Apr;69(4):652-657. doi: 10.1136/gutjnl-2019-318715. Epub 2019 Jun 22.


Faecal microbiota transplantation for treatment of recurrent or refractory Clostridioides difficile infection in Hong Kong.

Lui RN, Wong SH, Lau LHS, Chan TT, Cheung KCY, Li A, Chin ML, Tang W, Ching JYL, Lam KLY, Chan PKS, Wu JCY, Sung JJY, Chan FKL, Ng SC.

Hong Kong Med J. 2019 Jun;25(3):178-182. doi: 10.12809/hkmj197855. Epub 2019 May 29.


Prospective colonoscopic study to investigate risk of colorectal neoplasms in first-degree relatives of patients with non-advanced adenomas.

Ng SC, Kyaw MH, Suen BY, Tse YK, Wong MCS, Hui AJ, Tak HY, Lau JYW, Sung JJY, Chan FKL.

Gut. 2020 Feb;69(2):304-310. doi: 10.1136/gutjnl-2018-318117. Epub 2019 Apr 26.


TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.

Gou H, Liang JQ, Zhang L, Chen H, Zhang Y, Li R, Wang X, Ji J, Tong JH, To KF, Sung JJY, Chan FKL, Fang JY, Yu J.

Cancer Res. 2019 Jul 1;79(13):3332-3346. doi: 10.1158/0008-5472.CAN-18-2986. Epub 2019 Apr 24.


Gut mucosal virome alterations in ulcerative colitis.

Zuo T, Lu XJ, Zhang Y, Cheung CP, Lam S, Zhang F, Tang W, Ching JYL, Zhao R, Chan PKS, Sung JJY, Yu J, Chan FKL, Cao Q, Sheng JQ, Ng SC.

Gut. 2019 Jul;68(7):1169-1179. doi: 10.1136/gutjnl-2018-318131. Epub 2019 Mar 6.


Impact of Preservation Method and 16S rRNA Hypervariable Region on Gut Microbiota Profiling.

Chen Z, Hui PC, Hui M, Yeoh YK, Wong PY, Chan MCW, Wong MCS, Ng SC, Chan FKL, Chan PKS.

mSystems. 2019 Feb 26;4(1). pii: e00271-18. doi: 10.1128/mSystems.00271-18. eCollection 2019 Jan-Feb.


A Hybrid Residual Network and Long Short-Term Memory Method for Peptic Ulcer Bleeding Mortality Prediction.

Tan Q, Ma AJ, Deng H, Wong VW, Tse YK, Yip TC, Wong GL, Ching JY, Chan FK, Yuen PC.

AMIA Annu Symp Proc. 2018 Dec 5;2018:998-1007. eCollection 2018.


Machine learning model to predict recurrent ulcer bleeding in patients with history of idiopathic gastroduodenal ulcer bleeding.

Wong GL, Ma AJ, Deng H, Ching JY, Wong VW, Tse YK, Yip TC, Lau LH, Liu HH, Leung CM, Tsang SW, Chan CW, Lau JY, Yuen PC, Chan FK.

Aliment Pharmacol Ther. 2019 Apr;49(7):912-918. doi: 10.1111/apt.15145. Epub 2019 Feb 13.


Colorectal cancer screening in middle eastern countries: Current status and future strategies to enhance screening.

Wong MCS, Chan FKL.

Saudi J Gastroenterol. 2019 Jan-Feb;25(1):1-2. doi: 10.4103/sjg.SJG_611_18. No abstract available.


Changes in employer-sponsored private health insurance among retirees in Ontario: a cross-sectional study.

Chan FKI, McGrail K, Majumdar SR, Law MR.

CMAJ Open. 2019 Jan 21;7(1):E15-E22. doi: 10.9778/cmajo.20180067. Print 2019 Jan-Mar.


Impact of inter- and intra-individual variation, sample storage and sampling fraction on human stool microbial community profiles.

Yeoh YK, Chen Z, Hui M, Wong MCS, Ho WCS, Chin ML, Ng SC, Chan FKL, Chan PKS.

PeerJ. 2019 Jan 11;7:e6172. doi: 10.7717/peerj.6172. eCollection 2019.


Systematic review with meta-analysis: review of donor features, procedures and outcomes in 168 clinical studies of faecal microbiota transplantation.

Lai CY, Sung J, Cheng F, Tang W, Wong SH, Chan PKS, Kamm MA, Sung JJY, Kaplan G, Chan FKL, Ng SC.

Aliment Pharmacol Ther. 2019 Feb;49(4):354-363. doi: 10.1111/apt.15116. Epub 2019 Jan 9.


Risk of tuberculosis in patients with immune-mediated diseases on biological therapies: a population-based study in a tuberculosis endemic region.

Wang X, Wong SH, Wang XS, Tang W, Liu CQ, Niamul G, Wu B, Tam LS, Wu JCY, Chan FKL, Sung JJY, Ng SC.

Rheumatology (Oxford). 2019 May 1;58(5):803-810. doi: 10.1093/rheumatology/key364.


Questionnaire-Based Survey on Management of Ulcerative Colitis-Associated Cancer in East Asian Countries.

Yamaguchi S, Sasaki K, Kato H, Fukudo S, Iwakiri R, Kamiya T, Motoya S, Murakami K, Nagahara A, Suzuki H, Watanabe T, Takahashi S, Chan FKL, Hahm KB, Kachintorn U, Ming FK, Rani AA, Sollano JD, Zhu Q.

Digestion. 2019;99(1):86-94. doi: 10.1159/000494419. Epub 2018 Dec 14.


Risk of Postpolypectomy Bleeding With Uninterrupted Clopidogrel Therapy in an Industry-Independent, Double-Blind, Randomized Trial.

Chan FKL, Kyaw MH, Hsiang JC, Suen BY, Kee KM, Tse YK, Ching JYL, Cheong PK, Ng D, Lam K, Lo A, Lee V, Ng SC.

Gastroenterology. 2019 Mar;156(4):918-925.e1. doi: 10.1053/j.gastro.2018.10.036. Epub 2018 Oct 25.


Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer.

Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, Chan FKL, Sung JJY, Yu J.

Gut. 2019 Apr;68(4):654-662. doi: 10.1136/gutjnl-2018-317178. Epub 2018 Nov 24.


Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial.

Cheong PK, Ford AC, Cheung CKY, Ching JYL, Chan Y, Sung JJY, Chan FKL, Wu JCY.

Lancet Gastroenterol Hepatol. 2018 Dec;3(12):837-844. doi: 10.1016/S2468-1253(18)30303-0. Epub 2018 Oct 22.


Diversity of macaque microbiota compared to the human counterparts.

Chen Z, Yeoh YK, Hui M, Wong PY, Chan MCW, Ip M, Yu J, Burk RD, Chan FKL, Chan PKS.

Sci Rep. 2018 Oct 22;8(1):15573. doi: 10.1038/s41598-018-33950-6.


Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression.

Luz NF, Khouri R, Van Weyenbergh J, Zanette DL, Fiuza PP, Noronha A, Barral A, Boaventura VS, Prates DB, Chan FK, Andrade BB, Borges VM.

Front Microbiol. 2018 Sep 28;9:2283. doi: 10.3389/fmicb.2018.02283. eCollection 2018.


Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection.

Zuo T, Wong SH, Cheung CP, Lam K, Lui R, Cheung K, Zhang F, Tang W, Ching JYL, Wu JCY, Chan PKS, Sung JJY, Yu J, Chan FKL, Ng SC.

Nat Commun. 2018 Sep 10;9(1):3663. doi: 10.1038/s41467-018-06103-6.


Population Density and Risk of Inflammatory Bowel Disease: A Prospective Population-Based Study in 13 Countries or Regions in Asia-Pacific.

Ng SC, Kaplan GG, Tang W, Banerjee R, Adigopula B, Underwood FE, Tanyingoh D, Wei SC, Lin WC, Lin HH, Li J, Bell S, Niewiadomski O, Kamm MA, Zeng Z, Chen M, Hu P, Ong D, Ooi CJ, Ling KL, Miao Y, Miao J, Janaka de Silva H, Niriella M, Aniwan S, Limsrivilai J, Pisespongsa P, Wu K, Yang H, Ng KK, Yu HH, Wang Y, Ouyang Q, Abdullah M, Simadibrata M, Gunawan J, Hilmi I, Lee Goh K, Cao Q, Sheng H, Ong-Go A, Chong VH, Ching JYL, Wu JCY, Chan FKL, Sung JJY.

Am J Gastroenterol. 2019 Jan;114(1):107-115. doi: 10.1038/s41395-018-0233-2.


Significant Medical and Surgical Morbidity in Perianal Crohn's Disease: Results from a Territory-Wide Study.

Mak WY, Mak OS, Lee CK, Tang W, Leung WK, Wong MTL, Sze ASF, Li M, Leung CM, Lo FH, Lam BCY, Chan KH, Shan EHS, Tsang SWC, Hui AJ, Chow WH, Chan FKL, Sung JJY, Ng SC.

J Crohns Colitis. 2018 Nov 28;12(12):1392-1398. doi: 10.1093/ecco-jcc/jjy120.


RIPK1-RIPK3-MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils.

Barbosa LA, Fiuza PP, Borges LJ, Rolim FA, Andrade MB, Luz NF, Quintela-Carvalho G, Lima JB, Almeida RP, Chan FK, Bozza MT, Borges VM, Prates DB.

Front Immunol. 2018 Aug 14;9:1818. doi: 10.3389/fimmu.2018.01818. eCollection 2018.


Loss-of-Function RNAi Screen to Identify Necrosis-Signaling Molecules.

Moquin DM, Chan FK.

Methods Mol Biol. 2018;1857:11-18. doi: 10.1007/978-1-4939-8754-2_2.


Effectiveness of reminder strategies on cancer screening adherence: a randomised controlled trial.

Wong MC, Ching JY, Huang J, Wong JC, Lam TY, Chan VC, Ng SK, Hui Z, Luk AK, Wu JC, Chan FK.

Br J Gen Pract. 2018 Sep;68(674):e604-e611. doi: 10.3399/bjgp18X698369. Epub 2018 Aug 13.


When to Resume Direct Oral Anticoagulants Following Gastrointestinal Bleeding.

Kyaw MH, Chan FKL.

Clin Gastroenterol Hepatol. 2018 Dec;16(12):1870-1871. doi: 10.1016/j.cgh.2018.08.009. Epub 2018 Aug 9. No abstract available.


Necroptosis in anti-viral inflammation.

Nailwal H, Chan FK.

Cell Death Differ. 2019 Jan;26(1):4-13. doi: 10.1038/s41418-018-0172-x. Epub 2018 Jul 26. Review.


Epstein-Barr Virus-Induced Epigenetic Pathogenesis of Viral-Associated Lymphoepithelioma-Like Carcinomas and Natural Killer/T-Cell Lymphomas.

Li L, Ma BBY, Chan ATC, Chan FKL, Murray P, Tao Q.

Pathogens. 2018 Jul 18;7(3). pii: E63. doi: 10.3390/pathogens7030063. Review.


Gastrointestinal disease burden and mortality: A public hospital-based study from 2005 to 2014.

Chan JSH, Chao ACW, Cheung VCH, Wong SSK, Tang W, Wu JCY, Chan HLY, Chan FKL, Sung JJY, Ng SC.

J Gastroenterol Hepatol. 2019 Jan;34(1):124-131. doi: 10.1111/jgh.14377. Epub 2018 Jul 30.


Misoprostol Heals Small Bowel Ulcers in Aspirin Users With Small Bowel Bleeding.

Kyaw MH, Otani K, Ching JYL, Higashimori A, Kee KM, Watanabe T, Tse YK, Lee V, Tanigawa T, Cheong PK, Suen BY, Fujiwara Y, Lam K, Arakawa T, Chan FKL.

Gastroenterology. 2018 Oct;155(4):1090-1097.e1. doi: 10.1053/j.gastro.2018.06.056. Epub 2018 Sep 5.


Bitter melon seed oil increases mitochondrial content in gastrocnemius muscle and improves running endurance in sedentary C57BL/6J mice.

Chan FK, Hsu C, Li TC, Chen WH, Tseng KT, Chao PM.

J Nutr Biochem. 2018 Aug;58:150-157. doi: 10.1016/j.jnutbio.2018.05.008. Epub 2018 Jun 6.


Managing Antithrombotic Agents in the Setting of Acute Gastrointestinal Bleeding.

Kyaw MH, Chan FKL.

Gastrointest Endosc Clin N Am. 2018 Jul;28(3):351-361. doi: 10.1016/j.giec.2018.02.007. Review.


Risk factors for advanced colorectal neoplasms in the proximal colon in 6218 subjects undergoing complete colonoscopy.

Hirai HW, Ching JYL, Wu JCY, Sung JJY, Chan FKL, Ng SC.

J Gastroenterol Hepatol. 2019 Jan;34(1):113-119. doi: 10.1111/jgh.14357. Epub 2018 Jul 12.


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