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A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease).

Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Robin Eisch A, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM.

Commun Biol. 2019 Oct 31;2(1):398. doi: 10.1038/s42003-019-0647-4.


How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone.

Kambayashi R, Hagiwara-Nagasawa M, Kondo Y, Yeo ZJ, Goto A, Chiba K, Nunoi Y, Izumi-Nakaseko H, Leow JWH, Venkatesan G, Matsumoto A, Chan ECY, Sugiyama A.

Cardiovasc Toxicol. 2020 Jan 2. doi: 10.1007/s12012-019-09559-0. [Epub ahead of print]


Erratum: Author Correction: A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease).

Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Eisch AR, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM.

Commun Biol. 2019 Nov 25;2:439. doi: 10.1038/s42003-019-0691-0. eCollection 2019.


A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease).

Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Robin Eisch A, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM.

Commun Biol. 2019 Oct 31;2:398. doi: 10.1038/s42003-019-0647-4. eCollection 2019. Erratum in: Commun Biol. 2019 Nov 25;2:439.


Aspergillus fumigatus-Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma.

Redes JL, Basu T, Ram-Mohan S, Ghosh CC, Chan EC, Sek AC, Zhao M, Krishnan R, Rosenberg HF, Druey KM.

Immunohorizons. 2019 Aug 6;3(8):368-377. doi: 10.4049/immunohorizons.1900046.


Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban.

Cheong EJY, Teo DWX, Chua DXY, Chan ECY.

Drug Metab Dispos. 2019 Nov;47(11):1291-1306. doi: 10.1124/dmd.119.086918. Epub 2019 Sep 10.


Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: A focus on substrate inhibition.

Leow JWH, Chan ECY.

Biochem Pharmacol. 2019 Nov;169:113615. doi: 10.1016/j.bcp.2019.08.017. Epub 2019 Aug 21. Review.


Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing.

Chan JCY, Tan SPF, Upton Z, Chan ECY.

ALTEX. 2019;36(4):597-612. doi: 10.14573/altex.1812051. Epub 2019 May 10.


A biocompatible reverse thermoresponsive polymer for ocular drug delivery.

Balachandra A, Chan EC, Paul JP, Ng S, Chrysostomou V, Ngo S, Mayadunne R, van Wijngaarden P.

Drug Deliv. 2019 Dec;26(1):343-353. doi: 10.1080/10717544.2019.1587042.


Misleading Westerns: Common Quantification Mistakes in Western Blot Densitometry and Proposed Corrective Measures.

Butler TAJ, Paul JW, Chan EC, Smith R, Tolosa JM.

Biomed Res Int. 2019 Jan 21;2019:5214821. doi: 10.1155/2019/5214821. eCollection 2019.


Do estrogen receptor variants explain the enigma of human birth?

Smith R, Butler T, Chan EC.

EBioMedicine. 2019 Jan;39:25-26. doi: 10.1016/j.ebiom.2018.12.012. Epub 2018 Dec 13. No abstract available.


Recent advances in the applications of metabolomics in eye research.

Chen L, Gao Y, Wang LZ, Cheung N, Tan GSW, Cheung GCM, Beuerman RW, Wong TY, Chan ECY, Zhou L.

Anal Chim Acta. 2018 Dec 11;1037:28-40. doi: 10.1016/j.aca.2018.01.060. Epub 2018 Feb 7. Review.


Whole-Exome Sequencing of Adult and Pediatric Cohorts of the Rare Vascular Disorder Systemic Capillary Leak Syndrome.

Pierce R, Ji W, Chan EC, Xie Z, Long LM, Khokha M, Lakhani S, Druey KM.

Shock. 2019 Aug;52(2):183-190. doi: 10.1097/SHK.0000000000001254.


Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study.

Haldar S, Lee SH, Tan JJ, Chia SC, Henry CJ, Chan ECY.

Nutrients. 2018 Jul 20;10(7). pii: E934. doi: 10.3390/nu10070934.


Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity.

Chan JCY, Soh ACK, Kioh DYQ, Li J, Verma C, Koh SK, Beuerman RW, Zhou L, Chan ECY.

Mol Cell Proteomics. 2018 Oct;17(10):2034-2050. doi: 10.1074/mcp.RA118.000875. Epub 2018 Jul 13.


Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking.

Chan EC, Ren C, Xie Z, Jude J, Barker T, Koziol-White CA, Ma M, Panettieri RA Jr, Wu D, Rosenberg HF, Druey KM.

J Biol Chem. 2018 Aug 17;293(33):12690-12702. doi: 10.1074/jbc.RA118.002404. Epub 2018 Jun 21.


Assessing delay and lag in sagittal trunk control using a tracking task.

Reeves NP, Luis A, Chan EC, Sal Y Rosas VG, Tanaka ML.

J Biomech. 2018 May 17;73:33-39. doi: 10.1016/j.jbiomech.2018.03.029. Epub 2018 Mar 17.


Rivaroxaban With and Without Amiodarone in Renal Impairment.

Cheong EJY, Goh JJN, Hong Y, Kojodjojo P, Chan ECY.

J Am Coll Cardiol. 2018 Mar 27;71(12):1395-1397. doi: 10.1016/j.jacc.2018.01.044. No abstract available.


Methyl-Donor and Cofactor Nutrient Intakes in the First 2-3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study.

Taylor RM, Smith R, Collins CE, Mossman D, Wong-Brown MW, Chan EC, Evans TJ, Attia JR, Smith T, Butler T, Hure AJ.

Nutrients. 2018 Feb 27;10(3). pii: E273. doi: 10.3390/nu10030273.


Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids.

Karkhanis A, Leow JWH, Hagen T, Chan ECY.

Toxicol Sci. 2018 May 1;163(1):79-91. doi: 10.1093/toxsci/kfy011.


Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease).

Xie Z, Chen WS, Yin Y, Chan EC, Terai K, Long LM, Myers TG, Dudek AZ, Druey KM.

J Leukoc Biol. 2018 Apr;103(4):749-759. doi: 10.1002/JLB.5A0817-324R. Epub 2018 Jan 23.


Adventitial Activation in the Pathogenesis of Injury-Induced Arterial Remodeling: Potential Implications in Transplant Vasculopathy.

Wang J, Wang Y, Wang J, Guo X, Chan EC, Jiang F.

Am J Pathol. 2018 Apr;188(4):838-845. doi: 10.1016/j.ajpath.2017.12.002. Epub 2018 Jan 16. Review.


Polyphenol-rich curry made with mixed spices and vegetables benefits glucose homeostasis in Chinese males (Polyspice Study): a dose-response randomized controlled crossover trial.

Haldar S, Chia SC, Lee SH, Lim J, Leow MK, Chan ECY, Henry CJ.

Eur J Nutr. 2019 Feb;58(1):301-313. doi: 10.1007/s00394-017-1594-9. Epub 2017 Dec 13.


Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine.

Phua LC, Goh S, Tai DWM, Leow WQ, Alkaff SMF, Chan CY, Kam JH, Lim TKH, Chan ECY.

Cancer Chemother Pharmacol. 2018 Feb;81(2):277-289. doi: 10.1007/s00280-017-3475-6. Epub 2017 Dec 1.


Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of colorectal cancer.

Fan CW, Kuo YB, Lin GP, Chen SM, Chang SH, Li BA, Chan EC.

Clin Chim Acta. 2017 Dec;475:157-163. doi: 10.1016/j.cca.2017.10.022. Epub 2017 Oct 23.


Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids.

Karkhanis A, Tram NDT, Chan ECY.

Biochem Pharmacol. 2017 Dec 15;146:188-198. doi: 10.1016/j.bcp.2017.09.012. Epub 2017 Sep 25.


In Silico and in Vitro Interactions between Short Chain Fatty Acids and Human Histone Deacetylases.

Ho RH, Chan JCY, Fan H, Kioh DYQ, Lee BW, Chan ECY.

Biochemistry. 2017 Sep 12;56(36):4871-4878. doi: 10.1021/acs.biochem.7b00508. Epub 2017 Aug 24.


The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat.

Yip LY, Aw CC, Lee SH, Hong YS, Ku HC, Xu WH, Chan JMX, Cheong EJY, Chng KR, Ng AHQ, Nagarajan N, Mahendran R, Lee YK, Browne ER, Chan ECY.

Hepatology. 2018 Jan;67(1):282-295. doi: 10.1002/hep.29327. Epub 2017 Nov 19.


Transforming Growth Factor β1-Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts.

Brown KD, Shah MH, Liu GS, Chan EC, Crowston JG, Peshavariya HM.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3011-3017. doi: 10.1167/iovs.16-20633.


Combination of a biodegradable three-dimensional (3D) - printed cage for mechanical support and nanofibrous membranes for sustainable release of antimicrobial agents for treating the femoral metaphyseal comminuted fracture.

Chou YC, Lee D, Chang TM, Hsu YH, Yu YH, Chan EC, Liu SJ.

J Mech Behav Biomed Mater. 2017 Aug;72:209-218. doi: 10.1016/j.jmbbm.2017.05.002. Epub 2017 May 2.


OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis.

Wu RS, Hong JJ, Wu JF, Yan S, Wu D, Liu N, Liu QF, Wu QW, Xie YY, Liu YJ, Zheng ZZ, Chan EC, Zhang ZM, Li BA.

Oncotarget. 2017 Jun 13;8(24):39401-39416. doi: 10.18632/oncotarget.17031.


Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy.

Karkhanis A, Hong Y, Chan ECY.

Biochem Pharmacol. 2017 Jul 1;135:12-21. doi: 10.1016/j.bcp.2017.02.017. Epub 2017 Feb 23. Review.


A novel LCMSMS method for quantitative measurement of short-chain fatty acids in human stool derivatized with 12C- and 13C-labelled aniline.

Chan JC, Kioh DY, Yap GC, Lee BW, Chan EC.

J Pharm Biomed Anal. 2017 May 10;138:43-53. doi: 10.1016/j.jpba.2017.01.044. Epub 2017 Jan 28.


Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids.

Chen Q, Li C, Gong Z, Chan ECY, Snyder SA, Lam SH.

Chemosphere. 2017 Apr;172:429-439. doi: 10.1016/j.chemosphere.2017.01.036. Epub 2017 Jan 6.


Application of Static Modeling --in the Prediction of In Vivo Drug-Drug Interactions between Rivaroxaban and Antiarrhythmic Agents Based on In Vitro Inhibition Studies.

Cheong EJ, Goh JJ, Hong Y, Venkatesan G, Liu Y, Chiu GN, Kojodjojo P, Chan EC.

Drug Metab Dispos. 2017 Mar;45(3):260-268. doi: 10.1124/dmd.116.073890. Epub 2017 Jan 4.


Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells.

Chan JC, Ong PS, Lim P, Teng PX, Chan EC.

Cancer Chemother Pharmacol. 2017 Jan;79(1):117-130. doi: 10.1007/s00280-016-3211-7. Epub 2016 Dec 9.


Evaluating Polymyxin B-Based Combinations against Carbapenem-Resistant Escherichia coli in Time-Kill Studies and in a Hollow-Fiber Infection Model.

Cai Y, Lim TP, Teo JQ, Sasikala S, Chan EC, Hong YJ, Lee W, Tan TY, Tan TT, Koh TH, Hsu LY, Kwa AL.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01509-16. doi: 10.1128/AAC.01509-16. Print 2017 Jan.


3D Cell Culturing and Possibilities for Myometrial Tissue Engineering.

Heidari Kani M, Chan EC, Young RC, Butler T, Smith R, Paul JW.

Ann Biomed Eng. 2017 Jul;45(7):1746-1757. doi: 10.1007/s10439-016-1749-5. Epub 2016 Oct 21. Review.


NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing.

Chang PY, Chen JS, Chang NC, Chang SC, Wang MC, Tsai SH, Wen YH, Tsai WS, Chan EC, Lu JJ.

Oncotarget. 2016 Jun 21;7(25):37566-37580. doi: 10.18632/oncotarget.8885.


Dual delivery of active antibactericidal agents and bone morphogenetic protein at sustainable high concentrations using biodegradable sheath-core-structured drug-eluting nanofibers.

Hsu YH, Lin CT, Yu YH, Chou YC, Liu SJ, Chan EC.

Int J Nanomedicine. 2016 Aug 17;11:3927-37. doi: 10.2147/IJN.S107250. eCollection 2016.


Iohexol oral rinse to differentiate the palatoglossal surfaces in computed tomography of patients with obstructive sleep apnoea.

Sasaki R, Cheung YC, Chan EC, Lin CH, Chen YR.

Br J Oral Maxillofac Surg. 2017 Feb;55(2):207-208. doi: 10.1016/j.bjoms.2016.07.013. Epub 2016 Jul 30. No abstract available.


In Vitro Activity of Polymyxin B in Combination with Various Antibiotics against Extensively Drug-Resistant Enterobacter cloacae with Decreased Susceptibility to Polymyxin B.

Cai Y, Lim TP, Teo J, Sasikala S, Lee W, Hong Y, Chan EC, Tan TY, Tan TT, Koh TH, Hsu LY, Kwa AL.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5238-46. doi: 10.1128/AAC.00270-16. Print 2016 Sep.


The "self" in pain: the role of psychological inflexibility in chronic pain adjustment.

Kwok SS, Chan EC, Chen PP, Lo BC.

J Behav Med. 2016 Oct;39(5):908-15. doi: 10.1007/s10865-016-9750-x. Epub 2016 Jun 8.


Phase I Metabolic Stability and Electrophilic Reactivity of 2-Phenylaminophenylacetic Acid Derived Compounds.

Pang YY, Tan YM, Chan EC, Ho HK.

Chem Res Toxicol. 2016 Jul 18;29(7):1118-31. doi: 10.1021/acs.chemrestox.6b00042. Epub 2016 Jun 14.


Efficacy of vancomycin-releasing biodegradable poly(lactide-co-glycolide) antibiotics beads for treatment of experimental bone infection due to Staphylococcus aureus.

Ueng SW, Lin SS, Wang IC, Yang CY, Cheng RC, Liu SJ, Chan EC, Lai CF, Yuan LJ, Chan SC.

J Orthop Surg Res. 2016 Apr 27;11(1):52. doi: 10.1186/s13018-016-0386-x.


miR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers.

Lu YC, Chang JT, Chan EC, Chao YK, Yeh TS, Chen JS, Cheng AJ.

J Cancer. 2016 Mar 20;7(6):650-5. doi: 10.7150/jca.13460. eCollection 2016. Review.


Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites.

Karkhanis A, Lam HY, Venkatesan G, Koh SK, Chai CL, Zhou L, Hong Y, Kojodjojo P, Chan EC.

Biochem Pharmacol. 2016 May 1;107:67-80. doi: 10.1016/j.bcp.2016.03.005. Epub 2016 Mar 10.


Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish.

Li C, Li P, Tan YM, Lam SH, Chan EC, Gong Z.

PLoS One. 2016 Mar 11;11(3):e0151225. doi: 10.1371/journal.pone.0151225. eCollection 2016.


Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications.

Chan EC, Kuo SM, Kong AM, Morrison WA, Dusting GJ, Mitchell GM, Lim SY, Liu GS.

PLoS One. 2016 Feb 22;11(2):e0149799. doi: 10.1371/journal.pone.0149799. eCollection 2016.


MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection.

Chang PY, Chen CC, Chang YS, Tsai WS, You JF, Lin GP, Chen TW, Chen JS, Chan EC.

Oncotarget. 2016 Mar 1;7(9):10663-75. doi: 10.18632/oncotarget.7119.

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