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Development of a glycoproteomic strategy to detect more aggressive prostate cancer using lectin-immunoassays for serum fucosylated PSA.

Wang C, Höti N, Lih TM, Sokoll LJ, Zhang R, Zhang Z, Zhang H, Chan DW.

Clin Proteomics. 2019 Apr 6;16:13. doi: 10.1186/s12014-019-9234-4. eCollection 2019.


Novel Nuclear Partnering Role of EPS8 With FOXM1 in Regulating Cell Proliferation.

Ngan AWL, Grace Tsui M, So DHF, Leung WY, Chan DW, Yao KM.

Front Oncol. 2019 Mar 19;9:154. doi: 10.3389/fonc.2019.00154. eCollection 2019.


Pro-inflammatory, IL-17 pathways dominate the architecture of the immunome in pediatric refractory epilepsy.

Kumar P, Chan DWS, Lim A, Paleja B, Ling S, Yun LL, Poh SL, Ngoh A, Arkachaisri T, Yeo JG, Albani S.

JCI Insight. 2019 Mar 26;5. pii: 126337. doi: 10.1172/jci.insight.126337.


A multiplex immunoassay of serum biomarkers for the detection of uveal melanoma.

Song J, Merbs SL, Sokoll LJ, Chan DW, Zhang Z.

Clin Proteomics. 2019 Mar 5;16:10. doi: 10.1186/s12014-019-9230-8. eCollection 2019.


Validation of a novel model for the early detection of hepatocellular carcinoma.

Hemken PM, Sokoll LJ, Yang X, Dai J, Elliott D, Gawel SH, Lucht M, Feng Z, Marrero JA, Srivastava S, Chan DW, Davis GJ.

Clin Proteomics. 2019 Jan 16;16:2. doi: 10.1186/s12014-018-9222-0. eCollection 2019.


Cancer biomarker discovery and translation: proteomics and beyond.

Hristova VA, Chan DW.

Expert Rev Proteomics. 2019 Feb;16(2):93-103. doi: 10.1080/14789450.2019.1559062. Epub 2018 Dec 24.


Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors.

Song G, Chen L, Zhang B, Song Q, Yu Y, Moore C, Wang TL, Shih IM, Zhang H, Chan DW, Zhang Z, Zhu H.

Mol Cell Proteomics. 2019 Mar;18(3):448-460. doi: 10.1074/mcp.RA118.000851. Epub 2018 Dec 6.


DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.

Matsunuma R, Chan DW, Kim BJ, Singh P, Han A, Saltzman AB, Cheng C, Lei JT, Wang J, Roberto da Silva L, Sahin E, Leng M, Fan C, Perou CM, Malovannaya A, Ellis MJ.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11978-E11987. doi: 10.1073/pnas.1810598115. Epub 2018 Nov 29.


Young girl with bruising: Finding the X factor.

Chan DW, Lam JC.

J Paediatr Child Health. 2019 Apr;55(4):465-467. doi: 10.1111/jpc.14282. Epub 2018 Nov 13. No abstract available.


Parkinson disease: A systemic review of pain sensitivities and its association with clinical pain and response to dopaminergic stimulation.

Sung S, Vijiaratnam N, Chan DWC, Farrell M, Evans AH.

J Neurol Sci. 2018 Dec 15;395:172-206. doi: 10.1016/j.jns.2018.10.013. Epub 2018 Oct 19. Review.


Identification of Serum Biomarker Panels for the Early Detection of Pancreatic Cancer.

Song J, Sokoll LJ, Pasay JJ, Rubin AL, Li H, Bach DM, Chan DW, Zhang Z.

Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):174-182. doi: 10.1158/1055-9965.EPI-18-0483. Epub 2018 Oct 17.


miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer.

Sun J, Cai X, Yung MM, Zhou W, Li J, Zhang Y, Li Z, Liu SS, Cheung ANY, Ngan HYS, Li Y, Dai Z, Kai Y, Tzatsos A, Peng W, Chan DW, Zhu W.

Oncogene. 2019 Jan;38(4):564-580. doi: 10.1038/s41388-018-0459-x. Epub 2018 Aug 30.


gpGrouper: A Peptide Grouping Algorithm for Gene-Centric Inference and Quantitation of Bottom-Up Proteomics Data.

Saltzman AB, Leng M, Bhatt B, Singh P, Chan DW, Dobrolecki L, Chandrasekaran H, Choi JM, Jain A, Jung SY, Lewis MT, Ellis MJ, Malovannaya A.

Mol Cell Proteomics. 2018 Nov;17(11):2270-2283. doi: 10.1074/mcp.TIR118.000850. Epub 2018 Aug 9.


Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer.

Lei JT, Shao J, Zhang J, Iglesia M, Chan DW, Cao J, Anurag M, Singh P, He X, Kosaka Y, Matsunuma R, Crowder R, Hoog J, Phommaly C, Goncalves R, Ramalho S, Peres RMR, Punturi N, Schmidt C, Bartram A, Jou E, Devarakonda V, Holloway KR, Lai WV, Hampton O, Rogers A, Tobias E, Parikh PA, Davies SR, Li S, Ma CX, Suman VJ, Hunt KK, Watson MA, Hoadley KA, Thompson EA, Chen X, Kavuri SM, Creighton CJ, Maher CA, Perou CM, Haricharan S, Ellis MJ.

Cell Rep. 2018 Aug 7;24(6):1434-1444.e7. doi: 10.1016/j.celrep.2018.07.009.


Challenges and opportunities in the proteomic characterization of clear cell renal cell carcinoma (ccRCC): A critical step towards the personalized care of renal cancers.

Li QK, Pavlovich CP, Zhang H, Kinsinger CR, Chan DW.

Semin Cancer Biol. 2019 Apr;55:8-15. doi: 10.1016/j.semcancer.2018.06.004. Epub 2018 Jul 25. Review.


Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry.

Mertins P, Tang LC, Krug K, Clark DJ, Gritsenko MA, Chen L, Clauser KR, Clauss TR, Shah P, Gillette MA, Petyuk VA, Thomas SN, Mani DR, Mundt F, Moore RJ, Hu Y, Zhao R, Schnaubelt M, Keshishian H, Monroe ME, Zhang Z, Udeshi ND, Mani D, Davies SR, Townsend RR, Chan DW, Smith RD, Zhang H, Liu T, Carr SA.

Nat Protoc. 2018 Jul;13(7):1632-1661. doi: 10.1038/s41596-018-0006-9.


Changes over time in hip fracture risk: Greater improvements in men compared to women.

Smith R, Perera BK, Chan DWC.

Clin Endocrinol (Oxf). 2018 Sep;89(3):324-329. doi: 10.1111/cen.13763. Epub 2018 Jun 25.


PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers.

Ying L, Yan F, Meng Q, Yu L, Yuan X, Gantier MP, Williams BRG, Chan DW, Shi L, Tu Y, Ni P, Wang X, Chen W, Zang X, Xu D, Hu Y.

Oncoimmunology. 2018 Feb 20;7(6):e1433520. doi: 10.1080/2162402X.2018.1433520. eCollection 2018.


DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.

Meng Y, Chen CW, Yung MMH, Sun W, Sun J, Li Z, Li J, Li Z, Zhou W, Liu SS, Cheung ANY, Ngan HYS, Braisted JC, Kai Y, Peng W, Tzatsos A, Li Y, Dai Z, Zheng W, Chan DW, Zhu W.

Cancer Lett. 2018 Aug 1;428:104-116. doi: 10.1016/j.canlet.2018.04.029. Epub 2018 Apr 26.


Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance.

Zhou W, Sun W, Yung MMH, Dai S, Cai Y, Chen CW, Meng Y, Lee JB, Braisted JC, Xu Y, Southall NT, Shinn P, Huang X, Song Z, Chen X, Kai Y, Cai X, Li Z, Hao Q, Cheung ANY, Ngan HYS, Liu SS, Barak S, Hao J, Dai Z, Tzatsos A, Peng W, Pei H, Han Z, Chan DW, Zheng W, Zhu W.

Oncogene. 2018 Jul;37(29):3981-3997. doi: 10.1038/s41388-018-0238-8. Epub 2018 Apr 17.


Implementation of safety management systems in Hong Kong construction industry - A safety practitioner's perspective.

Yiu NSN, Sze NN, Chan DWM.

J Safety Res. 2018 Feb;64:1-9. doi: 10.1016/j.jsr.2017.12.011. Epub 2017 Dec 29.


Refractory hyperparathyroidism with a T3 bony lesion-differential diagnoses.

Chan DWC, Moir D, Standish R, Kotowicz MA.

Oxf Med Case Reports. 2018 Mar 20;2018(3):omx109. doi: 10.1093/omcr/omx109. eCollection 2018 Mar.


Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.

Nair A, Chung HC, Sun T, Tyagi S, Dobrolecki LE, Dominguez-Vidana R, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Schmitt E, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Zhang B, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne CK, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF.

Nat Med. 2018 May;24(4):505-511. doi: 10.1038/nm.4507. Epub 2018 Mar 26.


GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade.

Yung MM, Tang HW, Cai PC, Leung TH, Ngu SF, Chan KK, Xu D, Yang H, Ngan HY, Chan DW.

Theranostics. 2018 Feb 2;8(5):1270-1285. doi: 10.7150/thno.22536. eCollection 2018.


Pain sensitivity in Parkinson's disease: Systematic review and meta-analysis.

Sung S, Vijiaratnam N, Chan DWC, Farrell M, Evans AH.

Parkinsonism Relat Disord. 2018 Mar;48:17-27. doi: 10.1016/j.parkreldis.2017.12.031. Epub 2017 Dec 29.


Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.

Chen K, Liu MX, Mak CS, Yung MM, Leung TH, Xu D, Ngu SF, Chan KK, Yang H, Ngan HY, Chan DW.

Theranostics. 2018 Jan 1;8(2):423-436. doi: 10.7150/thno.22377. eCollection 2018.


ERBB2 mutation: A promising target in non-squamous cervical cancer.

Xiang L, Jiang W, Ye S, He T, Pei X, Li J, Chan DW, Ngan HYS, Li F, Tao P, Shen X, Zhou X, Wu X, Yang G, Yang H.

Gynecol Oncol. 2018 Feb;148(2):311-316. doi: 10.1016/j.ygyno.2017.12.023. Epub 2017 Dec 24.


A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils.

Gupta S, Chan DW, Zaal KJ, Kaplan MJ.

J Immunol. 2018 Jan 15;200(2):869-879. doi: 10.4049/jimmunol.1700905. Epub 2017 Dec 1.


Quality Assessments of Long-Term Quantitative Proteomic Analysis of Breast Cancer Xenograft Tissues.

Zhou JY, Chen L, Zhang B, Tian Y, Liu T, Thomas SN, Chen L, Schnaubelt M, Boja E, Hiltke T, Kinsinger CR, Rodriguez H, Davies SR, Li S, Snider JE, Erdmann-Gilmore P, Tabb DL, Townsend RR, Ellis MJ, Rodland KD, Smith RD, Carr SA, Zhang Z, Chan DW, Zhang H.

J Proteome Res. 2017 Dec 1;16(12):4523-4530. doi: 10.1021/acs.jproteome.7b00362. Epub 2017 Nov 16.


A field study of the effectiveness and practicality of a novel hybrid personal cooling vest worn during rest in Hong Kong construction industry.

Chan APC, Zhang Y, Wang F, Wong FFK, Chan DWM.

J Therm Biol. 2017 Dec;70(Pt A):21-27. doi: 10.1016/j.jtherbio.2017.07.012. Epub 2017 Jul 22.


Comparison of heat strain recovery in different anti-heat stress clothing ensembles after work to exhaustion.

Zhao Y, Yi W, Chan APC, Chan DWM.

J Therm Biol. 2017 Oct;69:311-318. doi: 10.1016/j.jtherbio.2017.09.004. Epub 2017 Sep 15.


Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry.

Ying L, Yan F, Meng Q, Yuan X, Yu L, Williams BRG, Chan DW, Shi L, Tu Y, Ni P, Wang X, Xu D, Hu Y.

J Transl Med. 2017 Oct 12;15(1):206. doi: 10.1186/s12967-017-1311-8.


Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness.

Leung TH, Tang HW, Siu MK, Chan DW, Chan KK, Cheung AN, Ngan HY.

J Pathol. 2018 Feb;244(2):151-163. doi: 10.1002/path.4991. Epub 2017 Dec 19.


Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry.

Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, Chan DW, Gibson BW, Gingras AC, Held JM, Hirayama-Kurogi M, Hou G, Krisp C, Larsen B, Lin L, Liu S, Molloy MP, Moritz RL, Ohtsuki S, Schlapbach R, Selevsek N, Thomas SN, Tzeng SC, Zhang H, Aebersold R.

Nat Commun. 2017 Aug 21;8(1):291. doi: 10.1038/s41467-017-00249-5.


Protein signatures of molecular pathways in non-small cell lung carcinoma (NSCLC): comparison of glycoproteomics and global proteomics.

Yang S, Chen L, Chan DW, Li QK, Zhang H.

Clin Proteomics. 2017 Aug 15;14:31. doi: 10.1186/s12014-017-9166-9. eCollection 2017.


Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants.

Wong JH, Sze SCW, Ng TB, Cheung RCF, Tam C, Zhang KY, Dan X, Chan YS, Shing Cho WC, Ng CCW, Waye MMY, Liang W, Zhang J, Yang J, Ye X, Lin J, Ye X, Wang H, Liu F, Chan DW, Ngan HYS, Sha O, Li G, Tse R, Tse TF, Chan H.

Curr Med Chem. 2018;25(40):5613-5630. doi: 10.2174/0929867324666170720165005. Review.


The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate.

Kim BJ, Chan DW, Jung SY, Chen Y, Qin J, Wang Y.

Cell Rep. 2017 May 30;19(9):1758-1766. doi: 10.1016/j.celrep.2017.05.027.


Association Between Combined TMPRSS2:ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer.

Sanda MG, Feng Z, Howard DH, Tomlins SA, Sokoll LJ, Chan DW, Regan MM, Groskopf J, Chipman J, Patil DH, Salami SS, Scherr DS, Kagan J, Srivastava S, Thompson IM Jr, Siddiqui J, Fan J, Joon AY, Bantis LE, Rubin MA, Chinnayian AM, Wei JT; and the EDRN-PCA3 Study Group, Bidair M, Kibel A, Lin DW, Lotan Y, Partin A, Taneja S.

JAMA Oncol. 2017 Aug 1;3(8):1085-1093. doi: 10.1001/jamaoncol.2017.0177.


Intracranial hypotension causing pituitary enlargement.

Chan DW, Wu AI, Wynne K.

BMJ Case Rep. 2017 May 12;2017. pii: bcr-2017-220057. doi: 10.1136/bcr-2017-220057. No abstract available.


An integrated proteomic and glycoproteomic approach uncovers differences in glycosylation occupancy from benign and malignant epithelial ovarian tumors.

Li QK, Shah P, Tian Y, Hu Y, Roden RBS, Zhang H, Chan DW.

Clin Proteomics. 2017 May 10;14:16. doi: 10.1186/s12014-017-9152-2. eCollection 2017.


Overexpression of the transcription factor ATF3 with a regulatory molecular signature associates with the pathogenic development of colorectal cancer.

Yan F, Ying L, Li X, Qiao B, Meng Q, Yu L, Yuan X, Ren ST, Chan DW, Shi L, Ni P, Wang X, Xu D, Hu Y.

Oncotarget. 2017 Jul 18;8(29):47020-47036. doi: 10.18632/oncotarget.16638.


MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis.

Mak CS, Yung MM, Hui LM, Leung LL, Liang R, Chen K, Liu SS, Qin Y, Leung TH, Lee KF, Chan KK, Ngan HY, Chan DW.

Mol Cancer. 2017 Jan 17;16(1):11. doi: 10.1186/s12943-017-0582-2.


Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction.

Wang J, Ma Z, Carr SA, Mertins P, Zhang H, Zhang Z, Chan DW, Ellis MJ, Townsend RR, Smith RD, McDermott JE, Chen X, Paulovich AG, Boja ES, Mesri M, Kinsinger CR, Rodriguez H, Rodland KD, Liebler DC, Zhang B.

Mol Cell Proteomics. 2017 Jan;16(1):121-134. doi: 10.1074/mcp.M116.060301. Epub 2016 Nov 11.


Understanding the Microstructure and Macrostructure of Passages Among Chinese Elementary School Children.

Lo LY, Ho CS, Wong YK, Chan DW, Chung KK.

J Psycholinguist Res. 2016 Dec;45(6):1287-1300.


Prostate Health Index improves multivariable risk prediction of aggressive prostate cancer.

Loeb S, Shin SS, Broyles DL, Wei JT, Sanda M, Klee G, Partin AW, Sokoll L, Chan DW, Bangma CH, van Schaik RHN, Slawin KM, Marks LS, Catalona WJ.

BJU Int. 2017 Jul;120(1):61-68. doi: 10.1111/bju.13676. Epub 2016 Nov 22.


Precision medicine: from pharmacogenomics to pharmacoproteomics.

Chambliss AB, Chan DW.

Clin Proteomics. 2016 Sep 26;13:25. eCollection 2016. Review.


Review of clinical studies of perampanel in adolescent patients.

Kim HD, Chi CS, Desudchit T, Nikanorova M, Visudtibhan A, Nabangchang C, Chan DW, Fong CY, Chang KP, Kwan SY, Reyes FL, Huang CC, Likasitwattanakul S, Lee WT, Yung A, Dash A.

Brain Behav. 2016 Jun 28;6(9):e00505. eCollection 2016 Sep. Review.


Focal status epilepticus and progressive dyskinesia: A novel phenotype for glycine receptor antibody-mediated neurological disease in children.

Chan DWS, Thomas T, Lim M, Ling S, Woodhall M, Vincent A.

Eur J Paediatr Neurol. 2017 Mar;21(2):414-417. doi: 10.1016/j.ejpn.2016.08.013. Epub 2016 Sep 12.


DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling.

Chan DW, Hui WW, Wang JJ, Yung MM, Hui LM, Qin Y, Liang RR, Leung TH, Xu D, Chan KK, Yao KM, Tsang BK, Ngan HY.

Oncogene. 2017 Mar;36(10):1404-1416. doi: 10.1038/onc.2016.307. Epub 2016 Sep 5.


Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.

Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Chen L, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IM, Cope L, Pandey A, Zhang B, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD; CPTAC Investigators.

Cell. 2016 Jul 28;166(3):755-765. doi: 10.1016/j.cell.2016.05.069. Epub 2016 Jun 29.

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