Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 422


Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry.

Mertins P, Tang LC, Krug K, Clark DJ, Gritsenko MA, Chen L, Clauser KR, Clauss TR, Shah P, Gillette MA, Petyuk VA, Thomas SN, Mani DR, Mundt F, Moore RJ, Hu Y, Zhao R, Schnaubelt M, Keshishian H, Monroe ME, Zhang Z, Udeshi ND, Mani D, Davies SR, Townsend RR, Chan DW, Smith RD, Zhang H, Liu T, Carr SA.

Nat Protoc. 2018 Jul 9. doi: 10.1038/s41596-018-0006-9. [Epub ahead of print]


Changes over time in hip fracture risk: Greater improvements in men compared to women.

Smith R, Perera BK, Chan DWC.

Clin Endocrinol (Oxf). 2018 Jun 9. doi: 10.1111/cen.13763. [Epub ahead of print]


PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers.

Ying L, Yan F, Meng Q, Yu L, Yuan X, Gantier MP, Williams BRG, Chan DW, Shi L, Tu Y, Ni P, Wang X, Chen W, Zang X, Xu D, Hu Y.

Oncoimmunology. 2018 Feb 20;7(6):e1433520. doi: 10.1080/2162402X.2018.1433520. eCollection 2018.


DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.

Meng Y, Chen CW, Yung MMH, Sun W, Sun J, Li Z, Li J, Li Z, Zhou W, Liu SS, Cheung ANY, Ngan HYS, Braisted JC, Kai Y, Peng W, Tzatsos A, Li Y, Dai Z, Zheng W, Chan DW, Zhu W.

Cancer Lett. 2018 Aug 1;428:104-116. doi: 10.1016/j.canlet.2018.04.029. Epub 2018 Apr 26.


Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance.

Zhou W, Sun W, Yung MMH, Dai S, Cai Y, Chen CW, Meng Y, Lee JB, Braisted JC, Xu Y, Southall NT, Shinn P, Huang X, Song Z, Chen X, Kai Y, Cai X, Li Z, Hao Q, Cheung ANY, Ngan HYS, Liu SS, Barak S, Hao J, Dai Z, Tzatsos A, Peng W, Pei H, Han Z, Chan DW, Zheng W, Zhu W.

Oncogene. 2018 Jul;37(29):3981-3997. doi: 10.1038/s41388-018-0238-8. Epub 2018 Apr 17.


Implementation of safety management systems in Hong Kong construction industry - A safety practitioner's perspective.

Yiu NSN, Sze NN, Chan DWM.

J Safety Res. 2018 Feb;64:1-9. doi: 10.1016/j.jsr.2017.12.011. Epub 2017 Dec 29.


Refractory hyperparathyroidism with a T3 bony lesion-differential diagnoses.

Chan DWC, Moir D, Standish R, Kotowicz MA.

Oxf Med Case Reports. 2018 Mar 20;2018(3):omx109. doi: 10.1093/omcr/omx109. eCollection 2018 Mar.


Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.

Nair A, Chung HC, Sun T, Tyagi S, Dobrolecki LE, Dominguez-Vidana R, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Schmitt E, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Zhang B, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne CK, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF.

Nat Med. 2018 May;24(4):505-511. doi: 10.1038/nm.4507. Epub 2018 Mar 26.


GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade.

Yung MM, Tang HW, Cai PC, Leung TH, Ngu SF, Chan KK, Xu D, Yang H, Ngan HY, Chan DW.

Theranostics. 2018 Feb 2;8(5):1270-1285. doi: 10.7150/thno.22536. eCollection 2018.


Pain sensitivity in Parkinson's disease: Systematic review and meta-analysis.

Sung S, Vijiaratnam N, Chan DWC, Farrell M, Evans AH.

Parkinsonism Relat Disord. 2018 Mar;48:17-27. doi: 10.1016/j.parkreldis.2017.12.031. Epub 2017 Dec 29. Review.


Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.

Chen K, Liu MX, Mak CS, Yung MM, Leung TH, Xu D, Ngu SF, Chan KK, Yang H, Ngan HY, Chan DW.

Theranostics. 2018 Jan 1;8(2):423-436. doi: 10.7150/thno.22377. eCollection 2018.


ERBB2 mutation: A promising target in non-squamous cervical cancer.

Xiang L, Jiang W, Ye S, He T, Pei X, Li J, Chan DW, Ngan HYS, Li F, Tao P, Shen X, Zhou X, Wu X, Yang G, Yang H.

Gynecol Oncol. 2018 Feb;148(2):311-316. doi: 10.1016/j.ygyno.2017.12.023. Epub 2017 Dec 24.


A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils.

Gupta S, Chan DW, Zaal KJ, Kaplan MJ.

J Immunol. 2018 Jan 15;200(2):869-879. doi: 10.4049/jimmunol.1700905. Epub 2017 Dec 1.


Quality Assessments of Long-Term Quantitative Proteomic Analysis of Breast Cancer Xenograft Tissues.

Zhou JY, Chen L, Zhang B, Tian Y, Liu T, Thomas SN, Chen L, Schnaubelt M, Boja E, Hiltke T, Kinsinger CR, Rodriguez H, Davies SR, Li S, Snider JE, Erdmann-Gilmore P, Tabb DL, Townsend RR, Ellis MJ, Rodland KD, Smith RD, Carr SA, Zhang Z, Chan DW, Zhang H.

J Proteome Res. 2017 Dec 1;16(12):4523-4530. doi: 10.1021/acs.jproteome.7b00362. Epub 2017 Nov 16.


A field study of the effectiveness and practicality of a novel hybrid personal cooling vest worn during rest in Hong Kong construction industry.

Chan APC, Zhang Y, Wang F, Wong FFK, Chan DWM.

J Therm Biol. 2017 Dec;70(Pt A):21-27. doi: 10.1016/j.jtherbio.2017.07.012. Epub 2017 Jul 22.


Comparison of heat strain recovery in different anti-heat stress clothing ensembles after work to exhaustion.

Zhao Y, Yi W, Chan APC, Chan DWM.

J Therm Biol. 2017 Oct;69:311-318. doi: 10.1016/j.jtherbio.2017.09.004. Epub 2017 Sep 15.


Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry.

Ying L, Yan F, Meng Q, Yuan X, Yu L, Williams BRG, Chan DW, Shi L, Tu Y, Ni P, Wang X, Xu D, Hu Y.

J Transl Med. 2017 Oct 12;15(1):206. doi: 10.1186/s12967-017-1311-8.


Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness.

Leung TH, Tang HW, Siu MK, Chan DW, Chan KK, Cheung AN, Ngan HY.

J Pathol. 2018 Feb;244(2):151-163. doi: 10.1002/path.4991. Epub 2017 Dec 19.


Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry.

Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, Chan DW, Gibson BW, Gingras AC, Held JM, Hirayama-Kurogi M, Hou G, Krisp C, Larsen B, Lin L, Liu S, Molloy MP, Moritz RL, Ohtsuki S, Schlapbach R, Selevsek N, Thomas SN, Tzeng SC, Zhang H, Aebersold R.

Nat Commun. 2017 Aug 21;8(1):291. doi: 10.1038/s41467-017-00249-5.


Protein signatures of molecular pathways in non-small cell lung carcinoma (NSCLC): comparison of glycoproteomics and global proteomics.

Yang S, Chen L, Chan DW, Li QK, Zhang H.

Clin Proteomics. 2017 Aug 15;14:31. doi: 10.1186/s12014-017-9166-9. eCollection 2017.


Apoptosis and anti-cancer drug discovery: the power of medicinal fungi and plants.

Wong JH, Cho Wing Sze S, Ng TB, Chi Fai Cheung R, Tam C, Zhang KY, Dan X, Chan YS, Chi Shing Cho W, Cheuk Wing Ng C, Miu Yee Waye M, Liang W, Zhang J, Yang J, Ye X, Lin J, Ye X, Wang H, Liu F, Chan DW, Yuen Sheung Ngan H, Sha O, Li G, Tse R, Tse TF, Chan H.

Curr Med Chem. 2017 Jul 20. doi: 10.2174/0929867324666170720165005. [Epub ahead of print]


The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate.

Kim BJ, Chan DW, Jung SY, Chen Y, Qin J, Wang Y.

Cell Rep. 2017 May 30;19(9):1758-1766. doi: 10.1016/j.celrep.2017.05.027.


Association Between Combined TMPRSS2:ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer.

Sanda MG, Feng Z, Howard DH, Tomlins SA, Sokoll LJ, Chan DW, Regan MM, Groskopf J, Chipman J, Patil DH, Salami SS, Scherr DS, Kagan J, Srivastava S, Thompson IM Jr, Siddiqui J, Fan J, Joon AY, Bantis LE, Rubin MA, Chinnayian AM, Wei JT; and the EDRN-PCA3 Study Group, Bidair M, Kibel A, Lin DW, Lotan Y, Partin A, Taneja S.

JAMA Oncol. 2017 Aug 1;3(8):1085-1093. doi: 10.1001/jamaoncol.2017.0177.


Intracranial hypotension causing pituitary enlargement.

Chan DW, Wu AI, Wynne K.

BMJ Case Rep. 2017 May 12;2017. pii: bcr-2017-220057. doi: 10.1136/bcr-2017-220057. No abstract available.


An integrated proteomic and glycoproteomic approach uncovers differences in glycosylation occupancy from benign and malignant epithelial ovarian tumors.

Li QK, Shah P, Tian Y, Hu Y, Roden RBS, Zhang H, Chan DW.

Clin Proteomics. 2017 May 10;14:16. doi: 10.1186/s12014-017-9152-2. eCollection 2017.


Overexpression of the transcription factor ATF3 with a regulatory molecular signature associates with the pathogenic development of colorectal cancer.

Yan F, Ying L, Li X, Qiao B, Meng Q, Yu L, Yuan X, Ren ST, Chan DW, Shi L, Ni P, Wang X, Xu D, Hu Y.

Oncotarget. 2017 Jul 18;8(29):47020-47036. doi: 10.18632/oncotarget.16638.


MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis.

Mak CS, Yung MM, Hui LM, Leung LL, Liang R, Chen K, Liu SS, Qin Y, Leung TH, Lee KF, Chan KK, Ngan HY, Chan DW.

Mol Cancer. 2017 Jan 17;16(1):11. doi: 10.1186/s12943-017-0582-2.


Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction.

Wang J, Ma Z, Carr SA, Mertins P, Zhang H, Zhang Z, Chan DW, Ellis MJ, Townsend RR, Smith RD, McDermott JE, Chen X, Paulovich AG, Boja ES, Mesri M, Kinsinger CR, Rodriguez H, Rodland KD, Liebler DC, Zhang B.

Mol Cell Proteomics. 2017 Jan;16(1):121-134. doi: 10.1074/mcp.M116.060301. Epub 2016 Nov 11.


Understanding the Microstructure and Macrostructure of Passages Among Chinese Elementary School Children.

Lo LY, Ho CS, Wong YK, Chan DW, Chung KK.

J Psycholinguist Res. 2016 Dec;45(6):1287-1300.


Prostate Health Index improves multivariable risk prediction of aggressive prostate cancer.

Loeb S, Shin SS, Broyles DL, Wei JT, Sanda M, Klee G, Partin AW, Sokoll L, Chan DW, Bangma CH, van Schaik RHN, Slawin KM, Marks LS, Catalona WJ.

BJU Int. 2017 Jul;120(1):61-68. doi: 10.1111/bju.13676. Epub 2016 Nov 22.


Precision medicine: from pharmacogenomics to pharmacoproteomics.

Chambliss AB, Chan DW.

Clin Proteomics. 2016 Sep 26;13:25. eCollection 2016. Review.


Review of clinical studies of perampanel in adolescent patients.

Kim HD, Chi CS, Desudchit T, Nikanorova M, Visudtibhan A, Nabangchang C, Chan DW, Fong CY, Chang KP, Kwan SY, Reyes FL, Huang CC, Likasitwattanakul S, Lee WT, Yung A, Dash A.

Brain Behav. 2016 Jun 28;6(9):e00505. eCollection 2016 Sep. Review.


Focal status epilepticus and progressive dyskinesia: A novel phenotype for glycine receptor antibody-mediated neurological disease in children.

Chan DW, Thomas T, Lim M, Ling S, Woodhall M, Vincent A.

Eur J Paediatr Neurol. 2017 Mar;21(2):414-417. doi: 10.1016/j.ejpn.2016.08.013. Epub 2016 Sep 12.


DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling.

Chan DW, Hui WW, Wang JJ, Yung MM, Hui LM, Qin Y, Liang RR, Leung TH, Xu D, Chan KK, Yao KM, Tsang BK, Ngan HY.

Oncogene. 2017 Mar;36(10):1404-1416. doi: 10.1038/onc.2016.307. Epub 2016 Sep 5.


Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.

Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Chen L, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IM, Cope L, Pandey A, Zhang B, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD; CPTAC Investigators.

Cell. 2016 Jul 28;166(3):755-765. doi: 10.1016/j.cell.2016.05.069. Epub 2016 Jun 29.


Expression and localization of the Xenopus laevis small heat shock protein, HSPB6 (HSP20), in A6 kidney epithelial cells.

Khamis I, Chan DW, Shirriff CS, Campbell JH, Heikkila JJ.

Comp Biochem Physiol A Mol Integr Physiol. 2016 Nov;201:12-21. doi: 10.1016/j.cbpa.2016.06.022. Epub 2016 Jun 21.


Predicting Ovarian Cancer Patients' Clinical Response to Platinum-Based Chemotherapy by Their Tumor Proteomic Signatures.

Yu KH, Levine DA, Zhang H, Chan DW, Zhang Z, Snyder M.

J Proteome Res. 2016 Aug 5;15(8):2455-65. doi: 10.1021/acs.jproteome.5b01129. Epub 2016 Jul 8.


Serial outcomes in acute necrotising encephalopathy of childhood: A medium and long term study.

Lim HY, Ho VP, Lim TC, Thomas T, Chan DW.

Brain Dev. 2016 Nov;38(10):928-936. doi: 10.1016/j.braindev.2016.05.002. Epub 2016 May 30.


Validation of a second-generation multivariate index assay for malignancy risk of adnexal masses.

Coleman RL, Herzog TJ, Chan DW, Munroe DG, Pappas TC, Smith A, Zhang Z, Wolf J.

Am J Obstet Gynecol. 2016 Jul;215(1):82.e1-82.e11. doi: 10.1016/j.ajog.2016.03.003. Epub 2016 Mar 10.


Guiding follow-up of paediatric idiopathic intracranial hypertension with optical coherence tomography.

Loo KG, Lim SA, Lim IL, Chan DW.

BMJ Case Rep. 2016 Mar 3;2016. pii: bcr2015213070. doi: 10.1136/bcr-2015-213070.


Using the CPTAC Assay Portal to Identify and Implement Highly Characterized Targeted Proteomics Assays.

Whiteaker JR, Halusa GN, Hoofnagle AN, Sharma V, MacLean B, Yan P, Wrobel JA, Kennedy J, Mani DR, Zimmerman LJ, Meyer MR, Mesri M, Boja E, Carr SA, Chan DW, Chen X, Chen J, Davies SR, Ellis MJ, Fenyö D, Hiltke T, Ketchum KA, Kinsinger C, Kuhn E, Liebler DC, Liu T, Loss M, MacCoss MJ, Qian WJ, Rivers R, Rodland KD, Ruggles KV, Scott MG, Smith RD, Thomas S, Townsend RR, Whiteley G, Wu C, Zhang H, Zhang Z, Rodriguez H, Paulovich AG.

Methods Mol Biol. 2016;1410:223-36. doi: 10.1007/978-1-4939-3524-6_13.


Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges.

Yung MM, Ngan HY, Chan DW.

Acta Biochim Biophys Sin (Shanghai). 2016 Apr;48(4):301-17. doi: 10.1093/abbs/gmv128. Epub 2016 Jan 12. Review.


Advances in mass spectrometry-based clinical biomarker discovery.

Crutchfield CA, Thomas SN, Sokoll LJ, Chan DW.

Clin Proteomics. 2016 Jan 7;13:1. doi: 10.1186/s12014-015-9102-9. eCollection 2016. Review.


Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based Assays.

Hoofnagle AN, Whiteaker JR, Carr SA, Kuhn E, Liu T, Massoni SA, Thomas SN, Townsend RR, Zimmerman LJ, Boja E, Chen J, Crimmins DL, Davies SR, Gao Y, Hiltke TR, Ketchum KA, Kinsinger CR, Mesri M, Meyer MR, Qian WJ, Schoenherr RM, Scott MG, Shi T, Whiteley GR, Wrobel JA, Wu C, Ackermann BL, Aebersold R, Barnidge DR, Bunk DM, Clarke N, Fishman JB, Grant RP, Kusebauch U, Kushnir MM, Lowenthal MS, Moritz RL, Neubert H, Patterson SD, Rockwood AL, Rogers J, Singh RJ, Van Eyk JE, Wong SH, Zhang S, Chan DW, Chen X, Ellis MJ, Liebler DC, Rodland KD, Rodriguez H, Smith RD, Zhang Z, Zhang H, Paulovich AG.

Clin Chem. 2016 Jan;62(1):48-69. doi: 10.1373/clinchem.2015.250563.


Reproducibility of Differential Proteomic Technologies in CPTAC Fractionated Xenografts.

Tabb DL, Wang X, Carr SA, Clauser KR, Mertins P, Chambers MC, Holman JD, Wang J, Zhang B, Zimmerman LJ, Chen X, Gunawardena HP, Davies SR, Ellis MJ, Li S, Townsend RR, Boja ES, Ketchum KA, Kinsinger CR, Mesri M, Rodriguez H, Liu T, Kim S, McDermott JE, Payne SH, Petyuk VA, Rodland KD, Smith RD, Yang F, Chan DW, Zhang B, Zhang H, Zhang Z, Zhou JY, Liebler DC.

J Proteome Res. 2016 Mar 4;15(3):691-706. doi: 10.1021/acs.jproteome.5b00859. Epub 2015 Dec 22.


Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides.

Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Höti N, Zhang Z, Chan DW, Zhang H.

Nat Biotechnol. 2016 Jan;34(1):84-8. doi: 10.1038/nbt.3403. Epub 2015 Nov 16.


Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade.

Yung MM, Ross FA, Hardie DG, Leung TH, Zhan J, Ngan HY, Chan DW.

Integr Cancer Ther. 2016 Sep;15(3):376-89. doi: 10.1177/1534735415611747. Epub 2015 Oct 19.


Oriented polyvinylidene fluoride-trifluoroethylene (P(VDF-TrFE)) films by Langmuir-Blodgett deposition: a synchrotron X-ray diffraction study.

Lindemann WR, Philiph RL, Chan DW, Ayers CT, Perez EM, Beckman SP, Strzalka J, Chaudhary S, Vaknin D.

Phys Chem Chem Phys. 2015 Nov 21;17(43):29335-9. doi: 10.1039/c5cp04307g.


Multiplexed Targeted Mass Spectrometry-Based Assays for the Quantification of N-Linked Glycosite-Containing Peptides in Serum.

Thomas SN, Harlan R, Chen J, Aiyetan P, Liu Y, Sokoll LJ, Aebersold R, Chan DW, Zhang H.

Anal Chem. 2015 Nov 3;87(21):10830-8. doi: 10.1021/acs.analchem.5b02063. Epub 2015 Oct 21.


Integrated glycoprotein immobilization method for glycopeptide and glycan analysis of cardiac hypertrophy.

Yang S, Mishra S, Chen L, Zhou JY, Chan DW, Chatterjee S, Zhang H.

Anal Chem. 2015 Oct 6;87(19):9671-8. doi: 10.1021/acs.analchem.5b01663.

Supplemental Content

Support Center