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Per- and polyfluoroalkyl substances impact human spermatogenesis in a stem-cell-derived model.

Steves AN, Turry A, Gill B, Clarkson-Townsend D, Bradner JM, Bachli I, Caudle WM, Miller GW, Chan AWS, Easley CA 4th.

Syst Biol Reprod Med. 2018 Aug;64(4):225-239. doi: 10.1080/19396368.2018.1481465. Epub 2018 Jun 18.


Liver- and Colon-Specific DNA Methylation Markers in Plasma for Investigation of Colorectal Cancers With or Without Liver Metastases.

Gai W, Ji L, Lam WKJ, Sun K, Jiang P, Chan AWH, Wong J, Lai PBS, Ng SSM, Ma BBY, Wong GLH, Wong VWS, Chan HLY, Chiu RWK, Lo YMD, Chan KCA.

Clin Chem. 2018 Jun 14. pii: clinchem.2018.290304. doi: 10.1373/clinchem.2018.290304. [Epub ahead of print]


Clinical learning experiences of nursing students using an innovative clinical partnership model: A non-randomized controlled trial.

Chan AWK, Tang FWK, Choi KC, Liu T, Taylor-Piliae RE.

Nurse Educ Today. 2018 Jun 5;68:121-127. doi: 10.1016/j.nedt.2018.06.001. [Epub ahead of print]


Ubiquitous Flame-Retardant Toxicants Impair Spermatogenesis in a Human Stem Cell Model.

Steves AN, Bradner JM, Fowler KL, Clarkson-Townsend D, Gill BJ, Turry AC, Caudle WM, Miller GW, Chan AWS, Easley CA 4th.

iScience. 2018 May 25;3:161-176. doi: 10.1016/j.isci.2018.04.014.


Improved keratinocyte carcinoma outcomes with annual dermatology assessment after solid organ transplantation: Population-based cohort study.

Chan AW, Fung K, Austin PC, Kim SJ, Singer LG, Baxter NN, Alhusayen R, Rochon PA.

Am J Transplant. 2018 Jun 13. doi: 10.1111/ajt.14966. [Epub ahead of print]


Repeating measurements by transient elastography in non-alcoholic fatty liver disease patients with high liver stiffness.

Chow JC, Wong GL, Chan AW, Shu SS, Chan CK, Leung JK, Choi PC, Chim AM, Chan HL, Wong VW.

J Gastroenterol Hepatol. 2018 Jun 11. doi: 10.1111/jgh.14311. [Epub ahead of print]


Prospective Validation of the Chinese Version of the Self-Efficacy for Exercise Scale Among Middle-Aged Patients With Coronary Heart Disease.

Wong EML, Leung DYP, Sit JWH, Chan AWK, Chair SY.

Rehabil Nurs. 2018 Jun 8. doi: 10.1097/rnj.0000000000000156. [Epub ahead of print]


Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway.

Pan Y, Cheung ST, Tong JHM, Tin KY, Kang W, Lung RWM, Wu F, Li H, Ng SSM, Mak TWC, To KF, Chan AWH.

J Transl Med. 2018 Jun 4;16(1):150. doi: 10.1186/s12967-018-1530-7.


The effects of global warming on allergic diseases.

Chan AW, Hon KL, Leung TF, Ho MH, Rosa Duque JS, Lee TH.

Hong Kong Med J. 2018 Jun;24(3):277-284. doi: 10.12809/hkmj177046. Epub 2018 May 29. Review.


Outcomes of salvage radiotherapy for recurrent prostate cancer after radical prostatectomy.

Lee EK, Mui WH, Chan AW, Tung Y, Wong FC.

Hong Kong Med J. 2018 Jun;24(3):218-225. doi: 10.12809/hkmj176888. Epub 2018 May 21.


Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer.

Chan SL, Chan AWH, Mo F, Ma BBY, Wong KCW, Lam D, Mok FST, Chan ATC, Mok T, Chan KCA.

Oncologist. 2018 May 25. pii: theoncologist.2017-0637. doi: 10.1634/theoncologist.2017-0637. [Epub ahead of print]


Assessment of programmed cell death ligand-1 expression by 4 diagnostic assays and its clinicopathological correlation in a large cohort of surgical resected non-small cell lung carcinoma.

Chan AWH, Tong JHM, Kwan JSH, Chow C, Chung LY, Chau SL, Lung RWM, Ng CSH, Wan IYP, Mok TSK, To KF.

Mod Pathol. 2018 Apr 30. doi: 10.1038/s41379-018-0053-3. [Epub ahead of print]


The prognostic impact of revascularization strategy in acute myocardial infarction and cardiogenic shock: Insights from the British Columbia Cardiac Registry.

McNeice A, Nadra IJ, Robinson SD, Fretz E, Ding L, Fung A, Aymong E, Chan AW, Hodge S, Webb J, Sheth T, Jolly SS, Mehta SR, Della Siega A, Wood DA, Iqbal MB; British Columbia Cardiac Registry Investigators.

Catheter Cardiovasc Interv. 2018 Apr 26. doi: 10.1002/ccd.27648. [Epub ahead of print]


Longitudinal Anthropometric Assessment of Rhesus Macaque (Macaca mulatta) Model of Huntington Disease.

Hunter CE, Pongos AL, Chi TY, Payne C, Stroud FC, Chan AWS.

Comp Med. 2018 Apr 2;68(2):163-167.


Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells.

Powell J, Mota F, Steadman D, Soudy C, Miyauchi JT, Crosby S, Jarvis A, Reisinger T, Winfield N, Evans G, Finniear A, Yelland T, Chou YT, Chan AWE, O'Leary A, Cheng L, Liu D, Fotinou C, Milagre C, Martin JF, Jia H, Frankel P, Djordjevic S, Tsirka SE, Zachary IC, Selwood DL.

J Med Chem. 2018 May 10;61(9):4135-4154. doi: 10.1021/acs.jmedchem.8b00210. Epub 2018 Apr 24.


SPIRIT promotes protocol sharing.

Chan AW, Moher D, Altman DG.

Lancet Psychiatry. 2018 May;5(5):390-391. doi: 10.1016/S2215-0366(18)30125-1. Epub 2018 Mar 29. No abstract available.


Treatment for Lentigo Maligna of the Head and Neck: Survey of Practices in Ontario, Canada.

Liu A, Botkin A, Murray C, Goldstein D, Hofer SOP, Solish N, Kitchen J, Chan AW.

Dermatol Surg. 2018 Jul;44(7):918-923. doi: 10.1097/DSS.0000000000001498.


Palliative Head and Neck Cancer Treatment for Asymptomatic Disease.

Yerramilli D, Kovatch KJ, Chan AW, Swiecicki P, Margalit DN, Shuman AG.

Otolaryngol Head Neck Surg. 2018 Jul;159(1):25-28. doi: 10.1177/0194599818761861. Epub 2018 Feb 27. No abstract available.


Promoting public access to clinical trial protocols: challenges and recommendations.

Chan AW, Hróbjartsson A.

Trials. 2018 Feb 17;19(1):116. doi: 10.1186/s13063-018-2510-1.


EUS-FNA using 22G nitinol or ProCore needles without on-site cytopathology.

Chong CCN, Teoh AYB, Tang RSY, Chan AWH, Ng EKW, Lai PBS.

Endosc Ultrasound. 2018 Jan-Feb;7(1):56-60. doi: 10.4103/eus.eus_113_17.


Architecture and hydration of the arginine-binding site of neuropilin-1.

Mota F, Fotinou C, Rana RR, Chan AWE, Yelland T, Arooz MT, O'Leary AP, Hutton J, Frankel P, Zachary I, Selwood D, Djordjevic S.

FEBS J. 2018 Apr;285(7):1290-1304. doi: 10.1111/febs.14405. Epub 2018 Feb 25.


Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols: The SPIRIT-PRO Extension.

Calvert M, Kyte D, Mercieca-Bebber R, Slade A, Chan AW, King MT; the SPIRIT-PRO Group, Hunn A, Bottomley A, Regnault A, Chan AW, Ells C, O'Connor D, Revicki D, Patrick D, Altman D, Basch E, Velikova G, Price G, Draper H, Blazeby J, Scott J, Coast J, Norquist J, Brown J, Haywood K, Johnson LL, Campbell L, Frank L, von Hildebrand M, Brundage M, Palmer M, Kluetz P, Stephens R, Golub RM, Mitchell S, Groves T.

JAMA. 2018 Feb 6;319(5):483-494. doi: 10.1001/jama.2017.21903.


Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer.

Addison D, Lawler PR, Emami H, Janjua SA, Staziaki PV, Hallett TR, Hennessy O, Lee H, Szilveszter B, Lu M, Mousavi N, Nayor MG, Delling FN, Romero JM, Wirth LJ, Chan AW, Hoffmann U, Neilan TG.

J Stroke. 2018 Jan;20(1):71-79. doi: 10.5853/jos.2017.01802. Epub 2018 Jan 31.


miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis.

Kang W, Huang T, Zhou Y, Zhang J, Lung RWM, Tong JHM, Chan AWH, Zhang B, Wong CC, Wu F, Dong Y, Wang S, Yang W, Pan Y, Chak WP, Cheung AHK, Pang JCS, Yu J, Cheng ASL, To KF.

Cell Death Dis. 2018 Jan 24;9(2):92. doi: 10.1038/s41419-017-0134-0.


Microwave ablation provides better survival than liver resection for hepatocellular carcinoma in patients with borderline liver function: application of ALBI score to patient selection.

Chong CCN, Lee KF, Chu CM, Chan AWH, Wong J, Chan SL, Lok HT, Fung AKY, Fong AKW, Cheung YS, Yu SCH, Johnson P, Lai PBS.

HPB (Oxford). 2018 Jun;20(6):546-554. doi: 10.1016/j.hpb.2017.12.001. Epub 2018 Jan 17.


Ablative Chemoembolization for Hepatocellular Carcinoma: A Prospective Phase I Case-Control Comparison with Conventional Chemoembolization.

Yu SCH, Chan SL, Lee KF, Hui JWY, Hui EP, Chu CM, Chan AW, Cheung S, Li L, Wong J, Yeo WMM.

Radiology. 2018 Apr;287(1):340-348. doi: 10.1148/radiol.2017170154. Epub 2017 Dec 22.


Increased expression of GATA zinc finger domain containing 1 through gene amplification promotes liver cancer by directly inducing phosphatase of regenerating liver 3.

Sun W, Zhang Y, Wong KC, Liu K, Yang Y, Wu B, Tong JHM, Chan AWH, Chan HLY, Yu J.

Hepatology. 2018 Jun;67(6):2302-2319. doi: 10.1002/hep.29750. Epub 2018 Mar 23.


Effects of Tai Chi-based cardiac rehabilitation on aerobic endurance, psychosocial well-being, and cardiovascular risk reduction among patients with coronary heart disease: A systematic review and meta-analysis.

Liu T, Chan AW, Liu YH, Taylor-Piliae RE.

Eur J Cardiovasc Nurs. 2018 Apr;17(4):368-383. doi: 10.1177/1474515117749592. Epub 2017 Dec 19.


EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma.

Lung RW, Hau PM, Yu KH, Yip KY, Tong JH, Chak WP, Chan AW, Lam KH, Lo AK, Tin EK, Chau SL, Pang JC, Kwan JS, Busson P, Young LS, Yap LF, Tsao SW, To KF, Lo KW.

J Pathol. 2018 Apr;244(4):394-407. doi: 10.1002/path.5018. Epub 2018 Feb 16.


Good Vibrations: Resting-State Functional Connectivity Reflects Entrainment of Vasomotion.

Chan AW, Murphy TH.

Neuron. 2017 Nov 15;96(4):716-717. doi: 10.1016/j.neuron.2017.10.035.


Progress in developing transgenic monkey model for Huntington's disease.

Snyder BR, Chan AWS.

J Neural Transm (Vienna). 2018 Mar;125(3):401-417. doi: 10.1007/s00702-017-1803-y. Epub 2017 Nov 10. Review.


Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?

Margetts J, Ogle LF, Chan SL, Chan AWH, Chan KCA, Jamieson D, Willoughby CE, Mann DA, Wilson CL, Manas DM, Yeo W, Reeves HL.

Br J Cancer. 2018 Jan;118(2):248-257. doi: 10.1038/bjc.2017.386. Epub 2017 Nov 9.


Advanced liver fibrosis but not steatosis is independently associated with albuminuria in Chinese patients with type 2 diabetes.

Yeung MW, Wong GL, Choi KC, Luk AO, Kwok R, Shu SS, Chan AW, Lau ESH, Ma RCW, Chan HL, Chan JC, Wong VW, Kong AP.

J Hepatol. 2017 Oct 6. pii: S0168-8278(17)32334-6. doi: 10.1016/j.jhep.2017.09.020. [Epub ahead of print]


Search for unpublished data by systematic reviewers: an audit.

Ziai H, Zhang R, Chan AW, Persaud N.

BMJ Open. 2017 Oct 6;7(10):e017737. doi: 10.1136/bmjopen-2017-017737. Review.


Classification trees for identifying non-use of community-based long-term care services among older adults.

Penkunas MJ, Eom KY, Chan AW.

Health Policy. 2017 Oct;121(10):1093-1099. doi: 10.1016/j.healthpol.2017.05.008. Epub 2017 May 23.


Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS.

Gut. 2018 May;67(5):931-944. doi: 10.1136/gutjnl-2017-314032. Epub 2017 Sep 22.


IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection.

Briggs LC, Chan AWE, Davis CA, Whitelock N, Hotiana HA, Baratchian M, Bagnéris C, Selwood DL, Collins MK, Barrett TE.

J Virol. 2017 Nov 14;91(23). pii: e01170-17. doi: 10.1128/JVI.01170-17. Print 2017 Dec 1.


Cortical functional hyperconnectivity in a mouse model of depression and selective network effects of ketamine.

McGirr A, LeDue J, Chan AW, Xie Y, Murphy TH.

Brain. 2017 Aug 1;140(8):2210-2225. doi: 10.1093/brain/awx142.


Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications.

Chan AW, Pello A, Kitchen J, Axentiev A, Virtanen JI, Liu A, Hemminki E.

JAMA. 2017 Nov 7;318(17):1709-1711. doi: 10.1001/jama.2017.13001. No abstract available.


Accuracy of Faecal Immunochemical Test to Predict Endoscopic and Histological Healing in Ulcerative Colitis: A Prospective Study Based on Validated Histological Scores.

Shi HY, Chan FKL, Chan AWH, Higashimori A, Kyaw M, Ching JYL, Luk AKC, Wong SH, Wu JCY, Sung JJY, Ng SC.

J Crohns Colitis. 2017 Sep 1;11(9):1071-1077. doi: 10.1093/ecco-jcc/jjx088.


The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma.

Zhang B, Zhang Y, Zou X, Chan AW, Zhang R, Lee TK, Liu H, Lau EY, Ho NP, Lai PB, Cheung YS, To KF, Wong HK, Choy KW, Keng VW, Chow LM, Chan KK, Cheng AS, Ko BC.

J Pathol. 2017 Dec;243(4):418-430. doi: 10.1002/path.4976. Epub 2017 Oct 27.


Human Papillomavirus Status and the Risk of Cerebrovascular Events Following Radiation Therapy for Head and Neck Cancer.

Addison D, Seidelmann SB, Janjua SA, Emami H, Staziaki PV, Hallett TR, Szilveszter B, Lu MT, Cambria RP, Hoffmann U, Chan AW, Wirth LJ, Neilan TG.

J Am Heart Assoc. 2017 Aug 30;6(9). pii: e006453. doi: 10.1161/JAHA.117.006453.


Trajectory of phantom limb pain relief using mirror therapy: Retrospective analysis of two studies.

Griffin SC, Curran S, Chan AWY, Finn SB, Baker CI, Pasquina PF, Tsao JW.

Scand J Pain. 2017 Apr;15:98-103. doi: 10.1016/j.sjpain.2017.01.007. Epub 2017 Mar 7.


Adult Congenital Heart Disease Intervention: The Canadian Landscape.

Frankfurter C, Asgar AW, Webb JG, Cantor WJ, Velianou JL, Gobeil F, Chan AW, Welsh RC, Love MP, Wood DA, McKenzie K, Horlick EM.

Can J Cardiol. 2017 Sep;33(9):1201-1205. doi: 10.1016/j.cjca.2017.05.018. Epub 2017 May 30.


Systematic Review of Sex-Specific Reporting of Data: Cholinesterase Inhibitor Example.

Mehta N, Rodrigues C, Lamba M, Wu W, Bronskill SE, Herrmann N, Gill SS, Chan AW, Mason R, Day S, Gurwitz JH, Rochon PA.

J Am Geriatr Soc. 2017 Oct;65(10):2213-2219. doi: 10.1111/jgs.15020. Epub 2017 Aug 18. Review.


Albumin-bilirubin grade predicts the outcomes of liver resection versus radiofrequency ablation for very early/early stage of hepatocellular carcinoma.

Chong CC, Chan AW, Wong J, Chu CM, Chan SL, Lee KF, Yu SC, To KF, Johnson P, Lai PB.

Surgeon. 2018 Jun;16(3):163-170. doi: 10.1016/j.surge.2017.07.003. Epub 2017 Aug 12.


DNA of Erythroid Origin Is Present in Human Plasma and Informs the Types of Anemia.

Lam WKJ, Gai W, Sun K, Wong RSM, Chan RWY, Jiang P, Chan NPH, Hui WWI, Chan AWH, Szeto CC, Ng SC, Law MF, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2017 Oct;63(10):1614-1623. doi: 10.1373/clinchem.2017.272401. Epub 2017 Aug 7.


Serial combination of non-invasive tools improves the diagnostic accuracy of severe liver fibrosis in patients with NAFLD.

Petta S, Wong VW, Cammà C, Hiriart JB, Wong GL, Vergniol J, Chan AW, Di Marco V, Merrouche W, Chan HL, Marra F, Le-Bail B, Arena U, Craxì A, de Ledinghen V.

Aliment Pharmacol Ther. 2017 Sep;46(6):617-627. doi: 10.1111/apt.14219. Epub 2017 Jul 27.


A prospective study on second-generation colon capsule endoscopy to detect mucosal lesions and disease activity in ulcerative colitis (with video).

Shi HY, Chan FKL, Higashimori A, Kyaw M, Ching JYL, Chan HCH, Chan JCH, Chan AWH, Lam KLY, Tang RSY, Wu JCY, Sung JJY, Ng SC.

Gastrointest Endosc. 2017 Dec;86(6):1139-1146.e6. doi: 10.1016/j.gie.2017.07.007. Epub 2017 Jul 14.


HHV8 genotype study in an HIV+ patient with concurrent Kaposi sarcoma and extracavitary primary effusion lymphoma.

Fung KH, Raghupathy R, Chan PD, Lui G, Lam CY, Cheung M, Chan AW, Lee N, Lee SS.

J Clin Pathol. 2017 Sep;70(9):814-816. doi: 10.1136/jclinpath-2017-204485. Epub 2017 Jul 13. No abstract available.


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