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Autism-associated PTEN missense mutation leads to enhanced nuclear localization and neurite outgrowth in an induced pluripotent stem cell line.

Wong CW, Wang Y, Liu T, Li L, Cheung SKK, Or PM, Cheng AS, Choy KW, Burbach JPH, Feng B, Chang RCC, Chan AM.

FEBS J. 2020 Mar 9. doi: 10.1111/febs.15287. [Epub ahead of print]


Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions.

Liu T, Wang Y, Wang Y, Chan AM.

Cancers (Basel). 2019 Aug 26;11(9). pii: E1247. doi: 10.3390/cancers11091247. Review.


MYB-NFIB gene fusions identified in archival adenoid cystic carcinoma tissue employing NanoString analysis: an exploratory study.

McIntyre JB, Ko JJ, Siever J, Chan AMY, Simpson RHW, Hao D, Lau HY.

Diagn Pathol. 2019 Jul 13;14(1):78. doi: 10.1186/s13000-019-0855-8.


Myoclonic jerks complicating treatment of acute promyelocytic leukemia: case report and literature review.

Rhee JY, Tremblay D, Chan AM, Tallman MS, Mascarenhas J.

Blood Adv. 2019 Jun 25;3(12):1854-1857. doi: 10.1182/bloodadvances.2019000249. No abstract available.


Cerebral aspergillosis within new tumour site presents as incidental new brain lesion in patient receiving temozolomide for glioblastoma multiforme.

Liu SA, Sullivan T, Bryce C, Chan AM, Cilmi S.

BMJ Case Rep. 2019 May 31;12(5). pii: e227500. doi: 10.1136/bcr-2018-227500.


Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease.

Dukhinova M, Veremeyko T, Yung AWY, Kuznetsova IS, Lau TYB, Kopeikina E, Chan AML, Ponomarev ED.

Neurobiol Aging. 2019 May;77:128-143. doi: 10.1016/j.neurobiolaging.2019.01.020. Epub 2019 Jan 30.


Antibiotic management of acute pharyngitis in primary care.

Advisory Group on Antibiotic Stewardship Programme in Primary Care, Chan AMW, Au WWY, Chao DVK, Choi K, Choi KW, Choi SMY, Chow Y, Fan CYM, Ho PL, Hui EMT, Kwong KH, Kwong BYS, Lam TP, Lam ETK, Lau KW, Lui L, Ng KHL, Wong MCS, Wong TY, Yeung CF, You JHS, Yung RWH.

Hong Kong Med J. 2019 Feb;25(1):58-63. doi: 10.12809/hkmj187544. Epub 2019 Jan 31.


Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model.

Sun MM, Chan AM, Law SM, Duarte S, Diaz-Aguilar D, Wadehra M, Gordon LK.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):245-254. doi: 10.1167/iovs.18-24345.


Paraneoplastic neurological syndromes: a single institution 10-year case series.

Chan AM, Baehring JM.

J Neurooncol. 2019 Jan;141(2):431-439. doi: 10.1007/s11060-018-03053-3. Epub 2019 Jan 3.


Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells.

Zhang C, He X, Kwok YK, Wang F, Xue J, Zhao H, Suen KW, Wang CC, Ren J, Chen GG, Lai PBS, Li J, Xia Y, Chan AM, Chan WY, Feng B.

BMC Biol. 2018 Dec 28;16(1):151. doi: 10.1186/s12915-018-0616-2.


Canadian perspectives: update on inhibition of ALK-positive tumours in advanced non-small-cell lung cancer.

Melosky B, Cheema P, Agulnik J, Albadine R, Bebb DG, Blais N, Burkes R, Butts C, Card PB, Chan AMY, Hirsh V, Ionescu DN, Juergens R, Morzycki W, Poonja Z, Sangha R, Tehfe M, Tsao MS, Vincent M, Xu Z, Liu G.

Curr Oncol. 2018 Oct;25(5):317-328. doi: 10.3747/co.25.4379. Epub 2018 Oct 31. Review.


Incidence and Outcomes of Intraoperative Descemet Membrane Perforations During Deep Anterior Lamellar Keratoplasty.

Huang OS, Htoon HM, Chan AM, Tan D, Mehta JS.

Am J Ophthalmol. 2019 Mar;199:9-18. doi: 10.1016/j.ajo.2018.10.026. Epub 2018 Nov 1.


Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.

Lee YY, Mok MT, Kang W, Yang W, Tang W, Wu F, Xu L, Yan M, Yu Z, Lee SD, Tong JHM, Cheung YS, Lai PBS, Yu DY, Wang Q, Wong GLH, Chan AM, Yip KY, To KF, Cheng ASL.

Nucleic Acids Res. 2018 Sep 28;46(17):8832-8847. doi: 10.1093/nar/gky589.


PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model.

Yan M, Wang Y, Wong CW, Or PM, Wong KL, Li L, Many AM, Guan H, Khoo US, Chan AM.

Cancer Lett. 2018 Aug 28;430:67-78. doi: 10.1016/j.canlet.2018.05.012. Epub 2018 May 14.


Transcriptional responses of the marine green alga Micromonas pusilla and an infecting prasinovirus under different phosphate conditions.

Bachy C, Charlesworth CJ, Chan AM, Finke JF, Wong CH, Wei CL, Sudek S, Coleman ML, Suttle CA, Worden AZ.

Environ Microbiol. 2018 Aug;20(8):2898-2912. doi: 10.1111/1462-2920.14273. Epub 2018 Sep 9.


Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma.

Wang Y, Wong CW, Yan M, Li L, Liu T, Or PM, Tsui SK, Waye MM, Chan AM.

Cancer Lett. 2018 Aug 10;429:54-65. doi: 10.1016/j.canlet.2018.04.040. Epub 2018 May 3.


Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly.

Wong CW, Or PMY, Wang Y, Li L, Li J, Yan M, Cao Y, Luk HM, Tong TMF, Leslie NR, Lo IF, Choy KW, Chan AML.

Autism Res. 2018 Aug;11(8):1098-1109. doi: 10.1002/aur.1950. Epub 2018 Apr 2.


The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer.

Thakur SS, Li H, Chan AMY, Tudor R, Bigras G, Morris D, Enwere EK, Yang H.

PLoS One. 2018 Jan 5;13(1):e0188983. doi: 10.1371/journal.pone.0188983. eCollection 2018.


The Genome of the Beluga Whale (Delphinapterus leucas).

Jones SJM, Taylor GA, Chan S, Warren RL, Hammond SA, Bilobram S, Mordecai G, Suttle CA, Miller KM, Schulze A, Chan AM, Jones SJ, Tse K, Li I, Cheung D, Mungall KL, Choo C, Ally A, Dhalla N, Tam AKY, Troussard A, Kirk H, Pandoh P, Paulino D, Coope RJN, Mungall AJ, Moore R, Zhao Y, Birol I, Ma Y, Marra M, Haulena M.

Genes (Basel). 2017 Dec 11;8(12). pii: E378. doi: 10.3390/genes8120378.


Disappearing Leukoencephalopathy : A Case of Relapsing-Remitting Intravascular Large B‑Cell Lymphoma with Transient Spontaneous Radiographic Regression.

Chan AM, Huttner A, Baehring J.

Clin Neuroradiol. 2018 Sep;28(3):455-459. doi: 10.1007/s00062-017-0650-4. Epub 2017 Dec 1. No abstract available.


Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Decrease the Development of Severe Experimental Autoimmune Uveitis in B10.RIII Mice.

Qin Y, Chan AM, Chang YL, Matynia A, Kouris NA, Kimbrel EA, Ashki N, Parikh S, Gorin MB, Lanza R, Levinson RD, Gordon LK.

Ocul Immunol Inflamm. 2018;26(8):1228-1236. doi: 10.1080/09273948.2017.1343356. Epub 2017 Sep 15.


Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas.

Chung LK, Pelargos PE, Chan AM, Demos JV, Lagman C, Sheppard JP, Nguyen T, Chang YL, Hojat SA, Prins RM, Liau LM, Nghiemphu L, Lai A, Cloughesy TF, Yong WH, Gordon LK, Wadehra M, Yang I.

Brain Tumor Pathol. 2018 Jan;35(1):1-9. doi: 10.1007/s10014-017-0300-1. Epub 2017 Sep 8.


Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer.

Zhou X, Yue GG, Chan AM, Tsui SK, Fung KP, Sun H, Pu J, Lau CB.

Biochem Pharmacol. 2017 Oct 15;142:58-70. doi: 10.1016/j.bcp.2017.06.133. Epub 2017 Jun 30.


Dissecting and modeling zeaxanthin- and lutein-dependent nonphotochemical quenching in Arabidopsis thaliana.

Leuenberger M, Morris JM, Chan AM, Leonelli L, Niyogi KK, Fleming GR.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E7009-E7017. doi: 10.1073/pnas.1704502114. Epub 2017 Jun 26.


A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase.

Liu WN, Yan M, Chan AM.

Cancer Lett. 2017 Sep 10;403:59-65. doi: 10.1016/j.canlet.2017.06.003. Epub 2017 Jun 10. Review.


Tree water dynamics in a drying and warming world.

Grossiord C, Sevanto S, Borrego I, Chan AM, Collins AD, Dickman LT, Hudson PJ, McBranch N, Michaletz ST, Pockman WT, Ryan M, Vilagrosa A, McDowell NG.

Plant Cell Environ. 2017 Sep;40(9):1861-1873. doi: 10.1111/pce.12991. Epub 2017 Jun 20.


Assessing the thermal dissipation sap flux density method for monitoring cold season water transport in seasonally snow-covered forests.

Chan AM, Bowling DR.

Tree Physiol. 2017 Jul 1;37(7):984-995. doi: 10.1093/treephys/tpx049.


Safety and Efficacy of Chloral Hydrate Sedation in Paediatric Sedation for Ophthalmic Procedures.

Chan AM, Tan GK, Loh HP, Lim SH, Chia AW.

Ann Acad Med Singapore. 2017 Apr;46(4):138-144.


Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation.

Zhao H, Nolley R, Chan AMW, Rankin EB, Peehl DM.

Cancer Biol Ther. 2017 Nov 2;18(11):863-871. doi: 10.1080/15384047.2016.1219816. Epub 2016 Aug 11.


Metagenomic Analysis Suggests Modern Freshwater Microbialites Harbor a Distinct Core Microbial Community.

White RA 3rd, Chan AM, Gavelis GS, Leander BS, Brady AL, Slater GF, Lim DS, Suttle CA.

Front Microbiol. 2016 Jan 28;6:1531. doi: 10.3389/fmicb.2015.01531. eCollection 2015.


Burnout Among Osteopathic Residents: A Cross-sectional Analysis.

Chan AM, Cuevas ST, Jenkins J 2nd.

J Am Osteopath Assoc. 2016 Feb;116(2):100-5. doi: 10.7556/jaoa.2016.023.


Carbon isotopic composition of forest soil respiration in the decade following bark beetle and stem girdling disturbances in the Rocky Mountains.

Maurer GE, Chan AM, Trahan NA, Moore DJ, Bowling DR.

Plant Cell Environ. 2016 Jul;39(7):1513-23. doi: 10.1111/pce.12716. Epub 2016 Apr 26.


PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.

Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA.

Nat Neurosci. 2016 Mar;19(3):443-53. doi: 10.1038/nn.4225. Epub 2016 Jan 18.


Erratum to: Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells.

Palen KA, Jing W, Weber JJ, Tilkens SB, Chan AM, Johnson BD, Gershan JA.

Cancer Microenviron. 2016 Apr;9(1):75. doi: 10.1007/s12307-015-0179-5. No abstract available.


R-Ras Regulates Murine T Cell Migration and Intercellular Adhesion Molecule-1 Binding.

Yan X, Yan M, Guo Y, Singh G, Chen Y, Yu M, Wang D, Hillery CA, Chan AM.

PLoS One. 2015 Dec 28;10(12):e0145218. doi: 10.1371/journal.pone.0145218. eCollection 2015.


The genetic landscapes of inflammation-driven gastrointestinal tract cancers.

Wang Y, Yan M, Or PM, Chan AM.

Curr Pharm Des. 2015;21(21):2924-41. Review.


(18)F-fluorodeoxyglucose positron-emission tomography-computed tomography to diagnose recurrent cancer.

You JJ, Cline KJ, Gu CS, Pritchard KI, Dayes IS, Gulenchyn KY, Inculet RI, Dhesy-Thind SK, Freeman MA, Chan AM, Julian JA, Levine MN.

Br J Cancer. 2015 May 26;112(11):1737-43. doi: 10.1038/bjc.2015.151. Epub 2015 May 5.


Polar freshwater cyanophage S-EIV1 represents a new widespread evolutionary lineage of phages.

Chénard C, Chan AM, Vincent WF, Suttle CA.

ISME J. 2015 Sep;9(9):2046-58. doi: 10.1038/ismej.2015.24. Epub 2015 Mar 27.


A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.

Feng H, Yu Z, Tian Y, Lee YY, Li MS, Go MY, Cheung YS, Lai PB, Chan AM, To KF, Chan HL, Sung JJ, Cheng AS.

J Hepatol. 2015 May;62(5):1100-11. doi: 10.1016/j.jhep.2014.11.040. Epub 2014 Dec 9.


An increase in tolerogenic dendritic cell and natural regulatory T cell numbers during experimental autoimmune encephalomyelitis in Rras-/- mice results in attenuated disease.

Ray A, Basu S, Miller NM, Chan AM, Dittel BN.

J Immunol. 2014 Jun 1;192(11):5109-17. doi: 10.4049/jimmunol.1302254. Epub 2014 Apr 25.


Genetic dissection of plexin signaling in vivo.

Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9. doi: 10.1073/pnas.1308418111. Epub 2014 Jan 27.


Photodecomposition of chloroform catalyzed by unmodified MCM-41 mesoporous silica.

Peña LA, Chan AM, Cohen LR, Hou K, Harvey BM, Hoggard PE.

Photochem Photobiol. 2014 Jul-Aug;90(4):760-6. doi: 10.1111/php.12245. Epub 2014 Feb 15.


Peroxynitrite upregulates angiogenic factors VEGF-A, BFGF, and HIF-1α in human corneal limbal epithelial cells.

Ashki N, Chan AM, Qin Y, Wang W, Kiyohara M, Lin L, Braun J, Wadehra M, Gordon LK.

Invest Ophthalmol Vis Sci. 2014 Mar 19;55(3):1637-46. doi: 10.1167/iovs.13-12410.


Wireless patch sensor for remote monitoring of heart rate, respiration, activity, and falls.

Chan AM, Selvaraj N, Ferdosi N, Narasimhan R.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:6115-8. doi: 10.1109/EMBC.2013.6610948.


Ambulatory respiratory rate detection using ECG and a triaxial accelerometer.

Chan AM, Ferdosi N, Narasimhan R.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:4058-61. doi: 10.1109/EMBC.2013.6610436.


Photodecomposition of dichloromethane catalyzed by tetrachloroferrate(III) supported on a Dowex anion exchange resin.

Chan AM, Harvey BM, Hoggard PE.

Photochem Photobiol Sci. 2013 Sep;12(9):1680-7. doi: 10.1039/c3pp50094b.


AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.

Hong SK, Jeong JH, Chan AM, Park JI.

Exp Cell Res. 2013 Jul 15;319(12):1732-43. doi: 10.1016/j.yexcr.2013.05.008. Epub 2013 May 20.


Speech-specific tuning of neurons in human superior temporal gyrus.

Chan AM, Dykstra AR, Jayaram V, Leonard MK, Travis KE, Gygi B, Baker JM, Eskandar E, Hochberg LR, Halgren E, Cash SS.

Cereb Cortex. 2014 Oct;24(10):2679-93. doi: 10.1093/cercor/bht127. Epub 2013 May 16.


Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model.

Sukhotinsky I, Chan AM, Ahmed OJ, Rao VR, Gradinaru V, Ramakrishnan C, Deisseroth K, Majewska AK, Cash SS.

PLoS One. 2013 Apr 24;8(4):e62013. doi: 10.1371/journal.pone.0062013. Print 2013.

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