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Items: 22


A New ESX-1 Substrate in Mycobacterium marinum That Is Required for Hemolysis but Not Host Cell Lysis.

Bosserman RE, Nicholson KR, Champion MM, Champion PA.

J Bacteriol. 2019 Jun 21;201(14). pii: e00760-18. doi: 10.1128/JB.00760-18. Print 2019 Jul 15.


Quantitative N-Terminal Footprinting of Pathogenic Mycobacteria Reveals Differential Protein Acetylation.

Thompson CR, Champion MM, Champion PA.

J Proteome Res. 2018 Sep 7;17(9):3246-3258. doi: 10.1021/acs.jproteome.8b00373. Epub 2018 Aug 16.


Esx Paralogs Are Functionally Equivalent to ESX-1 Proteins but Are Dispensable for Virulence in Mycobacterium marinum.

Bosserman RE, Thompson CR, Nicholson KR, Champion PA.

J Bacteriol. 2018 May 9;200(11). pii: e00726-17. doi: 10.1128/JB.00726-17. Print 2018 Jun 1.


The 24th Annual Midwest Microbial Pathogenesis Meeting.

Champion PA, Shrout JD.

J Bacteriol. 2018 Feb 26;200(11):e000950-18. doi: 10.1128/JB.00095-18. [Epub ahead of print]


WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum.

Bosserman RE, Nguyen TT, Sanchez KG, Chirakos AE, Ferrell MJ, Thompson CR, Champion MM, Abramovitch RB, Champion PA.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10772-E10781. doi: 10.1073/pnas.1710167114. Epub 2017 Nov 27.


Esx Systems and the Mycobacterial Cell Envelope: What's the Connection?

Bosserman RE, Champion PA.

J Bacteriol. 2017 Aug 8;199(17). pii: e00131-17. doi: 10.1128/JB.00131-17. Print 2017 Sep 1. Review.


A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism.

Williams EA, Mba Medie F, Bosserman RE, Johnson BK, Reyna C, Ferrell MJ, Champion MM, Abramovitch RB, Champion PA.

Infect Immun. 2017 Jan 26;85(2). pii: e00653-16. doi: 10.1128/IAI.00653-16. Print 2017 Feb.


Rational engineering of a virulence gene from Mycobacterium tuberculosis facilitates proteomic analysis of a natural protein N-terminus.

Reyna C, Mba Medie F, Champion MM, Champion PA.

Sci Rep. 2016 Sep 14;6:33265. doi: 10.1038/srep33265.


The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.

Johnson BK, Colvin CJ, Needle DB, Mba Medie F, Champion PA, Abramovitch RB.

Antimicrob Agents Chemother. 2015 Aug;59(8):4436-45. doi: 10.1128/AAC.00719-15. Epub 2015 May 18.


Coupling capillary zone electrophoresis with electron transfer dissociation and activated ion electron transfer dissociation for top-down proteomics.

Zhao Y, Riley NM, Sun L, Hebert AS, Yan X, Westphall MS, Rush MJ, Zhu G, Champion MM, Mba Medie F, Champion PA, Coon JJ, Dovichi NJ.

Anal Chem. 2015;87(10):5422-9. doi: 10.1021/acs.analchem.5b00883. Epub 2015 May 6.


Homeostasis of N-α-terminal acetylation of EsxA correlates with virulence in Mycobacterium marinum.

Mba Medie F, Champion MM, Williams EA, Champion PA.

Infect Immun. 2014 Nov;82(11):4572-86. doi: 10.1128/IAI.02153-14. Epub 2014 Aug 18.


Correlation of phenotypic profiles using targeted proteomics identifies mycobacterial esx-1 substrates.

Champion MM, Williams EA, Pinapati RS, Champion PA.

J Proteome Res. 2014 Nov 7;13(11):5151-64. doi: 10.1021/pr500484w. Epub 2014 Aug 25.


A novel ESX-1 locus reveals that surface-associated ESX-1 substrates mediate virulence in Mycobacterium marinum.

Kennedy GM, Hooley GC, Champion MM, Mba Medie F, Champion PA.

J Bacteriol. 2014 May;196(10):1877-88. doi: 10.1128/JB.01502-14. Epub 2014 Mar 7.


Disconnecting in vitro ESX-1 secretion from mycobacterial virulence.

Champion PA.

J Bacteriol. 2013 Dec;195(24):5418-20. doi: 10.1128/JB.01145-13. Epub 2013 Oct 11. No abstract available.


Direct detection of bacterial protein secretion using whole colony proteomics.

Champion MM, Williams EA, Kennedy GM, Champion PA.

Mol Cell Proteomics. 2012 Sep;11(9):596-604. doi: 10.1074/mcp.M112.017533. Epub 2012 May 10.


Conserved mechanisms of Mycobacterium marinum pathogenesis within the environmental amoeba Acanthamoeba castellanii.

Kennedy GM, Morisaki JH, Champion PA.

Appl Environ Microbiol. 2012 Mar;78(6):2049-52. doi: 10.1128/AEM.06965-11. Epub 2012 Jan 13.


To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?

Shiloh MU, Champion PA.

Curr Opin Microbiol. 2010 Feb;13(1):86-92. doi: 10.1016/j.mib.2009.11.006. Epub 2009 Dec 23. Review.


ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.

Champion PA, Champion MM, Manzanillo P, Cox JS.

Mol Microbiol. 2009 Sep;73(5):950-62. doi: 10.1111/j.1365-2958.2009.06821.x. Epub 2009 Aug 4.


Type VII secretion--mycobacteria show the way.

Abdallah AM, Gey van Pittius NC, Champion PA, Cox J, Luirink J, Vandenbroucke-Grauls CM, Appelmelk BJ, Bitter W.

Nat Rev Microbiol. 2007 Nov;5(11):883-91. Review.


Protein secretion systems in Mycobacteria.

Champion PA, Cox JS.

Cell Microbiol. 2007 Jun;9(6):1376-84. Epub 2007 Apr 25. Review.


C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.

Champion PA, Stanley SA, Champion MM, Brown EJ, Cox JS.

Science. 2006 Sep 15;313(5793):1632-6.

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