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Items: 44


A New ESX-1 Substrate in Mycobacterium marinum That Is Required for Hemolysis but Not Host Cell Lysis.

Bosserman RE, Nicholson KR, Champion MM, Champion PA.

J Bacteriol. 2019 Jun 21;201(14). pii: e00760-18. doi: 10.1128/JB.00760-18. Print 2019 Jul 15.


Capillary Zone Electrophoresis with Fraction Collection for Separation, Culturing, and Identification of Bacteria from an Environmental Microbiome.

Huge BJ, Champion MM, Dovichi NJ.

Anal Chem. 2019 Apr 2;91(7):4649-4655. doi: 10.1021/acs.analchem.8b05984. Epub 2019 Mar 11.


Author Correction: Phosphorylation Dynamics Dominate the Regulated Proteome during Early Xenopus Development.

Peuchen EH, Cox OF, Sun L, Hebert AS, Coon JJ, Champion MM, Dovichi NJ, Huber PW.

Sci Rep. 2018 Nov 21;8(1):17393. doi: 10.1038/s41598-018-35442-z.


Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma.

Robinson RM, Reyes L, Duncan RM, Bian H, Reitz AB, Manevich Y, McClure JJ, Champion MM, Chou CJ, Sharik ME, Chesi M, Bergsagel PL, Dolloff NG.

Leukemia. 2019 Apr;33(4):1011-1022. doi: 10.1038/s41375-018-0263-1. Epub 2018 Oct 12.


Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers.

Feng S, Cheng X, Zhang L, Lu X, Chaudhary S, Teng R, Frederickson C, Champion MM, Zhao R, Cheng L, Gong Y, Deng H, Lu X.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10094-10099. doi: 10.1073/pnas.1800695115. Epub 2018 Sep 19.


Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing.

Nguyen TT, Ding D, Wolter WR, Pérez RL, Champion MM, Mahasenan KV, Hesek D, Lee M, Schroeder VA, Jones JI, Lastochkin E, Rose MK, Peterson CE, Suckow MA, Mobashery S, Chang M.

J Med Chem. 2018 Oct 11;61(19):8825-8837. doi: 10.1021/acs.jmedchem.8b01005. Epub 2018 Sep 27.


Quantitative N-Terminal Footprinting of Pathogenic Mycobacteria Reveals Differential Protein Acetylation.

Thompson CR, Champion MM, Champion PA.

J Proteome Res. 2018 Sep 7;17(9):3246-3258. doi: 10.1021/acs.jproteome.8b00373. Epub 2018 Aug 16.


Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers.

Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, Pérez RL, Schroeder VA, Suckow MA, Mobashery S, Chang M.

Eur J Pharmacol. 2018 Sep 5;834:77-83. doi: 10.1016/j.ejphar.2018.07.014. Epub 2018 Jul 19.


WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum.

Bosserman RE, Nguyen TT, Sanchez KG, Chirakos AE, Ferrell MJ, Thompson CR, Champion MM, Abramovitch RB, Champion PA.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10772-E10781. doi: 10.1073/pnas.1710167114. Epub 2017 Nov 27.


Phosphorylation Dynamics Dominate the Regulated Proteome during Early Xenopus Development.

Peuchen EH, Cox OF, Sun L, Hebert AS, Coon JJ, Champion MM, Dovichi NJ, Huber PW.

Sci Rep. 2017 Nov 15;7(1):15647. doi: 10.1038/s41598-017-15936-y. Erratum in: Sci Rep. 2018 Nov 21;8(1):17393.


Genomewide Dam Methylation in Escherichia coli during Long-Term Stationary Phase.

Westphal LL, Sauvey P, Champion MM, Ehrenreich IM, Finkel SE.

mSystems. 2016 Dec 13;1(6). pii: e00130-16. eCollection 2016 Nov-Dec.


A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism.

Williams EA, Mba Medie F, Bosserman RE, Johnson BK, Reyna C, Ferrell MJ, Champion MM, Abramovitch RB, Champion PA.

Infect Immun. 2017 Jan 26;85(2). pii: e00653-16. doi: 10.1128/IAI.00653-16. Print 2017 Feb.


DegP Chaperone Suppresses Toxic Inner Membrane Translocation Intermediates.

Braselmann E, Chaney JL, Champion MM, Clark PL.

PLoS One. 2016 Sep 14;11(9):e0162922. doi: 10.1371/journal.pone.0162922. eCollection 2016.


Rational engineering of a virulence gene from Mycobacterium tuberculosis facilitates proteomic analysis of a natural protein N-terminus.

Reyna C, Mba Medie F, Champion MM, Champion PA.

Sci Rep. 2016 Sep 14;6:33265. doi: 10.1038/srep33265.


Capillary zone electrophoresis as a tool for bottom-up protein analysis.

Wojcik R, Zhu G, Zhang Z, Yan X, Zhao Y, Sun L, Champion MM, Dovichi NJ.

Bioanalysis. 2016;8(2):89-92. doi: 10.4155/bio.15.227. Epub 2015 Dec 10. Review. No abstract available.


Capillary zone electrophoresis for bottom-up analysis of complex proteomes.

Sun L, Zhu G, Yan X, Zhang Z, Wojcik R, Champion MM, Dovichi NJ.

Proteomics. 2016 Jan;16(2):188-96. doi: 10.1002/pmic.201500339. Epub 2015 Dec 20. Review.


Proteomics of Xenopus development.

Sun L, Champion MM, Huber PW, Dovichi NJ.

Mol Hum Reprod. 2016 Mar;22(3):193-9. doi: 10.1093/molehr/gav052. Epub 2015 Sep 22.


Coupling capillary zone electrophoresis with electron transfer dissociation and activated ion electron transfer dissociation for top-down proteomics.

Zhao Y, Riley NM, Sun L, Hebert AS, Yan X, Westphall MS, Rush MJ, Zhu G, Champion MM, Mba Medie F, Champion PA, Coon JJ, Dovichi NJ.

Anal Chem. 2015;87(10):5422-9. doi: 10.1021/acs.analchem.5b00883. Epub 2015 May 6.


Over 10,000 peptide identifications from the HeLa proteome by using single-shot capillary zone electrophoresis combined with tandem mass spectrometry.

Sun L, Hebert AS, Yan X, Zhao Y, Westphall MS, Rush MJ, Zhu G, Champion MM, Coon JJ, Dovichi NJ.

Angew Chem Int Ed Engl. 2014 Dec 8;53(50):13931-3. doi: 10.1002/anie.201409075. Epub 2014 Oct 24.


Identification of disulfide bond isomerase substrates reveals bacterial virulence factors.

Ren G, Champion MM, Huntley JF.

Mol Microbiol. 2014 Nov;94(4):926-44. doi: 10.1111/mmi.12808. Epub 2014 Oct 20.


Homeostasis of N-α-terminal acetylation of EsxA correlates with virulence in Mycobacterium marinum.

Mba Medie F, Champion MM, Williams EA, Champion PA.

Infect Immun. 2014 Nov;82(11):4572-86. doi: 10.1128/IAI.02153-14. Epub 2014 Aug 18.


Correlation of phenotypic profiles using targeted proteomics identifies mycobacterial esx-1 substrates.

Champion MM, Williams EA, Pinapati RS, Champion PA.

J Proteome Res. 2014 Nov 7;13(11):5151-64. doi: 10.1021/pr500484w. Epub 2014 Aug 25.


Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry for quantitative parallel reaction monitoring of peptide abundance and single-shot proteomic analysis of a human cell line.

Sun L, Zhu G, Mou S, Zhao Y, Champion MM, Dovichi NJ.

J Chromatogr A. 2014 Sep 12;1359:303-8. doi: 10.1016/j.chroma.2014.07.024. Epub 2014 Jul 17.


CAF-secreted IGFBPs regulate breast cancer cell anoikis.

Weigel KJ, Jakimenko A, Conti BA, Chapman SE, Kaliney WJ, Leevy WM, Champion MM, Schafer ZT.

Mol Cancer Res. 2014 Jun;12(6):855-66. doi: 10.1158/1541-7786.MCR-14-0090. Epub 2014 May 6.


Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry for top-down characterization of the Mycobacterium marinum secretome.

Zhao Y, Sun L, Champion MM, Knierman MD, Dovichi NJ.

Anal Chem. 2014 May 20;86(10):4873-8. doi: 10.1021/ac500092q. Epub 2014 Apr 28.


Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development.

Sun L, Bertke MM, Champion MM, Zhu G, Huber PW, Dovichi NJ.

Sci Rep. 2014 Mar 14;4:4365. doi: 10.1038/srep04365.


Profiling of human acquired immunity against the salivary proteins of Phlebotomus papatasi reveals clusters of differential immunoreactivity.

Geraci NS, Mukbel RM, Kemp MT, Wadsworth MN, Lesho E, Stayback GM, Champion MM, Bernard MA, Abo-Shehada M, Coutinho-Abreu IV, Ramalho-Ortigão M, Hanafi HA, Fawaz EY, El-Hossary SS, Wortmann G, Hoel DF, McDowell MA.

Am J Trop Med Hyg. 2014 May;90(5):923-938. doi: 10.4269/ajtmh.13-0130. Epub 2014 Mar 10.


A novel ESX-1 locus reveals that surface-associated ESX-1 substrates mediate virulence in Mycobacterium marinum.

Kennedy GM, Hooley GC, Champion MM, Mba Medie F, Champion PA.

J Bacteriol. 2014 May;196(10):1877-88. doi: 10.1128/JB.01502-14. Epub 2014 Mar 7.


Capillary zone electrophoresis for analysis of complex proteomes using an electrokinetically pumped sheath flow nanospray interface.

Sun L, Zhu G, Yan X, Champion MM, Dovichi NJ.

Proteomics. 2014 Mar;14(4-5):622-8. doi: 10.1002/pmic.201300295. Epub 2013 Nov 26. Review.


A chemical biological strategy to facilitate diabetic wound healing.

Gooyit M, Peng Z, Wolter WR, Pi H, Ding D, Hesek D, Lee M, Boggess B, Champion MM, Suckow MA, Mobashery S, Chang M.

ACS Chem Biol. 2014 Jan 17;9(1):105-10. doi: 10.1021/cb4005468. Epub 2013 Sep 26.


Daily rhythms in antennal protein and olfactory sensitivity in the malaria mosquito Anopheles gambiae.

Rund SS, Bonar NA, Champion MM, Ghazi JP, Houk CM, Leming MT, Syed Z, Duffield GE.

Sci Rep. 2013;3:2494. doi: 10.1038/srep02494.


Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site.

Alves NJ, Champion MM, Stefanick JF, Handlogten MW, Moustakas DT, Shi Y, Shaw BF, Navari RM, Kiziltepe T, Bilgicer B.

Biomaterials. 2013 Jul;34(22):5700-10. doi: 10.1016/j.biomaterials.2013.03.082. Epub 2013 Apr 16.


Capillary zone electrophoresis-multiple reaction monitoring from 100 pg of RAW 264.7 cell lysate digest.

Sun L, Li Y, Champion MM, Zhu G, Wojcik R, Dovichi NJ.

Analyst. 2013 Jun 7;138(11):3181-8. doi: 10.1039/c3an00287j.


Quantitative multiple reaction monitoring of peptide abundance introduced via a capillary zone electrophoresis-electrospray interface.

Li Y, Wojcik R, Dovichi NJ, Champion MM.

Anal Chem. 2012 Jul 17;84(14):6116-21. doi: 10.1021/ac300926h. Epub 2012 Jun 27.


Cutting edge: Evidence for a dynamically driven T cell signaling mechanism.

Hawse WF, Champion MM, Joyce MV, Hellman LM, Hossain M, Ryan V, Pierce BG, Weng Z, Baker BM.

J Immunol. 2012 Jun 15;188(12):5819-23. doi: 10.4049/jimmunol.1200952. Epub 2012 May 18.


Direct detection of bacterial protein secretion using whole colony proteomics.

Champion MM, Williams EA, Kennedy GM, Champion PA.

Mol Cell Proteomics. 2012 Sep;11(9):596-604. doi: 10.1074/mcp.M112.017533. Epub 2012 May 10.


Activation of BlaR1 protein of methicillin-resistant Staphylococcus aureus, its proteolytic processing, and recovery from induction of resistance.

Llarrull LI, Toth M, Champion MM, Mobashery S.

J Biol Chem. 2011 Nov 4;286(44):38148-58. doi: 10.1074/jbc.M111.288985. Epub 2011 Sep 6.


Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry.

Frase H, Smith CA, Toth M, Champion MM, Mobashery S, Vakulenko SB.

J Biol Chem. 2011 Apr 22;286(16):14396-409. doi: 10.1074/jbc.M110.208744. Epub 2011 Feb 22.


Importance of position 170 in the inhibition of GES-type β-lactamases by clavulanic acid.

Frase H, Toth M, Champion MM, Antunes NT, Vakulenko SB.

Antimicrob Agents Chemother. 2011 Apr;55(4):1556-62. doi: 10.1128/AAC.01292-10. Epub 2011 Jan 10.


ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.

Champion PA, Champion MM, Manzanillo P, Cox JS.

Mol Microbiol. 2009 Sep;73(5):950-62. doi: 10.1111/j.1365-2958.2009.06821.x. Epub 2009 Aug 4.


C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.

Champion PA, Stanley SA, Champion MM, Brown EJ, Cox JS.

Science. 2006 Sep 15;313(5793):1632-6.


Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410).

Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O.

Anal Biochem. 2005 Oct 1;345(1):122-32.


Proteome analysis of Escherichia coli K-12 by two-dimensional native-state chromatography and MALDI-MS.

Champion MM, Campbell CS, Siegele DA, Russell DH, Hu JC.

Mol Microbiol. 2003 Jan;47(2):383-96.

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