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Influence of Intraoperative Neuromonitoring on the Outcomes of Surgeries for Pediatric Scoliosis in the United States.

George J, Das S, Egger AC, Chambers RC, Kuivila TE, Goodwin RC.

Spine Deform. 2019 Jan;7(1):27-32. doi: 10.1016/j.jspd.2018.05.013. Epub 2019 Dec 30.


The circadian clock protein REVERBα inhibits pulmonary fibrosis development.

Cunningham PS, Meijer P, Nazgiewicz A, Anderson SG, Borthwick LA, Bagnall J, Kitchen GB, Lodyga M, Begley N, Venkateswaran RV, Shah R, Mercer PF, Durrington HJ, Henderson NC, Piper-Hanley K, Fisher AJ, Chambers RC, Bechtold DA, Gibbs JE, Loudon AS, Rutter MK, Hinz B, Ray DW, Blaikley JF.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1139-1147. doi: 10.1073/pnas.1912109117. Epub 2019 Dec 26.


The Natural History of Meniscus Tears.

Chambers HG, Chambers RC.

J Pediatr Orthop. 2019 Jul;39(Issue 6, Supplement 1 Suppl 1):S53-S55. doi: 10.1097/BPO.0000000000001386. Review.


mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.

Selvarajah B, Azuelos I, Platé M, Guillotin D, Forty EJ, Contento G, Woodcock HV, Redding M, Taylor A, Brunori G, Durrenberger PF, Ronzoni R, Blanchard AD, Mercer PF, Anastasiou D, Chambers RC.

Sci Signal. 2019 May 21;12(582). pii: eaav3048. doi: 10.1126/scisignal.aav3048.


A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis.

Lukey PT, Harrison SA, Yang S, Man Y, Holman BF, Rashidnasab A, Azzopardi G, Grayer M, Simpson JK, Bareille P, Paul L, Woodcock HV, Toshner R, Saunders P, Molyneaux PL, Thielemans K, Wilson FJ, Mercer PF, Chambers RC, Groves AM, Fahy WA, Marshall RP, Maher TM.

Eur Respir J. 2019 Mar 18;53(3). pii: 1801992. doi: 10.1183/13993003.01992-2018. Print 2019 Mar.


Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, Durrenberger PF, Hardavella G, Brown JM, Lynch AG, Farmery H, Paul DS, Chambers RC, McGranahan N, Navani N, Thakrar RM, Swanton C, Beck S, George PJ, Spira A, Campbell PJ, Thirlwell C, Janes SM.

Nat Med. 2019 Mar;25(3):517-525. doi: 10.1038/s41591-018-0323-0. Epub 2019 Jan 21.


The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.

Woodcock HV, Eley JD, Guillotin D, Platé M, Nanthakumar CB, Martufi M, Peace S, Joberty G, Poeckel D, Good RB, Taylor AR, Zinn N, Redding M, Forty EJ, Hynds RE, Swanton C, Karsdal M, Maher TM, Bergamini G, Marshall RP, Blanchard AD, Mercer PF, Chambers RC.

Nat Commun. 2019 Jan 2;10(1):6. doi: 10.1038/s41467-018-07858-8.


Influence of Intraoperative Neuromonitoring on the Outcomes of Surgeries for Pediatric Scoliosis in the United States.

George J, Das S, Egger AC, Chambers RC, Kuivila TE, Goodwin RC.

Spine Deform. 2019 Jan;7(1):27-32. doi: 10.1016/j.jspd.2018.05.013.


Characterization of AHR1 and its functional activity in Atlantic sturgeon and shortnose sturgeon.

Roy NK, DellaTorre M, Candelmo A, Chambers RC, Habeck E, Wirgin I.

Aquat Toxicol. 2018 Dec;205:25-35. doi: 10.1016/j.aquatox.2018.09.014. Epub 2018 Sep 29.


Cell-matrix interactions in lung disease and regeneration: ERS Lung Science Conference 2018 report.

Meiners S, Lloyd C, Chambers RC.

Eur Respir Rev. 2018 Jun 27;27(148). pii: 180040. doi: 10.1183/16000617.0040-2018. Print 2018 Jun 30. No abstract available.


Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq.

Martinez-Nunez RT, Rupani H, Platé M, Niranjan M, Chambers RC, Howarth PH, Sanchez-Elsner T.

J Immunol. 2018 Jul 1;201(1):251-263. doi: 10.4049/jimmunol.1701798. Epub 2018 May 16.


Characterization of AHR2 and CYP1A expression in Atlantic sturgeon and shortnose sturgeon treated with coplanar PCBs and TCDD.

Roy NK, Candelmo A, DellaTorre M, Chambers RC, Nádas A, Wirgin I.

Aquat Toxicol. 2018 Apr;197:19-31. doi: 10.1016/j.aquatox.2018.01.017. Epub 2018 Feb 2.


Towards a global initiative for fibrosis treatment (GIFT).

Molina-Molina M, Agusti A, Crestani B, Schwartz DA, Königshoff M, Chambers RC, Maher TM, Faner R, Mora AL, Rojas M, Antoniou KM, Sellares J.

ERJ Open Res. 2017 Dec 1;3(4). pii: 00106-2017. doi: 10.1183/23120541.00106-2017. eCollection 2017 Oct.


A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM, Kildemoes AO, Le Bihan T, Soares DC, Anderton SM, Brenn T, Wigmore SJ, Woodcock HV, Chambers RC, Hinck AP, McSorley HJ, Maizels RM.

Nat Commun. 2017 Nov 23;8(1):1741. doi: 10.1038/s41467-017-01886-6.


Acute Respiratory Distress Syndrome.

Thompson BT, Chambers RC, Liu KD.

N Engl J Med. 2017 Nov 9;377(19):1904-1905. doi: 10.1056/NEJMc1711824. No abstract available.


Indirect pars repair for pediatric isthmic spondylolysis: a case series.

Raudenbush BL, Chambers RC, Silverstein MP, Goodwin RC.

J Spine Surg. 2017 Sep;3(3):387-391. doi: 10.21037/jss.2017.08.08.


Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome.

Artim-Esen B, Smoktunowicz N, McDonnell T, Ripoll VM, Pericleous C, Mackie I, Robinson E, Isenberg D, Rahman A, Ioannou Y, Chambers RC, Giles I.

Sci Rep. 2017 Sep 7;7(1):10788. doi: 10.1038/s41598-017-11315-9.


Acute Respiratory Distress Syndrome.

Thompson BT, Chambers RC, Liu KD.

N Engl J Med. 2017 Aug 10;377(6):562-572. doi: 10.1056/NEJMra1608077. Review. No abstract available.


Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.

Gosens R, Giangreco A, Sahai E, Chambers RC.

Eur Respir Rev. 2017 Jun 28;26(144). pii: 170060. doi: 10.1183/16000617.0060-2017. Print 2017 Jun 30. No abstract available.


An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.

Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES; ATS Assembly on Respiratory Cell and Molecular Biology.

Am J Respir Cell Mol Biol. 2017 May;56(5):667-679. doi: 10.1165/rcmb.2017-0096ST.


Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis.

Mercer PF, Chambers RC.

Nat Med. 2016 Nov 8;22(11):1210-1212. doi: 10.1038/nm.4230. No abstract available.


Neutrophils and tissue damage: is hypoxia the key to excessive degranulation?

Williams AE, Chambers RC.

Thorax. 2016 Nov;71(11):977-978. doi: 10.1136/thoraxjnl-2016-208879. Epub 2016 Sep 1. No abstract available.


TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells.

Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC.

Oncotarget. 2016 Oct 4;7(40):65471-65484. doi: 10.18632/oncotarget.11472.


Evidence for chemokine synergy during neutrophil migration in ARDS.

Williams AE, José RJ, Mercer PF, Brealey D, Parekh D, Thickett DR, O'Kane C, McAuley DF, Chambers RC.

Thorax. 2017 Jan;72(1):66-73. doi: 10.1136/thoraxjnl-2016-208597. Epub 2016 Aug 5.


Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.

Mercer PF, Woodcock HV, Eley JD, Platé M, Sulikowski MG, Durrenberger PF, Franklin L, Nanthakumar CB, Man Y, Genovese F, McAnulty RJ, Yang S, Maher TM, Nicholson AG, Blanchard AD, Marshall RP, Lukey PT, Chambers RC.

Thorax. 2016 Aug;71(8):701-11. doi: 10.1136/thoraxjnl-2015-207429. Epub 2016 Apr 21.


Synthesis of novel and potent vorapaxar analogues.

Knight E, Robinson E, Smoktunowicz N, Chambers RC, Aliev AE, Inglis GG, Chudasama V, Caddick S.

Org Biomol Chem. 2016 Mar 28;14(12):3264-74. doi: 10.1039/c5ob02541a.


Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability.

Robinson E, Knight E, Smoktunowicz N, Chambers RC, Inglis GG, Chudasama V, Caddick S.

Org Biomol Chem. 2016 Mar 28;14(12):3198-201. doi: 10.1039/c6ob00332j.


Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.

Crowley C, Klanrit P, Butler CR, Varanou A, Platé M, Hynds RE, Chambers RC, Seifalian AM, Birchall MA, Janes SM.

Biomaterials. 2016 Mar;83:283-93. doi: 10.1016/j.biomaterials.2016.01.005. Epub 2016 Jan 5.


Cancer patients with community-acquired pneumonia treated in intensive care have poorer outcomes associated with increased illness severity and septic shock at admission to intensive care: a retrospective cohort study.

José RJP, Mohammed AO, Goldring JJP, Chambers RC, Brown JS, Agarwal B.

Pneumonia (Nathan). 2015 Dec 1;6:77-82. doi: 10.15172/pneu.2015.6/645. eCollection 2015.


BARD1 mediates TGF-β signaling in pulmonary fibrosis.

André PA, Prêle CM, Vierkotten S, Carnesecchi S, Donati Y, Chambers RC, Pache JC, Crestani B, Barazzone-Argiroffo C, Königshoff M, Laurent GJ, Irminger-Finger I.

Respir Res. 2015 Sep 29;16:118. doi: 10.1186/s12931-015-0278-3.


Role of a functional polymorphism in the F2R gene promoter in sarcoidosis.

Platé M, Lawson PJ, Hill MR, Marshall RP, Booth HL, Kumari M, Laurent GJ, Hurst JR, Chambers RC.

Respirology. 2015 Nov;20(8):1285-7. doi: 10.1111/resp.12608. Epub 2015 Aug 17.


The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.

Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC.

Dis Model Mech. 2015 Sep;8(9):1129-39. doi: 10.1242/dmm.019984. Epub 2015 Jul 2.


Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection.

José RJ, Williams AE, Mercer PF, Sulikowski MG, Brown JS, Chambers RC.

J Immunol. 2015 Jun 15;194(12):6024-34. doi: 10.4049/jimmunol.1500124. Epub 2015 May 6.


Mechanisms of alveolar epithelial injury, repair, and fibrosis.

Chambers RC, Mercer PF.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S16-20. doi: 10.1513/AnnalsATS.201410-448MG. Review.


Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.

Williams AE, José RJ, Brown JS, Chambers RC.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15;308(6):L539-49. doi: 10.1152/ajplung.00141.2014. Epub 2015 Jan 16.


Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants.

Chakraborty M, McGreal EP, Williams A, Davies PL, Powell W, Abdulla S, Voitenok NN, Hogwood J, Gray E, Spiller B, Chambers RC, Kotecha S.

PLoS One. 2014 Dec 4;9(12):e114524. doi: 10.1371/journal.pone.0114524. eCollection 2014.


Pulmonary venous hypertension and mechanical strain stimulate monocyte chemoattractant protein-1 release and structural remodelling of the lung in human and rodent chronic heart failure models.

Park JE, Lyon AR, Shao D, Hector LR, Xu H, O'Gara P, Pinhu L, Chambers RC, Wort SJ, Griffiths MJ.

Thorax. 2014 Dec;69(12):1120-7. doi: 10.1136/thoraxjnl-2013-204190. Epub 2014 Sep 15.


Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis.

Mahavadi P, Henneke I, Ruppert C, Knudsen L, Venkatesan S, Liebisch G, Chambers RC, Ochs M, Schmitz G, Vancheri C, Seeger W, Korfei M, Guenther A.

Toxicol Sci. 2014 Nov;142(1):285-97. doi: 10.1093/toxsci/kfu177. Epub 2014 Aug 27.


Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations.

Platé M, Lawson PJ, Hill MR, Quint JK, Kumari M, Laurent GJ, Wedzicha JA, Chambers RC, Hurst JR.

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15;307(4):L311-6. doi: 10.1152/ajplung.00128.2014. Epub 2014 Jun 27.


Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis.

Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ.

Br J Pharmacol. 2014 Jul;171(14):3463-75. doi: 10.1111/bph.12694.


Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.

Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ.

PLoS One. 2014 Jan 27;9(1):e86241. doi: 10.1371/journal.pone.0086241. eCollection 2014.


The mercurial nature of neutrophils: still an enigma in ARDS?

Williams AE, Chambers RC.

Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L217-30. doi: 10.1152/ajplung.00311.2013. Epub 2013 Dec 6. Review.


Thrombin induces epithelial-mesenchymal transition and collagen production by retinal pigment epithelial cells via autocrine PDGF-receptor signaling.

Bastiaans J, van Meurs JC, van Holten-Neelen C, Nagtzaam NM, van Hagen PM, Chambers RC, Hooijkaas H, Dik WA.

Invest Ophthalmol Vis Sci. 2013 Dec 19;54(13):8306-14. doi: 10.1167/iovs.13-12383.


Proteinase-activated receptors in fibroproliferative lung disease.

José RJ, Williams AE, Chambers RC.

Thorax. 2014 Feb;69(2):190-2. doi: 10.1136/thoraxjnl-2013-204367. Epub 2013 Nov 1.


Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease.

Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC.

J Immunol. 2013 Nov 1;191(9):4867-79. doi: 10.4049/jimmunol.1300588. Epub 2013 Sep 30.


Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation.

Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):144-57. doi: 10.1165/rcmb.2013-0142OC.


Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation.

Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC.

Eur Respir J. 2013 Dec;42(6):1633-45. doi: 10.1183/09031936.00182412. Epub 2013 Mar 21.


New tale for an old fox in IPF?

Mercer PF, Chambers RC.

Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L466-8. doi: 10.1152/ajplung.00286.2012. Epub 2013 Jan 11. No abstract available.


Coagulation and coagulation signalling in fibrosis.

Mercer PF, Chambers RC.

Biochim Biophys Acta. 2013 Jul;1832(7):1018-27. doi: 10.1016/j.bbadis.2012.12.013. Epub 2013 Jan 5. Review.


The pathogenesis of pulmonary fibrosis: a moving target.

Wuyts WA, Agostini C, Antoniou KM, Bouros D, Chambers RC, Cottin V, Egan JJ, Lambrecht BN, Lories R, Parfrey H, Prasse A, Robalo-Cordeiro C, Verbeken E, Verschakelen JA, Wells AU, Verleden GM.

Eur Respir J. 2013 May;41(5):1207-18. doi: 10.1183/09031936.00073012. Epub 2012 Oct 25. Review.

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