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Items: 1 to 50 of 130

1.

Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain.

Pringle RB, Meek EC, Chambers HW, Chambers JE.

Toxicol Sci. 2018 Dec 1;166(2):420-427. doi: 10.1093/toxsci/kfy212.

PMID:
30496567
2.

Single particle trajectories reveal active endoplasmic reticulum luminal flow.

Holcman D, Parutto P, Chambers JE, Fantham M, Young LJ, Marciniak SJ, Kaminski CF, Ron D, Avezov E.

Nat Cell Biol. 2018 Oct;20(10):1118-1125. doi: 10.1038/s41556-018-0192-2. Epub 2018 Sep 17.

PMID:
30224760
3.

Measuring the effects of α1 -antitrypsin polymerisation on the structure and biophysical properties of the endoplasmic reticulum.

Chambers JE, Dickens JA, Marciniak SJ.

Biol Cell. 2018 Nov;110(11):249-255. doi: 10.1111/boc.201800023. Epub 2018 Sep 10. Review.

PMID:
30129166
4.

Understanding child protection decisions involving parents with mental illness and substance abuse.

Roscoe JN, Lery B, Chambers JE.

Child Abuse Negl. 2018 Jul;81:235-248. doi: 10.1016/j.chiabu.2018.05.005. Epub 2018 May 14.

PMID:
29772468
5.

In vitro P-glycoprotein activity does not completely explain in vivo efficacy of novel centrally effective oxime acetylcholinesterase reactivators.

Dail MB, Meek EC, Chambers HW, Chambers JE.

Drug Chem Toxicol. 2018 May 3:1-6. doi: 10.1080/01480545.2018.1461902. [Epub ahead of print]

PMID:
29722548
6.

An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles.

Chambers JE, Kubánková M, Huber RG, López-Duarte I, Avezov E, Bond PJ, Marciniak SJ, Kuimova MK.

ACS Nano. 2018 May 22;12(5):4398-4407. doi: 10.1021/acsnano.8b00177. Epub 2018 Apr 18.

7.

The integrated stress response regulates BMP signalling through effects on translation.

Malzer E, Dominicus CS, Chambers JE, Dickens JA, Mookerjee S, Marciniak SJ.

BMC Biol. 2018 Apr 3;16(1):34. doi: 10.1186/s12915-018-0503-x.

8.

Pulmonary endoplasmic reticulum stress-scars, smoke, and suffocation.

Dickens JA, Malzer E, Chambers JE, Marciniak SJ.

FEBS J. 2019 Jan;286(2):322-341. doi: 10.1111/febs.14381. Epub 2018 Jan 22. Review.

PMID:
29323786
9.

A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus.

Crow JA, Meek EC, Wills RW, Chambers JE.

Diabetes Metab Res Rev. 2018 Mar;34(3). doi: 10.1002/dmrr.2967. Epub 2017 Dec 14.

PMID:
29156090
10.

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.

Crespillo-Casado A, Chambers JE, Fischer PM, Marciniak SJ, Ron D.

Elife. 2017 Apr 27;6. pii: e26109. doi: 10.7554/eLife.26109.

11.
12.
13.

The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.

Dickens JA, Ordóñez A, Chambers JE, Beckett AJ, Patel V, Malzer E, Dominicus CS, Bradley J, Peden AA, Prior IA, Lomas DA, Marciniak SJ.

FASEB J. 2016 Dec;30(12):4083-4097. Epub 2016 Sep 6.

14.

New Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms.

Marciniak SJ, Ordóñez A, Dickens JA, Chambers JE, Patel V, Dominicus CS, Malzer E.

Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S289-96. doi: 10.1513/AnnalsATS.201506-358KV. Review.

PMID:
27564663
15.
16.

Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.

Chambers JE, Chambers HW, Funck KE, Meek EC, Pringle RB, Ross MK.

Chem Biol Interact. 2016 Nov 25;259(Pt B):154-159. doi: 10.1016/j.cbi.2016.07.004. Epub 2016 Jul 5.

PMID:
27387540
17.

Geoelectrical monitoring of simulated subsurface leakage to support high-hazard nuclear decommissioning at the Sellafield Site, UK.

Kuras O, Wilkinson PB, Meldrum PI, Oxby LS, Uhlemann S, Chambers JE, Binley A, Graham J, Smith NT, Atherton N.

Sci Total Environ. 2016 Oct 1;566-567:350-359. doi: 10.1016/j.scitotenv.2016.04.212. Epub 2016 May 23.

18.

Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates.

Chambers JE, Meek EC, Chambers HW.

Ann N Y Acad Sci. 2016 Jun;1374(1):52-8. doi: 10.1111/nyas.13053. Epub 2016 May 6.

19.

Examining multi-session brief intervention for substance use in primary care: research methods of a randomized controlled trial.

Chambers JE, Brooks AC, Medvin R, Metzger DS, Lauby J, Carpenedo CM, Favor KE, Kirby KC.

Addict Sci Clin Pract. 2016 Apr 18;11(1):8. doi: 10.1186/s13722-016-0057-6.

20.

Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase.

Coban A, Carr RL, Chambers HW, Willeford KO, Chambers JE.

Toxicol Lett. 2016 Apr 25;248:39-45. doi: 10.1016/j.toxlet.2016.03.002. Epub 2016 Mar 7.

21.

The association of serum trans-nonachlor levels with atherosclerosis.

Mangum LC, Mangum LH, Chambers JE, Ross MK, Meek EC, Wills RW, Crow JA.

J Toxicol Environ Health A. 2016;79(5):210-20. doi: 10.1080/15287394.2016.1143901. Epub 2016 Mar 8.

22.

Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction.

Mangum LH, Crow JA, Stokes JV, Howell GE 3rd, Ross MK, Pruett SB, Chambers JE.

Toxicol Sci. 2016 Mar;150(1):169-77. doi: 10.1093/toxsci/kfv315. Epub 2016 Jan 8.

23.

Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates.

Chambers JE, Meek EC, Bennett JP, Bennett WS, Chambers HW, Leach CA, Pringle RB, Wills RW.

Toxicology. 2016 Jan 2;339:51-57. doi: 10.1016/j.tox.2015.12.001. Epub 2015 Dec 17.

PMID:
26705700
24.

Implementation of a Brief Treatment Counseling Toolkit in Federally Qualified Healthcare Centers: Patient and Clinician Utilization and Satisfaction.

Brooks AC, Chambers JE, Lauby J, Byrne E, Carpenedo CM, Benishek LA, Medvin R, Metzger DS, Kirby KC.

J Subst Abuse Treat. 2016 Jan;60:70-80. doi: 10.1016/j.jsat.2015.08.005. Epub 2015 Sep 8.

PMID:
26508714
25.

Spontaneous pneumothorax can be associated with TGFBR2 mutation.

Chambers JE, Dalton LE, Subramanian DN, Gooptu B, Balan A, Park SM, Holden S, Marciniak SJ.

Eur Respir J. 2015 Dec;46(6):1832-5. doi: 10.1183/13993003.00952-2015. Epub 2015 Oct 22. No abstract available.

26.

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker.

Preissler S, Chambers JE, Crespillo-Casado A, Avezov E, Miranda E, Perez J, Hendershot LM, Harding HP, Ron D.

Elife. 2015 Oct 16;4:e08961. doi: 10.7554/eLife.08961.

27.

The effect of PON1 enhancers on reducing acetylcholinesterase inhibition following organophosphate anticholinesterase exposure in rats.

Meek EC, Chambers HW, Pringle RB, Chambers JE.

Toxicology. 2015 Oct 2;336:79-83. doi: 10.1016/j.tox.2015.08.002. Epub 2015 Aug 11.

PMID:
26275814
28.

Exposure to p,p'-DDE enhances differentiation of 3T3-L1 preadipocytes in a model of sub-optimal differentiation.

Mangum LH, Howell GE 3rd, Chambers JE.

Toxicol Lett. 2015 Oct 14;238(2):65-71. doi: 10.1016/j.toxlet.2015.07.009. Epub 2015 Jul 19.

PMID:
26200599
29.

Discussion of transference-focused psychotherapy training during residency: an aide to learning psychodynamic psychotherapy.

Chambers JE.

Psychodyn Psychiatry. 2015 Jun;43(2):223-8. doi: 10.1521/pdps.2015.43.2.223. No abstract available.

PMID:
26039229
30.

Species differences in paraoxonase mediated hydrolysis of several organophosphorus insecticide metabolites.

Carr RL, Dail MB, Chambers HW, Chambers JE.

J Toxicol. 2015;2015:470189. doi: 10.1155/2015/470189. Epub 2015 Feb 15.

31.

Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.

Chambers JE, Dalton LE, Clarke HJ, Malzer E, Dominicus CS, Patel V, Moorhead G, Ron D, Marciniak SJ.

Elife. 2015 Mar 16;4. doi: 10.7554/eLife.04872.

32.

Organochlorine insecticides induce NADPH oxidase-dependent reactive oxygen species in human monocytic cells via phospholipase A2/arachidonic acid.

Mangum LC, Borazjani A, Stokes JV, Matthews AT, Lee JH, Chambers JE, Ross MK.

Chem Res Toxicol. 2015 Apr 20;28(4):570-84. doi: 10.1021/tx500323h. Epub 2015 Feb 11.

33.

Effect of chronic p,p'-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H mice.

Howell GE 3rd, Mulligan C, Meek E, Chambers JE.

Toxicology. 2015 Feb 3;328:112-22. doi: 10.1016/j.tox.2014.12.017. Epub 2014 Dec 23.

PMID:
25541407
34.

Association of type 2 diabetes mellitus with plasma organochlorine compound concentrations.

Eden PR, Meek EC, Wills RW, Olsen EV, Crow JA, Chambers JE.

J Expo Sci Environ Epidemiol. 2016 Mar-Apr;26(2):207-13. doi: 10.1038/jes.2014.69. Epub 2014 Oct 22.

PMID:
25335866
35.

Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates.

Chambers JE, Chambers HW, Meek EC, Funck KE, Bhavaraju MH, Gwaltney SR, Pringle RB.

Toxicol Sci. 2015 Jan;143(1):46-53. doi: 10.1093/toxsci/kfu205. Epub 2014 Oct 10.

PMID:
25304213
36.

Human paraoxonase 1 hydrolysis of nanomolar chlorpyrifos-oxon concentrations is unaffected by phenotype or Q192R genotype.

Coombes RH, Meek EC, Dail MB, Chambers HW, Chambers JE.

Toxicol Lett. 2014 Oct 1;230(1):57-61. doi: 10.1016/j.toxlet.2014.07.029. Epub 2014 Aug 2.

37.

Paraoxonase 1 polymorphisms within a Mississippi USA population as possible biomarkers of enzyme activities associated with disease susceptibility.

McDaniel CY, Dail MB, Wills RW, Chambers HW, Chambers JE.

Biochem Genet. 2014 Dec;52(11-12):509-23. doi: 10.1007/s10528-014-9663-8. Epub 2014 Jul 16.

PMID:
25027835
38.

Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress.

Chambers JE, Marciniak SJ.

Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C657-70. doi: 10.1152/ajpcell.00183.2014.

39.

Endoplasmic reticulum stress in malignancy.

Clarke HJ, Chambers JE, Liniker E, Marciniak SJ.

Cancer Cell. 2014 May 12;25(5):563-73. doi: 10.1016/j.ccr.2014.03.015. Review.

40.

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

van Galen P, Kreso A, Mbong N, Kent DG, Fitzmaurice T, Chambers JE, Xie S, Laurenti E, Hermans K, Eppert K, Marciniak SJ, Goodall JC, Green AR, Wouters BG, Wienholds E, Dick JE.

Nature. 2014 Jun 12;510(7504):268-72. doi: 10.1038/nature13228. Epub 2014 Apr 28.

PMID:
24776803
41.

The effect of in vitro dieldrin exposure on the rat paraoxonase 1 (pon1) promoter.

Dail MB, Pickin R, Crow JA, Chambers JE.

J Biochem Mol Toxicol. 2014 May;28(5):224-31. doi: 10.1002/jbt.21557. Epub 2014 Mar 10.

PMID:
24615737
42.

Exposure to p,p'-dichlorodiphenyldichloroethylene (DDE) induces fasting hyperglycemia without insulin resistance in male C57BL/6H mice.

Howell GE 3rd, Meek E, Kilic J, Mohns M, Mulligan C, Chambers JE.

Toxicology. 2014 Jun 5;320:6-14. doi: 10.1016/j.tox.2014.02.004. Epub 2014 Feb 26.

43.

Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole.

Chambers JE, Greim H, Kendall RJ, Segner H, Sharpe RM, Van Der Kraak G.

Crit Rev Toxicol. 2014 Feb;44(2):176-210. doi: 10.3109/10408444.2013.855163. Epub 2013 Nov 25. Review.

PMID:
24274332
44.

Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates.

Chambers JE, Chambers HW, Meek EC, Pringle RB.

Chem Biol Interact. 2013 Mar 25;203(1):135-8. doi: 10.1016/j.cbi.2012.10.017. Epub 2012 Nov 2.

PMID:
23123249
45.

The difficult patient: borderline personality disorder in the obstetrical and gynecological patient.

Ricke AK, Lee MJ, Chambers JE.

Obstet Gynecol Surv. 2012 Aug;67(8):495-502. doi: 10.1097/OGX.0b013e318267f1db. Review.

PMID:
22926274
46.

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load.

Chambers JE, Petrova K, Tomba G, Vendruscolo M, Ron D.

J Cell Biol. 2012 Aug 6;198(3):371-85. doi: 10.1083/jcb.201202005. Erratum in: J Cell Biol. 2014 Nov 24;207(4):569.

47.

Synthesis and in vitro and in vivo inhibition potencies of highly relevant nerve agent surrogates.

Meek EC, Chambers HW, Coban A, Funck KE, Pringle RB, Ross MK, Chambers JE.

Toxicol Sci. 2012 Apr;126(2):525-33. doi: 10.1093/toxsci/kfs013. Epub 2012 Jan 12.

PMID:
22247004
48.

Relationship of human paraoxonase-1 serum activity and genotype with atherosclerosis in individuals from the Deep South.

Coombes RH, Crow JA, Dail M, Chambers HW, Wills RW; Barry D. Bertolet for CARe, Chambers JE.

Pharmacogenet Genomics. 2011 Dec;21(12):867-875. doi: 10.1097/FPC.0b013e32834cebc6.

49.

Co-morbid intellectual disability and borderline personality disorder: a case series.

Wink LK, Erickson CA, Chambers JE, McDougle CJ.

Psychiatry. 2010 Fall;73(3):277-87. doi: 10.1521/psyc.2010.73.3.277.

PMID:
20843219
50.

Hydrogeophysical imaging of deposit heterogeneity and groundwater chemistry changes during DNAPL source zone bioremediation.

Chambers JE, Wilkinson PB, Wealthall GP, Loke MH, Dearden R, Wilson R, Allen D, Ogilvy RD.

J Contam Hydrol. 2010 Oct 21;118(1-2):43-61. doi: 10.1016/j.jconhyd.2010.07.001. Epub 2010 Jul 16.

PMID:
20728959

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