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Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis.

Krstic M, Hassan HM, Kolendowski B, Hague MN, Anborgh PH, Postenka CO, Torchia J, Chambers AF, Tuck AB.

Lab Invest. 2019 Sep 30. doi: 10.1038/s41374-019-0326-6. [Epub ahead of print]


TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG.

Krstic M, Kolendowski B, Cecchini MJ, Postenka CO, Hassan HM, Andrews J, MacMillan CD, Williams KC, Leong HS, Brackstone M, Torchia J, Chambers AF, Tuck AB.

J Pathol. 2019 Jun;248(2):191-203. doi: 10.1002/path.5245. Epub 2019 Apr 8.


Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis.

Williams KC, Cepeda MA, Javed S, Searle K, Parkins KM, Makela AV, Hamilton AM, Soukhtehzari S, Kim Y, Tuck AB, Ronald JA, Foster PJ, Chambers AF, Leong HS.

Oncogene. 2019 May;38(19):3598-3615. doi: 10.1038/s41388-018-0667-4. Epub 2019 Jan 16.


Role of osteopontin as a predictive biomarker for anti-EGFR therapy in triple-negative breast cancer.

Anborgh PH, Lee DJ, Stam PF, Tuck AB, Chambers AF.

Expert Opin Ther Targets. 2018 Aug;22(8):727-734. doi: 10.1080/14728222.2018.1502272. Epub 2018 Jul 26.


Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response.

Zarghami N, Murrell DH, Jensen MD, Dick FA, Chambers AF, Foster PJ, Wong E.

Radiat Oncol. 2018 Jun 1;13(1):104. doi: 10.1186/s13014-018-1028-8.


Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization.

Kolendowski B, Hassan H, Krstic M, Isovic M, Thillainadesan G, Chambers AF, Tuck AB, Torchia J.

Epigenetics Chromatin. 2018 Jan 29;11(1):5. doi: 10.1186/s13072-018-0176-2.


Generation and characterisation of two D2A1 mammary cancer sublines to model spontaneous and experimental metastasis in a syngeneic BALB/c host.

Jungwirth U, van Weverwijk A, Melake MJ, Chambers AF, Gao Q, Fivaz M, Isacke CM.

Dis Model Mech. 2018 Jan 18;11(1). pii: dmm031740. doi: 10.1242/dmm.031740.


Concurrent Neoadjuvant Chemotherapy and Radiation Therapy in Locally Advanced Breast Cancer.

Brackstone M, Palma D, Tuck AB, Scott L, Potvin K, Vandenberg T, Perera F, D'Souza D, Taves D, Kornecki A, Muscedere G, Chambers AF.

Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):769-776. doi: 10.1016/j.ijrobp.2017.06.005. Epub 2017 Jun 20.


Compound speckle model detects anti-angiogenic tumor response in preclinical nonlinear contrast-enhanced ultrasonography.

Lowerison MR, Tse JJ, Hague MN, Chambers AF, Holdsworth DW, Lacefield JC.

Med Phys. 2017 Jan;44(1):99-111. doi: 10.1002/mp.12030.


MRI surveillance of cancer cell fate in a brain metastasis model after early radiotherapy.

Murrell DH, Zarghami N, Jensen MD, Dickson F, Chambers AF, Wong E, Foster PJ.

Magn Reson Med. 2017 Oct;78(4):1506-1512. doi: 10.1002/mrm.26541. Epub 2016 Nov 14.


The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer.

Krstic M, Macmillan CD, Leong HS, Clifford AG, Souter LH, Dales DW, Postenka CO, Chambers AF, Tuck AB.

BMC Cancer. 2016 Aug 23;16(1):671. doi: 10.1186/s12885-016-2697-z.


Improved Linear Contrast-Enhanced Ultrasound Imaging via Analysis of First-Order Speckle Statistics.

Lowerison MR, Hague MN, Chambers AF, Lacefield JC.

IEEE Trans Ultrason Ferroelectr Freq Control. 2016 Sep;63(9):1409-1421. doi: 10.1109/TUFFC.2016.2578181. Epub 2016 Jun 7.


Evaluating Changes to Blood-Brain Barrier Integrity in Brain Metastasis over Time and after Radiation Treatment.

Murrell DH, Zarghami N, Jensen MD, Chambers AF, Wong E, Foster PJ.

Transl Oncol. 2016 Jun;9(3):219-27. doi: 10.1016/j.tranon.2016.04.006. Epub 2016 May 17.


Quantification of cancer cell extravasation in vivo.

Kim Y, Williams KC, Gavin CT, Jardine E, Chambers AF, Leong HS.

Nat Protoc. 2016 May;11(5):937-48. doi: 10.1038/nprot.2016.050. Epub 2016 Apr 21.


Primary melanoma tumor inhibits metastasis through alterations in systemic hemostasis.

Kirstein JM, Hague MN, McGowan PM, Tuck AB, Chambers AF.

J Mol Med (Berl). 2016 Aug;94(8):899-910. doi: 10.1007/s00109-016-1415-2. Epub 2016 Apr 6.


Prostate extracellular vesicles in patient plasma as a liquid biopsy platform for prostate cancer using nanoscale flow cytometry.

Biggs CN, Siddiqui KM, Al-Zahrani AA, Pardhan S, Brett SI, Guo QQ, Yang J, Wolf P, Power NE, Durfee PN, MacMillan CD, Townson JL, Brinker JC, Fleshner NE, Izawa JI, Chambers AF, Chin JL, Leong HS.

Oncotarget. 2016 Feb 23;7(8):8839-49. doi: 10.18632/oncotarget.6983.


Technical Note: Immunohistochemical evaluation of mouse brain irradiation targeting accuracy with 3D-printed immobilization device.

Zarghami N, Jensen MD, Talluri S, Foster PJ, Chambers AF, Dick FA, Wong E.

Med Phys. 2015 Nov;42(11):6507-13. doi: 10.1118/1.4933200.


Inhibition of endogenous hydrogen sulfide production in clear-cell renal cell carcinoma cell lines and xenografts restricts their growth, survival and angiogenic potential.

Sonke E, Verrydt M, Postenka CO, Pardhan S, Willie CJ, Mazzola CR, Hammers MD, Pluth MD, Lobb I, Power NE, Chambers AF, Leong HS, Sener A.

Nitric Oxide. 2015 Sep 15;49:26-39. doi: 10.1016/j.niox.2015.06.001. Epub 2015 Jun 9.


Role of plasma osteopontin as a biomarker in locally advanced breast cancer.

Anborgh PH, Caria LB, Chambers AF, Tuck AB, Stitt LW, Brackstone M.

Am J Transl Res. 2015 Apr 15;7(4):723-32. eCollection 2015.


Understanding Heterogeneity and Permeability of Brain Metastases in Murine Models of HER2-Positive Breast Cancer Through Magnetic Resonance Imaging: Implications for Detection and Therapy.

Murrell DH, Hamilton AM, Mallett CL, van Gorkum R, Chambers AF, Foster PJ.

Transl Oncol. 2015 Jun;8(3):176-84. doi: 10.1016/j.tranon.2015.03.009.


Invasion and metastasis--recent advances and future challenges.

Chambers AF, Werb Z.

J Mol Med (Berl). 2015 Apr;93(4):361-8. doi: 10.1007/s00109-015-1269-z. Epub 2015 Mar 15. No abstract available.


Evaluating the effectiveness of cancer drug sensitization in vitro and in vivo.

Rytelewski M, Buensuceso A, Leong HS, Deroo BJ, Chambers AF, Koropatnick J.

J Vis Exp. 2015 Feb 6;(96). doi: 10.3791/52388.


CORRIGENDUM: Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway.

MacMillan CD, Leong HS, Dales DW, Robertson AE, Lewis JD, Chambers AF, Tuck AB.

Sci Rep. 2015 Jan 23;5:7942. doi: 10.1038/srep07942. No abstract available.


Stage of breast cancer progression influences cellular response to activation of the WNT/planar cell polarity pathway.

MacMillan CD, Leong HS, Dales DW, Robertson AE, Lewis JD, Chambers AF, Tuck AB.

Sci Rep. 2014 Sep 10;4:6315. doi: 10.1038/srep06315. Erratum in: Sci Rep. 2015;5:7942. Dosage error in article text..


Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis.

Leong HS, Robertson AE, Stoletov K, Leith SJ, Chin CA, Chien AE, Hague MN, Ablack A, Carmine-Simmen K, McPherson VA, Postenka CO, Turley EA, Courtneidge SA, Chambers AF, Lewis JD.

Cell Rep. 2014 Sep 11;8(5):1558-70. doi: 10.1016/j.celrep.2014.07.050. Epub 2014 Aug 28.


Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin αvβ3 in mucoepidermoid carcinoma and acinic cell adenocarcinoma of salivary gland origin.

Fok TC, Lapointe H, Tuck AB, Chambers AF, Jackson-Boeters L, Daley TD, Darling MR.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Sep;118(3):320-9. doi: 10.1016/j.oooo.2014.05.004. Epub 2014 May 20.


Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts.

Ota D, Kanayama M, Matsui Y, Ito K, Maeda N, Kutomi G, Hirata K, Torigoe T, Sato N, Takaoka A, Chambers AF, Morimoto J, Uede T.

J Mol Med (Berl). 2014 Dec;92(12):1271-81. doi: 10.1007/s00109-014-1183-9. Epub 2014 Aug 8.


BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis.

Rytelewski M, Tong JG, Buensuceso A, Leong HS, Maleki Vareki S, Figueredo R, Di Cresce C, Wu SY, Herbrich SM, Baggerly KA, Romanow L, Shepherd T, Deroo BJ, Sood AK, Chambers AF, Vincent M, Ferguson PJ, Koropatnick J.

Mol Oncol. 2014 Dec;8(8):1429-40. doi: 10.1016/j.molonc.2014.05.017. Epub 2014 Jun 6.


Cyclin A2, a novel regulator of EMT.

Bendris N, Cheung CT, Leong HS, Lewis JD, Chambers AF, Blanchard JM, Lemmers B.

Cell Mol Life Sci. 2014 Dec;71(24):4881-94. doi: 10.1007/s00018-014-1654-8. Epub 2014 May 31.


A method to validate quantitative high-frequency power doppler ultrasound with fluorescence in vivo video microscopy.

Pinter SZ, Kim DR, Hague MN, Chambers AF, MacDonald IC, Lacefield JC.

Ultrasound Med Biol. 2014 Aug;40(8):1908-17. doi: 10.1016/j.ultrasmedbio.2014.02.030. Epub 2014 May 3.


Radiation-induced lung injury after concurrent neoadjuvant chemoradiotherapy for locally advanced breast cancer.

Chow TL, Louie AV, Palma DA, D'Souza DP, Perera F, Rodrigues GB, Warner A, Chambers AF, Brackstone M.

Acta Oncol. 2014 May;53(5):697-701. doi: 10.3109/0284186X.2013.871387. Epub 2014 Jan 23. No abstract available.


Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial.

Bramwell VH, Tuck AB, Chapman JA, Anborgh PH, Postenka CO, Al-Katib W, Shepherd LE, Han L, Wilson CF, Pritchard KI, Pollak MN, Chambers AF.

Breast Cancer Res. 2014 Jan 22;16(1):R8. doi: 10.1186/bcr3600.


Hypoxia promotes tumor cell motility via RhoA and ROCK1 signaling pathways.

Leong HS, Chambers AF.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):887-8. doi: 10.1073/pnas.1322484111. Epub 2014 Jan 7. No abstract available.


Brain metastases from breast cancer: lessons from experimental magnetic resonance imaging studies and clinical implications.

Murrell DH, Foster PJ, Chambers AF.

J Mol Med (Berl). 2014 Jan;92(1):5-12. doi: 10.1007/s00109-013-1108-z. Epub 2013 Dec 5. Review.


Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin αvβ3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma.

Fok TC, Lapointe H, Tuck AB, Chambers AF, Jackson-Boeters L, Daley TD, Darling MR.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):743-51. doi: 10.1016/j.oooo.2013.09.004.


Plasma osteopontin as a biomarker of prostate cancer aggression: relationship to risk category and treatment response.

Thoms JW, Dal Pra A, Anborgh PH, Christensen E, Fleshner N, Menard C, Chadwick K, Milosevic M, Catton C, Pintilie M, Chambers AF, Bristow RG.

Br J Cancer. 2012 Aug 21;107(5):840-6. doi: 10.1038/bjc.2012.345. Epub 2012 Aug 7.


In Vivo Magnetic Resonance Imaging for Investigating the Development and Distribution of Experimental Brain Metastases due to Breast Cancer.

Perera M, Ribot EJ, Percy DB, McFadden C, Simedrea C, Palmieri D, Chambers AF, Foster PJ.

Transl Oncol. 2012 Jun;5(3):217-25. Epub 2012 Jun 1.


Assessing cancer cell migration and metastatic growth in vivo in the chick embryo using fluorescence intravital imaging.

Leong HS, Chambers AF, Lewis JD.

Methods Mol Biol. 2012;872:1-14. doi: 10.1007/978-1-61779-797-2_1.


Co-expression of α9β1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN.

Majumder M, Tutunea-Fatan E, Xin X, Rodriguez-Torres M, Torres-Garcia J, Wiebe R, Timoshenko AV, Bhattacharjee RN, Chambers AF, Lala PK.

PLoS One. 2012;7(4):e35094. doi: 10.1371/journal.pone.0035094. Epub 2012 Apr 24.


Removal of a titanium ring using a dental saw.

Chambers AF, Harper A.

J Plast Reconstr Aesthet Surg. 2012 May;65(5):e128-9. doi: 10.1016/j.bjps.2011.12.024. Epub 2012 Jan 26.


Imaging the impact of chemically inducible proteins on cellular dynamics in vivo.

Leong HS, Lizardo MM, Ablack A, McPherson VA, Wandless TJ, Chambers AF, Lewis JD.

PLoS One. 2012;7(1):e30177. doi: 10.1371/journal.pone.0030177. Epub 2012 Jan 19.


An emerging role for the nuclear localization of maspin in the suppression of tumor progression and metastasis.

Goulet B, Chan G, Chambers AF, Lewis JD.

Biochem Cell Biol. 2012 Feb;90(1):22-38. doi: 10.1139/o11-053. Epub 2011 Nov 2. Review.


β1-integrin: a potential therapeutic target in the battle against cancer recurrence.

Barkan D, Chambers AF.

Clin Cancer Res. 2011 Dec 1;17(23):7219-23. doi: 10.1158/1078-0432.CCR-11-0642. Epub 2011 Sep 7. Review.


Neuropeptide Y stimulates proliferation and migration in the 4T1 breast cancer cell line.

Medeiros PJ, Al-Khazraji BK, Novielli NM, Postovit LM, Chambers AF, Jackson DN.

Int J Cancer. 2012 Jul 15;131(2):276-86. doi: 10.1002/ijc.26350. Epub 2011 Sep 16.


Osteopontin increases breast cancer cell sensitivity to specific signaling pathway inhibitors in preclinical models.

Mutrie JC, Chambers AF, Tuck AB.

Cancer Biol Ther. 2011 Oct 15;12(8):680-90. doi: 10.4161/cbt.12.8.16440. Epub 2011 Oct 15.


In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary magnetic resonance imaging approach.

Percy DB, Ribot EJ, Chen Y, McFadden C, Simedrea C, Steeg PS, Chambers AF, Foster PJ.

Invest Radiol. 2011 Nov;46(11):718-25. doi: 10.1097/RLI.0b013e318226c427.


In vivo single scan detection of both iron-labeled cells and breast cancer metastases in the mouse brain using balanced steady-state free precession imaging at 1.5 T.

Ribot EJ, Martinez-Santiesteban FM, Simedrea C, Steeg PS, Chambers AF, Rutt BK, Foster PJ.

J Magn Reson Imaging. 2011 Jul;34(1):231-8. doi: 10.1002/jmri.22593.


Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.

McGowan PM, Simedrea C, Ribot EJ, Foster PJ, Palmieri D, Steeg PS, Allan AL, Chambers AF.

Mol Cancer Res. 2011 Jul;9(7):834-44. doi: 10.1158/1541-7786.MCR-10-0457. Epub 2011 Jun 10.


Pre- and post-translational regulation of osteopontin in cancer.

Anborgh PH, Mutrie JC, Tuck AB, Chambers AF.

J Cell Commun Signal. 2011 Jun;5(2):111-22. doi: 10.1007/s12079-011-0130-6. Epub 2011 Apr 26.


Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis.

Goulet B, Kennette W, Ablack A, Postenka CO, Hague MN, Mymryk JS, Tuck AB, Giguère V, Chambers AF, Lewis JD.

Lab Invest. 2011 Aug;91(8):1181-7. doi: 10.1038/labinvest.2011.66. Epub 2011 Apr 18.

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