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S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19.

Ampah KK, Greaves J, Shun-Shion AS, Asnawi AW, Lidster JA, Chamberlain LH, Collins MO, Peden AA.

J Cell Sci. 2018 Oct 22;131(20). pii: jcs212498. doi: 10.1242/jcs.212498.


Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO, Chamberlain LH, Mastick GS, Insall RH, Machesky LM.

Nat Cell Biol. 2018 Oct;20(10):1159-1171. doi: 10.1038/s41556-018-0198-9. Epub 2018 Sep 24.


LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein.

Sutherland L, Ruhe M, Gattegno-Ho D, Mann K, Greaves J, Koscielniak M, Meek S, Lu Z, Waterfall M, Taylor R, Tsakiridis A, Brown H, Maciver SK, Joshi A, Clinton M, Chamberlain LH, Smith A, Burdon T.

J Cell Sci. 2018 Sep 20;131(18). pii: jcs222257. doi: 10.1242/jcs.222257.


Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse model.

Kouskou M, Thomson DM, Brett RR, Wheeler L, Tate RJ, Pratt JA, Chamberlain LH.

Exp Neurol. 2018 Oct;308:35-46. doi: 10.1016/j.expneurol.2018.06.014. Epub 2018 Jun 23.


Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy.

Jamieson LE, Greaves J, McLellan JA, Munro KR, Tomkinson NCO, Chamberlain LH, Faulds K, Graham D.

Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 15;197:30-36. doi: 10.1016/j.saa.2018.01.064. Epub 2018 Mar 7.


Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons.

Ritchie L, Tate R, Chamberlain LH, Robertson G, Zagnoni M, Sposito T, Wray S, Wright JA, Bryant CE, Gay NJ, Bushell TJ.

Neuropharmacology. 2018 Jun;135:1-10. doi: 10.1016/j.neuropharm.2018.02.025. Epub 2018 Mar 2.


Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.

Lemonidis K, MacLeod R, Baillie GS, Chamberlain LH.

J Biol Chem. 2017 Oct 20;292(42):17190-17202. doi: 10.1074/jbc.M117.799650. Epub 2017 Sep 7.


The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells.

Salaun C, Ritchie L, Greaves J, Bushell TJ, Chamberlain LH.

Mol Cell Neurosci. 2017 Dec;85:235-246. doi: 10.1016/j.mcn.2017.07.007. Epub 2017 Jul 30.


Substrate selectivity in the zDHHC family of S-acyltransferases.

Lemonidis K, Salaun C, Kouskou M, Diez-Ardanuy C, Chamberlain LH, Greaves J.

Biochem Soc Trans. 2017 Jun 15;45(3):751-758. doi: 10.1042/BST20160309. Review.


Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.

Greaves J, Munro KR, Davidson SC, Riviere M, Wojno J, Smith TK, Tomkinson NC, Chamberlain LH.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1365-E1374. doi: 10.1073/pnas.1612254114. Epub 2017 Feb 6.


A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis.

Diez-Ardanuy C, Greaves J, Munro KR, Tomkinson NC, Chamberlain LH.

Sci Rep. 2017 Jan 31;7(1):10. doi: 10.1038/s41598-017-00036-8.


Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels.

Illison J, Tian L, McClafferty H, Werno M, Chamberlain LH, Leiss V, Sassmann A, Offermanns S, Ruth P, Shipston MJ, Lukowski R.

Diabetes. 2016 Dec;65(12):3621-3635. Epub 2016 Sep 7.


Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases.

Lemonidis K, Sanchez-Perez MC, Chamberlain LH.

J Biol Chem. 2015 Sep 4;290(36):21939-50. doi: 10.1074/jbc.M115.657668. Epub 2015 Jul 21.


The zDHHC family of S-acyltransferases.

Lemonidis K, Werno MW, Greaves J, Diez-Ardanuy C, Sanchez-Perez MC, Salaun C, Thomson DM, Chamberlain LH.

Biochem Soc Trans. 2015 Apr;43(2):217-21. doi: 10.1042/BST20140270. Review.


The physiology of protein S-acylation.

Chamberlain LH, Shipston MJ.

Physiol Rev. 2015 Apr;95(2):341-76. doi: 10.1152/physrev.00032.2014. Review.


A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion.

Kavanagh DM, Smyth AM, Martin KJ, Dun A, Brown ER, Gordon S, Smillie KJ, Chamberlain LH, Wilson RS, Yang L, Lu W, Cousin MA, Rickman C, Duncan RR.

Nat Commun. 2014 Dec 17;5:5774. doi: 10.1038/ncomms6774.


The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity.

Lemonidis K, Gorleku OA, Sanchez-Perez MC, Grefen C, Chamberlain LH.

Mol Biol Cell. 2014 Dec 1;25(24):3870-83. doi: 10.1091/mbc.E14-06-1169. Epub 2014 Sep 24.


New links between S-acylation and cancer.

Greaves J, Chamberlain LH.

J Pathol. 2014 May;233(1):4-6. doi: 10.1002/path.4339.


The cytosolic N-terminus of CD317/tetherin is a membrane microdomain exclusion motif.

Billcliff PG, Gorleku OA, Chamberlain LH, Banting G.

Biol Open. 2013 Oct 15;2(11):1253-63. doi: 10.1242/bio.20135793. eCollection 2013.


Evolving views on protein palmitoylation (Comment on DOI 10.1002/bies.201300076).

Chamberlain LH.

Bioessays. 2013 Nov;35(11):928. doi: 10.1002/bies.201300121. Epub 2013 Sep 10. No abstract available.


Palmitoylation and the trafficking of peripheral membrane proteins.

Chamberlain LH, Lemonidis K, Sanchez-Perez M, Werno MW, Gorleku OA, Greaves J.

Biochem Soc Trans. 2013 Feb 1;41(1):62-6. doi: 10.1042/BST20120243.


Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis.

Greaves J, Lemonidis K, Gorleku OA, Cruchaga C, Grefen C, Chamberlain LH.

J Biol Chem. 2012 Oct 26;287(44):37330-9. doi: 10.1074/jbc.M112.389098. Epub 2012 Aug 19.


Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals.

Gorleku OA, Barns AM, Prescott GR, Greaves J, Chamberlain LH.

J Biol Chem. 2011 Nov 11;286(45):39573-84. doi: 10.1074/jbc.M111.272369. Epub 2011 Sep 18.


Regional and developmental brain expression patterns of SNAP25 splice variants.

Prescott GR, Chamberlain LH.

BMC Neurosci. 2011 Apr 28;12:35. doi: 10.1186/1471-2202-12-35.


The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain.

Greaves J, Carmichael JA, Chamberlain LH.

Mol Biol Cell. 2011 Jun 1;22(11):1887-95. doi: 10.1091/mbc.E10-11-0924. Epub 2011 Apr 6.


Differential palmitoylation regulates intracellular patterning of SNAP25.

Greaves J, Chamberlain LH.

J Cell Sci. 2011 Apr 15;124(Pt 8):1351-60. doi: 10.1242/jcs.079095. Epub 2011 Mar 23.


DHHC palmitoyl transferases: substrate interactions and (patho)physiology.

Greaves J, Chamberlain LH.

Trends Biochem Sci. 2011 May;36(5):245-53. doi: 10.1016/j.tibs.2011.01.003. Epub 2011 Mar 8. Review.


The intracellular dynamic of protein palmitoylation.

Salaun C, Greaves J, Chamberlain LH.

J Cell Biol. 2010 Dec 27;191(7):1229-38. doi: 10.1083/jcb.201008160. Review.


Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases.

Greaves J, Gorleku OA, Salaun C, Chamberlain LH.

J Biol Chem. 2010 Aug 6;285(32):24629-38. doi: 10.1074/jbc.M110.119289. Epub 2010 Jun 2.


Palmitoylation and testis-enriched expression of the cysteine-string protein beta isoform.

Gorleku OA, Chamberlain LH.

Biochemistry. 2010 Jun 29;49(25):5308-13. doi: 10.1021/bi100550h.


S-acylation by the DHHC protein family.

Greaves J, Chamberlain LH.

Biochem Soc Trans. 2010 Apr;38(2):522-4. doi: 10.1042/BST0380522. Review.


t-SNARE protein conformations patterned by the lipid microenvironment.

Rickman C, Medine CN, Dun AR, Moulton DJ, Mandula O, Halemani ND, Rizzoli SO, Chamberlain LH, Duncan RR.

J Biol Chem. 2010 Apr 30;285(18):13535-41. doi: 10.1074/jbc.M109.091058. Epub 2010 Jan 21.


Regulation of SNAP-25 trafficking and function by palmitoylation.

Greaves J, Prescott GR, Gorleku OA, Chamberlain LH.

Biochem Soc Trans. 2010 Feb;38(Pt 1):163-6. doi: 10.1042/BST0380163. Review.


Palmitoylation of the synaptic vesicle fusion machinery.

Prescott GR, Gorleku OA, Greaves J, Chamberlain LH.

J Neurochem. 2009 Aug;110(4):1135-49. doi: 10.1111/j.1471-4159.2009.06205.x. Epub 2009 Jun 5. Review.


Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity.

Bournazos S, Hart SP, Chamberlain LH, Glennie MJ, Dransfield I.

J Immunol. 2009 Jun 15;182(12):8026-36. doi: 10.4049/jimmunol.0900107.


The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.

Greenshields KN, Halstead SK, Zitman FM, Rinaldi S, Brennan KM, O'Leary C, Chamberlain LH, Easton A, Roxburgh J, Pediani J, Furukawa K, Furukawa K, Goodyear CS, Plomp JJ, Willison HJ.

J Clin Invest. 2009 Mar;119(3):595-610. doi: 10.1172/JCI37338. Epub 2009 Feb 16.


The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferases.

Greaves J, Prescott GR, Fukata Y, Fukata M, Salaun C, Chamberlain LH.

Mol Biol Cell. 2009 Mar;20(6):1845-54. doi: 10.1091/mbc.E08-09-0944. Epub 2009 Jan 21.


The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review).

Greaves J, Prescott GR, Gorleku OA, Chamberlain LH.

Mol Membr Biol. 2009 Jan;26(1):67-79. doi: 10.1080/09687680802620351. Epub 2008 Dec 29. Review.


Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels.

Tian L, Jeffries O, McClafferty H, Molyvdas A, Rowe IC, Saleem F, Chen L, Greaves J, Chamberlain LH, Knaus HG, Ruth P, Shipston MJ.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):21006-11. doi: 10.1073/pnas.0806700106. Epub 2008 Dec 19.


Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.

Greaves J, Salaun C, Fukata Y, Fukata M, Chamberlain LH.

J Biol Chem. 2008 Sep 5;283(36):25014-26. doi: 10.1074/jbc.M802140200. Epub 2008 Jul 2.


Munc18-1 prevents the formation of ectopic SNARE complexes in living cells.

Medine CN, Rickman C, Chamberlain LH, Duncan RR.

J Cell Sci. 2007 Dec 15;120(Pt 24):4407-15.


Palmitoylation-dependent protein sorting.

Greaves J, Chamberlain LH.

J Cell Biol. 2007 Jan 29;176(3):249-54. Epub 2007 Jan 22. Review.


Lipid raft association of SNARE proteins regulates exocytosis in PC12 cells.

Salaün C, Gould GW, Chamberlain LH.

J Biol Chem. 2005 May 20;280(20):19449-53. Epub 2005 Mar 15.


Evidence for a role of the exocyst in insulin-stimulated Glut4 trafficking in 3T3-L1 adipocytes.

Ewart MA, Clarke M, Kane S, Chamberlain LH, Gould GW.

J Biol Chem. 2005 Feb 4;280(5):3812-6. Epub 2004 Nov 17.


Plasma membrane targeting of exocytic SNARE proteins.

Salaün C, James DJ, Greaves J, Chamberlain LH.

Biochim Biophys Acta. 2004 Aug 23;1693(2):81-9. Review.


Lipid rafts and the regulation of exocytosis.

Salaün C, James DJ, Chamberlain LH.

Traffic. 2004 Apr;5(4):255-64. Review.


Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes.

James DJ, Salaün C, Brandie FM, Connell JM, Chamberlain LH.

J Biol Chem. 2004 May 14;279(20):20567-70. Epub 2004 Mar 15.

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