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Longitudinal PET Imaging of α7 Nicotinic Acetylcholine Receptors with [18F]ASEM in a Rat Model of Parkinson's Disease.

Vetel S, Vercouillie J, Buron F, Vergote J, Tauber C, Busson J, Chicheri G, Routier S, Sérrière S, Chalon S.

Mol Imaging Biol. 2019 Jul 8. doi: 10.1007/s11307-019-01400-y. [Epub ahead of print]


Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats.

Ouach A, Vercouillie J, Bertrand E, Rodrigues N, Pin F, Serriere S, Boiaryna L, Chartier A, Percina N, Tangpong P, Gulhan Z, Mothes C, Deloye JB, Guilloteau D, Page G, Suzenet F, Buron F, Chalon S, Routier S.

Eur J Med Chem. 2019 Oct 1;179:449-469. doi: 10.1016/j.ejmech.2019.06.049. Epub 2019 Jun 27.


The Story of the Dopamine Transporter PET Tracer LBT-999: From Conception to Clinical Use.

Chalon S, Vercouillie J, Payoux P, Deloye JB, Malherbe C, Le Jeune F, Arlicot N, Salabert AS, Guilloteau D, Emond P, Ribeiro MJ.

Front Med (Lausanne). 2019 May 3;6:90. doi: 10.3389/fmed.2019.00090. eCollection 2019. Review.


Inflammatory process in Parkinson disease: neuroprotection by neuropeptide Y.

Pain S, Vergote J, Gulhan Z, Bodard S, Chalon S, Gaillard A.

Fundam Clin Pharmacol. 2019 Oct;33(5):544-548. doi: 10.1111/fcp.12464. Epub 2019 Apr 1.


DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum.

Collins KA, Rückle T, Elliott S, Marquart L, Ballard E, Chalon S, Griffin P, Möhrle JJ, McCarthy JS.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01837-18. doi: 10.1128/AAC.01837-18. Print 2019 Apr.


Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches.

Vetel S, Sérrière S, Vercouillie J, Vergote J, Chicheri G, Deloye JB, Dollé F, Bodard S, Tronel C, Nadal-Desbarats L, Lefèvre A, Emond P, Chalon S.

Synapse. 2019 Mar;73(3):e22077. doi: 10.1002/syn.22077. Epub 2018 Nov 12.


Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer.

Elie J, Vercouillie J, Arlicot N, Lemaire L, Bidault R, Bodard S, Hosselet C, Deloye JB, Chalon S, Emond P, Guilloteau D, Buron F, Routier S.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1-7. doi: 10.1080/14756366.2018.1501043.


Alpha-7 nicotinic acetylcholine receptor agonist treatment in a rat model of Huntington's disease and involvement of heme oxygenase-1.

Foucault-Fruchard L, Tronel C, Bodard S, Gulhan Z, Busson J, Chalon S, Antier D.

Neural Regen Res. 2018 Apr;13(4):737-741. doi: 10.4103/1673-5374.230301.


Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.

Janssen B, Vugts DJ, Wilkinson SM, Ory D, Chalon S, Hoozemans JJM, Schuit RC, Beaino W, Kooijman EJM, van den Hoek J, Chishty M, Doméné A, Van der Perren A, Villa A, Maggi A, Molenaar GT, Funke U, Shevchenko RV, Baekelandt V, Bormans G, Lammertsma AA, Kassiou M, Windhorst AD.

Sci Rep. 2018 Apr 26;8(1):6580. doi: 10.1038/s41598-018-24814-0.


Brain plasticity from fundamental research to clinic.

Tillet Y, Chalon S.

J Chem Neuroanat. 2018 Apr;89:51-52. doi: 10.1016/j.jchemneu.2018.03.004. Epub 2018 Mar 13. No abstract available.


ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics.

Wei L, Syed Mortadza SA, Yan J, Zhang L, Wang L, Yin Y, Li C, Chalon S, Emond P, Belzung C, Li D, Lu C, Roger S, Jiang LH.

Neurosci Biobehav Rev. 2018 Apr;87:192-205. doi: 10.1016/j.neubiorev.2018.02.005. Epub 2018 Feb 14. Review.


The Dynamics of Liver Function Test Abnormalities after Malaria Infection: A Retrospective Observational Study.

Woodford J, Shanks GD, Griffin P, Chalon S, McCarthy JS.

Am J Trop Med Hyg. 2018 Apr;98(4):1113-1119. doi: 10.4269/ajtmh.17-0754. Epub 2018 Feb 8.


A controlled human malaria infection model enabling evaluation of transmission-blocking interventions.

Collins KA, Wang CY, Adams M, Mitchell H, Rampton M, Elliott S, Reuling IJ, Bousema T, Sauerwein R, Chalon S, Möhrle JJ, McCarthy JS.

J Clin Invest. 2018 Apr 2;128(4):1551-1562. doi: 10.1172/JCI98012. Epub 2018 Mar 12.


A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation.

Murphy SC, Duke ER, Shipman KJ, Jensen RL, Fong Y, Ferguson S, Janes HE, Gillespie K, Seilie AM, Hanron AE, Rinn L, Fishbaugher M, VonGoedert T, Fritzen E, Kappe SH, Chang M, Sousa JC, Marcsisin SR, Chalon S, Duparc S, Kerr N, Möhrle JJ, Andenmatten N, Rueckle T, Kublin JG.

J Infect Dis. 2018 Feb 14;217(5):693-702. doi: 10.1093/infdis/jix613. Erratum in: J Infect Dis. 2018 Jul 2;218(3):508.


Longitudinal Changes in Brain Metabolic Activity after Withdrawal from Escalation of Cocaine Self-Administration.

Nicolas C, Tauber C, Lepelletier FX, Chalon S, Belujon P, Galineau L, Solinas M.

Neuropsychopharmacology. 2017 Sep;42(10):1981-1990. doi: 10.1038/npp.2017.109. Epub 2017 May 29.


Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model.

Foucault-Fruchard L, Doméné A, Page G, Windsor M, Emond P, Rodrigues N, Dollé F, Damont A, Buron F, Routier S, Chalon S, Antier D.

Neuroscience. 2017 Jul 25;356:52-63. doi: 10.1016/j.neuroscience.2017.05.019. Epub 2017 May 18.


DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection.

Sulyok M, Rückle T, Roth A, Mürbeth RE, Chalon S, Kerr N, Samec SS, Gobeau N, Calle CL, Ibáñez J, Sulyok Z, Held J, Gebru T, Granados P, Brückner S, Nguetse C, Mengue J, Lalremruata A, Sim BKL, Hoffman SL, Möhrle JJ, Kremsner PG, Mordmüller B.

Lancet Infect Dis. 2017 Jun;17(6):636-644. doi: 10.1016/S1473-3099(17)30139-1. Epub 2017 Mar 28. Erratum in: Lancet Infect Dis. 2017 Jun;17(6):576.


Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.

McCarthy JS, Lotharius J, Rückle T, Chalon S, Phillips MA, Elliott S, Sekuloski S, Griffin P, Ng CL, Fidock DA, Marquart L, Williams NS, Gobeau N, Bebrevska L, Rosario M, Marsh K, Möhrle JJ.

Lancet Infect Dis. 2017 Jun;17(6):626-635. doi: 10.1016/S1473-3099(17)30171-8. Epub 2017 Mar 28.


Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography.

Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappatà S.

Q J Nucl Med Mol Imaging. 2017 Mar;61(1):60-75. doi: 10.23736/S1824-4785.16.02948-4. Epub 2016 Nov 18. Review.


Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer's Disease versus Age-Matched Controls: A Presymptomatic Stage Study.

Doméné A, Cavanagh C, Page G, Bodard S, Klein C, Delarasse C, Chalon S, Krantic S.

Int J Alzheimers Dis. 2016;2016:5696241. doi: 10.1155/2016/5696241. Epub 2016 Sep 8.


Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway.

Carloni S, Favrais G, Saliba E, Albertini MC, Chalon S, Longini M, Gressens P, Buonocore G, Balduini W.

J Pineal Res. 2016 Oct;61(3):370-80. doi: 10.1111/jpi.12354. Epub 2016 Aug 13.


Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [18F]DPA-714 PET Imaging.

Thomas C, Vercouillie J, Doméné A, Tauber C, Kassiou M, Guilloteau D, Destrieux C, Sérrière S, Chalon S.

Mol Imaging. 2016 Apr 26;15. pii: 1536012116639189. doi: 10.1177/1536012116639189. Print 2016.


Drug Delivery Systems for Imaging and Therapy of Parkinson's Disease.

Gunay MS, Ozer AY, Chalon S.

Curr Neuropharmacol. 2016;14(4):376-91. Review.


Design of α7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies.

Ouach A, Pin F, Bertrand E, Vercouillie J, Gulhan Z, Mothes C, Deloye JB, Guilloteau D, Suzenet F, Chalon S, Routier S.

Eur J Med Chem. 2016 Jan 1;107:153-64. doi: 10.1016/j.ejmech.2015.11.001. Epub 2015 Nov 10.


Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model.

Sérrière S, Doméné A, Vercouillie J, Mothes C, Bodard S, Rodrigues N, Guilloteau D, Routier S, Page G, Chalon S.

Front Med (Lausanne). 2015 Sep 2;2:61. doi: 10.3389/fmed.2015.00061. eCollection 2015.


PET tracers for imaging brain α7 nicotinic receptors: an update.

Chalon S, Vercouillie J, Guilloteau D, Suzenet F, Routier S.

Chem Commun (Camb). 2015 Oct 14;51(80):14826-31. doi: 10.1039/c5cc04536c.


Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study.

Sérrière S, Tauber C, Vercouillie J, Mothes C, Pruckner C, Guilloteau D, Kassiou M, Doméné A, Garreau L, Page G, Chalon S.

Neurobiol Aging. 2015 Apr;36(4):1639-1652. doi: 10.1016/j.neurobiolaging.2014.11.023. Epub 2015 Jan 16.


Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats.

Lepelletier FX, Tauber C, Nicolas C, Solinas M, Castelnau P, Belzung C, Emond P, Cortese S, Faraone SV, Chalon S, Galineau L.

Int J Neuropsychopharmacol. 2014 Oct 31;18(4). pii: pyu044. doi: 10.1093/ijnp/pyu044.


Variational segmentation of vector-valued images with gradient vector flow.

Jaouen V, González P, Stute S, Guilloteau D, Chalon S, Buvat I, Tauber C.

IEEE Trans Image Process. 2014 Nov;23(11):4773-85. doi: 10.1109/TIP.2014.2353854. Epub 2014 Sep 4.


Design of α7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [(18)F] quinuclidine derivative.

Pin F, Vercouillie J, Ouach A, Mavel S, Gulhan Z, Chicheri G, Jarry C, Massip S, Deloye JB, Guilloteau D, Suzenet F, Chalon S, Routier S.

Eur J Med Chem. 2014 Jul 23;82:214-24. doi: 10.1016/j.ejmech.2014.04.057. Epub 2014 May 9.


Translocator protein (18 kDa) mapping with [125I]-CLINDE in the quinolinic acid rat model of excitotoxicity: a longitudinal comparison with microglial activation, astrogliosis, and neuronal death.

Arlicot N, Tronel C, Bodard S, Garreau L, de la Crompe B, Vandevelde I, Guilloteau D, Antier D, Chalon S.

Mol Imaging. 2014;13:4-11.


Effect of moxidectin on CYP3A4 activity as evaluated by oral midazolam pharmacokinetics in healthy subjects.

Korth-Bradley JM, Parks V, Wagner F, Chalon S, Gourley I, Matschke K, Gossart S, Ripp SL, Fleckenstein L.

Clin Pharmacol Drug Dev. 2014 Mar;3(2):151-7. doi: 10.1002/cpdd.81. Epub 2013 Oct 22.


The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.

Tronel C, Page G, Bodard S, Chalon S, Antier D.

Neurochem Int. 2014 Jan;64:73-83. doi: 10.1016/j.neuint.2013.10.012. Epub 2013 Nov 6.


In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999.

Sérrière S, Tauber C, Vercouillie J, Guilloteau D, Deloye JB, Garreau L, Galineau L, Chalon S.

Nucl Med Biol. 2014 Jan;41(1):106-13. doi: 10.1016/j.nucmedbio.2013.09.007. Epub 2013 Oct 8.


Neuroinflammation and β amyloid deposition in Alzheimer's disease: in vivo quantification with molecular imaging.

Hommet C, Mondon K, Camus V, Ribeiro MJ, Beaufils E, Arlicot N, Corcia P, Paccalin M, Minier F, Gosselin T, Page G, Guilloteau D, Chalon S.

Dement Geriatr Cogn Disord. 2014;37(1-2):1-18. doi: 10.1159/000354363. Epub 2013 Oct 1. Review.


Segmentation of dynamic PET images with kinetic spectral clustering.

Mouysset S, Zbib H, Stute S, Girault JM, Charara J, Noailles J, Chalon S, Buvat I, Tauber C.

Phys Med Biol. 2013 Oct 7;58(19):6931-44. doi: 10.1088/0031-9155/58/19/6931. Epub 2013 Sep 13.


Oxidative stress is related to the deleterious effects of heme oxygenase-1 in an in vivo neuroinflammatory rat model.

Tronel C, Rochefort GY, Arlicot N, Bodard S, Chalon S, Antier D.

Oxid Med Cell Longev. 2013;2013:264935. doi: 10.1155/2013/264935. Epub 2013 Mar 5.


Maternal exposure to lipopolysaccharide leads to transient motor dysfunction in neonatal rats.

Rousset CI, Kassem J, Aubert A, Planchenault D, Gressens P, Chalon S, Belzung C, Saliba E.

Dev Neurosci. 2013;35(2-3):172-81. doi: 10.1159/000346579. Epub 2013 Feb 27.


Toxicity of MPTP on neurotransmission in three mouse models of Parkinson's disease.

Pain S, Gochard A, Bodard S, Gulhan Z, Prunier-Aesch C, Chalon S.

Exp Toxicol Pathol. 2013 Jul;65(5):689-94. doi: 10.1016/j.etp.2012.09.001. Epub 2012 Oct 16.


Evaluation of the pharmacokinetics and safety of bosutinib in patients with chronic hepatic impairment and matched healthy subjects.

Abbas R, Chalon S, Leister C, El Gaaloul M, Sonnichsen D.

Cancer Chemother Pharmacol. 2013 Jan;71(1):123-32. doi: 10.1007/s00280-012-1987-7. Epub 2012 Sep 30.


Ascending single-dose study of the safety profile, tolerability, and pharmacokinetics of bosutinib coadministered with ketoconazole to healthy adult subjects.

Abbas R, Leister C, El Gaaloul M, Chalon S, Sonnichsen D.

Clin Ther. 2012 Sep;34(9):2011-9.e1. doi: 10.1016/j.clinthera.2012.07.006. Epub 2012 Aug 9.


Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic-acid-injected rat striatum.

Leaver KR, Reynolds A, Bodard S, Guilloteau D, Chalon S, Kassiou M.

ACS Chem Neurosci. 2012 Feb 15;3(2):114-9. doi: 10.1021/cn200099e. Epub 2011 Dec 12.


Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?

Farooq RK, Isingrini E, Tanti A, Le Guisquet AM, Arlicot N, Minier F, Leman S, Chalon S, Belzung C, Camus V.

Behav Brain Res. 2012 May 16;231(1):130-7. doi: 10.1016/j.bbr.2012.03.020. Epub 2012 Mar 20.


Longitudinal and parallel monitoring of neuroinflammation and neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease.

Maia S, Arlicot N, Vierron E, Bodard S, Vergote J, Guilloteau D, Chalon S.

Synapse. 2012 Jul;66(7):573-83. doi: 10.1002/syn.21543. Epub 2012 Feb 15.


Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Aβ42 levels in the late stages of the Alzheimer's disease.

Couturier J, Paccalin M, Lafay-Chebassier C, Chalon S, Ingrand I, Pinguet J, Pontcharraud R, Guillard O, Fauconneau B, Page G.

Curr Alzheimer Res. 2012 Mar;9(3):344-60.


The effect of a high-fat breakfast on the pharmacokinetics of moxidectin in healthy male subjects: a randomized phase I trial.

Korth-Bradley JM, Parks V, Chalon S, Gourley I, Matschke K, Cailleux K, Fitoussi S, Fleckenstein L.

Am J Trop Med Hyg. 2012 Jan;86(1):122-125. doi: 10.4269/ajtmh.2012.11-0415.


Spatio-temporal diffusion of dynamic PET images.

Tauber C, Stute S, Chau M, Spiteri P, Chalon S, Guilloteau D, Buvat I.

Phys Med Biol. 2011 Oct 21;56(20):6583-96. doi: 10.1088/0031-9155/56/20/004. Epub 2011 Sep 21.


Excretion of moxidectin into breast milk and pharmacokinetics in healthy lactating women.

Korth-Bradley JM, Parks V, Chalon S, Gourley I, Matschke K, Gossart S, Bryson P, Fleckenstein L.

Antimicrob Agents Chemother. 2011 Nov;55(11):5200-4. doi: 10.1128/AAC.00311-11. Epub 2011 Sep 6.


Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease.

Decressac M, Pain S, Chabeauti PY, Frangeul L, Thiriet N, Herzog H, Vergote J, Chalon S, Jaber M, Gaillard A.

Neurobiol Aging. 2012 Sep;33(9):2125-37. doi: 10.1016/j.neurobiolaging.2011.06.018. Epub 2011 Aug 3.


Concomitant blockade of 5-HT(1A) receptor and 5-HT transporter: use of the Hunter Serotonin toxicity criteria in a clinical pharmacology study.

Parks V, Philipp AW, Raje S, Plotka A, Schechter LE, Connell J, Chalon S.

Eur Neuropsychopharmacol. 2012 Feb;22(2):92-9. doi: 10.1016/j.euroneuro.2011.06.002. Epub 2011 Jul 5.


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