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Items: 26


Hypotonic stress enhances colon cancer cell death induced by platinum derivatives and immunologically improves antitumor efficacy of intraperitoneal chemotherapy.

Demontoux L, Derangère V, Pilot T, Thinselin C, Chevriaux A, Chalmin F, Bouyer F, Ghiringhelli F, Rébé C.

Int J Cancer. 2019 Dec 1;145(11):3101-3111. doi: 10.1002/ijc.32590. Epub 2019 Aug 28.


Regulation of T cell antitumor immune response by tumor induced metabolic stress.

Chalmin F, Bruchard M, Vegran F, Ghiringhelli F.

Cell Stress. 2018 Nov 27;3(1):9-18. doi: 10.15698/cst2019.01.171. Review.


Transcriptional Programs Underlying Cd4 T Cell Differentiation and Functions.

Chalmin F, Humblin E, Ghiringhelli F, Végran F.

Int Rev Cell Mol Biol. 2018;341:1-61. doi: 10.1016/bs.ircmb.2018.07.002. Epub 2018 Aug 20. Review.


PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer.

Dosset M, Vargas TR, Lagrange A, Boidot R, Végran F, Roussey A, Chalmin F, Dondaine L, Paul C, Lauret Marie-Joseph E, Martin F, Ryffel B, Borg C, Adotévi O, Ghiringhelli F, Apetoh L.

Oncoimmunology. 2018 Mar 15;7(6):e1433981. doi: 10.1080/2162402X.2018.1433981. eCollection 2018.


IRF8-dependent molecular complexes control the Th9 transcriptional program.

Humblin E, Thibaudin M, Chalmin F, Derangère V, Limagne E, Richard C, Flavell RA, Chevrier S, Ladoire S, Berger H, Boidot R, Apetoh L, Végran F, Ghiringhelli F.

Nat Commun. 2017 Dec 12;8(1):2085. doi: 10.1038/s41467-017-01070-w.


IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production.

Vigne S, Chalmin F, Duc D, Clottu AS, Apetoh L, Lobaccaro JA, Christen I, Zhang J, Pot C.

Front Immunol. 2017 Sep 25;8:1184. doi: 10.3389/fimmu.2017.01184. eCollection 2017.


Vitamin E-Coated and Heparin-Coated Dialyzer Membranes for Heparin-Free Hemodialysis: A Multicenter, Randomized, Crossover Trial.

Islam MS, Hassan ZA, Chalmin F, Vido S, Berrada M, Verhelst D, Donnadieu P, Moranne O, Esnault VL.

Am J Kidney Dis. 2016 Nov;68(5):752-762. doi: 10.1053/j.ajkd.2016.05.013. Epub 2016 Jun 23.


Corrigendum: The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F.

Nat Immunol. 2015 Dec;16(12):1292. doi: 10.1038/ni1215-1292a. No abstract available.


IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling.

Peters A, Fowler KD, Chalmin F, Merkler D, Kuchroo VK, Pot C.

J Immunol. 2015 Nov 1;195(9):4144-53. doi: 10.4049/jimmunol.1302246. Epub 2015 Sep 25.


The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F.

Nat Immunol. 2015 Aug;16(8):859-70. doi: 10.1038/ni.3202. Epub 2015 Jun 22. Erratum in: Nat Immunol. 2015 Dec;16(12):1292.


Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.

Chalmin F, Rochemont V, Lippens C, Clottu A, Sailer AW, Merkler D, Hugues S, Pot C.

J Autoimmun. 2015 Jan;56:45-55. doi: 10.1016/j.jaut.2014.10.001. Epub 2014 Nov 10.


Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells.

Derangère V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, Causse SZ, Limagne E, Végran F, Ladoire S, Simon B, Boireau W, Hichami A, Apetoh L, Mignot G, Ghiringhelli F, Rébé C.

Cell Death Differ. 2014 Dec;21(12):1914-24. doi: 10.1038/cdd.2014.117. Epub 2014 Aug 15.


The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.

Végran F, Berger H, Boidot R, Mignot G, Bruchard M, Dosset M, Chalmin F, Rébé C, Dérangère V, Ryffel B, Kato M, Prévost-Blondel A, Ghiringhelli F, Apetoh L.

Nat Immunol. 2014 Aug;15(8):758-66. doi: 10.1038/ni.2925. Epub 2014 Jun 29.


Phenomenology and psychopathology of excessive indoor tanning.

Petit A, Karila L, Chalmin F, Lejoyeux M.

Int J Dermatol. 2014 Jun;53(6):664-72. doi: 10.1111/ijd.12336. Epub 2014 Mar 6. Review.


Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells.

Bugaut H, Bruchard M, Berger H, Derangère V, Odoul L, Euvrard R, Ladoire S, Chalmin F, Végran F, Rébé C, Apetoh L, Ghiringhelli F, Mignot G.

PLoS One. 2013 Jun 7;8(6):e65181. doi: 10.1371/journal.pone.0065181. Print 2013.


SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.

Berger H, Végran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, Mignot G, Chalmin F, Bruchard M, Derangère V, Chevriaux A, Rébé C, Ryffel B, Pot C, Hichami A, Desvergne B, Ghiringhelli F, Apetoh L.

Cancer Res. 2013 Jun 15;73(12):3578-90. doi: 10.1158/0008-5472.CAN-12-4018. Epub 2013 Apr 25.


Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.

Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Végran F, Boireau W, Simon B, Ryffel B, Connat JL, Kanellopoulos J, Martin F, Rébé C, Apetoh L, Ghiringhelli F.

Nat Med. 2013 Jan;19(1):57-64. doi: 10.1038/nm.2999. Epub 2012 Dec 2.


Production of adenosine by ectonucleotidases: a key factor in tumor immunoescape.

Ghiringhelli F, Bruchard M, Chalmin F, Rébé C.

J Biomed Biotechnol. 2012;2012:473712. doi: 10.1155/2012/473712. Epub 2012 Oct 14. Review.


Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.

Hervieu A, Rébé C, Végran F, Chalmin F, Bruchard M, Vabres P, Apetoh L, Ghiringhelli F, Mignot G.

J Invest Dermatol. 2013 Feb;133(2):499-508. doi: 10.1038/jid.2012.273. Epub 2012 Sep 6.


Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.

Chalmin F, Mignot G, Bruchard M, Chevriaux A, Végran F, Hichami A, Ladoire S, Derangère V, Vincent J, Masson D, Robson SC, Eberl G, Pallandre JR, Borg C, Ryffel B, Apetoh L, Rébé C, Ghiringhelli F.

Immunity. 2012 Mar 23;36(3):362-73. doi: 10.1016/j.immuni.2011.12.019. Epub 2012 Mar 8.


Tumor exosome-mediated MDSC activation.

Mignot G, Chalmin F, Ladoire S, Rébé C, Ghiringhelli F.

Am J Pathol. 2011 Mar;178(3):1403-4; author reply 1404-5. doi: 10.1016/j.ajpath.2010.11.078. No abstract available.


[Myeloid-derived suppressor cells: a key player in cancer].

Chalmin F, Mignot G, Ghiringhelli F.

Med Sci (Paris). 2010 Jun-Jul;26(6-7):576-9. doi: 10.1051/medsci/2010266-7576. French. No abstract available.


5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.

Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, Chevriaux A, Martin F, Apetoh L, Rébé C, Ghiringhelli F.

Cancer Res. 2010 Apr 15;70(8):3052-61. doi: 10.1158/0008-5472.CAN-09-3690. Epub 2010 Apr 13.


Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy.

Ladoire S, Arnould L, Mignot G, Coudert B, Rébé C, Chalmin F, Vincent J, Bruchard M, Chauffert B, Martin F, Fumoleau P, Ghiringhelli F.

Breast Cancer Res Treat. 2011 Jan;125(1):65-72. doi: 10.1007/s10549-010-0831-1. Epub 2010 Mar 13.


Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.

Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin JP, Boireau W, Rouleau A, Simon B, Lanneau D, De Thonel A, Multhoff G, Hamman A, Martin F, Chauffert B, Solary E, Zitvogel L, Garrido C, Ryffel B, Borg C, Apetoh L, Rébé C, Ghiringhelli F.

J Clin Invest. 2010 Feb;120(2):457-71. doi: 10.1172/JCI40483. Epub 2010 Jan 19.


CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer.

Roux S, Apetoh L, Chalmin F, Ladoire S, Mignot G, Puig PE, Lauvau G, Zitvogel L, Martin F, Chauffert B, Yagita H, Solary E, Ghiringhelli F.

J Clin Invest. 2008 Nov;118(11):3751-61. doi: 10.1172/JCI35890. Epub 2008 Oct 1.

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