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RNA profiling of human testicular cells identifies syntenic lncRNAs associated with spermatogenesis.

Rolland AD, Evrard B, Darde TA, Le Béguec C, Le Bras Y, Bensalah K, Lavoué S, Jost B, Primig M, Dejucq-Rainsford N, Chalmel F, Jégou B.

Hum Reprod. 2019 Jul 8;34(7):1278-1290. doi: 10.1093/humrep/dez063.


Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses.

Schwartz CL, Vinggaard AM, Christiansen S, Darde TA, Chalmel F, Svingen T.

Toxicol Sci. 2019 May 1;169(1):303-311. doi: 10.1093/toxsci/kfz046.


Deciphering the Molecular Mechanisms Sustaining the Estrogenic Activity of the Two Major Dietary Compounds Zearalenone and Apigenin in ER-Positive Breast Cancer Cell Lines.

Lecomte S, Demay F, Pham TH, Moulis S, Efstathiou T, Chalmel F, Pakdel F.

Nutrients. 2019 Jan 22;11(2). pii: E237. doi: 10.3390/nu11020237.


The ReproGenomics Viewer: a multi-omics and cross-species resource compatible with single-cell studies for the reproductive science community.

Darde TA, Lecluze E, Lardenois A, Stévant I, Alary N, Tüttelmann F, Collin O, Nef S, Jégou B, Rolland AD, Chalmel F.

Bioinformatics. 2019 Jan 22. doi: 10.1093/bioinformatics/btz047. [Epub ahead of print]


Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation.

Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Sérandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zörnig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB.

Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756.


Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene.

Liamin M, Le Mentec H, Evrard B, Huc L, Chalmel F, Boutet-Robinet E, Le Ferrec E, Sparfel L.

Int J Mol Sci. 2018 Nov 17;19(11). pii: E3626. doi: 10.3390/ijms19113626.


New transcriptomic tools to understand testis development and functions.

Lecluze E, Jégou B, Rolland AD, Chalmel F.

Mol Cell Endocrinol. 2018 Jun 15;468:47-59. doi: 10.1016/j.mce.2018.02.019. Epub 2018 Mar 1. Review.


TOXsIgN: a cross-species repository for toxicogenomic signatures.

Darde TA, Gaudriault P, Beranger R, Lancien C, Caillarec-Joly A, Sallou O, Bonvallot N, Chevrier C, Mazaud-Guittot S, Jégou B, Collin O, Becker E, Rolland AD, Chalmel F.

Bioinformatics. 2018 Jun 15;34(12):2116-2122. doi: 10.1093/bioinformatics/bty040.


Evaluation of apoptotic- and autophagic-related protein expressions before and after IVM of fresh, slow-frozen and vitrified pre-pubertal mouse testicular tissue.

Dumont L, Chalmel F, Oblette A, Berby B, Rives A, Duchesne V, Rondanino C, Rives N.

Mol Hum Reprod. 2017 Nov 1;23(11):738-754. doi: 10.1093/molehr/gax054.


Glyceollins trigger anti-proliferative effects through estradiol-dependent and independent pathways in breast cancer cells.

Lecomte S, Chalmel F, Ferriere F, Percevault F, Plu N, Saligaut C, Surel C, Lelong M, Efstathiou T, Pakdel F.

Cell Commun Signal. 2017 Jun 30;15(1):26. doi: 10.1186/s12964-017-0182-1.


Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis.

Carrière V, Arshad MI, Le Seyec J, Lefevre B, Farooq M, Jan A, Manuel C, Touami-Bernard L, Lucas-Clerc C, Genet V, Gascan H, Girard JP, Chalmel F, Lamontagne L, Piquet-Pellorce C, Samson M.

Mediators Inflamm. 2017;2017:1359064. doi: 10.1155/2017/1359064. Epub 2017 May 4.


Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry.

Jégou B, Sankararaman S, Rolland AD, Reich D, Chalmel F.

Mol Biol Evol. 2017 Aug 1;34(8):1974-1980. doi: 10.1093/molbev/msx141.


Cytosine modifications modulate the chromatin architecture of transcriptional enhancers.

Mahé EA, Madigou T, Sérandour AA, Bizot M, Avner S, Chalmel F, Palierne G, Métivier R, Salbert G.

Genome Res. 2017 Jun;27(6):947-958. doi: 10.1101/gr.211466.116. Epub 2017 Apr 10.


Defining the human sperm microtubulome: an integrated genomics approach.

Jumeau F, Chalmel F, Fernandez-Gomez FJ, Carpentier C, Obriot H, Tardivel M, Caillet-Boudin ML, Rigot JM, Rives N, Buée L, Sergeant N, Mitchell V.

Biol Reprod. 2017 Jan 1;96(1):93-106. doi: 10.1095/biolreprod.116.143479.


Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.

Borowiec AS, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, Bokhobza A, Derouiche S, Dewailly E, Slomianny C, Mauduit C, Benahmed M, Roudbaraki M, Jégou B, Prevarskaya N, Bidaux G.

FASEB J. 2016 Sep;30(9):3155-70. doi: 10.1096/fj.201600257R. Epub 2016 Jun 17.


PepPSy: a web server to prioritize gene products in experimental and biocuration workflows.

Sallou O, Duek PD, Darde TA, Collin O, Lane L, Chalmel F.

Database (Oxford). 2016 May 12;2016. pii: baw070. doi: 10.1093/database/baw070. Print 2016.


The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine.

Gely-Pernot A, Hao C, Becker E, Stuparevic I, Kervarrec C, Chalmel F, Primig M, Jégou B, Smagulova F.

BMC Genomics. 2015 Oct 30;16:885. doi: 10.1186/s12864-015-2095-y.


DICER Regulates the Formation and Maintenance of Cell-Cell Junctions in the Mouse Seminiferous Epithelium.

Korhonen HM, Yadav RP, Da Ros M, Chalmel F, Zimmermann C, Toppari J, Nef S, Kotaja N.

Biol Reprod. 2015 Dec;93(6):139. doi: 10.1095/biolreprod.115.131938. Epub 2015 Oct 28.


Linking transcriptomics and proteomics in spermatogenesis.

Chalmel F, Rolland AD.

Reproduction. 2015 Nov;150(5):R149-57. doi: 10.1530/REP-15-0073. Review.


The ReproGenomics Viewer: an integrative cross-species toolbox for the reproductive science community.

Darde TA, Sallou O, Becker E, Evrard B, Monjeaud C, Le Bras Y, Jégou B, Collin O, Rolland AD, Chalmel F.

Nucleic Acids Res. 2015 Jul 1;43(W1):W109-16. doi: 10.1093/nar/gkv345. Epub 2015 Apr 16.


Research resource: the dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis.

Zimmermann C, Stévant I, Borel C, Conne B, Pitetti JL, Calvel P, Kaessmann H, Jégou B, Chalmel F, Nef S.

Mol Endocrinol. 2015 Apr;29(4):627-42. doi: 10.1210/me.2014-1356. Epub 2015 Feb 24.


Combining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human.

Petit FG, Kervarrec C, Jamin SP, Smagulova F, Hao C, Becker E, Jégou B, Chalmel F, Primig M.

Biol Reprod. 2015 Mar;92(3):71. doi: 10.1095/biolreprod.114.126250. Epub 2015 Jan 21.


Forty-four novel protein-coding loci discovered using a proteomics informed by transcriptomics (PIT) approach in rat male germ cells.

Chocu S, Evrard B, Lavigne R, Rolland AD, Aubry F, Jégou B, Chalmel F, Pineau C.

Biol Reprod. 2014 Nov;91(5):123. doi: 10.1095/biolreprod.114.122416. Epub 2014 Sep 10.


An integrative omics strategy to assess the germ cell secretome and to decipher sertoli-germ cell crosstalk in the Mammalian testis.

Chalmel F, Com E, Lavigne R, Hernio N, Teixeira-Gomes AP, Dacheux JL, Pineau C.

PLoS One. 2014 Aug 11;9(8):e104418. doi: 10.1371/journal.pone.0104418. eCollection 2014.


Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2.

Kroiss A, Vincent S, Decaussin-Petrucci M, Meugnier E, Viallet J, Ruffion A, Chalmel F, Samarut J, Allioli N.

Oncogene. 2015 May 28;34(22):2846-55. doi: 10.1038/onc.2014.222. Epub 2014 Jul 28.


Proteomics and integrative genomics for unraveling the mysteries of spermatogenesis: the strategies of a team.

Com E, Melaine N, Chalmel F, Pineau C.

J Proteomics. 2014 Jul 31;107:128-43. doi: 10.1016/j.jprot.2014.04.013. Epub 2014 Apr 18. Review.


High-resolution profiling of novel transcribed regions during rat spermatogenesis.

Chalmel F, Lardenois A, Evrard B, Rolland AD, Sallou O, Dumargne MC, Coiffec I, Collin O, Primig M, Jégou B.

Biol Reprod. 2014 Jul;91(1):5. doi: 10.1095/biolreprod.114.118166. Epub 2014 Apr 16.


An atlas of chromatoid body components.

Meikar O, Vagin VV, Chalmel F, Sõstar K, Lardenois A, Hammell M, Jin Y, Da Ros M, Wasik KA, Toppari J, Hannon GJ, Kotaja N.

RNA. 2014 Apr;20(4):483-95. doi: 10.1261/rna.043729.113. Epub 2014 Feb 19.


C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human.

Bontems F, Fish RJ, Borlat I, Lembo F, Chocu S, Chalmel F, Borg JP, Pineau C, Neerman-Arbez M, Bairoch A, Lane L.

PLoS One. 2014 Jan 27;9(1):e86476. doi: 10.1371/journal.pone.0086476. eCollection 2014.


Systemic compensatory response to neonatal estradiol exposure does not prevent depletion of the oocyte pool in the rat.

Chalmey C, Giton F, Chalmel F, Fiet J, Jégou B, Mazaud-Guittot S.

PLoS One. 2013 Dec 16;8(12):e82175. doi: 10.1371/journal.pone.0082175. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/2cd33d2f-684d-44ae-9888-bcac7d69c1e9. Giton, Franck [corrected to Giton, Frank].


Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis.

Amiot L, Vu N, Rauch M, L'Helgoualc'h A, Chalmel F, Gascan H, Turlin B, Guyader D, Samson M.

J Hepatol. 2014 Feb;60(2):245-52. doi: 10.1016/j.jhep.2013.09.006. Epub 2013 Sep 12.


Expression screening of cancer/testis genes in prostate cancer identifies NR6A1 as a novel marker of disease progression and aggressiveness.

Mathieu R, Evrard B, Fromont G, Rioux-Leclercq N, Godet J, Cathelineau X, Guillé F, Primig M, Chalmel F.

Prostate. 2013 Jul;73(10):1103-14. doi: 10.1002/pros.22659. Epub 2013 Mar 26.


Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse.

Chalmel F, Lardenois A, Georg I, Barrionuevo F, Demougin P, Jégou B, Scherer G, Primig M.

Andrology. 2013 Mar;1(2):281-92. doi: 10.1111/j.2047-2927.2012.00049.x. Epub 2013 Jan 13.


Profiling of androgen response in rainbow trout pubertal testis: relevance to male gonad development and spermatogenesis.

Rolland AD, Lardenois A, Goupil AS, Lareyre JJ, Houlgatte R, Chalmel F, Le Gac F.

PLoS One. 2013;8(1):e53302. doi: 10.1371/journal.pone.0053302. Epub 2013 Jan 3.


Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility.

Chalmel F, Lardenois A, Evrard B, Mathieu R, Feig C, Demougin P, Gattiker A, Schulze W, Jégou B, Kirchhoff C, Primig M.

Hum Reprod. 2012 Nov;27(11):3233-48. doi: 10.1093/humrep/des301. Epub 2012 Aug 27.


GPSy: a cross-species gene prioritization system for conserved biological processes--application in male gamete development.

Britto R, Sallou O, Collin O, Michaux G, Primig M, Chalmel F.

Nucleic Acids Res. 2012 Jul;40(Web Server issue):W458-65. doi: 10.1093/nar/gks380. Epub 2012 May 8.


Profiling spermatogenic failure in adult testes bearing Sox9-deficient Sertoli cells identifies genes involved in feminization, inflammation and stress.

Lardenois A, Chalmel F, Barrionuevo F, Demougin P, Scherer G, Primig M.

Reprod Biol Endocrinol. 2010 Dec 23;8:154. doi: 10.1186/1477-7827-8-154.


Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6.

Lardenois A, Liu Y, Walther T, Chalmel F, Evrard B, Granovskaia M, Chu A, Davis RW, Steinmetz LM, Primig M.

Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1058-63. doi: 10.1073/pnas.1016459108. Epub 2010 Dec 13.


GermOnline 4.0 is a genomics gateway for germline development, meiosis and the mitotic cell cycle.

Lardenois A, Gattiker A, Collin O, Chalmel F, Primig M.

Database (Oxford). 2010 Dec 11;2010:baq030. doi: 10.1093/database/baq030. Print 2010.


Role of miR-34c microRNA in the late steps of spermatogenesis.

Bouhallier F, Allioli N, Lavial F, Chalmel F, Perrard MH, Durand P, Samarut J, Pain B, Rouault JP.

RNA. 2010 Apr;16(4):720-31. doi: 10.1261/rna.1963810. Epub 2010 Feb 11.


Fhl5/Act, a CREM-binding transcriptional activator required for normal sperm maturation and morphology, is not essential for testicular gene expression.

Lardenois A, Chalmel F, Demougin P, Kotaja N, Sassone-Corsi P, Primig M.

Reprod Biol Endocrinol. 2009 Nov 24;7:133. doi: 10.1186/1477-7827-7-133.


Expression profiling of rainbow trout testis development identifies evolutionary conserved genes involved in spermatogenesis.

Rolland AD, Lareyre JJ, Goupil AS, Montfort J, Ricordel MJ, Esquerré D, Hugot K, Houlgatte R, Chalmel F, Le Gac F.

BMC Genomics. 2009 Nov 20;10:546. doi: 10.1186/1471-2164-10-546.


Temporally regulated traffic of HuR and its associated ARE-containing mRNAs from the chromatoid body to polysomes during mouse spermatogenesis.

Nguyen Chi M, Chalmel F, Agius E, Vanzo N, Khabar KS, Jégou B, Morello D.

PLoS One. 2009;4(3):e4900. doi: 10.1371/journal.pone.0004900. Epub 2009 Mar 31.


CLPH, a novel casein kinase 2-phosphorylated disordered protein, is specifically associated with postmeiotic germ cells in rat spermatogenesis.

Calvel P, Kervarrec C, Lavigne R, Vallet-Erdtmann V, Guerrois M, Rolland AD, Chalmel F, Jégou B, Pineau C.

J Proteome Res. 2009 Jun;8(6):2953-65. doi: 10.1021/pr900082m.


Chromosomal gene movements reflect the recent origin and biology of therian sex chromosomes.

Potrzebowski L, Vinckenbosch N, Marques AC, Chalmel F, Jégou B, Kaessmann H.

PLoS Biol. 2008 Apr 1;6(4):e80. doi: 10.1371/journal.pbio.0060080.


The Annotation, Mapping, Expression and Network (AMEN) suite of tools for molecular systems biology.

Chalmel F, Primig M.

BMC Bioinformatics. 2008 Feb 6;9:86. doi: 10.1186/1471-2105-9-86.


Cross-platform gene expression signature of human spermatogenic failure reveals inflammatory-like response.

Spiess AN, Feig C, Schulze W, Chalmel F, Cappallo-Obermann H, Primig M, Kirchhoff C.

Hum Reprod. 2007 Nov;22(11):2936-46. Epub 2007 Oct 6.


Toward understanding the core meiotic transcriptome in mammals and its implications for somatic cancer.

Chalmel F, Lardenois A, Primig M.

Ann N Y Acad Sci. 2007 Dec;1120:1-15. Epub 2007 Oct 2. Review.


Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential.

Chalmel F, Léveillard T, Jaillard C, Lardenois A, Berdugo N, Morel E, Koehl P, Lambrou G, Holmgren A, Sahel JA, Poch O.

BMC Mol Biol. 2007 Aug 31;8:74.


Design and evaluation of Actichip, a thematic microarray for the study of the actin cytoskeleton.

Muller J, Mehlen A, Vetter G, Yatskou M, Muller A, Chalmel F, Poch O, Friederich E, Vallar L.

BMC Genomics. 2007 Aug 29;8:294.

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