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Items: 1 to 50 of 102

1.

Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group.

Zhou S, Song L, Masschelein J, Sumang FAM, Papa IA, Zulaybar TO, Custodio AB, Zabala D, Alcantara EP, de Los Santos ELC, Challis GL.

ACS Chem Biol. 2019 May 31. doi: 10.1021/acschembio.9b00270. [Epub ahead of print]

PMID:
31095370
2.

Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria.

Mullins AJ, Murray JAH, Bull MJ, Jenner M, Jones C, Webster G, Green AE, Neill DR, Connor TR, Parkhill J, Challis GL, Mahenthiralingam E.

Nat Microbiol. 2019 Jun;4(6):996-1005. doi: 10.1038/s41564-019-0383-z. Epub 2019 Mar 4.

PMID:
30833726
3.

Anti-microfouling Activity of Glycomyces sediminimaris UTMC 2460 on Dominant Fouling Bacteria of Iran Marine Habitats.

Heidarian S, Mohammadipanah F, Maghsoudlou A, Dashti Y, Challis GL.

Front Microbiol. 2019 Jan 9;9:3148. doi: 10.3389/fmicb.2018.03148. eCollection 2018.

4.

Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC.

Alkhalaf LM, Barry SM, Rea D, Gallo A, Griffiths D, Lewandowski JR, Fulop V, Challis GL.

J Am Chem Soc. 2019 Jan 9;141(1):216-222. doi: 10.1021/jacs.8b08864. Epub 2018 Dec 19.

PMID:
30516965
5.

Understanding biosynthetic protein-protein interactions.

Ackerley DF, Challis GL, Cryle MJ.

Nat Prod Rep. 2018 Nov 14;35(11):1118-1119. doi: 10.1039/c8np90037j. No abstract available.

PMID:
30345450
6.

Protein-protein interactions in trans-AT polyketide synthases.

Kosol S, Jenner M, Lewandowski JR, Challis GL.

Nat Prod Rep. 2018 Oct 17;35(10):1097-1109. doi: 10.1039/c8np00066b. Review.

PMID:
30280735
7.

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.

Ronan JL, Kadi N, McMahon SA, Naismith JH, Alkhalaf LM, Challis GL.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170068. doi: 10.1098/rstb.2017.0068.

8.

Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis.

Perry C, de Los Santos ELC, Alkhalaf LM, Challis GL.

Nat Prod Rep. 2018 Jul 18;35(7):622-632. doi: 10.1039/c8np00004b. Review.

PMID:
29651484
9.

Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases.

Jenner M, Kosol S, Griffiths D, Prasongpholchai P, Manzi L, Barrow AS, Moses JE, Oldham NJ, Lewandowski JR, Challis GL.

Nat Chem Biol. 2018 Mar;14(3):270-275. doi: 10.1038/nchembio.2549. Epub 2018 Jan 8.

10.

In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily.

Schwalen CJ, Hudson GA, Kosol S, Mahanta N, Challis GL, Mitchell DA.

J Am Chem Soc. 2017 Dec 20;139(50):18154-18157. doi: 10.1021/jacs.7b09899. Epub 2017 Dec 4.

11.

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.

Masschelein J, Jenner M, Challis GL.

Nat Prod Rep. 2017 Jul 1;34(7):712-783. doi: 10.1039/c7np00010c. Epub 2017 Jun 26. Review.

PMID:
28650032
12.

Watasemycin biosynthesis in Streptomyces venezuelae: thiazoline C-methylation by a type B radical-SAM methylase homologue.

Inahashi Y, Zhou S, Bibb MJ, Song L, Al-Bassam MM, Bibb MJ, Challis GL.

Chem Sci. 2017 Apr 1;8(4):2823-2831. doi: 10.1039/c6sc03533g. Epub 2017 Jan 19.

13.

Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis.

Song L, Jenner M, Masschelein J, Jones C, Bull MJ, Harris SR, Hartkoorn RC, Vocat A, Romero-Canelon I, Coupland P, Webster G, Dunn M, Weiser R, Paisey C, Cole ST, Parkhill J, Mahenthiralingam E, Challis GL.

J Am Chem Soc. 2017 Jun 14;139(23):7974-7981. doi: 10.1021/jacs.7b03382. Epub 2017 Jun 5.

14.

Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis.

Awodi UR, Ronan JL, Masschelein J, de Los Santos ELC, Challis GL.

Chem Sci. 2017 Jan 1;8(1):411-415. doi: 10.1039/c6sc02803a. Epub 2016 Aug 22.

15.

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.

Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC, Challis GL.

Nat Commun. 2016 Dec 21;7:13609. doi: 10.1038/ncomms13609.

16.

Mechanistic insights into class B radical-S-adenosylmethionine methylases: ubiquitous tailoring enzymes in natural product biosynthesis.

Zhou S, Alkhalaf LM, de Los Santos EL, Challis GL.

Curr Opin Chem Biol. 2016 Dec;35:73-79. doi: 10.1016/j.cbpa.2016.08.021. Epub 2016 Sep 12. Review.

PMID:
27632683
17.

Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster.

Thanapipatsiri A, Gomez-Escribano JP, Song L, Bibb MJ, Al-Bassam M, Chandra G, Thamchaipenet A, Challis GL, Bibb MJ.

Chembiochem. 2016 Nov 17;17(22):2189-2198. doi: 10.1002/cbic.201600396. Epub 2016 Oct 13.

18.

Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products.

Hu DX, Withall DM, Challis GL, Thomson RJ.

Chem Rev. 2016 Jul 27;116(14):7818-53. doi: 10.1021/acs.chemrev.6b00024. Epub 2016 Jun 17. Review.

19.

A Flavin-Dependent Decarboxylase-Dehydrogenase-Monooxygenase Assembles the Warhead of α,β-Epoxyketone Proteasome Inhibitors.

Zabala D, Cartwright JW, Roberts DM, Law BJ, Song L, Samborskyy M, Leadlay PF, Micklefield J, Challis GL.

J Am Chem Soc. 2016 Apr 6;138(13):4342-5. doi: 10.1021/jacs.6b01619. Epub 2016 Mar 25.

PMID:
26999044
20.

Editorial: Biosynthetic assembly lines themed issue.

Challis GL, Wilkinson B.

Nat Prod Rep. 2016 Feb;33(2):120-1. doi: 10.1039/c6np90004f. No abstract available.

PMID:
26804663
21.

Correction: Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264.

Liu N, Song L, Liu M, Shang F, Anderson Z, Fox DJ, Challis GL, Huang Y.

Chem Sci. 2016 Jan 1;7(1):810. doi: 10.1039/c5sc90063h. Epub 2015 Nov 5.

22.

Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264.

Liu N, Song L, Liu M, Shang F, Anderson Z, Fox DJ, Challis GL, Huang Y.

Chem Sci. 2016 Jan 1;7(1):482-488. doi: 10.1039/c5sc03021h. Epub 2015 Oct 6. Erratum in: Chem Sci. 2016 Jan 1;7(1):810.

23.

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18.

Wang WG, Li A, Yan BC, Niu SB, Tang JW, Li XN, Du X, Challis GL, Che Y, Sun HD, Pu JX.

J Nat Prod. 2016 Jan 22;79(1):149-55. doi: 10.1021/acs.jnatprod.5b00814. Epub 2015 Dec 18.

PMID:
26677752
24.

Discovery of microbial natural products by activation of silent biosynthetic gene clusters.

Rutledge PJ, Challis GL.

Nat Rev Microbiol. 2015 Aug;13(8):509-23. doi: 10.1038/nrmicro3496. Epub 2015 Jun 29. Review.

PMID:
26119570
25.

Stereochemistry and Mechanism of Undecylprodigiosin Oxidative Carbocyclization to Streptorubin B by the Rieske Oxygenase RedG.

Withall DM, Haynes SW, Challis GL.

J Am Chem Soc. 2015 Jun 24;137(24):7889-97. doi: 10.1021/jacs.5b03994. Epub 2015 Jun 12.

PMID:
26023709
26.

SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.

Schäfer M, Le TB, Hearnshaw SJ, Maxwell A, Challis GL, Wilkinson B, Buttner MJ.

J Mol Biol. 2015 Jun 19;427(12):2192-204. doi: 10.1016/j.jmb.2015.03.019. Epub 2015 Apr 8.

27.

A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics.

Masschelein J, Clauwers C, Awodi UR, Stalmans K, Vermaelen W, Lescrinier E, Aertsen A, Michiels C, Challis GL, Lavigne R.

Chem Sci. 2015 Feb 1;6(2):923-929. doi: 10.1039/c4sc01927j. Epub 2014 Oct 15.

28.

Editorial: fungal natural products themed issue.

Challis GL, Tsai SC.

Nat Prod Rep. 2014 Oct;31(10):1241. doi: 10.1039/c4np90033b. No abstract available.

PMID:
25182525
29.

Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products.

Gubbens J, Zhu H, Girard G, Song L, Florea BI, Aston P, Ichinose K, Filippov DV, Choi YH, Overkleeft HS, Challis GL, van Wezel GP.

Chem Biol. 2014 Jun 19;21(6):707-18. doi: 10.1016/j.chembiol.2014.03.011. Epub 2014 May 8.

30.

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways.

Challis GL.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):219-32. doi: 10.1007/s10295-013-1383-2. Epub 2013 Dec 10. Review.

PMID:
24322202
31.

Genome mining of Streptomyces ambofaciens.

Aigle B, Lautru S, Spiteller D, Dickschat JS, Challis GL, Leblond P, Pernodet JL.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):251-63. doi: 10.1007/s10295-013-1379-y. Epub 2013 Nov 21. Review.

PMID:
24258629
32.

Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases.

Barry SM, Challis GL.

ACS Catal. 2013 Oct 4;3(10). doi: 10.1021/cs400087p.

33.

Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis.

Song L, Laureti L, Corre C, Leblond P, Aigle B, Challis GL.

J Antibiot (Tokyo). 2014 Jan;67(1):71-6. doi: 10.1038/ja.2013.119. Epub 2013 Nov 13.

PMID:
24220109
34.

Structure and biosynthesis of scabichelin, a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.22.

Kodani S, Bicz J, Song L, Deeth RJ, Ohnishi-Kameyama M, Yoshida M, Ochi K, Challis GL.

Org Biomol Chem. 2013 Jul 28;11(28):4686-94. doi: 10.1039/c3ob40536b. Epub 2013 Jun 11.

PMID:
23752895
35.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.

36.

Oxidative tailoring reactions catalyzed by nonheme iron-dependent enzymes: streptorubin B biosynthesis as an example.

Sydor PK, Challis GL.

Methods Enzymol. 2012;516:195-218. doi: 10.1016/B978-0-12-394291-3.00002-2. Review.

PMID:
23034230
37.

Tailoring reactions catalyzed by heme-dependent enzymes: spectroscopic characterization of the L-tryptophan-nitrating cytochrome P450 TxtE.

Barry SM, Challis GL.

Methods Enzymol. 2012;516:171-94. doi: 10.1016/B978-0-12-394291-3.00001-0. Review.

PMID:
23034229
38.

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin.

Gerc AJ, Song L, Challis GL, Stanley-Wall NR, Coulthurst SJ.

PLoS One. 2012;7(9):e44673. doi: 10.1371/journal.pone.0044673. Epub 2012 Sep 18.

39.

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis.

Barry SM, Kers JA, Johnson EG, Song L, Aston PR, Patel B, Krasnoff SB, Crane BR, Gibson DM, Loria R, Challis GL.

Nat Chem Biol. 2012 Oct;8(10):814-6.

40.

A sweet origin for the key congocidine precursor 4-acetamidopyrrole-2-carboxylate.

Lautru S, Song L, Demange L, Lombès T, Galons H, Challis GL, Pernodet JL.

Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7454-8. doi: 10.1002/anie.201201445. Epub 2012 Jun 15. No abstract available.

PMID:
22707277
41.

Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis.

Nusca TD, Kim Y, Maltseva N, Lee JY, Eschenfeldt W, Stols L, Schofield MM, Scaglione JB, Dixon SD, Oves-Costales D, Challis GL, Hanna PC, Pfleger BF, Joachimiak A, Sherman DH.

J Biol Chem. 2012 May 4;287(19):16058-72. doi: 10.1074/jbc.M112.359349. Epub 2012 Mar 9.

42.

Structural changes in freshwater fish and chironomids exposed to bacterial exotoxins.

Lewis JW, Morley NJ, Ahmad M, Challis GL, Wright R, Bicker R, Morritt D.

Ecotoxicol Environ Saf. 2012 Jun;80:37-44. doi: 10.1016/j.ecoenv.2012.02.006. Epub 2012 Feb 28.

PMID:
22381615
43.

Structural basis for acyl acceptor specificity in the achromobactin biosynthetic enzyme AcsD.

Schmelz S, Botting CH, Song L, Kadi NF, Challis GL, Naismith JH.

J Mol Biol. 2011 Sep 23;412(3):495-504. doi: 10.1016/j.jmb.2011.07.059. Epub 2011 Aug 1.

44.

The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins.

Seipke RF, Song L, Bicz J, Laskaris P, Yaxley AM, Challis GL, Loria R.

Microbiology. 2011 Sep;157(Pt 9):2681-93. doi: 10.1099/mic.0.047977-0. Epub 2011 Jul 14.

PMID:
21757492
45.

Antimalarial activity of natural and synthetic prodiginines.

Papireddy K, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, Haynes SW, Challis GL, Reynolds KA.

J Med Chem. 2011 Aug 11;54(15):5296-306. doi: 10.1021/jm200543y. Epub 2011 Jul 8.

46.

Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic Burkholderia ambifaria Genomic Island.

Mahenthiralingam E, Song L, Sass A, White J, Wilmot C, Marchbank A, Boaisha O, Paine J, Knight D, Challis GL.

Chem Biol. 2011 May 27;18(5):665-77. doi: 10.1016/j.chembiol.2011.01.020.

47.

Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor.

Whicher JR, Florova G, Sydor PK, Singh R, Alhamadsheh M, Challis GL, Reynolds KA, Smith JL.

J Biol Chem. 2011 Jun 24;286(25):22558-69. doi: 10.1074/jbc.M110.213512. Epub 2011 May 3.

48.

The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus.

Davis C, Carberry S, Schrettl M, Singh I, Stephens JC, Barry SM, Kavanagh K, Challis GL, Brougham D, Doyle S.

Chem Biol. 2011 Apr 22;18(4):542-52. doi: 10.1016/j.chembiol.2010.12.022.

49.

Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes.

Sydor PK, Barry SM, Odulate OM, Barona-Gomez F, Haynes SW, Corre C, Song L, Challis GL.

Nat Chem. 2011 May;3(5):388-92. doi: 10.1038/nchem.1024. Epub 2011 Apr 17.

50.

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.

Laureti L, Song L, Huang S, Corre C, Leblond P, Challis GL, Aigle B.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6258-63. doi: 10.1073/pnas.1019077108. Epub 2011 Mar 28.

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