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Items: 42

1.

What is the appropriate management of nonfunctioning pancreatic neuroendocrine tumours disclosed on screening in adult patients with multiple endocrine neoplasia type 1?

Challis BG, Casey RT, Grossman A, Newell-Price J, Newey P, Thakker RV.

Clin Endocrinol (Oxf). 2019 Sep 10. doi: 10.1111/cen.14094. [Epub ahead of print]

PMID:
31505044
2.

SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice.

Casey RT, Ten Hoopen R, Ochoa E, Challis BG, Whitworth J, Smith PS, Martin JE, Clark GR, Rodger F, Maranian M, Allinson K, Madhu B, Roberts T, Campos L, Anstee J, Park SM, Marker A, Watts C, Bulusu VR, Giger OT, Maher ER.

Sci Rep. 2019 Jul 15;9(1):10244. doi: 10.1038/s41598-019-46124-9.

3.

Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.

Casey RT, McLean MA, Madhu B, Challis BG, Ten Hoopen R, Roberts T, Clark GR, Pittfield D, Simpson HL, Bulusu VR, Allinson K, Happerfield L, Park SM, Marker A, Giger O, Maher ER, Gallagher FA.

JCO Precis Oncol. 2018 Mar 29;2:1-12. doi: 10.1200/PO.17.00191.

4.

Glucagonoma-associated dilated cardiomyopathy refractory to somatostatin analogue therapy.

Barabas M, Huang-Doran I, Pitfield D, Philips H, Goonewardene M, Casey RT, Challis BG.

Endocrinol Diabetes Metab Case Rep. 2019 Mar 5;2019. pii: EDM180157. doi: 10.1530/EDM-18-0157. [Epub ahead of print]

5.

Clinical Practice Guidance: Surveillance for phaeochromocytoma and paraganglioma in paediatric succinate dehydrogenase gene mutation carriers.

Wong MY, Andrews KA, Challis BG, Park SM, Acerini CL, Maher ER, Casey RT.

Clin Endocrinol (Oxf). 2019 Apr;90(4):499-505. doi: 10.1111/cen.13926. Epub 2019 Jan 29. Review.

PMID:
30589099
6.

CT Characteristics of Pheochromocytoma: Relevance for the Evaluation of Adrenal Incidentaloma.

Canu L, Van Hemert JAW, Kerstens MN, Hartman RP, Khanna A, Kraljevic I, Kastelan D, Badiu C, Ambroziak U, Tabarin A, Haissaguerre M, Buitenwerf E, Visser A, Mannelli M, Arlt W, Chortis V, Bourdeau I, Gagnon N, Buchy M, Borson-Chazot F, Deutschbein T, Fassnacht M, Hubalewska-Dydejczyk A, Motyka M, Rzepka E, Casey RT, Challis BG, Quinkler M, Vroonen L, Spyroglou A, Beuschlein F, Lamas C, Young WF, Bancos I, Timmers HJLM.

J Clin Endocrinol Metab. 2019 Feb 1;104(2):312-318. doi: 10.1210/jc.2018-01532.

PMID:
30383267
7.

Rapid disease progression in a patient with mismatch repair-deficient and cortisol secreting adrenocortical carcinoma treated with pembrolizumab.

Casey RT, Giger O, Seetho I, Marker A, Pitfield D, Boyle LH, Gurnell M, Shaw A, Tischkowitz M, Maher ER, Chatterjee VK, Janowitz T, Mells G, Corrie P, Challis BG.

Semin Oncol. 2018 Jun;45(3):151-155. doi: 10.1053/j.seminoncol.2018.06.001. Epub 2018 Jun 21.

8.

Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours.

Kay RG, Challis BG, Casey RT, Roberts GP, Meek CL, Reimann F, Gribble FM.

Rapid Commun Mass Spectrom. 2018 Aug 30;32(16):1414-1424. doi: 10.1002/rcm.8183.

9.

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.

Sng CCT, O'Byrne S, Prigozhin DM, Bauer MR, Harvey JC, Ruhle M, Challis BG, Lear S, Roberts LD, Workman S, Janowitz T, Magiera L, Doffinger R, Buckland MS, Jodrell DJ, Semple RK, Wilson TJ, Modis Y, Thaventhiran JED.

J Allergy Clin Immunol. 2018 Jul;142(1):311-314.e6. doi: 10.1016/j.jaci.2018.01.048. Epub 2018 Mar 6. No abstract available.

10.

Management of an acute catecholamine-induced cardiomyopathy and circulatory collapse: a multidisciplinary approach.

Casey RT, Challis BG, Pitfield D, Mahroof RM, Jamieson N, Bhagra CJ, Vuylsteke A, Pettit SJ, Chatterjee KC.

Endocrinol Diabetes Metab Case Rep. 2017 Nov 9;2017. pii: 17-0122. doi: 10.1530/EDM-17-0122. eCollection 2017.

11.

Clinical and Molecular Features of Renal and Pheochromocytoma/Paraganglioma Tumor Association Syndrome (RAPTAS): Case Series and Literature Review.

Casey RT, Warren AY, Martin JE, Challis BG, Rattenberry E, Whitworth J, Andrews KA, Roberts T, Clark GR, West H, Smith PS, Docquier FM, Rodger F, Murray V, Simpson HL, Wallis Y, Giger O, Tran M, Tomkins S, Stewart GD, Park SM, Woodward ER, Maher ER.

J Clin Endocrinol Metab. 2017 Nov 1;102(11):4013-4022. doi: 10.1210/jc.2017-00562. Review.

12.

Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.

Challis BG, Powlson AS, Casey RT, Pearson C, Lam BY, Ma M, Pitfield D, Yeo GSH, Godfrey E, Cheow HK, Chatterjee VK, Carroll NR, Shaw A, Buscombe JR, Simpson HL.

Endocr Connect. 2017 Oct;6(7):540-548. doi: 10.1530/EC-17-0076. Epub 2017 Aug 7.

13.

A case of a metastatic SDHA mutated paraganglioma re-presenting twenty-three years after initial surgery.

Casey RT, Challis BG, Marker A, Pitfield D, Cheow HK, Shaw A, Park SM, Simpson HL, Maher ER.

Endocr Relat Cancer. 2017 Aug;24(8):L69-L71. doi: 10.1530/ERC-17-0206. No abstract available.

14.

Radiological surveillance in multiple endocrine neoplasia type 1: a double-edged sword?

Casey RT, Saunders D, Challis BG, Pitfield D, Cheow H, Shaw A, Simpson HL.

Endocr Connect. 2017 Apr;6(3):151-158. doi: 10.1530/EC-17-0006. Epub 2017 Mar 15.

15.

Is there an optimal preoperative management strategy for phaeochromocytoma/paraganglioma?

Challis BG, Casey RT, Simpson HL, Gurnell M.

Clin Endocrinol (Oxf). 2017 Feb;86(2):163-167. doi: 10.1111/cen.13252. Epub 2016 Oct 24. Review.

PMID:
27696513
16.

Glucocorticoid-induced hyperglycaemia in respiratory disease: a systematic review and meta-analysis.

Breakey S, Sharp SJ, Adler AI, Challis BG.

Diabetes Obes Metab. 2016 Dec;18(12):1274-1278. doi: 10.1111/dom.12739. Epub 2016 Aug 4. Review.

17.

The McKittrick-Wheelock syndrome: a rare cause of curable diabetes.

Challis BG, Lim CT, Cluroe A, Cameron E, O'Rahilly S.

Endocrinol Diabetes Metab Case Rep. 2016;2016:160013. doi: 10.1530/EDM-16-0013. Epub 2016 May 1.

18.

Familial Adrenocortical Carcinoma in Association With Lynch Syndrome.

Challis BG, Kandasamy N, Powlson AS, Koulouri O, Annamalai AK, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M.

J Clin Endocrinol Metab. 2016 Jun;101(6):2269-72. doi: 10.1210/jc.2016-1460. Epub 2016 May 4.

19.

Do glucagonomas always produce glucagon?

Wewer Albrechtsen NJ, Challis BG, Damjanov I, Holst JJ.

Bosn J Basic Med Sci. 2016 Feb 1;16(1):1-7. doi: 10.17305/bjbms.2015.794. Review.

20.

Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2.

Powlson AS, Challis BG, Halsall DJ, Schoenmakers E, Gurnell M.

Clin Endocrinol (Oxf). 2016 Aug;85(2):306-12. doi: 10.1111/cen.13011. Epub 2016 Feb 4.

PMID:
26715131
21.

Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides.

Challis BG, Albrechtsen NJ, Bansiya V, Burling K, Barker P, Hartmann B, Gribble F, O'Rahilly S, Holst JJ, Simpson HL.

Endocrinol Diabetes Metab Case Rep. 2015;2015:150105. doi: 10.1530/EDM-15-0105. Epub 2015 Dec 1.

22.

Familial adult onset hyperinsulinism due to an activating glucokinase mutation: implications for pharmacological glucokinase activation.

Challis BG, Harris J, Sleigh A, Isaac I, Orme SM, Seevaratnam N, Dhatariya K, Simpson HL, Semple RK.

Clin Endocrinol (Oxf). 2014 Dec;81(6):855-61. doi: 10.1111/cen.12517. Epub 2014 Jul 2.

23.

Proopiomelanocortin Deficiency.

Challis BG, Millington GWM.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2013 Dec 12.

24.

Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.

Corander MP, Rimmington D, Challis BG, O'Rahilly S, Coll AP.

Endocrinology. 2011 May;152(5):1819-28. doi: 10.1210/en.2010-1450. Epub 2011 Mar 1.

25.

The effects of neurokinin B upon gonadotrophin release in male rodents.

Corander MP, Challis BG, Thompson EL, Jovanovic Z, Loraine Tung YC, Rimmington D, Huhtaniemi IT, Murphy KG, Topaloglu AK, Yeo GS, O'Rahilly S, Dhillo WS, Semple RK, Coll AP.

J Neuroendocrinol. 2010 Mar;22(3):181-7. doi: 10.1111/j.1365-2826.2009.01951.x. Epub 2009 Dec 23.

PMID:
20041982
26.

Orexin expression is regulated by alpha-melanocyte-stimulating hormone.

López M, Lage R, Tung YC, Challis BG, Varela L, Virtue S, O'Rahilly S, Vidal-Puig A, Diéguez C, Coll AP.

J Neuroendocrinol. 2007 Sep;19(9):703-7.

27.

Heterozygosity for a POMC-null mutation and increased obesity risk in humans.

Farooqi IS, Drop S, Clements A, Keogh JM, Biernacka J, Lowenbein S, Challis BG, O'Rahilly S.

Diabetes. 2006 Sep;55(9):2549-53.

28.

Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production.

Coll AP, Fassnacht M, Klammer S, Hahner S, Schulte DM, Piper S, Tung YC, Challis BG, Weinstein Y, Allolio B, O'Rahilly S, Beuschlein F.

J Endocrinol. 2006 Aug;190(2):515-25.

29.

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.

Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D, Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, Blackwood A, Hung CC, Wareham NJ, Froguel P, Millhauser GL, O'Rahilly S, Farooqi IS.

Cell Metab. 2006 Feb;3(2):135-40.

30.

Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids.

Coll AP, Challis BG, López M, Piper S, Yeo GS, O'Rahilly S.

Diabetes. 2005 Aug;54(8):2269-76.

31.

Past, present and future strategies to study the genetics of body weight regulation.

Challis BG, Yeo GS.

Brief Funct Genomic Proteomic. 2002 Oct;1(3):290-304. Review.

PMID:
15239895
32.

The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin.

Coll AP, Challis BG, Yeo GS, Snell K, Piper SJ, Halsall D, Thresher RR, O'Rahilly S.

Endocrinology. 2004 Oct;145(10):4721-7. Epub 2004 Jul 1.

PMID:
15231703
33.

Proopiomelanocortin and energy balance: insights from human and murine genetics.

Coll AP, Farooqi IS, Challis BG, Yeo GS, O'Rahilly S.

J Clin Endocrinol Metab. 2004 Jun;89(6):2557-62. Review.

PMID:
15181023
34.

Peptide YY3-36 and satiety: clarity or confusion?

Coll AP, Challis BG, O'Rahilly S.

Endocrinology. 2004 Jun;145(6):2582-4. No abstract available.

PMID:
15140836
35.

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4695-700. Epub 2004 Mar 15.

36.

Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians.

Challis BG, Luan J, Keogh J, Wareham NJ, Farooqi IS, O'Rahilly S.

Int J Obes Relat Metab Disord. 2004 Mar;28(3):442-6.

PMID:
14724656
37.

Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse.

Challis BG, Pinnock SB, Coll AP, Carter RN, Dickson SL, O'Rahilly S.

Biochem Biophys Res Commun. 2003 Nov 28;311(4):915-9.

PMID:
14623268
38.

Minireview: human obesity-lessons from monogenic disorders.

O'Rahilly S, Farooqi IS, Yeo GS, Challis BG.

Endocrinology. 2003 Sep;144(9):3757-64. Review.

PMID:
12933645
39.

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.

Yeo GS, Lank EJ, Farooqi IS, Keogh J, Challis BG, O'Rahilly S.

Hum Mol Genet. 2003 Mar 1;12(5):561-74.

PMID:
12588803
40.

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.

Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S.

Hum Mol Genet. 2002 Aug 15;11(17):1997-2004.

PMID:
12165561
41.

The CART gene and human obesity: mutational analysis and population genetics.

Challis BG, Yeo GS, Farooqi IS, Luan J, Aminian S, Halsall DJ, Keogh JM, Wareham NJ, O'Rahilly S.

Diabetes. 2000 May;49(5):872-5.

PMID:
10905499
42.

The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models.

Yeo GS, Farooqi IS, Challis BG, Jackson RS, O'Rahilly S.

QJM. 2000 Jan;93(1):7-14. Review.

PMID:
10623776

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