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Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability.

Caslin HL, Abebayehu D, Abdul Qayum A, Haque TT, Taruselli MT, Paez PA, Pondicherry N, Barnstein BO, Hoeferlin LA, Chalfant CE, Ryan JJ.

J Immunol. 2019 Jun 3. pii: ji1801005. doi: 10.4049/jimmunol.1801005. [Epub ahead of print]



DeLigio JT, Stevens SC, Nazario-Munoz GS, MacKnight HP, Doe KK, Chalfant CE, Park MA.

Mol Cancer Res. 2019 May 28. pii: molcanres.1291.2018. doi: 10.1158/1541-7786.MCR-18-1291. [Epub ahead of print]


Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2α.

Hirano Y, Gao YG, Stephenson DJ, Vu NT, Malinina L, Simanshu DK, Chalfant CE, Patel DJ, Brown RE.

Elife. 2019 May 3;8. pii: e44760. doi: 10.7554/eLife.44760.


Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens.

Cockburn CL, Green RS, Damle SR, Martin RK, Ghahrai NN, Colonne PM, Fullerton MS, Conrad DH, Chalfant CE, Voth DE, Rucks EA, Gilk SD, Carlyon JA.

Life Sci Alliance. 2019 Mar 22;2(2). pii: e201800292. doi: 10.26508/lsa.201800292. Print 2019 Apr.


Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells.

Mishra SK, Stephenson DJ, Chalfant CE, Brown RE.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):158-167. doi: 10.1016/j.bbalip.2018.11.002. Epub 2018 Nov 22.


PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas.

Hill KS, Roberts ER, Wang X, Marin E, Park TD, Son S, Ren Y, Fang B, Yoder S, Kim S, Wan L, Sarnaik AA, Koomen JM, Messina JL, Teer JK, Kim Y, Wu J, Chalfant CE, Kim M.

Mol Cancer Res. 2019 Feb;17(2):583-593. doi: 10.1158/1541-7786.MCR-18-0777. Epub 2018 Oct 24.


CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation.

Mishra SK, Gao YG, Deng Y, Chalfant CE, Hinchcliffe EH, Brown RE.

Autophagy. 2018;14(5):862-879. doi: 10.1080/15548627.2017.1393129. Epub 2018 Feb 21.


Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase.

Karandashova S, Kummarapurugu AB, Zheng S, Chalfant CE, Voynow JA.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L206-L214. doi: 10.1152/ajplung.00322.2017. Epub 2017 Oct 12.


Splice variants of cytosolic polyadenylation element-binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis.

DeLigio JT, Lin G, Chalfant CE, Park MA.

J Biol Chem. 2017 Oct 27;292(43):17909-17918. doi: 10.1074/jbc.M117.810127. Epub 2017 Sep 13.


Lipidomics in translational research and the clinical significance of lipid-based biomarkers.

Stephenson DJ, Hoeferlin LA, Chalfant CE.

Transl Res. 2017 Nov;189:13-29. doi: 10.1016/j.trsl.2017.06.006. Epub 2017 Jun 15. Review.


Impact of high dose vitamin C on platelet function.

Mohammed BM, Sanford KW, Fisher BJ, Martin EJ, Contaifer D Jr, Warncke UO, Wijesinghe DS, Chalfant CE, Brophy DF, Fowler Iii AA, Natarajan R.

World J Crit Care Med. 2017 Feb 4;6(1):37-47. doi: 10.5492/wjccm.v6.i1.37. eCollection 2017 Feb 4.


Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients.

Qi H, Priyadarsini S, Nicholas SE, Sarker-Nag A, Allegood J, Chalfant CE, Mandal NA, Karamichos D.

J Lipid Res. 2017 Apr;58(4):636-648. doi: 10.1194/jlr.M067264. Epub 2017 Feb 10.


PRMT2 interacts with splicing factors and regulates the alternative splicing of BCL-X.

Vhuiyan MI, Pak ML, Park MA, Thomas D, Lakowski TM, Chalfant CE, Frankel A.

J Biochem. 2017 Jul 1;162(1):17-25. doi: 10.1093/jb/mvw102.


Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients.

Contaifer D Jr, Carl DE, Warncke UO, Martin EJ, Mohammed BM, Van Tassell B, Brophy DF, Chalfant CE, Wijesinghe DS.

J Lipid Res. 2017 Mar;58(3):586-599. doi: 10.1194/jlr.P068833. Epub 2016 Dec 19.


Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis.

Shapiro BA, Vu NT, Shultz MD, Shultz JC, Mietla JA, Gouda MM, Yacoub A, Dent P, Fisher PB, Park MA, Chalfant CE.

J Biol Chem. 2016 Oct 7;291(41):21669-21681. Epub 2016 Aug 12.


Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis.

Vu NT, Park MA, Shultz MD, Bulut GB, Ladd AC, Chalfant CE.

Cancer Res. 2016 May 15;76(10):2977-89. doi: 10.1158/0008-5472.CAN-15-2512. Epub 2016 Mar 29.


Role of integrin α7β1 signaling in myoblast differentiation on aligned polydioxanone scaffolds.

McClure MJ, Clark NM, Hyzy SL, Chalfant CE, Olivares-Navarrete R, Boyan BD, Schwartz Z.

Acta Biomater. 2016 Jul 15;39:44-54. doi: 10.1016/j.actbio.2016.04.046. Epub 2016 Apr 30.


Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration.

Stiles M, Qi H, Sun E, Tan J, Porter H, Allegood J, Chalfant CE, Yasumura D, Matthes MT, LaVail MM, Mandal NA.

J Lipid Res. 2016 May;57(5):818-31. doi: 10.1194/jlr.M063719. Epub 2016 Mar 5.


Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects.

Kolawole EM, McLeod JJ, Ndaw V, Abebayehu D, Barnstein BO, Faber T, Spence AJ, Taruselli M, Paranjape A, Haque TT, Qayum AA, Kazmi QA, Wijesinghe DS, Sturgill JL, Chalfant CE, Straus DB, Oskeritzian CA, Ryan JJ.

J Immunol. 2016 Feb 15;196(4):1461-70. doi: 10.4049/jimmunol.1501932. Epub 2016 Jan 15.


Exogenous ceramide-1-phosphate (C1P) and phospho-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors.

Katz S, Ernst O, Avni D, Athamna M, Philosoph A, Arana L, Ouro A, Hoeferlin LA, Meijler MM, Chalfant CE, Gómez-Muñoz A, Zor T.

Immunol Lett. 2016 Jan;169:73-81. doi: 10.1016/j.imlet.2015.12.001. Epub 2015 Dec 3.


The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer.

Johnson RM, Vu NT, Griffin BP, Gentry AE, Archer KJ, Chalfant CE, Park MA.

J Biol Chem. 2015 Oct 16;290(42):25717-27. doi: 10.1074/jbc.M115.671206. Epub 2015 Aug 24.


Anaplasma phagocytophilum Rab10-dependent parasitism of the trans-Golgi network is critical for completion of the infection cycle.

Truchan HK, VieBrock L, Cockburn CL, Ojogun N, Griffin BP, Wijesinghe DS, Chalfant CE, Carlyon JA.

Cell Microbiol. 2016 Feb;18(2):260-81. doi: 10.1111/cmi.12500. Epub 2015 Oct 7.


Arachidonic acid-derived signaling lipids and functions in impaired healing.

Dhall S, Wijesinghe DS, Karim ZA, Castro A, Vemana HP, Khasawneh FT, Chalfant CE, Martins-Green M.

Wound Repair Regen. 2015 Sep;23(5):644-56. doi: 10.1111/wrr.12337. Epub 2015 Sep 14.


Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension.

Al-Husseini A, Wijesinghe DS, Farkas L, Kraskauskas D, Drake JI, Van Tassel B, Abbate A, Chalfant CE, Voelkel NF.

PLoS One. 2015 Mar 18;10(3):e0120157. doi: 10.1371/journal.pone.0120157. eCollection 2015.


Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.

Barbour SE, Nguyen PT, Park M, Emani B, Lei X, Kambalapalli M, Shultz JC, Wijesinghe D, Chalfant CE, Ramanadham S.

J Biol Chem. 2015 Apr 24;290(17):11021-31. doi: 10.1074/jbc.M115.648956. Epub 2015 Mar 11.


The Lipid Portion of Activated Platelet-Rich Plasma Significantly Contributes to Its Wound Healing Properties.

Hoeferlin LA, Huynh QK, Mietla JA, Sell SA, Tucker J, Chalfant CE, Wijesinghe DS.

Adv Wound Care (New Rochelle). 2015 Feb 1;4(2):100-109.


A novel model of chronic wounds: importance of redox imbalance and biofilm-forming bacteria for establishment of chronicity.

Dhall S, Do D, Garcia M, Wijesinghe DS, Brandon A, Kim J, Sanchez A, Lyubovitsky J, Gallagher S, Nothnagel EA, Chalfant CE, Patel RP, Schiller N, Martins-Green M.

PLoS One. 2014 Oct 14;9(10):e109848. doi: 10.1371/journal.pone.0109848. eCollection 2014.


Resolution of sterile inflammation: role for vitamin C.

Mohammed BM, Fisher BJ, Huynh QK, Wijesinghe DS, Chalfant CE, Brophy DF, Fowler AA 3rd, Natarajan R.

Mediators Inflamm. 2014;2014:173403. doi: 10.1155/2014/173403. Epub 2014 Sep 9.


Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts.

Wijesinghe DS, Brentnall M, Mietla JA, Hoeferlin LA, Diegelmann RF, Boise LH, Chalfant CE.

J Lipid Res. 2014 Jul;55(7):1298-309. doi: 10.1194/jlr.M048207. Epub 2014 May 13.


Structural Stereochemistry of Androstene Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoid Receptors.

Shaak TL, Wijesinghe DS, Chalfant CE, Diegelmann RF, Ward KR, Loria RM.

Int J Med Chem. 2013 Mar 14;2013:203606.


Dietary fish oil improves endothelial function and lowers blood pressure via suppression of sphingolipid-mediated contractions in spontaneously hypertensive rats.

van den Elsen LW, Spijkers LJ, van den Akker RF, van Winssen AM, Balvers M, Wijesinghe DS, Chalfant CE, Garssen J, Willemsen LE, Alewijnse AE, Peters SL.

J Hypertens. 2014 May;32(5):1050-8; discussion 1058. doi: 10.1097/HJH.0000000000000131.


Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids.

Simanshu DK, Kamlekar RK, Wijesinghe DS, Zou X, Zhai X, Mishra SK, Molotkovsky JG, Malinina L, Hinchcliffe EH, Chalfant CE, Brown RE, Patel DJ.

Nature. 2013 Aug 22;500(7463):463-7. doi: 10.1038/nature12332. Epub 2013 Jul 17.


OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2.

West NW, Garcia-Vargas A, Chalfant CE, Park MA.

BMC Cancer. 2013 May 24;13:256. doi: 10.1186/1471-2407-13-256.


Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size.

Khanna S, Rink C, Ghoorkhanian R, Gnyawali S, Heigel M, Wijesinghe DS, Chalfant CE, Chan YC, Banerjee J, Huang Y, Roy S, Sen CK.

J Cereb Blood Flow Metab. 2013 Aug;33(8):1197-206. doi: 10.1038/jcbfm.2013.68. Epub 2013 May 1.


The role of ceramide-1-phosphate in biological functions.

Hoeferlin LA, Wijesinghe DS, Chalfant CE.

Handb Exp Pharmacol. 2013;(215):153-66. doi: 10.1007/978-3-7091-1368-4_8. Review.


Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase.

Mietla JA, Wijesinghe DS, Hoeferlin LA, Shultz MD, Natarajan R, Fowler AA 3rd, Chalfant CE.

J Lipid Res. 2013 Jul;54(7):1834-47. doi: 10.1194/jlr.M035683. Epub 2013 Apr 10.


hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.

Vu NT, Park MA, Shultz JC, Goehe RW, Hoeferlin LA, Shultz MD, Smith SA, Lynch KW, Chalfant CE.

J Biol Chem. 2013 Mar 22;288(12):8575-84. doi: 10.1074/jbc.M112.443333. Epub 2013 Feb 8.


The molecular basis of ceramide-1-phosphate recognition by C2 domains.

Ward KE, Bhardwaj N, Vora M, Chalfant CE, Lu H, Stahelin RV.

J Lipid Res. 2013 Mar;54(3):636-48. doi: 10.1194/jlr.M031088. Epub 2012 Dec 31.


Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.

Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell B, Natarajan R, dos Remedios CG, Drake JI, Farkas L, Kraskauskas D, Wijesinghe DS, Chalfant CE, Bigbee J, Abbate A, Lesnefsky EJ, Bogaard HJ, Voelkel NF.

Circ Heart Fail. 2013 Jan;6(1):136-44. doi: 10.1161/CIRCHEARTFAILURE.111.966127. Epub 2012 Nov 14.


Metallofullerene-nanoplatform-delivered interstitial brachytherapy improved survival in a murine model of glioblastoma multiforme.

Wilson JD, Broaddus WC, Dorn HC, Fatouros PP, Chalfant CE, Shultz MD.

Bioconjug Chem. 2012 Sep 19;23(9):1873-80. Epub 2012 Aug 21.


The Proto-oncogene PKCι regulates the alternative splicing of Bcl-x pre-mRNA.

Shultz JC, Vu N, Shultz MD, Mba MU, Shapiro BA, Chalfant CE.

Mol Cancer Res. 2012 May;10(5):660-9. doi: 10.1158/1541-7786.MCR-11-0363. Epub 2012 Apr 20.


The flip-flop HuR: part of the problem or the solution in fighting cancer?

Shultz JC, Chalfant CE.

J Clin Invest. 2012 Jan;122(1):16-9. doi: 10.1172/JCI61677. Epub 2011 Dec 27.


Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats.

Spijkers LJ, Janssen BJ, Nelissen J, Meens MJ, Wijesinghe D, Chalfant CE, De Mey JG, Alewijnse AE, Peters SL.

PLoS One. 2011;6(12):e29222. doi: 10.1371/journal.pone.0029222. Epub 2011 Dec 15.


Characterization of lysophosphatidic acid subspecies produced by autotaxin using a modified HPLC ESI-MS/MS method.

Wijesinghe DS, Mayton EK, Mietla JA, Mukherjee A, Wu J, Fang X, Chalfant CE.

Anal Methods. 2011 Nov 1;3(12):2822-2828.


Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme.

Lamour NF, Wijesinghe DS, Mietla JA, Ward KE, Stahelin RV, Chalfant CE.

J Biol Chem. 2011 Dec 16;286(50):42808-17. doi: 10.1074/jbc.M111.310169. Epub 2011 Oct 18.


WITHDRAWN: Ceramide kinase regulates the production of TNF{alpha} via inhibition of TNF{alpha}-converting enzyme.

Lamour NF, Wijesinghe DS, Mietla JA, Ward KE, Stahelin RV, Chalfant CE.

J Biol Chem. 2011 Sep 27. [Epub ahead of print]


Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide.

Spijkers LJ, van den Akker RF, Janssen BJ, Debets JJ, De Mey JG, Stroes ES, van den Born BJ, Wijesinghe DS, Chalfant CE, MacAleese L, Eijkel GB, Heeren RM, Alewijnse AE, Peters SL.

PLoS One. 2011;6(7):e21817. doi: 10.1371/journal.pone.0021817. Epub 2011 Jul 19.


SRSF1 regulates the alternative splicing of caspase 9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cells.

Shultz JC, Goehe RW, Murudkar CS, Wijesinghe DS, Mayton EK, Massiello A, Hawkins AJ, Mukerjee P, Pinkerman RL, Park MA, Chalfant CE.

Mol Cancer Res. 2011 Jul;9(7):889-900. doi: 10.1158/1541-7786.MCR-11-0061. Epub 2011 May 26.


Caspase 9b: a new target for therapy in non-small-cell lung cancer.

Shultz JC, Chalfant CE.

Expert Rev Anticancer Ther. 2011 Apr;11(4):499-502. doi: 10.1586/era.11.23. Review. No abstract available.


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