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Items: 1 to 50 of 149

1.

Understanding the Phase Behavior of Energetically Similar Polymorphs to achieve Controlled Crystallization for a Nav1.7 Pain Inhibitor Compound.

Chakravarty P, DiPasquale A, Stumpf A, Lubach JW, Nagapudi K.

Mol Pharm. 2018 Sep 14. doi: 10.1021/acs.molpharmaceut.8b00658. [Epub ahead of print]

PMID:
30216726
2.

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.

Böttcher JP, Bonavita E, Chakravarty P, Blees H, Cabeza-Cabrerizo M, Sammicheli S, Rogers NC, Sahai E, Zelenay S, Reis e Sousa C.

Cell. 2018 Feb 22;172(5):1022-1037.e14. doi: 10.1016/j.cell.2018.01.004. Epub 2018 Feb 8.

3.

Determination of Fragility in Organic Small Molecular Glass Forming Liquids: Comparison of Calorimetric and Spectroscopic Data and Commentary on Pharmaceutical Importance.

Chakravarty P, Pandya K, Nagapudi K.

Mol Pharm. 2018 Mar 5;15(3):1248-1257. doi: 10.1021/acs.molpharmaceut.7b01068. Epub 2018 Feb 7.

PMID:
29384682
4.

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.

Ramachandran A, Vizán P, Das D, Chakravarty P, Vogt J, Rogers KW, Müller P, Hinck AP, Sapkota GP, Hill CS.

Elife. 2018 Jan 29;7. pii: e31756. doi: 10.7554/eLife.31756.

5.

Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate.

Kümper S, Gantke T, Chen CS, Soneji Y, Pattison MJ, Chakravarty P, Kjær S, Thomas D, Haslam C, Leavens BJ, House D, Powell DJ, Ley SC.

Biochem J. 2018 Jan 11;475(1):329-340. doi: 10.1042/BCJ20170579.

6.

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers.

Pearce OMT, Delaine-Smith RM, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight MM, Balkwill FR.

Cancer Discov. 2018 Mar;8(3):304-319. doi: 10.1158/2159-8290.CD-17-0284. Epub 2017 Dec 1.

7.

Primary versus secondary tracheoesophageal puncture: systematic review and meta-analysis.

Chakravarty PD, McMurran AEL, Banigo A, Shakeel M, Ah-See KW.

J Laryngol Otol. 2018 Jan;132(1):14-21. doi: 10.1017/S0022215117002390. Epub 2017 Nov 27. Review.

PMID:
29173195
8.

Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ, Chakravarty P, Nurse P.

J Cell Sci. 2017 Dec 15;130(24):4144-4154. doi: 10.1242/jcs.208066. Epub 2017 Oct 30.

9.

PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs.

Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI.

Cancer Res. 2017 Nov 15;77(22):6365-6374. doi: 10.1158/0008-5472.CAN-16-3453. Epub 2017 Sep 25.

PMID:
28947422
10.

Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia.

Passaro D, Di Tullio A, Abarrategi A, Rouault-Pierre K, Foster K, Ariza-McNaughton L, Montaner B, Chakravarty P, Bhaw L, Diana G, Lassailly F, Gribben J, Bonnet D.

Cancer Cell. 2017 Sep 11;32(3):324-341.e6. doi: 10.1016/j.ccell.2017.08.001. Epub 2017 Sep 1.

11.

Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors.

Helft J, Anjos-Afonso F, van der Veen AG, Chakravarty P, Bonnet D, Reis e Sousa C.

Cell Rep. 2017 Jul 18;20(3):529-537. doi: 10.1016/j.celrep.2017.06.075.

12.

A rational approach towards development of amorphous solid dispersions: Experimental and computational techniques.

Chakravarty P, Lubach JW, Hau J, Nagapudi K.

Int J Pharm. 2017 Mar 15;519(1-2):44-57. doi: 10.1016/j.ijpharm.2017.01.003. Epub 2017 Jan 4.

PMID:
28063904
13.

Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster.

Srinivasan N, Gordon O, Ahrens S, Franz A, Deddouche S, Chakravarty P, Phillips D, Yunus AA, Rosen MK, Valente RS, Teixeira L, Thompson B, Dionne MS, Wood W, Reis e Sousa C.

Elife. 2016 Nov 22;5. pii: e19662. doi: 10.7554/eLife.19662.

14.

Cutis laxa autosomal recessive type II or wrinkly skin syndrome?

Arora P, Chakravarty P, Khanna D, Gupta R.

Indian Dermatol Online J. 2016 Sep-Oct;7(5):440-442. No abstract available.

15.

The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.

Torres CM, Biran A, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben-Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E, Scaffidi P.

Science. 2016 Sep 30;353(6307). pii: aaf1644. doi: 10.1126/science.aaf1644.

16.

The Immunogenicity of Peptoid-Protein Conjugates.

Case A, Desmond A, Lopes D, Dye K, Mapes K, Ruback S, Pop I, Kim JK, Chakravarty P, Smallshaw JE, Pop LM, Vitetta ES.

J Vaccines Vaccin. 2016 Aug;7(4). pii: 329. Epub 2016 Jul 11.

17.

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells.

Vaidyanathan A, Sawers L, Gannon AL, Chakravarty P, Scott AL, Bray SE, Ferguson MJ, Smith G.

Br J Cancer. 2016 Aug 9;115(4):431-41. doi: 10.1038/bjc.2016.203. Epub 2016 Jul 14.

18.

A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases.

Montfort A, Pearce O, Maniati E, Vincent BG, Bixby L, Böhm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M, Balkwill FR.

Clin Cancer Res. 2017 Jan 1;23(1):250-262. doi: 10.1158/1078-0432.CCR-16-0081. Epub 2016 Jun 27.

19.

Probing the Distribution of Water in a Multi-Component System by Solid-State NMR Spectroscopy.

Mistry P, Chakravarty P, Lubach JW.

Pharm Res. 2016 Oct;33(10):2470-80. doi: 10.1007/s11095-016-1972-7. Epub 2016 Jun 20.

PMID:
27324960
20.

Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma.

Böhm S, Montfort A, Pearce OM, Topping J, Chakravarty P, Everitt GL, Clear A, McDermott JR, Ennis D, Dowe T, Fitzpatrick A, Brockbank EC, Lawrence AC, Jeyarajah A, Faruqi AZ, McNeish IA, Singh N, Lockley M, Balkwill FR.

Clin Cancer Res. 2016 Jun 15;22(12):3025-36. doi: 10.1158/1078-0432.CCR-15-2657.

21.

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window.

Rudolph J, Murray LJ, Ndubaku CO, O'Brien T, Blackwood E, Wang W, Aliagas I, Gazzard L, Crawford JJ, Drobnick J, Lee W, Zhao X, Hoeflich KP, Favor DA, Dong P, Zhang H, Heise CE, Oh A, Ong CC, La H, Chakravarty P, Chan C, Jakubiak D, Epler J, Ramaswamy S, Vega R, Cain G, Diaz D, Zhong Y.

J Med Chem. 2016 Jun 9;59(11):5520-41. doi: 10.1021/acs.jmedchem.6b00638. Epub 2016 May 24.

PMID:
27167326
22.

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.

Ranes M, Boeing S, Wang Y, Wienholz F, Menoni H, Walker J, Encheva V, Chakravarty P, Mari PO, Stewart A, Giglia-Mari G, Snijders AP, Vermeulen W, Svejstrup JQ.

Nucleic Acids Res. 2016 Jun 20;44(11):5246-55. doi: 10.1093/nar/gkw216. Epub 2016 Apr 7.

23.

N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cells.

Brown PJ, Gascoyne DM, Lyne L, Spearman H, Felce SL, McFadden N, Chakravarty P, Barrans S, Lynham S, Calado DP, Ward M, Banham AH.

Haematologica. 2016 Jul;101(7):861-71. doi: 10.3324/haematol.2016.142141. Epub 2016 Apr 7.

24.

Effect of thawing methods on frozen semen quality of yak (Poephagus grunniens L.) bulls.

Borah BK, Deka BC, Biswas RK, Chakravarty P, Deori S, Sinha S, Ahmed K.

Vet World. 2015 Jul;8(7):831-4. doi: 10.14202/vetworld.2015.831-834. Epub 2015 Jul 7.

25.

Intraoperative salvage does not affect expression of markers for erythrophagocytosis.

Chakravarty PD, Porter C, Cao H, Cairns L, Moss M, Duthie R, Ashcroft P, Jeffrey R, Gibson G, Buchan K, Erwig L, Barker RN, Vickers MA.

Transfus Med. 2016 Apr;26(2):147-9. doi: 10.1111/tme.12288. Epub 2016 Mar 22. No abstract available.

PMID:
27000682
26.

Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation.

Wang Y, Jones-Tabah J, Chakravarty P, Stewart A, Muotri A, Laposa RR, Svejstrup JQ.

Cell Rep. 2016 Mar 22;14(11):2554-61. doi: 10.1016/j.celrep.2016.02.051. Epub 2016 Mar 10.

27.

Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells.

Kulbe H, Iorio F, Chakravarty P, Milagre CS, Moore R, Thompson RG, Everitt G, Canosa M, Montoya A, Drygin D, Braicu I, Sehouli J, Saez-Rodriguez J, Cutillas PR, Balkwill FR.

Oncotarget. 2016 Mar 29;7(13):15648-61. doi: 10.18632/oncotarget.7255.

28.

Linear Nevoid Epidermolytic Hyperkeratosis Localized to the Sole.

Khanna D, Chakravarty P, Das P, Bansal P.

Skinmed. 2015 Oct 1;13(5):399-401. eCollection 2015.

PMID:
26790514
29.

Alive but Confused: Heterogeneity of CD11c(+) MHC Class II(+) Cells in GM-CSF Mouse Bone Marrow Cultures.

Helft J, Böttcher JP, Chakravarty P, Zelenay S, Huotari J, Schraml BU, Goubau D, Reis e Sousa C.

Immunity. 2016 Jan 19;44(1):3-4. doi: 10.1016/j.immuni.2015.12.014. No abstract available.

30.

Parameters affecting intracellular delivery of molecules using laser-activated carbon nanoparticles.

Chakravarty P, Lane CD, Orlando TM, Prausnitz MR.

Nanomedicine. 2016 May;12(4):1003-1011. doi: 10.1016/j.nano.2015.12.380. Epub 2016 Jan 7.

PMID:
26772422
31.

When young are more conspicuous than adults: a new ranid species (Anura: Ranidae) revealed by its tadpole.

Grosjean S, Bordoloi S, Chuaynkern Y, Chakravarty P, Ohler A.

Zootaxa. 2015 Dec 18;4058(4):471-98. doi: 10.11646/zootaxa.4058.4.2.

PMID:
26701541
32.

Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130.

Joachim J, Jefferies HB, Razi M, Frith D, Snijders AP, Chakravarty P, Judith D, Tooze SA.

Mol Cell. 2015 Dec 17;60(6):899-913. doi: 10.1016/j.molcel.2015.11.018.

33.

Analysis of Signaling Endosome Composition and Dynamics Using SILAC in Embryonic Stem Cell-Derived Neurons.

Debaisieux S, Encheva V, Chakravarty P, Snijders AP, Schiavo G.

Mol Cell Proteomics. 2016 Feb;15(2):542-57. doi: 10.1074/mcp.M115.051649. Epub 2015 Dec 18.

34.

Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.

Del Pozo Martin Y, Park D, Ramachandran A, Ombrato L, Calvo F, Chakravarty P, Spencer-Dene B, Derzsi S, Hill CS, Sahai E, Malanchi I.

Cell Rep. 2015 Dec 22;13(11):2456-2469. doi: 10.1016/j.celrep.2015.11.025. Epub 2015 Dec 6.

35.

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

Goubau D, van der Veen AG, Chakravarty P, Lin R, Rogers N, Rehwinkel J, Deddouche S, Rosewell I, Hiscott J, Reis e Sousa C.

Eur J Immunol. 2015 Dec;45(12):3386-403. doi: 10.1002/eji.201545794. Epub 2015 Oct 12.

36.

Tumour-suppression function of KLF12 through regulation of anoikis.

Godin-Heymann N, Brabetz S, Murillo MM, Saponaro M, Santos CR, Lobley A, East P, Chakravarty P, Matthews N, Kelly G, Jordan S, Castellano E, Downward J.

Oncogene. 2016 Jun 23;35(25):3324-34. doi: 10.1038/onc.2015.394. Epub 2015 Oct 12.

37.

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

Zelenay S, van der Veen AG, Böttcher JP, Snelgrove KJ, Rogers N, Acton SE, Chakravarty P, Girotti MR, Marais R, Quezada SA, Sahai E, Reis e Sousa C.

Cell. 2015 Sep 10;162(6):1257-70. doi: 10.1016/j.cell.2015.08.015. Epub 2015 Sep 3.

38.

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

McGarry DJ, Chakravarty P, Wolf CR, Henderson CJ.

J Pharmacol Exp Ther. 2015 Nov;355(2):137-44. doi: 10.1124/jpet.115.227389. Epub 2015 Aug 26.

39.

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.

Helft J, Böttcher J, Chakravarty P, Zelenay S, Huotari J, Schraml BU, Goubau D, Reis e Sousa C.

Immunity. 2015 Jun 16;42(6):1197-211. doi: 10.1016/j.immuni.2015.05.018.

40.

Novel Kidins220/ARMS Splice Isoforms: Potential Specific Regulators of Neuronal and Cardiovascular Development.

Schmieg N, Thomas C, Yabe A, Lynch DS, Iglesias T, Chakravarty P, Schiavo G.

PLoS One. 2015 Jun 17;10(6):e0129944. doi: 10.1371/journal.pone.0129944. eCollection 2015.

41.

Attachment and Differentiation of Human Umbilical Cord Stem Cells on to the Tooth Root Surface with and without the Use of Fibroblast Growth Factor-An In Vitro Study.

George JP, Chakravarty P, Chowdhary KY, Purushothama H, Rao JA.

Int J Stem Cells. 2015 May;8(1):90-8. doi: 10.15283/ijsc.2015.8.1.90.

42.

Solid-State Characterization of Novel Propylene Glycol Ester Solvates Isolated from Lipid Formulations.

Chakravarty P, Kothari S, Deese A, Lubach JW.

Mol Pharm. 2015 Jul 6;12(7):2551-7. doi: 10.1021/mp5007695. Epub 2015 Jun 3.

PMID:
26013841
43.

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.

Swamy M, Abeler-Dörner L, Chettle J, Mahlakõiv T, Goubau D, Chakravarty P, Ramsay G, Reis e Sousa C, Staeheli P, Blacklaws BA, Heeney JL, Hayday AC.

Nat Commun. 2015 May 19;6:7090. doi: 10.1038/ncomms8090.

44.

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms.

Amankwatia EB, Chakravarty P, Carey FA, Weidlich S, Steele RJ, Munro AJ, Wolf CR, Smith G.

Br J Cancer. 2015 Apr 28;112(9):1480-90. doi: 10.1038/bjc.2015.125.

45.

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver.

McGarry DJ, Chen W, Chakravarty P, Lamont DL, Wolf CR, Henderson CJ.

Biochem J. 2015 Jul 1;469(1):25-32. doi: 10.1042/BJ20141256. Epub 2015 Apr 20.

PMID:
25891661
46.

Simultaneous determination of mercury and organic carbon in sediment and soils using a direct mercury analyzer based on thermal decomposition-atomic absorption spectrophotometry.

Chen J, Chakravarty P, Davidson GR, Wren DG, Locke MA, Zhou Y, Brown G Jr, Cizdziel JV.

Anal Chim Acta. 2015 Apr 29;871:9-17. doi: 10.1016/j.aca.2015.03.011. Epub 2015 Mar 10.

PMID:
25847156
47.

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme.

Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P, Dankworth B, Alibhai D, Harris AL, Schulze A.

Oncogene. 2015 Oct 1;34(40):5128-40. doi: 10.1038/onc.2014.439. Epub 2015 Jan 26.

PMID:
25619842
48.

Large multifocal cutaneous hemangioma along lines of Blaschko with cardiac failure treated with propranolol.

Khanna D, Chakravarty P, Arora P, Jain R, Mittal M.

Pediatr Dermatol. 2015 Jan-Feb;32(1):e18-22. doi: 10.1111/pde.12476. Epub 2014 Dec 16.

PMID:
25516210
49.

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.

Wang Y, Chakravarty P, Ranes M, Kelly G, Brooks PJ, Neilan E, Stewart A, Schiavo G, Svejstrup JQ.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14454-9. doi: 10.1073/pnas.1412569111. Epub 2014 Sep 23.

50.

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines.

Sawers L, Ferguson MJ, Ihrig BR, Young HC, Chakravarty P, Wolf CR, Smith G.

Br J Cancer. 2014 Sep 9;111(6):1150-8. doi: 10.1038/bjc.2014.386. Epub 2014 Jul 10.

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