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Prospective Longitudinal Evaluation of Nascent Geographic Atrophy in Age-Related Macular Degeneration.

Wu Z, Luu CD, Hodgson LAB, Caruso E, Tindill N, Aung KZ, McGuinness MB, Makeyeva G, Chen FK, Chakravarthy U, Arnold JJ, Heriot WJ, Durkin SR, Guymer RH.

Ophthalmol Retina. 2019 Dec 16. pii: S2468-6530(19)30675-X. doi: 10.1016/j.oret.2019.12.011. [Epub ahead of print]


Association between visual acuity, lesion activity markers and retreatment decisions in neovascular age-related macular degeneration.

Chakravarthy U, Pillai N, Syntosi A, Barclay L, Best C, Sagkriotis A.

Eye (Lond). 2020 Feb 17. doi: 10.1038/s41433-020-0799-y. [Epub ahead of print]


Glaucoma in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA): cohort profile, prevalence, awareness and associations.

McCann P, Hogg R, Wright DM, Pose-Bazarra S, Chakravarthy U, Peto T, Cruise S, McGuinness B, Young IS, Kee F, Azuara-Blanco A.

Br J Ophthalmol. 2020 Feb 7. pii: bjophthalmol-2019-315330. doi: 10.1136/bjophthalmol-2019-315330. [Epub ahead of print]


Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial.

Lotery A, Sivaprasad S, O'Connell A, Harris RA, Culliford L, Ellis L, Cree A, Madhusudhan S, Behar-Cohen F, Chakravarthy U, Peto T, Rogers CA, Reeves BC; VICI trial investigators.

Lancet. 2020 Jan 25;395(10220):294-303. doi: 10.1016/S0140-6736(19)32981-2.


Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group.

Spaide RF, Jaffe GJ, Sarraf D, Freund KB, Sadda SR, Staurenghi G, Waheed NK, Chakravarthy U, Rosenfeld PJ, Holz FG, Souied EH, Cohen SY, Querques G, Ohno-Matsui K, Boyer D, Gaudric A, Blodi B, Baumal CR, Li X, Coscas GJ, Brucker A, Singerman L, Luthert P, Schmitz-Valckenberg S, Schmidt-Erfurth U, Grossniklaus HE, Wilson DJ, Guymer R, Yannuzzi LA, Chew EY, Csaky K, Monés JM, Pauleikhoff D, Tadayoni R, Fujimoto J.

Ophthalmology. 2019 Nov 14. pii: S0161-6420(19)32243-2. doi: 10.1016/j.ophtha.2019.11.004. [Epub ahead of print]


Core outcomes for geographic atrophy trials.

Krezel AK, Hogg R, Lohfeld L, Chakravarthy U, Azuara-Blanco A.

Br J Ophthalmol. 2019 Dec 17. pii: bjophthalmol-2019-314949. doi: 10.1136/bjophthalmol-2019-314949. [Epub ahead of print]



Guymer RH, Wu Z, Chen FK, Chakravarthy U, Arnold JJ, Heriot WJ, Durkin SR, Luu CD; LEAD Study Group.

Ophthalmology. 2019 Dec;126(12):e92-e93. doi: 10.1016/j.ophtha.2019.07.017. No abstract available.


Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4.

Guymer RH, Rosenfeld PJ, Curcio CA, Holz FG, Staurenghi G, Freund KB, Schmitz-Valckenberg S, Sparrow J, Spaide RF, Tufail A, Chakravarthy U, Jaffe GJ, Csaky K, Sarraf D, Monés JM, Tadayoni R, Grunwald J, Bottoni F, Liakopoulos S, Pauleikhoff D, Pagliarini S, Chew EY, Viola F, Fleckenstein M, Blodi BA, Lim TH, Chong V, Lutty J, Bird AC, Sadda SR.

Ophthalmology. 2020 Mar;127(3):394-409. doi: 10.1016/j.ophtha.2019.09.035. Epub 2019 Sep 30.


Properties of the Impact of Vision Impairment and Night Vision Questionnaires Among People With Intermediate Age-Related Macular Degeneration.

McGuinness MB, Finger RP, Wu Z, Luu CD, Chen FK, Arnold JJ, Chakravarthy U, Heriot WJ, Runciman J, Guymer RH; LEAD Study Group.

Transl Vis Sci Technol. 2019 Sep 11;8(5):3. doi: 10.1167/tvst.8.5.3. eCollection 2019 Sep.


Secondary and Exploratory Outcomes of the Subthreshold Nanosecond Laser Intervention Randomized Trial in Age-Related Macular Degeneration: A LEAD Study Report.

Wu Z, Luu CD, Hodgson LAB, Caruso E, Brassington KH, Tindill N, Aung KZ, Harper CA, Wickremasinghe SS, Sandhu SS, McGuinness MB, Chen FK, Chakravarthy U, Arnold JJ, Heriot WJ, Durkin SR, Wintergerst MWM, Gorgi Zadeh S, Schultz T, Finger RP, Cohn AC, Baglin EK, Sharangan P, Guymer RH; LEAD Study Group.

Ophthalmol Retina. 2019 Dec;3(12):1026-1034. doi: 10.1016/j.oret.2019.07.008. Epub 2019 Jul 22.


Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial.

Hykin P, Prevost AT, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Hounsome B, Yang Y, Harding SP, Lotery A, Chakravarthy U, Sivaprasad S; LEAVO Study Group.

JAMA Ophthalmol. 2019 Aug 29. doi: 10.1001/jamaophthalmol.2019.3305. [Epub ahead of print]


The Evolution of Fibrosis and Atrophy and Their Relationship with Visual Outcomes in Asian Persons with Neovascular Age-Related Macular Degeneration.

Cheung CMG, Grewal DS, Teo KYC, Gan A, Mohla A, Chakravarthy U, Wong TY, Jaffe GJ.

Ophthalmol Retina. 2019 Dec;3(12):1045-1055. doi: 10.1016/j.oret.2019.06.002. Epub 2019 Jun 12.



Bailey C, Scott LJ, Rogers CA, Reeves BC, Hamill B, Peto T, Chakravarthy U, Harding SP.

Ophthalmology. 2019 Sep;126(9):e72-e73. doi: 10.1016/j.ophtha.2019.04.026. No abstract available.


Direct Ophthalmic Healthcare Resource Use among Patients with Geographic Atrophy in a Large Cohort from the United Kingdom.

Chakravarthy U, Bailey CC, Scanlon PH, McKibbin M, Khan RS, Mahmood S, Downey L, Dhingra N, Brand C, Brittain CJ, Willis JR, Venerus A, Muthutantri A, Cantrell RA.

Ophthalmol Retina. 2019 Nov;3(11):920-926. doi: 10.1016/j.oret.2019.06.012. Epub 2019 Jul 8.


Paracentral acute middle maculopathy as a cause of unexplained visual loss in central retinal vein occlusion.

Casalino G, Coppola M, Earley O, Contieri F, Bandello F, Chakravarthy U.

Saudi J Ophthalmol. 2019 Apr-Jun;33(2):168-171. doi: 10.1016/j.sjopt.2018.07.005. Epub 2018 Jul 29.


First-line treatment algorithm and guidelines in center-involving diabetic macular edema.

Kodjikian L, Bellocq D, Bandello F, Loewenstein A, Chakravarthy U, Koh A, Augustin A, de Smet MD, Chhablani J, Tufail A, García-Layana A, Sudhalkar A, Mathis T.

Eur J Ophthalmol. 2019 Nov;29(6):573-584. doi: 10.1177/1120672119857511. Epub 2019 Jun 26. Review.


Patient-reported outcomes in the RELIGHT clinical trial of ranibizumab in diabetic macular oedema.

Chakravarthy U, Pearce I, Banerjee S, Burton BJL, Downey L, Gale R, Patel J, Patra S, Sivaprasad S, Stevenson M, Lupton S.

BMJ Open Ophthalmol. 2019 Apr 30;4(1):e000226. doi: 10.1136/bmjophth-2018-000226. eCollection 2019.


Combined Multimodal Analysis of Peripheral Retinal and Macular Circulation in Diabetic Retinopathy (COPRA Study).

Or C, Das R, Despotovic I, Alibhai AY, Moult E, Waheed NK, Chakravarthy U.

Ophthalmol Retina. 2019 Jul;3(7):580-588. doi: 10.1016/j.oret.2019.03.001. Epub 2019 Mar 20.


Tomographic Biomarkers Predicting Progression to Fibrosis in Treated Neovascular Age-Related Macular Degeneration: A Multimodal Imaging Study.

Casalino G, Stevenson MR, Bandello F, Chakravarthy U.

Ophthalmol Retina. 2018 May;2(5):451-461. doi: 10.1016/j.oret.2017.08.019. Epub 2017 Oct 26.


Changes in Retinal Layer Thickness in the Contralateral Eye of Patients with Unilateral Neovascular Age-Related Macular Degeneration.

Nittala MG, Hogg RE, Luo Y, Velaga SB, Silva R, Alves D, Staurenghi G, Chakravarthy U, Sadda SR.

Ophthalmol Retina. 2019 Feb;3(2):112-121. doi: 10.1016/j.oret.2018.09.017. Epub 2018 Sep 27.


Effectiveness of Continued Ranibizumab Therapy in Neovascular Age-Related Macular Degeneration versus Switch to Aflibercept: Real World Evidence.

Chakravarthy U, Bezlyak V, Sagkriotis A, Griner R, Skelly A, Boyer DS, Milnes F.

Ophthalmol Retina. 2019 Jan;3(1):8-15.e1. doi: 10.1016/j.oret.2018.09.001. Epub 2018 Sep 15.


Spontaneous retinal pigment epithelial tear in type 2 choroidal neovascularization: repair mechanisms following anti-VEGF therapy.

Casalino G, Sivagnanavel V, Dowlut S, Keane PA, Chakravarthy U.

Int J Retina Vitreous. 2019 Jan 23;5:4. doi: 10.1186/s40942-019-0155-1. eCollection 2019.


Confocal infrared imaging with optical coherence tomography provides superior detection of a number of common macular lesions compared to colour fundus photography.

Quinn NB, Chakravarthy U, Muldrew KA, Hamill B, McGuinness B, Young IS, Kee F, Hogg RE.

Ophthalmic Physiol Opt. 2018 Nov;38(6):574-583. doi: 10.1111/opo.12592.


Serum Vascular Endothelial Growth Factor Levels in the IVAN Trial; Relationships with Drug, Dosing, and Systemic Serious Adverse Events.

Rogers CA, Scott LJ, Reeves BC, Downes S, Lotery AJ, Dick AD, Chakravarthy U.

Ophthalmol Retina. 2018 Feb;2(2):118-127. doi: 10.1016/j.oret.2017.05.015.


Ophthalmology research in the UK's National Health Service: the structure and performance of the NIHR's Ophthalmology research portfolio.

Dawson SR, Linton E, Beicher K, Gale R, Patel P, Ghanchi F, Beresford MW, Poustie V, Chakravarthy U, Bourne RRA; NIHR Ophthalmology Specialty Group.

Eye (Lond). 2019 Apr;33(4):610-618. doi: 10.1038/s41433-018-0251-8. Epub 2018 Nov 20.


Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract.

Ravindran RD, Sundaresan P, Krishnan T, Vashist P, Maraini G, Saravanan V, Chakravarthy U, Smeeth L, Nitsch D, Young IS, Fletcher AE.

Br J Ophthalmol. 2019 Sep;103(9):1223-1227. doi: 10.1136/bjophthalmol-2018-312257. Epub 2018 Nov 15.


The diagnostic accuracy of OCT angiography in naive and treated neovascular age-related macular degeneration: a review.

Perrott-Reynolds R, Cann R, Cronbach N, Neo YN, Ho V, McNally O, Madi HA, Cochran C, Chakravarthy U.

Eye (Lond). 2019 Feb;33(2):274-282. doi: 10.1038/s41433-018-0229-6. Epub 2018 Oct 31. Review.


Factors associated with serum 25-hydroxyvitamin D concentrations in older people in Europe: the EUREYE study.

Casey C, Woodside JV, McGinty A, Young IS, McPeake J, Chakravarthy U, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Fletcher AE.

Eur J Clin Nutr. 2019 Feb;73(2):319-328. doi: 10.1038/s41430-018-0353-1. Epub 2018 Oct 26.


Intralesional Macular Atrophy in Anti-Vascular Endothelial Growth Factor Therapy for Age-Related Macular Degeneration in the IVAN Trial.

Bailey C, Scott LJ, Rogers CA, Reeves BC, Hamill B, Peto T, Chakravarthy U, Harding SP; writing committee for the IVAN Study Group.

Ophthalmology. 2019 Jan;126(1):75-86. doi: 10.1016/j.ophtha.2018.07.013. Epub 2018 Oct 6.


United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group: report 4, real-world data on the impact of deprivation on the presentation of diabetic eye disease at hospital services.

Denniston AK, Lee AY, Lee CS, Crabb DP, Bailey C, Lip PL, Taylor P, Pikoula M, Cook E, Akerele T, Antcliff R, Brand C, Chakravarthy U, Chavan R, Dhingra N, Downey L, Eleftheriadis H, Ghanchi F, Khan R, Kumar V, Lobo A, Lotery A, Menon G, Mukherjee R, Palmer H, Patra S, Paul B, Sim DA, Talks JS, Wilkinson E, Tufail A, Egan CA; UK DR EMR Users Group.

Br J Ophthalmol. 2019 Jun;103(6):837-843. doi: 10.1136/bjophthalmol-2018-312568. Epub 2018 Sep 29.


Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical Trial.

Guymer RH, Wu Z, Hodgson LAB, Caruso E, Brassington KH, Tindill N, Aung KZ, McGuinness MB, Fletcher EL, Chen FK, Chakravarthy U, Arnold JJ, Heriot WJ, Durkin SR, Lek JJ, Harper CA, Wickremasinghe SS, Sandhu SS, Baglin EK, Sharangan P, Braat S, Luu CD; Laser Intervention in Early Stages of Age-Related Macular Degeneration Study Group.

Ophthalmology. 2019 Jun;126(6):829-838. doi: 10.1016/j.ophtha.2018.09.015. Epub 2018 Sep 20.


Changes in intraocular pressure after intravitreal fluocinolone acetonide (ILUVIEN): real-world experience in three European countries.

Chakravarthy U, Taylor SR, Koch FHJ, Castro de Sousa JP, Bailey C; ILUVIEN Registry Safety Study (IRISS) Investigators Group.

Br J Ophthalmol. 2019 Aug;103(8):1072-1077. doi: 10.1136/bjophthalmol-2018-312284. Epub 2018 Sep 21.


Clinical efficacy of eplerenone versus placebo for central serous chorioretinopathy: study protocol for the VICI randomised controlled trial.

Willcox A, Culliford L, Ellis L, Rogers CA, Cree A, Chakravarthy U, Ennis S, Behar-Cohen F, Reeves BC, Sivaprasad S, Lotery A.

Eye (Lond). 2019 Feb;33(2):295-303. doi: 10.1038/s41433-018-0212-2. Epub 2018 Sep 7.


Microvascular abnormalities secondary to radiation therapy in neovascular age-related macular degeneration: findings from the INTREPID clinical trial.

Freiberg FJ, Michels S, Muldrew A, Slakter J, O'Shaughnessy D, Czeszynski A, Danielson L, Jackson TL, Chakravarthy U.

Br J Ophthalmol. 2019 Apr;103(4):469-474. doi: 10.1136/bjophthalmol-2018-311865. Epub 2018 Jun 21.


Association of Genetic Variants With Response to Anti-Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration.

Lorés-Motta L, Riaz M, Grunin M, Corominas J, van Asten F, Pauper M, Leenders M, Richardson AJ, Muether P, Cree AJ, Griffiths HL, Pham C, Belanger MC, Meester-Smoor MA, Ali M, Heid IM, Fritsche LG, Chakravarthy U, Gale R, McKibbin M, Inglehearn CF, Schlingemann RO, Omar A, Chen J, Koenekoop RK, Fauser S, Guymer RH, Hoyng CB, de Jong EK, Lotery AJ, Mitchell P, den Hollander AI, Baird PN, Chowers I.

JAMA Ophthalmol. 2018 Aug 1;136(8):875-884. doi: 10.1001/jamaophthalmol.2018.2019.


Prevalence and risk factors for myopia and other refractive errors in an adult population in southern India.

Joseph S, Krishnan T, Ravindran RD, Maraini G, Camparini M, Chakravarthy U, Ravilla TD, Hutchings A, Fletcher AE.

Ophthalmic Physiol Opt. 2018 May;38(3):346-358. doi: 10.1111/opo.12447. Epub 2018 Mar 25.


Prevalence of diabetic retinopathy and visual impairment in patients with diabetes mellitus in Zambia through the implementation of a mobile diabetic retinopathy screening project in the Copperbelt province: a cross-sectional study.

Lewis AD, Hogg RE, Chandran M, Musonda L, North L, Chakravarthy U, Sivaprasad S, Menon G.

Eye (Lond). 2018 Jul;32(7):1201-1208. doi: 10.1038/s41433-018-0055-x. Epub 2018 Mar 5.


Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population.

Connolly E, Rhatigan M, O'Halloran AM, Muldrew KA, Chakravarthy U, Cahill M, Kenny RA, Doyle SL.

Br J Ophthalmol. 2018 Dec;102(12):1691-1695. doi: 10.1136/bjophthalmol-2017-311673. Epub 2018 Feb 16.


Solitary Idiopathic Choroiditis Coexisting with Cuticular Drusen.

Casalino G, Jothi VG, Chakravarthy U.

Ophthalmol Retina. 2018 Feb;2(2):167. doi: 10.1016/j.oret.2017.09.001. Epub 2018 Feb 2. No abstract available.


Characterizing Disease Burden and Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Chakravarthy U, Bailey CC, Johnston RL, McKibbin M, Khan RS, Mahmood S, Downey L, Dhingra N, Brand C, Brittain CJ, Willis JR, Rabhi S, Muthutantri A, Cantrell RA.

Ophthalmology. 2018 Jun;125(6):842-849. doi: 10.1016/j.ophtha.2017.11.036. Epub 2018 Feb 1.


Disorganization of Inner Retina and Outer Retinal Morphology in Diabetic Macular Edema.

Das R, Spence G, Hogg RE, Stevenson M, Chakravarthy U.

JAMA Ophthalmol. 2018 Feb 1;136(2):202-208. doi: 10.1001/jamaophthalmol.2017.6256.


Genetic risk factors for late age-related macular degeneration in India.

Rajendran A, Dhoble P, Sundaresan P, Saravanan V, Vashist P, Nitsch D, Smeeth L, Chakravarthy U, Ravindran RD, Fletcher AE.

Br J Ophthalmol. 2018 Sep;102(9):1213-1217. doi: 10.1136/bjophthalmol-2017-311384. Epub 2017 Dec 19.


Multimodal imaging of posterior ocular involvement in McArdle's disease.

Casalino G, Chan W, McAvoy C, Coppola M, Bandello F, Bird AC, Chakravarthy U.

Clin Exp Optom. 2018 May;101(3):412-415. doi: 10.1111/cxo.12635. Epub 2017 Nov 26. No abstract available.


Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT: Classification of Atrophy Report 3.

Sadda SR, Guymer R, Holz FG, Schmitz-Valckenberg S, Curcio CA, Bird AC, Blodi BA, Bottoni F, Chakravarthy U, Chew EY, Csaky K, Danis RP, Fleckenstein M, Freund KB, Grunwald J, Hoyng CB, Jaffe GJ, Liakopoulos S, Monés JM, Pauleikhoff D, Rosenfeld PJ, Sarraf D, Spaide RF, Tadayoni R, Tufail A, Wolf S, Staurenghi G.

Ophthalmology. 2018 Apr;125(4):537-548. doi: 10.1016/j.ophtha.2017.09.028. Epub 2017 Nov 2. Erratum in: Ophthalmology. 2019 Jan;126(1):177.


An overview of the clinical applications of optical coherence tomography angiography.

Tan ACS, Tan GS, Denniston AK, Keane PA, Ang M, Milea D, Chakravarthy U, Cheung CMG.

Eye (Lond). 2018 Feb;32(2):262-286. doi: 10.1038/eye.2017.181. Epub 2017 Sep 8. Review.


IDENTIFYING FEATURES OF EARLY AND LATE AGE-RELATED MACULAR DEGENERATION: A Comparison of Multicolor Versus Traditional Color Fundus Photography.

Graham KW, Chakravarthy U, Hogg RE, Muldrew KA, Young IS, Kee F.

Retina. 2018 Sep;38(9):1751-1758. doi: 10.1097/IAE.0000000000001777.


Evaluation of coronary artery disease as a risk factor for reticular pseudodrusen.

McCarter RV, McKay GJ, Quinn NB, Chakravarthy U, MacGillivray TJ, Robertson G, Pellegrini E, Trucco E, Williams MC, Peto T, Dhillon B, van Beek EJ, Newby DE, Kee F, Young IS, Hogg RE.

Br J Ophthalmol. 2018 Apr;102(4):483-489. doi: 10.1136/bjophthalmol-2017-310526. Epub 2017 Aug 19.


Real-world experience with 0.2 μg/day fluocinolone acetonide intravitreal implant (ILUVIEN) in the United Kingdom.

Bailey C, Chakravarthy U, Lotery A, Menon G, Talks J; Medisoft Audit Group.

Eye (Lond). 2017 Dec;31(12):1707-1715. doi: 10.1038/eye.2017.125. Epub 2017 Jul 24.


The Economic Impact of Blindness in Europe.

Chakravarthy U, Biundo E, Saka RO, Fasser C, Bourne R, Little JA.

Ophthalmic Epidemiol. 2017 Aug;24(4):239-247. doi: 10.1080/09286586.2017.1281426. Epub 2017 Jun 30.


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