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Items: 1 to 50 of 58

1.

Synthesis and evaluation of cyclic sulfite diesters as sulfur dioxide (SO2) donors.

Malwal S, Pardeshi KA, Chakrapani H.

Chembiochem. 2019 Nov 10. doi: 10.1002/cbic.201900614. [Epub ahead of print]

PMID:
31709695
2.

Carbonyl Sulfide (COS) Donor Induced Protein Persulfidation Protects against Oxidative Stress.

Chauhan P, Gupta K, Ravikumar G, Saini DK, Chakrapani H.

Chem Asian J. 2019 Sep 10. doi: 10.1002/asia.201901148. [Epub ahead of print]

PMID:
31502759
3.

Chemoproteomics of an Indole-Based Quinone Epoxide Identifies Druggable Vulnerabilities in Vancomycin-Resistant Staphylococcus aureus.

Kulkarni A, Soni I, Kelkar DS, Dharmaraja AT, Sankar RK, Beniwal G, Rajendran A, Tamhankar S, Chopra S, Kamat SS, Chakrapani H.

J Med Chem. 2019 Jul 25;62(14):6785-6795. doi: 10.1021/acs.jmedchem.9b00774. Epub 2019 Jul 15.

4.

Photocontrolled endogenous reactive oxygen species (ROS) generation.

Sharma AK, Singh H, Chakrapani H.

Chem Commun (Camb). 2019 May 8;55(36):5259-5262. doi: 10.1039/c9cc01747j. Epub 2019 Apr 17.

PMID:
30993280
5.

A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase.

Kelkar DS, Ravikumar G, Mehendale N, Singh S, Joshi A, Sharma AK, Mhetre A, Rajendran A, Chakrapani H, Kamat SS.

Nat Chem Biol. 2019 Feb;15(2):169-178. doi: 10.1038/s41589-018-0195-0. Epub 2019 Jan 14.

6.

Targeted Antibacterial Activity Guided by Bacteria-Specific Nitroreductase Catalytic Activation to Produce Ciprofloxacin.

Pardeshi KA, Kumar TA, Ravikumar G, Shukla M, Kaul G, Chopra S, Chakrapani H.

Bioconjug Chem. 2019 Mar 20;30(3):751-759. doi: 10.1021/acs.bioconjchem.8b00887. Epub 2019 Feb 22.

PMID:
30615427
7.

A Vinyl-Boronate Ester-Based Persulfide Donor Controllable by Hydrogen Peroxide, a Reactive Oxygen Species (ROS).

Bora P, Chauhan P, Manna S, Chakrapani H.

Org Lett. 2018 Dec 21;20(24):7916-7920. doi: 10.1021/acs.orglett.8b03471. Epub 2018 Dec 7.

PMID:
30525675
8.

Visible-Light Controlled Release of a Fluoroquinolone Antibiotic for Antimicrobial Photopharmacology.

Kumari P, Kulkarni A, Sharma AK, Chakrapani H.

ACS Omega. 2018 Feb 28;3(2):2155-2160. doi: 10.1021/acsomega.7b01906. Epub 2018 Feb 21.

9.

Reactive Oxygen Species-Triggered Tunable Hydrogen Sulfide Release.

Chauhan P, Jos S, Chakrapani H.

Org Lett. 2018 Jul 6;20(13):3766-3770. doi: 10.1021/acs.orglett.8b01356. Epub 2018 Jun 21.

PMID:
29927612
10.

Redox-guided small molecule antimycobacterials.

Kulkarni A, Sharma AK, Chakrapani H.

IUBMB Life. 2018 Sep;70(9):826-835. doi: 10.1002/iub.1867. Epub 2018 May 14. Review.

11.

Esterase Sensitive Self-Immolative Sulfur Dioxide Donors.

Pardeshi KA, Ravikumar G, Chakrapani H.

Org Lett. 2018 Jan 5;20(1):4-7. doi: 10.1021/acs.orglett.7b02544. Epub 2017 Dec 13.

PMID:
29235873
12.

A small molecule for theraNOstic targeting of cancer cells.

Ravikumar G, Bagheri M, Saini DK, Chakrapani H.

Chem Commun (Camb). 2017 Dec 14;53(100):13352-13355. doi: 10.1039/c7cc08526e.

PMID:
29192700
13.

"On demand" redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor.

Shukla P, Khodade VS, SharathChandra M, Chauhan P, Mishra S, Siddaramappa S, Pradeep BE, Singh A, Chakrapani H.

Chem Sci. 2017 Jul 1;8(7):4967-4972. doi: 10.1039/c7sc00873b. Epub 2017 Apr 27.

14.

Visible-Light-Triggered Uncaging of Carbonyl Sulfide for Hydrogen Sulfide (H2S) Release.

Sharma AK, Nair M, Chauhan P, Gupta K, Saini DK, Chakrapani H.

Org Lett. 2017 Sep 15;19(18):4822-4825. doi: 10.1021/acs.orglett.7b02259. Epub 2017 Sep 5.

PMID:
28872885
15.

FLUORO/NO: A Nitric Oxide Donor with a Fluorescence Reporter.

Ravikumar G, Bagheri M, Saini DK, Chakrapani H.

Chembiochem. 2017 Aug 4;18(15):1529-1534. doi: 10.1002/cbic.201700155. Epub 2017 Jun 26.

PMID:
28470863
16.

Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors.

Chauhan P, Bora P, Ravikumar G, Jos S, Chakrapani H.

Org Lett. 2017 Jan 6;19(1):62-65. doi: 10.1021/acs.orglett.6b03336. Epub 2016 Dec 20.

PMID:
27996277
17.

A Small Molecule for Controlled Generation of Peroxynitrite.

Khodade VS, Kulkarni A, Sen Gupta A, Sengupta K, Chakrapani H.

Org Lett. 2016 Mar 18;18(6):1274-7. doi: 10.1021/acs.orglett.6b00186. Epub 2016 Mar 2.

PMID:
26933774
18.

Draft Genome Sequence of Methicillin-Sensitive Staphylococcus aureus ATCC 29213.

Soni I, Chakrapani H, Chopra S.

Genome Announc. 2015 Sep 24;3(5). pii: e01095-15. doi: 10.1128/genomeA.01095-15.

19.

Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors.

Pardeshi KA, Malwal SR, Banerjee A, Lahiri S, Rangarajan R, Chakrapani H.

Bioorg Med Chem Lett. 2015 Jul 1;25(13):2694-7. doi: 10.1016/j.bmcl.2015.04.046. Epub 2015 Apr 23.

PMID:
25981687
20.

Mycobacterium tuberculosis has diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide.

Tyagi P, Dharmaraja AT, Bhaskar A, Chakrapani H, Singh A.

Free Radic Biol Med. 2015 Jul;84:344-354. doi: 10.1016/j.freeradbiomed.2015.03.008. Epub 2015 Mar 27.

21.

Benzosulfones as photochemically activated sulfur dioxide (SO2) donors.

Malwal SR, Chakrapani H.

Org Biomol Chem. 2015 Feb 28;13(8):2399-406. doi: 10.1039/c4ob02466d.

PMID:
25563212
22.

A phenacrylate scaffold for tunable thiol activation and release.

Sankar RK, Kumbhare RS, Dharmaraja AT, Chakrapani H.

Chem Commun (Camb). 2014 Dec 18;50(97):15323-6. doi: 10.1039/c4cc07343f. Epub 2014 Oct 27.

PMID:
25347732
23.

Substituent effects on reactive oxygen species (ROS) generation by hydroquinones.

Dharmaraja AT, Jain C, Chakrapani H.

J Org Chem. 2014 Oct 3;79(19):9413-7. doi: 10.1021/jo501796z. Epub 2014 Sep 19.

PMID:
25207805
24.

A highly selective sulfinate ester probe for thiol bioimaging.

Malwal SR, Labade A, Andhalkar AS, Sengupta K, Chakrapani H.

Chem Commun (Camb). 2014 Oct 9;50(78):11533-5. doi: 10.1039/c4cc05462h.

PMID:
25133745
25.

Site-directed delivery of nitric oxide to cancers.

Sharma K, Chakrapani H.

Nitric Oxide. 2014 Dec 1;43:8-16. doi: 10.1016/j.niox.2014.07.005. Epub 2014 Aug 11. Review.

PMID:
25124221
26.

Bioreductively Activated Reactive Oxygen Species (ROS) Generators as MRSA Inhibitors.

Khodade VS, Sharath Chandra M, Banerjee A, Lahiri S, Pulipeta M, Rangarajan R, Chakrapani H.

ACS Med Chem Lett. 2014 May 18;5(7):777-81. doi: 10.1021/ml5001118. eCollection 2014 Jul 10.

27.

Arylboronate ester based diazeniumdiolates (BORO/NO), a class of hydrogen peroxide inducible nitric oxide (NO) donors.

Dharmaraja AT, Ravikumar G, Chakrapani H.

Org Lett. 2014 May 16;16(10):2610-3. doi: 10.1021/ol5010643. Epub 2014 May 5.

PMID:
24796212
28.

A small molecule for controlled generation of reactive oxygen species (ROS).

Dharmaraja AT, Chakrapani H.

Org Lett. 2014 Jan 17;16(2):398-401. doi: 10.1021/ol403300a. Epub 2013 Dec 27.

PMID:
24372330
29.

Nitroreductase-activated nitric oxide (NO) prodrugs.

Sharma K, Sengupta K, Chakrapani H.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5964-7. doi: 10.1016/j.bmcl.2013.08.066. Epub 2013 Aug 22.

PMID:
24050886
30.

INDQ/NO, a bioreductively activated nitric oxide prodrug.

Sharma K, Iyer A, Sengupta K, Chakrapani H.

Org Lett. 2013 Jun 7;15(11):2636-9. doi: 10.1021/ol400884v. Epub 2013 May 9.

PMID:
23659457
31.

Benzosultines as sulfur dioxide (SO2) donors.

Malwal SR, Gudem M, Hazra A, Chakrapani H.

Org Lett. 2013 Mar 1;15(5):1116-9. doi: 10.1021/ol400190f. Epub 2013 Feb 20.

PMID:
23421429
32.

Cross-linking protein glutathionylation mediated by O2-arylated bis-diazeniumdiolate "Double JS-K".

Holland RJ, Maciag AE, Kumar V, Shi L, Saavedra JE, Prud'homme RK, Chakrapani H, Keefer LK.

Chem Res Toxicol. 2012 Dec 17;25(12):2670-7. doi: 10.1021/tx3003142. Epub 2012 Nov 9.

33.

Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors.

Dharmaraja AT, Alvala M, Sriram D, Yogeeswari P, Chakrapani H.

Chem Commun (Camb). 2012 Oct 25;48(83):10325-7.

PMID:
22977884
34.

Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2).

Malwal SR, Sriram D, Yogeeswari P, Chakrapani H.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3603-6. doi: 10.1016/j.bmcl.2012.04.048. Epub 2012 Apr 17.

PMID:
22572576
35.

Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones.

Khodade VS, Dharmaraja AT, Chakrapani H.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3766-9. doi: 10.1016/j.bmcl.2012.04.009. Epub 2012 Apr 9.

PMID:
22542016
36.

Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class.

Maciag AE, Holland RJ, Saavedra JE, Chakrapani H, Shami PJ, Keefer LK.

For Immunopathol Dis Therap. 2012;3(2):91-95.

37.

Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO₂) as antimycobacterial agents.

Malwal SR, Sriram D, Yogeeswari P, Konkimalla VB, Chakrapani H.

J Med Chem. 2012 Jan 12;55(1):553-7. doi: 10.1021/jm201023g. Epub 2011 Dec 19.

PMID:
22128803
38.

Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.

Maciag AE, Nandurdikar RS, Hong SY, Chakrapani H, Diwan B, Morris NL, Shami PJ, Shiao YH, Anderson LM, Keefer LK, Saavedra JE.

J Med Chem. 2011 Nov 24;54(22):7751-8. doi: 10.1021/jm2004128. Epub 2011 Oct 28.

39.

The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline.

Hong SY, Borchert GL, Maciag AE, Nandurdikar RS, Saavedra JE, Keefer LK, Phang JM, Chakrapani H.

ACS Med Chem Lett. 2010 Nov 11;1(8):386-389.

40.

The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species.

Maciag AE, Chakrapani H, Saavedra JE, Morris NL, Holland RJ, Kosak KM, Shami PJ, Anderson LM, Keefer LK.

J Pharmacol Exp Ther. 2011 Feb;336(2):313-20. doi: 10.1124/jpet.110.174904. Epub 2010 Oct 20.

41.

Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and Double JS-K, through incorporation into PEG-protected nanoparticles.

Kumar V, Hong SY, Maciag AE, Saavedra JE, Adamson DH, Prud'homme RK, Keefer LK, Chakrapani H.

Mol Pharm. 2010 Feb 1;7(1):291-8. doi: 10.1021/mp900245h.

42.

Glycosylated PROLI/NO derivatives as nitric oxide prodrugs.

Nandurdikar RS, Maciag AE, Hong SY, Chakrapani H, Citro ML, Keefer LK, Saavedra JE.

Org Lett. 2010 Jan 1;12(1):56-9. doi: 10.1021/ol902481s.

43.

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.

Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, Williams DL, Thomas CJ.

J Med Chem. 2009 Oct 22;52(20):6474-83. doi: 10.1021/jm901021k.

44.

The nitric oxide prodrug JS-K and its structural analogues as cancer therapeutic agents.

Maciag AE, Saavedra JE, Chakrapani H.

Anticancer Agents Med Chem. 2009 Sep;9(7):798-803. Epub 2009 Sep 1. Review.

PMID:
19538173
45.

Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound.

Nandurdikar RS, Maciag AE, Citro ML, Shami PJ, Keefer LK, Saavedra JE, Chakrapani H.

Bioorg Med Chem Lett. 2009 May 15;19(10):2760-2. doi: 10.1016/j.bmcl.2009.03.115. Epub 2009 Mar 28.

46.

C-nitroso donors of nitric oxide.

Chakrapani H, Bartberger MD, Toone EJ.

J Org Chem. 2009 Feb 20;74(4):1450-3. doi: 10.1021/jo802517t.

PMID:
19146387
47.

Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities.

Andrei D, Maciag AE, Chakrapani H, Citro ML, Keefer LK, Saavedra JE.

J Med Chem. 2008 Dec 25;51(24):7944-52. doi: 10.1021/jm800831y.

48.

Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs.

Chakrapani H, Maciag AE, Citro ML, Keefer LK, Saavedra JE.

Org Lett. 2008 Nov 20;10(22):5155-8. doi: 10.1021/ol8020989. Epub 2008 Oct 29.

PMID:
18956868
49.

Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.

Chakrapani H, Kalathur RC, Maciag AE, Citro ML, Ji X, Keefer LK, Saavedra JE.

Bioorg Med Chem. 2008 Nov 15;16(22):9764-71. doi: 10.1016/j.bmc.2008.09.063. Epub 2008 Sep 30.

50.

Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound.

Chakrapani H, Goodblatt MM, Udupi V, Malaviya S, Shami PJ, Keefer LK, Saavedra JE.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3. doi: 10.1016/j.bmcl.2007.12.044. Epub 2008 Jan 4.

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