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Items: 14

1.

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.

McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr.

Cell. 2018 Sep 10. pii: S0092-8674(18)31099-7. doi: 10.1016/j.cell.2018.08.038. [Epub ahead of print]

PMID:
30220459
2.

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.

Chakraborty AA, Nakamura E, Qi J, Creech A, Jaffe JD, Paulk J, Novak JS, Nagulapalli K, McBrayer SK, Cowley GS, Pineda J, Song J, Wang YE, Carr SA, Root DE, Signoretti S, Bradner JE, Kaelin WG Jr.

Sci Transl Med. 2017 Jul 12;9(398). pii: eaal5272. doi: 10.1126/scitranslmed.aal5272.

3.

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.

Cho H, Du X, Rizzi JP, Liberzon E, Chakraborty AA, Gao W, Carvo I, Signoretti S, Bruick RK, Josey JA, Wallace EM, Kaelin WG.

Nature. 2016 Nov 3;539(7627):107-111. doi: 10.1038/nature19795. Epub 2016 Sep 5.

4.

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.

Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG Jr, Wei W.

Science. 2016 Aug 26;353(6302):929-32. doi: 10.1126/science.aad5755.

5.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr.

Cell. 2016 Apr 7;165(2):497. doi: 10.1016/j.cell.2016.03.037. No abstract available.

6.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr.

Cell. 2016 Feb 25;164(5):884-95. doi: 10.1016/j.cell.2016.02.006. Erratum in: Cell. 2016 Apr 7;165(2):497.

7.

Do changes in the c-MYC coding sequence contribute to tumorigenesis?

Chakraborty AA, Tansey WP.

Mol Cell Oncol. 2014 Oct 30;2(2):e965631. doi: 10.4161/23723548.2014.965631. eCollection 2015 Apr-Jun.

8.

A common functional consequence of tumor-derived mutations within c-MYC.

Chakraborty AA, Scuoppo C, Dey S, Thomas LR, Lorey SL, Lowe SW, Tansey WP.

Oncogene. 2015 Apr 30;34(18):2406-9. doi: 10.1038/onc.2014.186. Epub 2014 Jul 7.

9.

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q.

Genes Dev. 2014 Jul 1;28(13):1429-44. doi: 10.1101/gad.242131.114.

10.

Inference of cell cycle-dependent proteolysis by laser scanning cytometry.

Chakraborty AA, Tansey WP.

Exp Cell Res. 2009 Jun 10;315(10):1772-8. doi: 10.1016/j.yexcr.2009.01.011. Epub 2009 Jan 27.

11.

Adenoviral E1A function through Myc.

Chakraborty AA, Tansey WP.

Cancer Res. 2009 Jan 1;69(1):6-9. doi: 10.1158/0008-5472.CAN-08-3026. Review.

12.

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.

Tworkowski KA, Chakraborty AA, Samuelson AV, Seger YR, Narita M, Hannon GJ, Lowe SW, Tansey WP.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6103-8. doi: 10.1073/pnas.0802095105. Epub 2008 Apr 14.

13.
14.

Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein.

Gohil K, Schock BC, Chakraborty AA, Terasawa Y, Raber J, Farese RV Jr, Packer L, Cross CE, Traber MG.

Free Radic Biol Med. 2003 Dec 1;35(11):1343-54.

PMID:
14642382

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